Ngf (nerve growth factor) - Rat Genome Database

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Gene: Ngf (nerve growth factor) Rattus norvegicus
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Symbol: Ngf
Name: nerve growth factor
RGD ID: 1598328
Description: Predicted to enable nerve growth factor receptor binding activity; peptidase regulator activity; and signaling receptor activator activity. Involved in several processes, including negative regulation of apoptotic process; nervous system development; and positive regulation of ERK1 and ERK2 cascade. Acts upstream of or within positive regulation of DNA-binding transcription factor activity; positive regulation of neurotrophin TRK receptor signaling pathway; and positive regulation of protein autophosphorylation. Located in extracellular space. Used to study several diseases, including bladder neck obstruction; bone disease (multiple); middle cerebral artery infarction; neurogenic bladder; and overactive bladder syndrome. Biomarker of several diseases, including alcohol dependence; alcohol use disorder; borna disease; cryptorchidism; and hyperhomocysteinemia. Human ortholog(s) of this gene implicated in several diseases, including IgA glomerulonephritis; end stage renal disease; hereditary sensory and autonomic neuropathy type 5; interstitial cystitis; and opiate dependence (multiple). Orthologous to human NGF (nerve growth factor); PARTICIPATES IN apoptotic cell death pathway; mitogen activated protein kinase signaling pathway; neurotrophic factor signaling pathway; INTERACTS WITH (+)-pilocarpine; (+)-taxifolin; (R)-noradrenaline.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: beta-nerve growth factor; beta-NGF; nerve growth factor (beta polypeptide); nerve growth factor, beta; nerve growth factor, beta (mapped); Ngfb; Ngfb_mapped; pro-nerve growth factor long
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Candidate Gene For: Cia10
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr82192,589,580 - 192,642,971 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl2192,589,582 - 192,643,834 (+)EnsemblGRCr8
mRatBN7.22189,901,058 - 189,954,452 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl2189,901,058 - 189,954,452 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx2197,519,156 - 197,572,237 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.02195,377,191 - 195,431,562 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.02190,206,371 - 190,261,316 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.02204,886,158 - 204,939,523 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2204,886,202 - 204,940,453 (+)Ensemblrn6Rnor6.0
Rnor_5.02224,316,210 - 224,369,663 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.42197,621,726 - 197,632,960 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera2182,322,945 - 182,375,918 (+)NCBICelera
RH 3.4 Map21294.4RGD
Cytogenetic Map2q34NCBI
JBrowse:




Disease Annotations     Click to see Annotation Detail View
Acute Lung Injury  (ISO)
alcohol dependence  (IEP,ISO)
alcohol use disorder  (IEP,ISO)
