Cav1 (caveolin 1) - Rat Genome Database

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Gene: Cav1 (caveolin 1) Rattus norvegicus
Analyze
Symbol: Cav1
Name: caveolin 1
RGD ID: 2280
Description: Enables several functions, including enzyme binding activity; syntaxin binding activity; and transmembrane transporter binding activity. Involved in several processes, including negative regulation of cation transmembrane transport; positive regulation of cellular component organization; and regulation of endothelial cell proliferation. Located in several cellular components, including basal plasma membrane; focal adhesion; and peroxisomal membrane. Part of protein-containing complex. Biomarker of several diseases, including artery disease (multiple); brain ischemia (multiple); obesity; osteoarthritis; and sciatic neuropathy. Human ortholog(s) of this gene implicated in several diseases, including breast cancer (multiple); lipodystrophy (multiple); primary open angle glaucoma; primary pulmonary hypertension; and systemic scleroderma (multiple). Orthologous to human CAV1 (caveolin 1); PARTICIPATES IN transforming growth factor-beta signaling pathway; insulin signaling pathway; platelet-derived growth factor signaling pathway; INTERACTS WITH 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine; 2-ethoxyethanol.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: Cav; caveolin; caveolin 1, caveolae protein; Caveolin caveolae protein 22 kDa; caveolin, caveolae protein 1; Caveolin, caveolae protein, 22 kDa; caveolin-1; caveolin-like; LOC100362870; MGC187299
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Is Marker For: Strains:   BB/OK  
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8446,606,538 - 46,639,616 (+)NCBIGRCr8
mRatBN7.2445,640,624 - 45,673,708 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl445,634,918 - 45,673,705 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx450,634,317 - 50,667,383 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0446,555,310 - 46,588,376 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0444,969,814 - 45,002,892 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0444,597,123 - 44,630,206 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl444,597,123 - 44,630,200 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0445,203,494 - 45,236,461 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4442,956,102 - 42,989,057 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1443,098,177 - 43,130,873 (+)NCBI
Celera440,918,628 - 40,949,677 (+)NCBICelera
Cytogenetic Map4q22NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


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Object Symbol
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Original Reference(s)
Cav1Ratabdominal aortic aneurysm  ISOCav1 (Mus musculus)8661789associated with HypertensionRGD 
Cav1Ratacoustic neuroma  ISOCAV1 (Homo sapiens)8661782 RGD 
Cav1RatAcute Lung Injury treatmentIEP 10045573 RGD 
Cav1RatAlcoholic Liver Diseases treatmentIEP 8662277 RGD 
Cav1Ratatherosclerosis treatmentIEP 8662275 RGD 
Cav1Ratbrain ischemia  IEP 1581152 RGD 
Cav1Ratbreast cancer disease_progressionISOCAV1 (Homo sapiens)8661766 RGD 
Cav1Ratbreast cancer  ISOCAV1 (Homo sapiens)2289105DNA more ...RGD 
Cav1Ratbreast cancer no_associationISOCAV1 (Homo sapiens)8661769DNA:SNPs: :multipleRGD 
Cav1Ratbreast cancer  ISOCAV1 (Homo sapiens)8661769DNA:SNPs: :14713G>A (rs3807987), 29107T>A (rs7804372) (human)RGD 
Cav1Ratbreast carcinoma  ISOCAV1 (Homo sapiens)8661775DNA:missense mutation: :p.P132L (human)RGD 
Cav1Ratbreast carcinoma  ISOCAV1 (Homo sapiens)2289101protein:increased expression:breastRGD 
Cav1RatCardiomegaly  IEP 2289120protein:increased expression:aortaRGD 
Cav1RatDermal Fibrosis  ISOCav1 (Mus musculus)8661773 RGD 
Cav1RatDiabetic Nephropathies  ISOCAV1 (Homo sapiens)401851916mRNA:increased expression:nephron tubule (human)RGD 
Cav1Ratdiabetic neuropathy  ISOCav1 (Mus musculus)8661787associated with Diabetes Mellitus and ExperimentalRGD 
Cav1Ratdiffuse scleroderma susceptibilityISOCAV1 (Homo sapiens)8661768DNA:SNPs:intron more ...RGD 
Cav1Ratdiffuse scleroderma no_associationISOCAV1 (Homo sapiens)8661768DNA:SNPs:enhancer and intron:multipleRGD 
Cav1Ratexfoliation syndrome no_associationISOCAV1 (Homo sapiens)8661783DNA:SNP:promoter:rs4236601 (human)RGD 
Cav1RatExperimental Autoimmune Myocarditis  IEP 1625364 RGD 
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Original Reference(s)
Cav1Ratcongenital generalized lipodystrophy type 3  ISOCAV1 (Homo sapiens)8554872ClinVar Annotator: match by term: Congenital generalized lipodystrophy type 3ClinVarPMID:18211975 more ...
Cav1Ratcystic fibrosis  ISOCAV1 (Homo sapiens)8554872ClinVar Annotator: match by term: Cystic fibrosisClinVarPMID:11781704 more ...
Cav1Ratdiabetes mellitus  ISOCAV1 (Homo sapiens)8554872ClinVar Annotator: match by term: Monogenic diabetesClinVarPMID:25741868 and PMID:28492532
Cav1RatFamilial Partial Lipodystrophy Type 7  ISOCAV1 (Homo sapiens)8554872ClinVar Annotator: match by term: Partial lipodystrophy more ...ClinVarPMID:11739396 more ...
Cav1Ratgenetic disease  ISOCAV1 (Homo sapiens)8554872ClinVar Annotator: match by term: Inborn genetic diseasesClinVarPMID:25356970 more ...
Cav1Ratpleomorphic xanthoastrocytoma  ISOCAV1 (Homo sapiens)8554872ClinVar Annotator: match by term: Pleomorphic xanthoastrocytomaClinVarPMID:28299358
Cav1Ratprimary pulmonary hypertension 3  ISOCAV1 (Homo sapiens)8554872ClinVar Annotator: match by term: Pulmonary hypertension more ...ClinVarPMID:22474227 more ...
Cav1RatPulmonary Arterial Hypertension  ISOCAV1 (Homo sapiens)8554872ClinVar Annotator: match by term: Pulmonary arterial hypertension associated with congenital heart diseaseClinVarPMID:25741868 more ...
Cav1RatRadioulnar Synostosis with Amegakaryocytic Thrombocytopenia 2  ISOCAV1 (Homo sapiens)8554872ClinVar Annotator: match by term: Radioulnar synostosis with amegakaryocytic thrombocytopenia 2ClinVarPMID:25741868 and PMID:38177409
Cav1Ratrenal cell carcinoma  ISOCAV1 (Homo sapiens)8554872ClinVar Annotator: match by term: Renal cell carcinomaClinVarPMID:28492532
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Cav1Ratatrial fibrillation  ISOCAV1 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:20062060 more ...
Cav1Ratbasal cell carcinoma  ISOCAV1 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:36428691
Cav1RatBreast Neoplasms  ISOCAV1 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:19234134 more ...
Cav1RatCarcinogenesis  ISOCAV1 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:29247004
Cav1RatCardiomegaly  ISOCAV1 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:17487232
Cav1Ratcongenital generalized lipodystrophy type 3  ISOCAV1 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTD 
Cav1RatExperimental Diabetes Mellitus  ISOCAV1 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:18266981
Cav1RatExperimental Liver Cirrhosis  ISOCAV1 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:25380136
Cav1Ratfamilial partial lipodystrophy  ISOCAV1 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:19793595
Cav1Rathypertension  ISOCAV1 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:1798635
Cav1RatLung Neoplasms  ISOCAV1 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:29247004
Cav1RatNeoplasm Metastasis  ISOCAV1 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:20562527
Cav1Ratopen-angle glaucoma  ISOCAV1 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:20835238
Cav1Ratovarian carcinoma  ISOCAV1 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:35622184
Cav1RatOvarian Neoplasms  ISOCAV1 (Homo sapiens)11554173CTD Direct Evidence: therapeuticCTDPMID:15674352
Cav1Ratprimary pulmonary hypertension  ISOCAV1 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTD 
Cav1RatProstatic Neoplasms  ISOCAV1 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:15948133 and PMID:22159333
Cav1Ratpulmonary fibrosis  ISOCAV1 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:36053221
Cav1Ratsilicosis  ISOCAV1 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:36053221
Cav1RatStevens-Johnson syndrome  ISOCAV1 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:25811541
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Original Reference(s)
Cav1RatAlzheimer's disease  ISSCav1 (Mus musculus)13592920OMIM:104300 more ...MouseDO 
Cav1Ratbreast cancer  ISSCav1 (Mus musculus)13592920OMIM:114480MouseDO 
Cav1Rathypertrophic cardiomyopathy  ISSCav1 (Mus musculus)13592920 MouseDO 

