RGD Reference Report - Dietary restriction suppresses inflammation and delays the onset of stroke in stroke-prone spontaneously hypertensive rats. - Rat Genome Database

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Dietary restriction suppresses inflammation and delays the onset of stroke in stroke-prone spontaneously hypertensive rats.

Authors: Chiba, T  Ezaki, O 
Citation: Chiba T and Ezaki O, Biochem Biophys Res Commun. 2010 Aug 13;399(1):98-103. Epub 2010 Jul 17.
RGD ID: 4145376
Pubmed: PMID:20643106   (View Abstract at PubMed)
DOI: DOI:10.1016/j.bbrc.2010.07.048   (Journal Full-text)

Subjects with high blood levels of inflammatory markers and patients with chronic inflammatory disorders are at high risk for stroke. Dietary restriction (DR) suppresses systemic inflammation to deter age-related chronic diseases. To examine whether DR delays the onset of stroke, 10-week-old stroke-prone spontaneously hypertensive rats (SHRSP) were assigned to either a control (ad libitum) or DR (50% diet of control) group, and day of stroke onset and lifespan were observed. DR markedly delayed the onset of stroke in SHRSP compared to control without affecting blood pressure. Day of stroke onset (median) in the control group was 34days, whereas it was 70days in the DR group. After 2weeks of DR and before the onset of stroke, plasma levels of interleukin-1beta (IL-1beta), tumor necrosis factor-alpha (TNF-alpha), and monocyte chemoattractant protein-1 (MCP-1) and their mRNA expression levels in adipose tissue were significantly lower in the DR rats than in the control rats. Intercellular adhesion molecule-1 (ICAM-1) and vascular cell adhesion molecule-1 (VCAM-1) mRNA expression levels in cerebrovascular endothelial cells (CVECs), and macrophage infiltration into brain were lower in the DR rats than in the control rats. IL-1beta and TNF-alpha treatment in CVECs increased MCP-1, C-reactive protein, ICAM-1, and VCAM-1 mRNA and their protein levels in vitro. In conclusion, suppression of inflammation in response to DR may lead to a delay in the onset of stroke independent of any effect on blood pressure in SHRSP.

Gene Ontology Annotations    Click to see Annotation Detail View

Biological Process
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
cellular response to interleukin-1  IEP 4145376 RGD 
cellular response to nutrient levels  IEP 4145376 RGD 

Objects Annotated

Genes (Rattus norvegicus)
Icam1  (intercellular adhesion molecule 1)


Additional Information