Alcohol Withdrawal Delirium  (ISO)
alcohol withdrawal syndrome  (ISO)
Alcohol-Related Disorders  (IEP,ISO)
Alcoholic Intoxication  (ISO)
Alzheimer's disease  (IEP)
amnestic disorder  (ISO)
asthma  (ISO)
atherosclerosis  (ISO)
atopic dermatitis  (ISO)
bacterial meningitis  (IEP)
bipolar disorder  (ISO)
bladder disease  (ISO)
bladder neck obstruction  (IDA)
borna disease  (IEP)
Bronchial Hyperreactivity  (ISO)
Burns  (IMP)
cannabis abuse  (ISO)
chronic asthma  (IMP)
chronic kidney disease  (ISO)
chronic pancreatitis  (IEP)
chronic ulcer of skin  (ISO)
cocaine dependence  (ISO)
Cocaine-Related Disorders  (ISO)
Congenital Pain Insensitivity  (ISO)
corneal ulcer  (ISO)
coronary artery disease  (ISO)
cryptorchidism  (IEP)
cystitis  (IMP,ISO)
degenerative disc disease  (IMP)
depressive disorder  (IEP)
diabetic encephalopathy  (ISO)
diabetic neuropathy  (IEP)
diabetic retinopathy  (IMP,ISO)
end stage renal disease  (ISO)
epilepsy with generalized tonic-clonic seizures  (ISO)
Experimental Autoimmune Encephalomyelitis  (IEP)
Experimental Diabetes Mellitus  (IEP,ISO)
glaucoma  (IEP)
glomerulonephritis  (ISO)
hereditary sensory and autonomic neuropathy type 5  (ISO)
hereditary sensory neuropathy  (ISO)
heroin dependence  (ISO)
Hyperalgesia  (IDA,IMP,ISO)
hyperhomocysteinemia  (IEP)
Hyperkinesis  (ISO)
hypertension  (IEP)
hypothyroidism  (IEP)
IgA glomerulonephritis  (ISO)
Inflammation  (IEP,ISO)
interstitial cystitis  (IEP,ISO)
interstitial lung disease  (ISO)
interstitial nephritis  (ISO)
Lewy body dementia  (ISO)
Lung Injury  (ISO)
malignant mesothelioma  (ISO)
metabolic dysfunction-associated steatotic liver disease  (ISO)
Metabolic Syndrome  (ISO)
middle cerebral artery infarction  (IMP,ISO)
morphine dependence  (IEP)
myocardial infarction  (ISO)
myofascial pain syndrome  (IEP)
Nerve Degeneration  (ISO)
nervous system disease  (ISO)
Neurobehavioral Manifestations  (ISO)
neurodegenerative disease  (ISO)
neurogenic bladder  (IDA,ISO)
Neurogenic Inflammation  (ISO)
nicotine dependence  (ISO)
obstructive sleep apnea  (ISO)
opiate dependence  (ISO)
opiate withdrawal syndrome  (ISO)
Optic Nerve Injuries  (IEP)
osteoarthritis  (IMP)
overactive bladder syndrome  (IDA,ISO)
Pain  (IMP,ISO)
Parkinson's disease  (ISO)
Parkinsonism  (IEP,ISO)
Peripheral Nerve Injuries  (IEP,IMP,ISO)
peripheral nervous system disease  (ISO)
Postoperative Cognitive Dysfunction  (IEP,ISO)
Prenatal Exposure Delayed Effects  (IEP)
pulmonary fibrosis  (ISO)
pulmonary sarcoidosis  (ISO)
respiratory syncytial virus infectious disease  (IEP)
retinal vascular disease  (ISO)
retinitis pigmentosa  (IEP)
Retrograde Degeneration  (IMP)
rhinitis  (ISO)
Rib Fractures  (IEP)
Rotator Cuff Injuries  (IEP)
schizophrenia  (ISO)
sciatic neuropathy  (ISO)
sensorineural hearing loss  (ISO)
separation anxiety disorder  (IEP)
Skeletal Muscle Injuries  (IMP)
Spinal Cord Injuries  (IEP,IMP)
status epilepticus  (ISO)
stress-related disorder  (IEP)
stroke  (IMP)
systemic scleroderma  (ISO)
traumatic brain injury  (IMP)
withdrawal disorder  (IEP,ISO)

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-pilocarpine  (EXP)