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Original Reference(s)
Cav1Rat(-)-anisomycin multiple interactionsISOCAV1 (Homo sapiens)6480464wogonin inhibits the reaction [Anisomycin results in increased phosphorylation of CAV1 protein]CTDPMID:23246481
Cav1Rat(-)-anisomycin increases phosphorylationISOCAV1 (Homo sapiens)6480464Anisomycin results in increased phosphorylation of CAV1 proteinCTDPMID:23246481
Cav1Rat(1->4)-beta-D-glucan multiple interactionsISOCav1 (Mus musculus)6480464[perfluorooctane sulfonic acid co-treated with Cellulose] results in increased expression of CAV1 mRNACTDPMID:36331819
Cav1Rat(R,R,R)-alpha-tocopherol multiple interactionsISOCAV1 (Homo sapiens)6480464alpha-Tocopherol inhibits the reaction [Lysophosphatidylcholines results in increased expression of CAV1 mRNA]CTDPMID:27257344
Cav1Rat1,1-bis(2-aminoethyl)-2-hydroxy-3-oxotriazane increases expressionISOCAV1 (Homo sapiens)64804642 and 2'-(hydroxynitrosohydrazono)bis-ethanamine results in increased expression of CAV1 proteinCTDPMID:19706615
Cav1Rat1,1-bis(2-aminoethyl)-2-hydroxy-3-oxotriazane multiple interactionsISOCAV1 (Homo sapiens)64804642 more ...CTDPMID:19706615
Cav1Rat1,2-dimethylhydrazine decreases expressionISOCav1 (Mus musculus)64804641 and 2-Dimethylhydrazine results in decreased expression of CAV1 mRNACTDPMID:22206623
Cav1Rat1,2-dimethylhydrazine multiple interactionsISOCav1 (Mus musculus)6480464[1 and 2-Dimethylhydrazine co-treated with Folic Acid] results in decreased expression of CAV1 mRNACTDPMID:22206623
Cav1Rat13-HPODE increases expressionISOCAV1 (Homo sapiens)648046413-hydroperoxy-9 and 11-octadecadienoic acid results in increased expression of CAV1 mRNACTDPMID:27257344
Cav1Rat17beta-estradiol multiple interactionsISOCAV1 (Homo sapiens)6480464[Estradiol co-treated with Tetrachlorodibenzodioxin] results in decreased expression of CAV1 mRNA and Estradiol inhibits the reaction [Fulvestrant results in decreased expression of CAV1 mRNA]CTDPMID:19619570 and PMID:31646340
Cav1Rat17beta-estradiol multiple interactionsEXP 6480464[Estradiol co-treated with bisphenol A] results in decreased expression of CAV1 mRNACTDPMID:35700937
Cav1Rat17beta-estradiol increases expressionISOCAV1 (Homo sapiens)6480464Estradiol results in increased expression of CAV1 mRNACTDPMID:31646340
Cav1Rat17beta-estradiol decreases expressionEXP 6480464Estradiol results in decreased expression of CAV1 mRNACTDPMID:27174447
Cav1Rat17beta-estradiol increases phosphorylationISOCAV1 (Homo sapiens)6480464Estradiol results in increased phosphorylation of CAV1 proteinCTDPMID:18296501
Cav1Rat17beta-estradiol decreases expressionISOCAV1 (Homo sapiens)6480464Estradiol results in decreased expression of CAV1 mRNACTDPMID:19619570
Cav1Rat2,3,7,8-tetrachlorodibenzodioxine multiple interactionsISOCAV1 (Homo sapiens)6480464[Estradiol co-treated with Tetrachlorodibenzodioxin] results in decreased expression of CAV1 mRNACTDPMID:19619570
Cav1Rat2,3,7,8-tetrachlorodibenzodioxine increases expressionISOCav1 (Mus musculus)6480464Tetrachlorodibenzodioxin results in increased expression of CAV1 mRNACTDPMID:28238261
Cav1Rat2,3,7,8-tetrachlorodibenzodioxine multiple interactionsISOCav1 (Mus musculus)6480464[TIPARP gene mutant form results in increased susceptibility to Tetrachlorodibenzodioxin] which results in increased expression of CAV1 mRNACTDPMID:25975270
Cav1Rat2,3,7,8-tetrachlorodibenzodioxine decreases expressionISOCAV1 (Homo sapiens)6480464Tetrachlorodibenzodioxin results in decreased expression of CAV1 mRNACTDPMID:19619570 more ...
Cav1Rat2,3,7,8-tetrachlorodibenzodioxine increases expressionEXP 6480464Tetrachlorodibenzodioxin results in increased expression of CAV mRNACTDPMID:15358164

