RGD Reference Report - Elevated soluble intercellular adhesion molecule-1 levels in obesity: relationship to insulin resistance and tumor necrosis factor-alpha system activity.

General

Elevated soluble intercellular adhesion molecule-1 levels in obesity: relationship to insulin resistance and tumor necrosis factor-alpha system activity.
Authors:	Straczkowski, M Lewczuk, P Dzienis-Straczkowska, S Kowalska, I Stepien, A Kinalska, I
Citation:	Straczkowski M, etal., Metabolism. 2002 Jan;51(1):75-8.
RGD ID:	1625753
Pubmed:	PMID:11782876 (View Abstract at PubMed)
Intercellular adhesion molecule-1 (ICAM-1) is 1 of the possible factors linking obesity and diabetes with cardiovascular disease, however, the mechanism of the increase in ICAM-1 concentration in obesity remains unclear. Therefore, the aim of the present study was to assess plasma soluble ICAM-1 (sICAM-1) levels in obese subjects with normal glucose tolerance and to evaluate whether those levels may be related to insulin resistance and tumor necrosis factor-alpha (TNFalpha) system activity. The study was performed in 8 lean and 15 obese subjects. Anthropometric and biochemical parameters were measured, and insulin sensitivity was evaluated using the euglycemic hyperinsulinemic clamp technique (insulin infusion, 50 mU x kg(-1) x h(-1)). Obese subjects were markedly more hyperinsulinemic and insulin resistant and had higher plasma soluble TNF receptor 2 (sTNFR2) and sICAM-1 levels. sICAM-1 was related positively to body mass index (BMI), waist-to-hip ratio (WHR), percent of body fat, glycated hemoglobin (HbA(1c)), plasma insulin and triglycerides (TG), TNFalpha, and sTNFR2 and negatively to insulin sensitivity. Multiple regression analysis showed that only sTNFR2 and insulin sensitivity were independent predictors of sICAM-1 concentrations and were responsible for 66% of sICAM-1 variability. We conclude that an increase in plasma sICAM-1 concentration in obesity is related to TNFalpha system activation and insulin resistance.

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Term	Qualifier	Evidence	With	Reference	Notes	Source	Original Reference(s)
Insulin Resistance		IEP		1625753	associated with Obesity and protein:increased secretion:plasma (human)	RGD
Insulin Resistance		ISO	ICAM1 (Homo sapiens)	1625753; 1625753	associated with Obesity and protein:increased secretion:plasma (human)	RGD

Objects Annotated

Genes (Rattus norvegicus)

Icam1 (intercellular adhesion molecule 1)

Genes (Mus musculus)

Icam1 (intercellular adhesion molecule 1)

Genes (Homo sapiens)

ICAM1 (intercellular adhesion molecule 1)

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Elevated soluble intercellular adhesion molecule-1 levels in obesity: relationship to insulin resistance and tumor necrosis factor-alpha system activity.