(+)-taxifolin  (EXP)
(R)-noradrenaline  (EXP)
(S)-amphetamine  (EXP)
(S)-nicotine  (EXP,ISO)
1-chloro-2,4,6-trinitrobenzene  (ISO)
13,14-dihydro-Delta(12)-prostaglandin J2  (EXP)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (EXP,ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,3,7,8-Tetrachlorodibenzofuran  (EXP)
2,4,6-trinitrobenzenesulfonic acid  (EXP)
2,4-dibromophenyl 2,4,5-tribromophenyl ether  (ISO)
2,6-di-tert-butyl-4-methylphenol  (EXP)
2-amino-2-deoxy-D-glucopyranose  (EXP)
2-hydroxypropanoic acid  (ISO)
3',5'-cyclic AMP  (EXP)
3,3',4,4',5-pentachlorobiphenyl  (ISO)
3,3',5,5'-tetrabromobisphenol A  (ISO)
3-\{1-[3-(dimethylamino)propyl]-1H-indol-3-yl\}-4-(1H-indol-3-yl)-1H-pyrrole-2,5-dione  (EXP,ISO)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
3-methylcholanthrene  (ISO)
4-methylcatechol  (EXP)
5-aza-2'-deoxycytidine  (ISO)
5-chloro-7-iodoquinolin-8-ol  (ISO)
5-Isoxazoleacetic acid, 4,5-dihydro-3-(4-hydroxyphenyl)-, methyl ester  (ISO)
6-propyl-2-thiouracil  (EXP)
8-Br-cAMP  (ISO)
acrylamide  (EXP)
actinomycin D  (EXP)
aflatoxin B1  (ISO)
agathisflavone  (EXP)
aldehydo-D-glucosamine  (EXP)
aldehydo-D-glucose  (EXP,ISO)
all-trans-retinoic acid  (EXP,ISO)
amitrole  (EXP)
ammonium chloride  (EXP)
anthra[1,9-cd]pyrazol-6(2H)-one  (EXP,ISO)
arachidonic acid  (EXP)
aristolochic acid A  (ISO)
arsane  (EXP)
arsenic atom  (EXP)
arsenite(3-)  (ISO)
asiaticoside  (EXP)
ATP  (EXP)
atrazine  (EXP)
azamethiphos  (EXP)
Bay-K-8644  (EXP)
benzo[a]pyrene  (ISO)
benzo[a]pyrene diol epoxide I  (ISO)
berberine  (ISO)
beta-D-glucosamine  (EXP)
bicuculline  (EXP)
bis(2-chloroethyl) sulfide  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
bromocriptine  (ISO)
bucladesine  (ISO)
C60 fullerene  (EXP)
cabergoline  (ISO)
cadmium acetate  (EXP)
cadmium atom  (EXP)
cadmium dichloride  (EXP,ISO)
Calcimycin  (ISO)
calcitriol  (ISO)
calcium atom  (EXP)
calcium(0)  (EXP)
calmidazolium  (EXP)
cannabidiol  (ISO)
capsaicin  (EXP,ISO)
carbon monoxide  (EXP)
carmustine  (EXP)
carrageenan  (EXP)
celecoxib  (EXP)
CGP 52608  (ISO)
chlorpyrifos  (EXP,ISO)
choline  (ISO)
chrysin  (ISO)
cisplatin  (EXP,ISO)
cobalt dichloride  (EXP)
cocaine  (ISO)
colforsin daropate hydrochloride  (EXP)
colistin  (EXP)
copper atom  (ISO)
copper(0)  (ISO)
corticosterone  (EXP)
Cuprizon  (EXP)
cyanocob(III)alamin  (EXP)
cycloheximide  (ISO)
cyclophosphamide  (EXP,ISO)
cyclosporin A  (EXP,ISO)
cyhalothrin  (EXP)
D-glucose  (EXP,ISO)
dapagliflozin  (EXP)
dexamethasone  (EXP,ISO)
diazinon  (EXP,ISO)
dibutyl phthalate  (EXP)
dieldrin  (EXP,ISO)
dihydrolipoic acid  (ISO)
dioxygen  (EXP,ISO)
disodium selenite  (ISO)
dopaminechrome (enol form)  (EXP)
doxorubicin  (ISO)
ebselen  (ISO)
echinacoside  (EXP)
edaravone  (ISO)
endosulfan  (EXP)
epalrestat  (EXP)
epinastine  (ISO)
epothilone B  (EXP)
etacrynic acid  (ISO)
ethanol  (EXP,ISO)
ethylparaben  (ISO)
everolimus  (EXP)
Evodiamine  (ISO)
excitatory amino acid agonist  (EXP)
fenthion  (ISO)
ferrostatin-1  (EXP)
fluphenazine  (EXP)
flutamide  (EXP)
folic acid  (ISO)
formaldehyde  (ISO)
formononetin  (EXP)