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Biological Process
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Original Reference(s)
Cav1Ratangiogenesis acts_upstream_of_or_withinISOCav1 (Mus musculus)1624291MGI:95516 PMID:12759260RGDPMID:12759260
Cav1Ratangiogenesis acts_upstream_of_or_withinIEAUniProtKB:P49817 and ensembl:ENSMUSP000000077991600115GO_REF:0000107EnsemblGO_REF:0000107
Cav1Ratangiotensin-activated signaling pathway involved_inIEAUniProtKB:P49817 and ensembl:ENSMUSP000000077991600115GO_REF:0000107EnsemblGO_REF:0000107
Cav1Ratangiotensin-activated signaling pathway involved_inISOCav1 (Mus musculus)1624291UniProtKB:P09470 and PMID:25017399RGDPMID:25017399
Cav1Ratanimal organ regeneration  IEP 6784521 RGD 
Cav1Ratapoptotic signaling pathway involved_inISOCAV1 (Homo sapiens)1624291 PMID:21382479RGDPMID:21382479
Cav1Ratapoptotic signaling pathway involved_inIEAUniProtKB:Q03135 and ensembl:ENSP000003391911600115GO_REF:0000107EnsemblGO_REF:0000107
Cav1Ratbasement membrane organization acts_upstream_of_or_withinISOCav1 (Mus musculus)1624291MGI:2180364 PMID:11884617RGDPMID:11884617
Cav1Ratbasement membrane organization acts_upstream_of_or_withinIEAUniProtKB:P49817 and ensembl:ENSMUSP000000077991600115GO_REF:0000107EnsemblGO_REF:0000107
Cav1Ratcalcium ion homeostasis acts_upstream_of_or_withinISOCav1 (Mus musculus)1624291MGI:2654177 PMID:12651616RGDPMID:12651616
Cav1Ratcalcium ion homeostasis acts_upstream_of_or_withinIEAUniProtKB:P49817 and ensembl:ENSMUSP000000077991600115GO_REF:0000107EnsemblGO_REF:0000107
Cav1Ratcalcium ion transport acts_upstream_of_or_withinISOCav1 (Mus musculus)1624291MGI:2154537 PMID:17416589RGDPMID:17416589
Cav1Ratcalcium ion transport acts_upstream_of_or_withinIEAUniProtKB:P49817 and ensembl:ENSMUSP000000077991600115GO_REF:0000107EnsemblGO_REF:0000107
Cav1Ratcanonical Wnt signaling pathway involved_inIEAUniProtKB:Q03135 and ensembl:ENSP000003391911600115GO_REF:0000107EnsemblGO_REF:0000107
Cav1Ratcanonical Wnt signaling pathway involved_inISOCAV1 (Homo sapiens)1624291 PMID:16890161RGDPMID:16890161
Cav1Ratcaveola assembly involved_inIEAUniProtKB:Q03135 and ensembl:ENSP000003391911600115GO_REF:0000107EnsemblGO_REF:0000107
Cav1Ratcaveola assembly acts_upstream_of_or_withinIEAUniProtKB:P49817 and ensembl:ENSMUSP000000077991600115GO_REF:0000107EnsemblGO_REF:0000107
Cav1Ratcaveola assembly acts_upstream_of_or_withinISOCav1 (Mus musculus)1624291MGI:2180372 PMID:11884617 and PMID:12759260RGDPMID:11884617 and PMID:12759260
Cav1Ratcaveola assembly involved_inIBAMGI:102709 more ...1600115GO_REF:0000033GO_CentralGO_REF:0000033
Cav1Ratcaveola assembly involved_inIEAInterPro:IPR0016121600115GO_REF:0000002InterProGO_REF:0000002
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Cellular Component
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Original Reference(s)
Cav1Ratacrosomal membrane located_inIEAUniProtKB:P49817 and ensembl:ENSMUSP000000077991600115GO_REF:0000107EnsemblGO_REF:0000107
Cav1Ratacrosomal membrane located_inISOCav1 (Mus musculus)1624291 PMID:11784086RGDPMID:11784086
Cav1Ratapical plasma membrane located_inISOCAV1 (Homo sapiens) and UniProtKB:Q03135-11624291 PMID:16904002RGDPMID:16904002
Cav1Ratbasal plasma membrane  IDA 1582171 RGD 
Cav1Ratbasolateral plasma membrane located_inISOCAV1 (Homo sapiens) and UniProtKB:Q03135-11624291 PMID:16904002RGDPMID:16904002
Cav1Ratcaveola  IDA 1601538 RGD 
Cav1Ratcaveola  IDA 1582162 RGD 
Cav1Ratcaveola located_inIEAUniProtKB:Q03135 and ensembl:ENSP000003391911600115GO_REF:0000107EnsemblGO_REF:0000107
Cav1Ratcaveola located_inIEAUniProtKB:P49817 and ensembl:ENSMUSP000000077991600115GO_REF:0000107EnsemblGO_REF:0000107
