RGD Reference Report - Expression of caveolin-1, -2, and -3 in the spinal cords of Lewis rats with experimental autoimmune encephalomyelitis. - Rat Genome Database

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Expression of caveolin-1, -2, and -3 in the spinal cords of Lewis rats with experimental autoimmune encephalomyelitis.

Authors: Shin, T  Kim, H  Jin, JK  Moon, C  Ahn, M  Tanuma, N  Matsumoto, Y 
Citation: Shin T, etal., J Neuroimmunol. 2005 Aug;165(1-2):11-20.
RGD ID: 1582168
Pubmed: PMID:15925413   (View Abstract at PubMed)
DOI: DOI:10.1016/j.jneuroim.2005.03.019   (Journal Full-text)

The expression of caveolin-1, -2, and -3 in the spinal cords of Lewis rats with experimental autoimmune encephalomyelitis (EAE) was analyzed. Western blot analysis showed that three isotypes of caveolins including caveolin-1, -2 and -3 increased significantly in the spinal cords of rats during the early stage of EAE, as compared with the levels in control animals (p<0.05); the elevated level of each caveolin persisted during the peak and recovery stage of EAE. Immunohistochemistry demonstrated that caveolin-1 and -2 were expressed constitutively in the vascular endothelial cells and ependymal cells of the normal rat spinal cord, whereas caveolin-3 was almost exclusively localized in astrocytes. In EAE lesions, the immunoreactivity of caveolin-1 was increased in the ependymal cells, some astrocytes, and some inflammatory cells of the spinal cord, while that of caveolin-2 showed an intense immunoreactivity. Caveolin-3 was expressed constitutively in some astrocytes, but not in endothelial cells; its immunoreactivity was increased in reactive astrocytes in EAE lesions. The results of the Western blot analysis largely confirmed the observations obtained with immunohistochemistry. Taking all the findings into consideration, we postulate that the expression levels of each caveolin begin to increase when EAE is initiated, possibly contributing to the modulation of signal transduction pathways in the affected cells.

RGD Manual Disease Annotations    Click to see Annotation Detail View
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
Experimental Autoimmune Encephalomyelitis onsetISOCav3 (Rattus norvegicus)1582168; 1582168Protein:increased expression:spinal cord and astrocyteRGD 
Experimental Autoimmune Encephalomyelitis onsetIEP 1582168Protein:increased expression:spinal cord and astrocyteRGD 

Objects Annotated

Genes (Rattus norvegicus)
Cav3  (caveolin 3)

Genes (Mus musculus)
Cav3  (caveolin 3)

Genes (Homo sapiens)
CAV3  (caveolin 3)

Objects referenced in this article
Gene Cav1 caveolin 1 Rattus norvegicus

Additional Information