fructose  (EXP)
Fusarenone X  (ISO)
galanthamine  (EXP)
galanthamine Trifluoroacetic acid  (EXP)
Geniposide pentaacetate  (EXP)
genistein  (EXP)
gentamycin  (EXP)
ginsenoside Rd  (ISO)
ginsenoside Re  (ISO)
glucose  (EXP,ISO)
glutathione  (EXP,ISO)
glutathione disulfide  (ISO)
glycidol  (EXP)
Goe 6976  (EXP)
heptachlor  (EXP)
heroin  (ISO)
histamine  (EXP)
hydrogen peroxide  (EXP)
imiquimod  (ISO)
indometacin  (ISO)
inulin  (ISO)
isoprenaline  (EXP)
ketamine  (EXP)
ketotifen  (EXP)
L-methionine  (ISO)
lead diacetate  (EXP,ISO)
lidocaine  (ISO)
lipopolysaccharide  (EXP,ISO)
LY294002  (EXP,ISO)
malathion  (EXP)
manganese atom  (EXP)
manganese(0)  (EXP)
manganese(II) chloride  (ISO)
mangiferin  (ISO)
masoprocol  (EXP)
mepyramine  (EXP)
mercury atom  (EXP,ISO)
mercury(0)  (EXP,ISO)
methamphetamine  (EXP,ISO)
Methanandamide  (ISO)
methapyrilene  (EXP)
methotrexate  (ISO)
methoxychlor  (EXP)
microcystin-LR  (ISO)
mithramycin  (ISO)
mono(2-ethylhexyl) phthalate  (EXP,ISO)
N,N-diethyl-m-toluamide  (EXP)
N-acetyl-L-cysteine  (EXP,ISO)
N-acetylsphingosine  (EXP)
N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal  (ISO)
N-methyl-4-phenylpyridinium  (ISO)
N1'-[2-[[5-[(dimethylamino)methyl]-2-furanyl]methylthio]ethyl]-N1-methyl-2-nitroethene-1,1-diamine  (EXP)
naphthalene  (ISO)
naproxen  (EXP)
nickel atom  (EXP,ISO)
nicotine  (EXP,ISO)
nifedipine  (EXP)
nimesulide  (EXP)
nitrates  (EXP)
nitric oxide  (EXP)
nocodazole  (EXP)
Nonylphenol  (EXP)
O-acetyl-L-carnitine  (EXP)
okadaic acid  (EXP,ISO)
oxidopamine  (ISO)
ozone  (EXP,ISO)
paclitaxel  (EXP)
panaxydol  (EXP)
paracetamol  (EXP,ISO)
parathion-methyl  (EXP)
PD-166866  (EXP)
pentane-2,3-dione  (EXP)
perfluorooctane-1-sulfonic acid  (EXP,ISO)
pergolide  (ISO)
permethrin  (EXP)
peroxynitrous acid  (EXP)
phenethyl caffeate  (EXP)
phorbol 13-acetate 12-myristate  (EXP,ISO)
pirinixic acid  (ISO)
PNU-282987  (EXP)
potassium atom  (EXP)
procymidone  (EXP)
progesterone  (EXP)
promethazine  (EXP)
propofol  (EXP)
propranolol  (EXP)
prostaglandin E2  (EXP)
Ptaquiloside  (ISO)
Pyridostigmine bromide  (EXP)
pyrrolidine dithiocarbamate  (EXP)
quercetin  (EXP)
rac-lactic acid  (ISO)
ranitidine  (EXP)
reactive oxygen species  (EXP,ISO)
reserpine  (EXP)
resveratrol  (EXP)
rofecoxib  (EXP)
roflumilast  (EXP)
rotenone  (EXP)
rottlerin  (ISO)
S-(1,2-dichlorovinyl)-L-cysteine  (ISO)
S-butyl-DL-homocysteine (S,R)-sulfoximine  (ISO)
Salidroside  (EXP)
salubrinal  (ISO)
SB 203580  (EXP)
scopolamine  (EXP,ISO)
SKF 38393  (ISO)
sodium arsenite  (ISO)
sodium fluoride  (ISO)
sorbinil  (EXP)
staurosporine  (EXP,ISO)
streptozocin  (EXP)
sulforaphane  (ISO)
sumatriptan  (EXP)
tacrolimus hydrate  (EXP)
taurine  (EXP)
temozolomide  (ISO)
terbutaline  (EXP)
tert-butyl hydroperoxide  (ISO)
tetrachloromethane  (ISO)
thimerosal  (ISO)
thiopental  (EXP)
thymoquinone  (EXP)
titanium dioxide  (ISO)
toluene  (ISO)
toluene 2,4-diisocyanate  (EXP)
trichloroethene  (ISO)
trichostatin A  (ISO)
triclosan  (ISO)
triprolidine  (EXP)
Triptolide  (EXP)
triptonide  (ISO)
udenafil  (EXP)
valproic acid  (ISO)
vincaleukoblastine  (EXP)
vinclozolin  (EXP)