Cav1Ratcaveola located_inIEAUniProtKB-SubCell:SL-00351600115GO_REF:0000044UniProtGO_REF:0000044
Cav1Ratcaveola located_inISOCAV1 (Sus scrofa)1624291 PMID:15140193RGDPMID:15140193
Cav1Ratcaveola located_inISOCAV1 (Canis lupus familiaris)1624291 PMID:8385608RGDPMID:8385608
Cav1Ratcaveola located_inISOCav1 (Mus musculus)1624291 PMID:11884617 more ...RGDPMID:11884617 more ...
Cav1Ratcaveola located_inIEAARBA:ARBA000284051600115GO_REF:0000117UniProtGO_REF:0000117
Cav1Ratcaveola located_inISSUniProtKB:Q031351600115GO_REF:0000024UniProtGO_REF:0000024
Cav1Ratcaveola located_inIDA 2326037PMID:19931615UniProt 
Cav1Ratcaveola located_inISOCAV1 (Homo sapiens)1624291 PMID:15219854 more ...RGDPMID:15219854 more ...
Cav1Ratcaveola located_inIDA 8554773PMID:18054955MGI 
Cav1Ratcaveolar macromolecular signaling complex part_ofIEAUniProtKB:P49817 and ensembl:ENSMUSP000000077991600115GO_REF:0000107EnsemblGO_REF:0000107
Cav1Ratcaveolar macromolecular signaling complex part_ofISOCav1 (Mus musculus)1624291 PMID:11884617RGDPMID:11884617
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Molecular Function
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Cav1RatATPase binding enablesISOCAV1 (Homo sapiens)1624291UniProtKB:P55072 and PMID:24089527RGDPMID:24089527
Cav1RatATPase binding enablesIEAUniProtKB:Q03135 and ensembl:ENSP000003391911600115GO_REF:0000107EnsemblGO_REF:0000107
Cav1Ratenzyme binding enablesISOCAV1 (Homo sapiens)1624291UniProtKB:Q16647 and PMID:20122998RGDPMID:20122998
Cav1Ratenzyme binding enablesIEAUniProtKB:Q03135 and ensembl:ENSP000003391911600115GO_REF:0000107EnsemblGO_REF:0000107
Cav1Ratidentical protein binding enablesIEAUniProtKB:P49817 and ensembl:ENSMUSP000000077991600115GO_REF:0000107EnsemblGO_REF:0000107
Cav1Ratidentical protein binding enablesISOCav1 (Mus musculus)1624291PR:P49817 PMID:8552590RGDPMID:8552590
Cav1Ratidentical protein binding enablesISOCAV1 (Homo sapiens)1624291UniProtKB:Q03135 and PMID:25006397RGDPMID:25006397
Cav1Ratidentical protein binding enablesIEAUniProtKB:Q03135 and ensembl:ENSP000003391911600115GO_REF:0000107EnsemblGO_REF:0000107
Cav1Ratinward rectifier potassium channel inhibitor activity enablesIEAUniProtKB:Q03135 and ensembl:ENSP000003391911600115GO_REF:0000107EnsemblGO_REF:0000107
Cav1Ratinward rectifier potassium channel inhibitor activity enablesISOCAV1 (Homo sapiens)1624291 PMID:18923542RGDPMID:18923542
Cav1Ratkinase binding  IPIHk1 (Rattus norvegicus)1601538 RGD 
Cav1Ratmolecular adaptor activity enablesISOCav1 (Mus musculus)1624291 PMID:25017399RGDPMID:25017399
Cav1Ratmolecular adaptor activity enablesIBAMGI:102709 more ...1600115GO_REF:0000033GO_CentralGO_REF:0000033
Cav1Ratmolecular adaptor activity enablesIEAUniProtKB:P49817 and ensembl:ENSMUSP000000077991600115GO_REF:0000107EnsemblGO_REF:0000107
Cav1Ratnitric-oxide synthase binding enablesISOCAV1 (Homo sapiens)1624291UniProtKB:P29474 and PMID:12852865RGDPMID:12852865
Cav1Ratnitric-oxide synthase binding  IPINos3 (Rattus norvegicus)1600213 RGD 
Cav1Ratnitric-oxide synthase binding enablesISOCav1 (Mus musculus)1624291UniProtKB:P70313 and PMID:25017399RGDPMID:25017399
Cav1Ratnitric-oxide synthase binding enablesIEAUniProtKB:P49817 and ensembl:ENSMUSP000000077991600115GO_REF:0000107EnsemblGO_REF:0000107
Cav1Ratnitric-oxide synthase binding enablesIEAUniProtKB:Q03135 and ensembl:ENSP000003391911600115GO_REF:0000107EnsemblGO_REF:0000107
Cav1Ratnitric-oxide synthase inhibitor activity enablesISOCAV1 (Homo sapiens)1624291 PMID:9325253 and PMID:9712842RGDPMID:9325253 and PMID:9712842
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RGD Manual Annotations


