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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2857 Species: Rattus norvegicus RGD Object: Gene Symbol: Icam1 Name: intercellular adhesion molecule 1

Acc ID: CHEBI:28393 Term: beta-D-glucosamine Definition: A 2-amino-2-deoxy-D-glucopyranose that has formula C6H13NO5. CasRN: 3416-24-8 Chemical ID: MESH:D005944

Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.

Qualifier	Evidence	With	Reference	Source	Notes	Original Reference(s)
multiple interactions	ISO	RGD:69659	6480464	CTD	Alloxan inhibits the reaction [Glucosamine inhibits the reaction [CAP18 lipopolysaccharide-binding protein results in increased expression of ICAM1 protein]] Glucosamine inhibits the reaction [CAP18 lipopolysaccharide-binding protein results in increased expression of ICAM1 mRNA]	PMID:18949387
multiple interactions	ISO	RGD:69659	6480464	CTD	Glucosamine inhibits the reaction [IFNG promotes the reaction [TNF results in increased expression of ICAM1 protein]] Glucosamine inhibits the reaction [IL1B results in increased expression of ICAM1 protein] Glucosamine inhibits the reaction [TNF promotes the reaction [IL1B results in increased expression of ICAM1 protein]] Glucosamine inhibits the reaction [TNF promotes the reaction [IFNG results in increased expression of ICAM1 protein]] Glucosamine inhibits the reaction [IL1B promotes the reaction [TNF results in increased expression of ICAM1 protein]]	PMID:17238806 PMID:16822504
multiple interactions	ISO	RGD:69659	6480464	CTD	Glucosamine inhibits the reaction [IFNG results in increased expression of ICAM1 mRNA]	PMID:16431966
multiple interactions	ISO	RGD:69659	6480464	CTD	Glucosamine inhibits the reaction [IFNG results in increased expression of ICAM1 protein]	PMID:16431966 PMID:16822504 PMID:17238806
multiple interactions	ISO	RGD:69659	6480464	CTD	Glucosamine inhibits the reaction [IL1B promotes the reaction [TNF results in increased expression of ICAM1 protein]] Glucosamine inhibits the reaction [TNF promotes the reaction [IFNG results in increased expression of ICAM1 protein]] Glucosamine inhibits the reaction [IFNG promotes the reaction [TNF results in increased expression of ICAM1 protein]] Glucosamine inhibits the reaction [IL1B results in increased expression of ICAM1 protein] Glucosamine inhibits the reaction [TNF promotes the reaction [IL1B results in increased expression of ICAM1 protein]]	PMID:16822504 PMID:17238806
multiple interactions	ISO	RGD:69659	6480464	CTD	Glucosamine inhibits the reaction [IL1B results in increased expression of ICAM1 mRNA] Glucosamine inhibits the reaction [[IL6 co-treated with TNF] results in increased expression of ICAM1 protein] Glucosamine inhibits the reaction [IL6 results in increased expression of ICAM1 protein]	PMID:16822504
multiple interactions	ISO	RGD:69659	6480464	CTD	Glucosamine inhibits the reaction [TNF results in increased expression of ICAM1 mRNA]	PMID:19020780 PMID:16431966 PMID:17238806
multiple interactions	ISO	RGD:69659	6480464	CTD	Glucosamine inhibits the reaction [TNF results in increased expression of ICAM1 protein]	PMID:17238806 PMID:16822504 PMID:19020780 PMID:16431966
multiple interactions	EXP		6480464	CTD	Glucosamine inhibits the reaction [Lipopolysaccharides results in increased expression of ICAM1 protein]	PMID:19098112
decreases activity	EXP		6480464	CTD	Glucosamine results in decreased activity of ICAM1 protein	PMID:19098112
multiple interactions	ISO	RGD:69659	6480464	CTD	Glucosamine inhibits the reaction [IFNG results in increased expression of ICAM1 protein]	PMID:17238806 PMID:16822504 PMID:16431966
multiple interactions	ISO	RGD:69659	6480464	CTD	Glucosamine inhibits the reaction [TNF results in increased expression of ICAM1 mRNA]	PMID:16431966 PMID:19020780 PMID:17238806
multiple interactions	ISO	RGD:69659	6480464	CTD	Glucosamine inhibits the reaction [IFNG results in increased expression of ICAM1 protein]	PMID:16822504 PMID:16431966 PMID:17238806
multiple interactions	ISO	RGD:69659	6480464	CTD	Glucosamine inhibits the reaction [TNF results in increased expression of ICAM1 protein]	PMID:16822504 PMID:17238806 PMID:19020780 PMID:16431966
multiple interactions	ISO	RGD:69659	6480464	CTD	Glucosamine inhibits the reaction [TNF results in increased expression of ICAM1 mRNA]	PMID:17238806 PMID:16431966 PMID:19020780
multiple interactions	ISO	RGD:69659	6480464	CTD	Glucosamine inhibits the reaction [TNF results in increased expression of ICAM1 protein]	PMID:17238806 PMID:19020780 PMID:16431966 PMID:16822504
multiple interactions	ISO	RGD:69659	6480464	CTD	Glucosamine inhibits the reaction [IFNG results in increased expression of ICAM1 protein]	PMID:16431966 PMID:17238806 PMID:16822504
multiple interactions	ISO	RGD:69659	6480464	CTD	Glucosamine inhibits the reaction [TNF results in increased expression of ICAM1 mRNA]	PMID:17238806 PMID:19020780 PMID:16431966
multiple interactions	ISO	RGD:69659	6480464	CTD	Glucosamine inhibits the reaction [TNF results in increased expression of ICAM1 protein]	PMID:17238806 PMID:16822504 PMID:16431966 PMID:19020780
multiple interactions	ISO	RGD:69659	6480464	CTD	Glucosamine inhibits the reaction [TNF results in increased expression of ICAM1 mRNA]	PMID:16431966 PMID:17238806 PMID:19020780
multiple interactions	ISO	RGD:69659	6480464	CTD	Glucosamine inhibits the reaction [TNF results in increased expression of ICAM1 protein]	PMID:16431966 PMID:16822504 PMID:17238806 PMID:19020780