vincristine  (EXP)
vindesine  (EXP)
wortmannin  (EXP,ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
adult locomotory behavior  (IMP)
cell population proliferation  (IMP)
cell proliferation in forebrain  (IMP)
cell surface receptor protein tyrosine kinase signaling pathway  (IBA)
circadian rhythm  (ISO)
extrinsic apoptotic signaling pathway in absence of ligand  (ISO)
extrinsic apoptotic signaling pathway via death domain receptors  (IEA,ISO)
memory  (IMP)
modulation of chemical synaptic transmission  (IBA)
negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway  (NAS)
negative regulation of neuron apoptotic process  (IBA,IMP,ISO)
negative regulation of type B pancreatic cell apoptotic process  (IMP)
nerve development  (IBA)
nerve growth factor signaling pathway  (IBA,ISO)
neuron apoptotic process  (ISO)
neuron differentiation  (IMP)
neuron projection development  (IDA,ISO)
neuron projection morphogenesis  (IBA,ISO)
neurotrophin TRK receptor signaling pathway  (ISO)
peripheral nervous system development  (ISO)
positive regulation of axon extension  (ISO)
positive regulation of cell growth  (IDA)
positive regulation of cell population proliferation  (IDA)
positive regulation of collateral sprouting  (ISO)
positive regulation of ERK1 and ERK2 cascade  (IDA,ISO)
positive regulation of gene expression  (IEA,ISO)
positive regulation of neuron differentiation  (IDA)
positive regulation of neuron maturation  (ISO)
positive regulation of neuron projection development  (ISO)
positive regulation of neurotrophin TRK receptor signaling pathway  (IDA)
positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction  (ISO)
positive regulation of protein autophosphorylation  (IDA)
positive regulation of protein phosphorylation  (IDA,ISO)
positive regulation of protein ubiquitination  (ISO)
positive regulation of Ras protein signal transduction  (ISO)
positive regulation of stem cell proliferation  (IDA)
positive regulation of transcription by RNA polymerase II  (IDA)
regulation of neuron differentiation  (ISO)
regulation of neurotransmitter secretion  (ISO)
regulation of release of sequestered calcium ion into cytosol  (ISO)
response to electrical stimulus  (IEP)
response to glucocorticoid  (IEP)
response to lipopolysaccharide  (IEP)
response to mechanical stimulus  (IEP)
response to nicotine  (IEP)
response to ozone  (IEP)
response to peptide hormone  (IEP)
response to xenobiotic stimulus  (IEP)
sensory perception of hot stimulus  (IDA)
sensory perception of pain  (ISO)
signal transduction  (IEA)
spermatogenesis  (IEP)

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. [Effect of semax on the temporary dynamics of brain-derived neurotrophic factor and nerve growth factor gene expression in the rat hippocampus and frontal cortex] Agapova TIu, etal., Mol Gen Mikrobiol Virusol. 2008;(3):28-32.
2. Epicatechin blocks pro-nerve growth factor (proNGF)-mediated retinal neurodegeneration via inhibition of p75 neurotrophin receptor expression in a rat model of diabetes . Al-Gayyar MM, etal., Diabetologia. 2011 Mar;54(3):669-80. Epub 2010 Dec 7.
