RGD Reference Report - Caveolin-1 expression by means of p38beta mitogen-activated protein kinase mediates the antiproliferative effect of carbon monoxide. - Rat Genome Database

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Caveolin-1 expression by means of p38beta mitogen-activated protein kinase mediates the antiproliferative effect of carbon monoxide.

Authors: Kim, HP  Wang, X  Nakao, A  Kim, SI  Murase, N  Choi, ME  Ryter, SW  Choi, AM 
Citation: Kim HP, etal., Proc Natl Acad Sci U S A. 2005 Aug 9;102(32):11319-24. Epub 2005 Jul 28.
RGD ID: 1582167
Pubmed: PMID:16051704   (View Abstract at PubMed)
PMCID: PMC1183544   (View Article at PubMed Central)
DOI: DOI:10.1073/pnas.0501345102   (Journal Full-text)

During vascular injury, the proliferation and migration of smooth muscle cells leads to characteristic neointima formation, which can be exacerbated by genetic depletion of caveolin-1 or heme oxygenase 1 (HO-1), and inhibited by carbon monoxide (CO), a by-product of heme oxygenase 1 activity. CO inhibited smooth muscle cell proliferation by activating p38 mitogen-activated protein kinase (MAPK) and p21(Waf1/Cip1). Exposure to CO increased caveolin-1 expression in neointimal lesions of injured aorta and in vitro by activating guanylyl cyclase and p38 MAPK. p38beta-/- fibroblasts did not induce caveolin-1 in response to CO, and exhibited a diminished basal caveolin-1 expression, which was restored by p38beta gene transfer. p38beta MAPK down-regulated extracellular signal-regulated protein kinase 1/2 (ERK-1/2), which can repress caveolin-1 transcription. Genetic depletion of caveolin-1 abolished the antiproliferative effect of CO. Thus, we demonstrate that CO, by activating p38beta MAPK, up-regulates caveolin-1, which acts as a tumor suppressor protein that mediates the growth inhibitory properties of this gas.

Gene Ontology Annotations    Click to see Annotation Detail View

Biological Process
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
negative regulation of endothelial cell proliferation  IMP 1582167 RGD 

Objects Annotated

Genes (Rattus norvegicus)
Cav1  (caveolin 1)


Additional Information