  
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Original Reference(s)
Cav1Ratreverse cholesterol transport pathway  ISOCAV1 (Homo sapiens)1600654 RGD 
Cav1Ratreverse cholesterol transport pathway  TAS 1600659 RGD 
Cav1Rattransforming growth factor-beta signaling pathway  IMP 151347449 RGD 

Imported Annotations - KEGG (archival)

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Cav1Ratendocytosis pathway  IEA 6907045 KEGGrno:04144
Cav1Ratmyocarditis pathway  IEA 6907045 KEGGrno:05416

Imported Annotations - PID (archival)


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Reference Title
Reference Citation
1. Global gene expression profiling and tissue microarray reveal novel candidate genes and down-regulation of the tumor suppressor gene CAV1 in sporadic vestibular schwannomas. Aarhus M, etal., Neurosurgery. 2010 Oct;67(4):998-1019; discussion 1019. doi: 10.1227/NEU.0b013e3181ec7b71.
2. Lack of association of SNP rs4236601 near CAV1 and CAV2 with POAG in a Saudi cohort. Abu-Amero KK, etal., Mol Vis. 2012;18:1960-5. Epub 2012 Jul 18.
3. Caveolin-1 assembles type 1 inositol 1,4,5-trisphosphate receptors and canonical transient receptor potential 3 channels into a functional signaling complex in arterial smooth muscle cells. Adebiyi A, etal., J Biol Chem. 2011 Feb 11;286(6):4341-8. Epub 2010 Nov 23.
4. Increased expression of caveolin-1 and -2 in the hearts of Lewis rats with experimental autoimmune myocarditis. Ahn M, etal., Autoimmunity. 2006 Sep;39(6):489-95.
5. Contribution of caveolin-1 to ventricular nitric oxide in age-related adaptation to hypovolemic state. Arreche ND, etal., Regul Pept. 2012 Nov 10;179(1-3):43-9. doi: 10.1016/j.regpep.2012.08.002. Epub 2012 Sep 3.
6. Downmodulation of caveolin-1 expression in human ovarian carcinoma is directly related to alpha-folate receptor overexpression. Bagnoli M, etal., Oncogene. 2000 Sep 28;19(41):4754-63.
7. Effect of insulin on caveolin-enriched membrane domains in rat liver. Balbis A, etal., J Biol Chem. 2004 Sep 17;279(38):39348-57. Epub 2004 Jul 12.
8. Cell selective glucocorticoid induction of caveolin-1 and caveolae in differentiating pulmonary alveolar epithelial cell cultures. Barar J, etal., Biochem Biophys Res Commun. 2007 Jul 27;359(2):360-6. Epub 2007 May 24.
9. Opposite pattern of MDR1 and caveolin-1 gene expression in human atherosclerotic lesions and proliferating human smooth muscle cells. Batetta B, etal., Cell Mol Life Sci. 2001 Jul;58(8):1113-20.
10. Integrins regulate opioid receptor signaling in trigeminal ganglion neurons. Berg KA, etal., Neuroscience. 2007 Feb 9;144(3):889-97. Epub 2006 Dec 8.
11. Caveolin-1 interacts with 5-HT2A serotonin receptors and profoundly modulates the signaling of selected Galphaq-coupled protein receptors. Bhatnagar A, etal., J Biol Chem. 2004 Aug 13;279(33):34614-23. Epub 2004 Jun 9.
12. Ruscogenin attenuates monocrotaline-induced pulmonary hypertension in rats. Bi LQ, etal., Int Immunopharmacol. 2013 May;16(1):7-16. doi: 10.1016/j.intimp.2013.03.010. Epub 2013 Mar 26.
13. Caveolin-1/PTRF upregulation constitutes a mechanism for mediating p53-induced cellular senescence: implications for evidence-based therapy of delayed wound healing in diabetes. Bitar MS, etal., Am J Physiol Endocrinol Metab. 2013 Oct 15;305(8):E951-63. doi: 10.1152/ajpendo.00189.2013. Epub 2013 Aug 13.
14. Downregulation and altered spatial pattern of caveolin-1 in chronic plaque psoriasis. Campbell L, etal., Br J Dermatol. 2002 Oct;147(4):701-9.
15. Choroid plexus megalin is involved in neuroprotection by serum insulin-like growth factor I. Carro E, etal., J Neurosci. 2005 Nov 23;25(47):10884-93. doi: 10.1523/JNEUROSCI.2909-05.2005.
16. Evidence for Na+/Ca2+ exchanger 1 association with caveolin-1 and -2 in C6 glioma cells. Cha SH, etal., IUBMB Life. 2004 Oct;56(10):621-7.
17. Cellular localization and interaction of ABCA1 and caveolin-1 in aortic endothelial cells after HDL incubation. Chao WT, etal., Biochem Biophys Res Commun. 2005 Jul 8;332(3):743-9.
18. Caveolae: biochemical analysis. Chatenay-Rivauday C, etal., Mol Biol Rep. 2004 Jun;31(2):67-84.
19. Mutational, epigenetic and expressional analyses of caveolin-1 gene in breast cancers. Chen ST, etal., Int J Mol Med. 2004 Oct;14(4):577-82.
20. Serotonin inhibits voltage-gated K+ currents in pulmonary artery smooth muscle cells: role of 5-HT2A receptors, caveolin-1, and KV1.5 channel internalization. Cogolludo A, etal., Circ Res. 2006 Apr 14;98(7):931-8. Epub 2006 Mar 9.
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PMID:7568142   PMID:8385608   PMID:8552590   PMID:9008709   PMID:9148942   PMID:9361015   PMID:10197531   PMID:10460238   PMID:10631317   PMID:10787428   PMID:10816572   PMID:11294831  
PMID:11316799   PMID:11707266   PMID:11784086   PMID:11865038   PMID:11884617   PMID:12091389   PMID:12138167   PMID:12177436   PMID:12388077   PMID:12388596   PMID:12388746   PMID:12477932  
PMID:12562842   PMID:12633858   PMID:12651616   PMID:12743374   PMID:12759260   PMID:12832401   PMID:12852865   PMID:12927782   PMID:14559243   PMID:14581507   PMID:14600260   PMID:14681230  
PMID:14705150   PMID:14991836   PMID:15007081   PMID:15072971   PMID:15140193   PMID:15164767   PMID:15184077   PMID:15219810   PMID:15219854   PMID:15226268   PMID:15511630   PMID:15640522  
PMID:15657086   PMID:15703204   PMID:15829407   PMID:15863835   PMID:15968633   PMID:16332692   PMID:16380094   PMID:16405917   PMID:16513830   PMID:16565301   PMID:16601228   PMID:16603689  
PMID:16645331   PMID:16672766   PMID:16676355   PMID:16731532   PMID:16733664   PMID:16782699   PMID:16890161   PMID:17010968   PMID:17069850   PMID:17098833   PMID:17200204   PMID:17202321  
PMID:17287217   PMID:17326770   PMID:17349656   PMID:17375463   PMID:17416589   PMID:17431219   PMID:17464513   PMID:17482312   PMID:17684756   PMID:17687559   PMID:17848177   PMID:17982011  
PMID:18079116   PMID:18081315   PMID:18364076   PMID:18485890   PMID:18504258   PMID:18511851   PMID:18657009   PMID:18757837   PMID:18794328   PMID:18951881   PMID:19013132   PMID:19052258  
PMID:19067793   PMID:19275878   PMID:19369293   PMID:19457127   PMID:19508446   PMID:19525939   PMID:19657060   PMID:19713536   PMID:19965594   PMID:20025630   PMID:20044047   PMID:20101198  
PMID:20122998   PMID:20299334   PMID:20407877   PMID:20444327   PMID:20501440   PMID:20553910   PMID:20584649   PMID:20605793   PMID:20682791   PMID:20724702   PMID:21036148   PMID:21047970  
1 to 10 of 20 rows