3. Compromise of cortical proNGF maturation causes selective retrograde atrophy in cholinergic nucleus basalis neurons. Allard S, etal., Neurobiol Aging. 2018 Jul;67:10-20. doi: 10.1016/j.neurobiolaging.2018.03.002. Epub 2018 Mar 9.
4. Changes in human plasma nerve growth factor level after chronic alcohol consumption and withdrawal. Aloe L, etal., Alcohol Clin Exp Res. 1996 May;20(3):462-5. doi: 10.1111/j.1530-0277.1996.tb01076.x.
5. Reduced serum concentrations of nerve growth factor, but not brain-derived neurotrophic factor, in chronic cannabis abusers. Angelucci F, etal., Eur Neuropsychopharmacol. 2008 Dec;18(12):882-7. doi: 10.1016/j.euroneuro.2008.07.008. Epub 2008 Sep 6.
6. Chronic heroin and cocaine abuse is associated with decreased serum concentrations of the nerve growth factor and brain-derived neurotrophic factor. Angelucci F, etal., J Psychopharmacol. 2007 Nov;21(8):820-5. doi: 10.1177/0269881107078491. Epub 2007 Aug 22.
7. Prenatal ethanol effects on NGF level, NPY and ChAT immunoreactivity in mouse entorhinal cortex: a preliminary study. Angelucci F, etal., Neurotoxicol Teratol. 1999 Jul-Aug;21(4):415-25. doi: 10.1016/s0892-0362(99)00005-7.
8. Nerve growth factor and its monocyte receptors are affected in kidney disease. Antonucci MT, etal., Nephron Clin Pract. 2009;111(1):c21-8. doi: 10.1159/000178819. Epub 2008 Dec 9.
9. Limonene, a food additive, and its active metabolite perillyl alcohol improve regeneration and attenuate neuropathic pain after peripheral nerve injury: Evidence for IL-1β, TNF-α, GAP, NGF and ERK involvement. Araújo-Filho HG, etal., Int Immunopharmacol. 2020 Sep;86:106766. doi: 10.1016/j.intimp.2020.106766. Epub 2020 Jul 8.
10. Evaluation of the brain-derived neurotrophic factor, nerve growth factor and memory in adult rats survivors of the neonatal meningitis by Streptococcus agalactiae. Barichello T, etal., Brain Res Bull. 2013 Mar;92:56-9. doi: 10.1016/j.brainresbull.2012.05.014. Epub 2012 Jun 7.
11. Endothelin ETA receptor antagonist reverses naloxone-precipitated opioid withdrawal in mice. Bhalla S, etal., Can J Physiol Pharmacol. 2015 Nov;93(11):935-44. doi: 10.1139/cjpp-2015-0022. Epub 2015 Apr 28.
12. Upregulation of nerve growth factor in central amygdala increases sensitivity to opioid reward. Bie B, etal., Neuropsychopharmacology. 2012 Dec;37(13):2780-8. doi: 10.1038/npp.2012.144. Epub 2012 Aug 8.
13. Intravesical Escherichia coli lipopolysaccharide stimulates an increase in bladder nerve growth factor. Bjorling DE, etal., BJU Int. 2001 May;87(7):697-702.
14. Functional characterization of a chronic cyclophosphamide-induced overactive bladder model in mice. Boudes M, etal., Neurourol Urodyn. 2011 Nov;30(8):1659-65. doi: 10.1002/nau.21180. Epub 2011 Jun 29.
15. Expression of nerve growth factor carried by pseudotyped lentivirus improves neuron survival and cognitive functional recovery of post-ischemia in rats. Cao JY, etal., CNS Neurosci Ther. 2018 Jun;24(6):508-518. doi: 10.1111/cns.12818. Epub 2018 Feb 6.
16. NGF and BDNF long-term variations in the thyroid, testis and adrenal glands of a mouse model of fetal alcohol spectrum disorders. Ceccanti M, etal., Ann Ist Super Sanita. 2013;49(4):383-90. doi: 10.4415/ANN_13_04_11.
17. NGF, BDNF, leptin, and mast cells in human coronary atherosclerosis and metabolic syndrome. Chaldakov GN, etal., Arch Physiol Biochem. 2001 Oct;109(4):357-60.
18. Nerve growth factor levels and mast cell distribution in human coronary atherosclerosis. Chaldakov GN, etal., Atherosclerosis. 2001 Nov;159(1):57-66.
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96. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
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150. p38 Mitogen-activated protein kinase activation by nerve growth factor in primary sensory neurons upregulates mu-opioid receptors to enhance opioid responsiveness toward better pain control. Yamdeu RS, etal., Anesthesiology. 2011 Jan;114(1):150-61.
151. Use new PLGL-RGD-NGF nerve conduits for promoting peripheral nerve regeneration. Yan Q, etal., Biomed Eng Online. 2012 Jul 9;11:36. doi: 10.1186/1475-925X-11-36.
152. Intrastriatal gene delivery of GDNF persistently attenuates methamphetamine self-administration and relapse in mice. Yan Y, etal., Int J Neuropsychopharmacol. 2013 Aug;16(7):1559-67. doi: 10.1017/S1461145712001575. Epub 2013 Feb 22.
153. Possible role of nerve growth factor in the pathogenesis of alcohol dependence. Yoon SJ, etal., Alcohol Clin Exp Res. 2006 Jun;30(6):1060-5. doi: 10.1111/j.1530-0277.2006.00120.x.
154. Bladder overactivity and hyperexcitability of bladder afferent neurons after intrathecal delivery of nerve growth factor in rats. Yoshimura N, etal., J Neurosci. 2006 Oct 18;26(42):10847-55.
155. Overexpression of β-NGF promotes differentiation of bone marrow mesenchymal stem cells into neurons through regulation of AKT and MAPK pathway. Yuan J, etal., Mol Cell Biochem. 2013 Nov;383(1-2):201-11. doi: 10.1007/s11010-013-1768-6. Epub 2013 Aug 10.
156. Improvement of postoperative cognitive dysfunction and attention network function of patients with ischemic cerebrovascular disease via dexmedetomidine. Zhang J, etal., Exp Ther Med. 2018 Mar;15(3):2968-2972. doi: 10.3892/etm.2018.5806. Epub 2018 Jan 30.
157. Effects of postnatal thyroid hormone deficiency on neurogenesis in the juvenile and adult rat. Zhang L, etal., Neurobiol Dis. 2009 Feb 19.
158. Alterations in neurotrophin and neurotrophin receptor gene expression patterns in the rat central nervous system following perinatal Borna disease virus infection. Zocher M, etal., J Neurovirol. 2000 Dec;6(6):462-77.
Additional References at PubMed
PMID:2025430   PMID:3184206   PMID:6470042   PMID:7854358   PMID:8137419   PMID:8861722   PMID:10362258   PMID:10485890   PMID:10908605   PMID:11278445   PMID:11731452   PMID:11835310  
PMID:11877426   PMID:11927634   PMID:12376548   PMID:12388545   PMID:12473665   PMID:12857442   PMID:14623868   PMID:14736860   PMID:14985763   PMID:15033464   PMID:15262992   PMID:15572370  
PMID:15739121   PMID:16079148   PMID:16153003   PMID:16298082   PMID:16516892   PMID:16854632   PMID:16956580   PMID:17013810   PMID:17045017   PMID:17663741   PMID:17724343   PMID:17764660  
PMID:17870109   PMID:17952852   PMID:17999938   PMID:18006272   PMID:18052984   PMID:18345501   PMID:18351465   PMID:18496748   PMID:18561899   PMID:18601856   PMID:18628984   PMID:18635195  
PMID:18660503   PMID:18690044   PMID:18709849   PMID:18728191   PMID:18817846   PMID:19013137   PMID:19019738   PMID:19036963   PMID:19100726   PMID:19104181   PMID:19125373   PMID:19150448  
PMID:19229990   PMID:19265194   PMID:19286942   PMID:19286963   PMID:19288273   PMID:19291685   PMID:19368814   PMID:19372237   PMID:19473768   PMID:19505442   PMID:19524110   PMID:19581298  