Cav1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8446,606,538 - 46,639,616 (+)NCBIGRCr8
mRatBN7.2445,640,624 - 45,673,708 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl445,634,918 - 45,673,705 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx450,634,317 - 50,667,383 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0446,555,310 - 46,588,376 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0444,969,814 - 45,002,892 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0444,597,123 - 44,630,206 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl444,597,123 - 44,630,200 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0445,203,494 - 45,236,461 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4442,956,102 - 42,989,057 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1443,098,177 - 43,130,873 (+)NCBI
Celera440,918,628 - 40,949,677 (+)NCBICelera
Cytogenetic Map4q22NCBI
CAV1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh387116,525,009 - 116,561,185 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl7116,524,994 - 116,561,179 (+)EnsemblGRCh38hg38GRCh38
GRCh377116,165,063 - 116,201,239 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 367115,952,075 - 115,988,466 (+)NCBINCBI36Build 36hg18NCBI36
Build 347115,758,789 - 115,795,181NCBI
Celera7110,972,249 - 111,008,654 (+)NCBICelera
Cytogenetic Map7q31.2NCBI
HuRef7110,530,835 - 110,566,784 (+)NCBIHuRef
CHM1_17116,098,482 - 116,134,827 (+)NCBICHM1_1
T2T-CHM13v2.07117,840,041 - 117,876,175 (+)NCBIT2T-CHM13v2.0
CRA_TCAGchr7v27115,560,275 - 115,596,679 (+)NCBI
Cav1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39617,306,387 - 17,341,323 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl617,306,334 - 17,341,451 (+)EnsemblGRCm39 Ensembl
GRCm38617,306,335 - 17,341,328 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl617,306,335 - 17,341,452 (+)EnsemblGRCm38mm10GRCm38
MGSCv37617,256,370 - 17,291,324 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36617,256,370 - 17,291,324 (+)NCBIMGSCv36mm8
Celera617,378,835 - 17,414,670 (+)NCBICelera
Cytogenetic Map6A2NCBI
cM Map67.73NCBI
Cav1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495543222,258,250 - 22,292,403 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495543222,258,262 - 22,292,403 (+)NCBIChiLan1.0ChiLan1.0
CAV1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v26153,356,633 - 153,393,045 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan175,367,106 - 5,403,301 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v07108,497,125 - 108,533,090 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.17121,193,678 - 121,229,655 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl7121,193,424 - 121,229,655 (+)Ensemblpanpan1.1panPan2
CAV1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11455,458,934 - 55,494,563 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1455,461,048 - 55,492,935 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1454,856,462 - 54,888,069 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01455,500,946 - 55,536,541 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1455,503,040 - 55,536,538 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11455,530,973 - 55,562,566 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01455,219,411 - 55,251,015 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01455,590,528 - 55,622,125 (+)NCBIUU_Cfam_GSD_1.0
Cav1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440511844,152,891 - 44,185,619 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365892,504,224 - 2,537,170 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365892,504,235 - 2,536,778 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
CAV1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1829,649,992 - 29,682,465 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11829,648,120 - 29,682,451 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21831,745,664 - 31,778,987 (-)NCBISscrofa10.2Sscrofa10.2susScr3
CAV1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12185,222,724 - 85,258,562 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2185,222,879 - 85,258,627 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604218,474,866 - 18,510,943 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Cav1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248272,844,115 - 2,879,179 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248272,844,855 - 2,878,367 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

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Variants in Cav1
98 total Variants

Predicted Target Of
Summary Value
Count of predictions:179
Count of miRNA genes:135
Interacting mature miRNAs:153
Transcripts:ENSRNOT00000009253
Prediction methods:Miranda
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


1 to 10 of 38 rows
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD ID
Symbol
Name
LOD
P Value
Trait
Sub Trait
Chr
Start
Stop
Species
2302371Stl22Serum triglyceride level QTL 225.15blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)4521829457114705Rat
2303585Bw86Body weight QTL 864body mass (VT:0001259)body weight (CMO:0000012)41467806559678065Rat
1358352Srcrt3Stress Responsive Cort QTL 32.29blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)438465774146803430Rat
61445Strs3Sensitivity to stroke QTL 33cerebrum integrity trait (VT:0010549)post-insult time to onset of cerebrovascular lesion (CMO:0002343)44043338885433388Rat
6893678Bw108Body weight QTL 1082.60.006body mass (VT:0001259)body weight (CMO:0000012)44345797688457976Rat
8552906Pigfal3Plasma insulin-like growth factor 1 level QTL 3blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)41008408955084089Rat
10755501Bp390Blood pressure QTL 3902.5arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)426775591168368347Rat
1331807Rf31Renal function QTL 312.988urine potassium amount (VT:0010539)urine potassium level (CMO:0000128)43952426474726312Rat
6478766Anxrr47Anxiety related response QTL 470.09637locomotor behavior trait (VT:0001392)number of entries into a discrete space in an experimental apparatus (CMO:0000960)41008408955084089Rat
8552782Vie1Viral induced encephalitis QTL 126.4brain integrity trait (VT:0010579)encephalitis incidence/prevalence measurement (CMO:0002361)43443048482490359Rat

1 to 10 of 38 rows
RH142797  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2445,672,046 - 45,672,280 (+)MAPPERmRatBN7.2
Rnor_6.0444,628,545 - 44,628,778NCBIRnor6.0
Rnor_5.0445,234,800 - 45,235,033UniSTSRnor5.0
RGSC_v3.4442,987,400 - 42,987,633UniSTSRGSC3.4
Celera440,948,019 - 40,948,252UniSTS
RH 3.4 Map4284.1UniSTS
Cytogenetic Map4q21UniSTS
AA946480  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2445,673,157 - 45,673,362 (+)MAPPERmRatBN7.2
Rnor_6.0444,629,656 - 44,629,860NCBIRnor6.0
Rnor_5.0445,235,911 - 45,236,115UniSTSRnor5.0
Celera440,949,130 - 40,949,334UniSTS
RH 3.4 Map4282.8UniSTS
Cytogenetic Map4q21UniSTS


The following Strains have been annotated to Cav1
BB/OK    




alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 11 49 113 91 90 59 25 59 6 218 97 93 45 60 31


1 to 20 of 20 rows
RefSeq Transcripts NM_031556 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_133651 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006236130 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AC087102 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AC110102 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF439778 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF439779 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF489529 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC078744 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC104689 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC128717 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC161826 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CB698936 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH473959 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CK364516 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  DP000027 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FM039194 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ224228 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAXUCZ010000004 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  Z46614 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
1 to 20 of 20 rows

Ensembl Acc Id: ENSRNOT00000078250   ⟹   ENSRNOP00000073712
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl445,640,546 - 45,673,705 (+)Ensembl
Rnor_6.0 Ensembl444,597,123 - 44,630,200 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000105620   ⟹   ENSRNOP00000087572
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl445,634,918 - 45,673,700 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000111645   ⟹   ENSRNOP00000097222
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl445,641,877 - 45,673,700 (+)Ensembl
RefSeq Acc Id: NM_031556   ⟹   NP_113744
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8446,606,538 - 46,639,616 (+)NCBI
mRatBN7.2445,640,624 - 45,673,705 (+)NCBI
Rnor_6.0444,597,123 - 44,630,203 (+)NCBI
Rnor_5.0445,203,494 - 45,236,461 (+)NCBI
RGSC_v3.4442,956,102 - 42,989,057 (+)RGD
Celera440,918,628 - 40,949,677 (+)NCBI
Sequence:
RefSeq Acc Id: NM_133651   ⟹   NP_598412
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8446,607,972 - 46,639,616 (+)NCBI
mRatBN7.2445,642,058 - 45,673,705 (+)NCBI
Rnor_6.0444,598,557 - 44,630,203 (+)NCBI
Rnor_5.0445,203,494 - 45,236,461 (+)NCBI
RGSC_v3.4442,956,102 - 42,989,057 (+)RGD
Celera440,920,068 - 40,949,677 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006236130   ⟹   XP_006236192
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8446,607,268 - 46,639,616 (+)NCBI
mRatBN7.2445,641,347 - 45,673,708 (+)NCBI
Rnor_6.0444,597,846 - 44,630,206 (+)NCBI
Rnor_5.0445,203,494 - 45,236,461 (+)NCBI
Sequence:
RefSeq Acc Id: NP_113744   ⟸   NM_031556
- Peptide Label: isoform alpha
- UniProtKB: Q8VIK9 (UniProtKB/Swiss-Prot),   Q8VIK8 (UniProtKB/Swiss-Prot),   P41350 (UniProtKB/Swiss-Prot),   Q2IBC6 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_598412   ⟸   NM_133651
- Peptide Label: isoform beta
- UniProtKB: B1WBN8 (UniProtKB/TrEMBL),   Q3MHT6 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006236192   ⟸   XM_006236130
- Peptide Label: isoform X1
- UniProtKB: B1WBN8 (UniProtKB/TrEMBL),   Q3MHT6 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000073712   ⟸   ENSRNOT00000078250
Ensembl Acc Id: ENSRNOP00000087572   ⟸   ENSRNOT00000105620

Name Modeler Protein Id AA Range Protein Structure
AF-P41350-F1-model_v2 AlphaFold P41350 1-178 view protein structure


eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

RGD ID:13692892
Promoter ID:EPDNEW_R3416
Type:initiation region
Name:Cav1_1
Description:caveolin 1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0444,597,216 - 44,597,276EPDNEW


1 to 30 of 30 rows
Database
Acc Id
Source(s)
BIND 134453
  134455
  134456
  134458
BioCyc Gene G2FUF-45566 BioCyc
Ensembl Genes ENSRNOG00000056836 Ensembl, ENTREZGENE
Ensembl Transcript ENSRNOT00000078250 ENTREZGENE
  ENSRNOT00000157538 ENTREZGENE
InterPro Caveolin UniProtKB/Swiss-Prot
  Caveolin_CS UniProtKB/Swiss-Prot
NCBI Gene 25404 ENTREZGENE
PANTHER PTHR10844 UniProtKB/Swiss-Prot
  PTHR10844:SF18 UniProtKB/Swiss-Prot
Pfam Caveolin UniProtKB/Swiss-Prot
PharmGKB CAV1 RGD
PhenoGen Cav1 PhenoGen
PROSITE CAVEOLIN UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000056836 RatGTEx
UniProt A0A0G2K682_RAT UniProtKB/TrEMBL
  A0A8I6A884_RAT UniProtKB/TrEMBL
  A0A8I6AS98_RAT UniProtKB/TrEMBL
  A2VCW2_RAT UniProtKB/TrEMBL
  B1WBN8 ENTREZGENE, UniProtKB/TrEMBL
  CAV1_RAT UniProtKB/Swiss-Prot, ENTREZGENE
  Q2IBC6 ENTREZGENE, UniProtKB/TrEMBL
  Q3MHT6 ENTREZGENE, UniProtKB/TrEMBL
  Q8VIK8 ENTREZGENE
  Q8VIK9 ENTREZGENE
UniProt Secondary Q8VIK8 UniProtKB/Swiss-Prot
  Q8VIK9 UniProtKB/Swiss-Prot
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Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-02-25 Cav1  caveolin 1  Cav1  caveolin 1, caveolae protein  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2013-03-29 Cav1  caveolin 1, caveolae protein  LOC100362870  caveolin-like  Data merged from RGD:2323909 737654 PROVISIONAL
2012-08-14 Cav1  caveolin 1, caveolae protein  Cav1  caveolin 1  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2012-08-13 Cav1  caveolin 1  Cav1  caveolin 1, caveolae protein  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2010-05-06 LOC100362870  caveolin-like      Symbol and Name status set to provisional 70820 PROVISIONAL
2008-09-18 Cav1  caveolin 1, caveolae protein  Cav1  caveolin, caveolae protein 1  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2007-10-01 Cav1  caveolin, caveolae protein 1  Cav  caveolin  Symbol and Name updated to reflect Human and Mouse nomenclature 1299863 APPROVED
2003-04-09 Cav  caveolin      Symbol and Name updated 629477 APPROVED
2003-03-10 Cav  caveolin  Cav1    Data merged from RGD:620347 628472 PROVISIONAL
2002-08-07 Cav1        Symbol and Name status set to provisional 70820 PROVISIONAL
2002-06-10 Cav  Caveolin, caveolae protein, 22 kDa      Symbol and Name status set to approved 70586 APPROVED

Note Type Note Reference
gene_disease upregulated in uterine tumors 70348
gene_disease upregulated in uterine tumors 70557
gene_expression expressed in uterus 70348
gene_expression expressed in uterus 70557
gene_function binds cholesterol and acts as a cholesterol shuttling protein 1298592
gene_process inhibits the activity of the Erb B2 tyrosine kinase receptor for neuregulins 1298592