PMID:19585233   PMID:19596387   PMID:19662538   PMID:19696022   PMID:19722155   PMID:19726646   PMID:19762468   PMID:19802389   PMID:20155803   PMID:20164177   PMID:20170723   PMID:20220009  
PMID:20333299   PMID:20335077   PMID:20388358   PMID:20473744   PMID:20490673   PMID:20495008   PMID:20644345   PMID:20683769   PMID:20965859   PMID:21111819   PMID:21137370   PMID:21207218  
PMID:21270900   PMID:21295348   PMID:21312342   PMID:21408608   PMID:21473865   PMID:21549807   PMID:21561603   PMID:21640078   PMID:21642505   PMID:21677785   PMID:21889978   PMID:21938476  
PMID:21961236   PMID:22038828   PMID:22065583   PMID:22073361   PMID:22141271   PMID:22147490   PMID:22233577   PMID:22238106   PMID:22280975   PMID:22323714   PMID:22384148   PMID:22384237  
PMID:22411744   PMID:22479579   PMID:22496904   PMID:22500463   PMID:22532231   PMID:22580175   PMID:22742729   PMID:22744968   PMID:22834730   PMID:23015435   PMID:23157347   PMID:23158009  
PMID:23190308   PMID:23234417   PMID:23255148   PMID:23460346   PMID:23468336   PMID:23559405   PMID:23743199   PMID:23785138   PMID:23872662   PMID:23874817   PMID:23959444   PMID:24006456  
PMID:24154957   PMID:24265601   PMID:24270184   PMID:24303055   PMID:24327613   PMID:24380503   PMID:24508054   PMID:24620979   PMID:24713110   PMID:24733831   PMID:24760869   PMID:24771956  
PMID:24913185   PMID:24921856   PMID:24978930   PMID:25049196   PMID:25231981   PMID:25297375   PMID:25394845   PMID:25397406   PMID:25401376   PMID:25542970   PMID:25644424   PMID:25691569  
PMID:25801841   PMID:25897972   PMID:26121254   PMID:26347141   PMID:26521746   PMID:26588713   PMID:26608656   PMID:26681653   PMID:26709397   PMID:26724365   PMID:26966186   PMID:27569259  
PMID:27655914   PMID:27762470   PMID:27789288   PMID:27830679   PMID:27978417   PMID:28549966   PMID:28685530   PMID:28843696   PMID:28865749   PMID:29052293   PMID:29202822   PMID:29420916  
PMID:29483280   PMID:29523370   PMID:29895019   PMID:29901090   PMID:30553789   PMID:30592331   PMID:30911955   PMID:31298358   PMID:31575913   PMID:31638328   PMID:31875259   PMID:31980031  
PMID:32083755   PMID:32169062   PMID:32246947   PMID:32279149   PMID:32685448   PMID:33191703   PMID:33476055   PMID:33529756   PMID:33716987   PMID:34209299   PMID:34943971   PMID:34969767  
PMID:36232740   PMID:36766714   PMID:37699453   PMID:38312021   PMID:38637413   PMID:38725127   PMID:38875221   PMID:38926110  


Genomics

Comparative Map Data
Ngf
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr82192,589,580 - 192,642,971 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl2192,589,582 - 192,643,834 (+)EnsemblGRCr8
mRatBN7.22189,901,058 - 189,954,452 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl2189,901,058 - 189,954,452 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx2197,519,156 - 197,572,237 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.02195,377,191 - 195,431,562 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.02190,206,371 - 190,261,316 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.02204,886,158 - 204,939,523 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2204,886,202 - 204,940,453 (+)Ensemblrn6Rnor6.0
Rnor_5.02224,316,210 - 224,369,663 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.42197,621,726 - 197,632,960 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera2182,322,945 - 182,375,918 (+)NCBICelera
RH 3.4 Map21294.4RGD
Cytogenetic Map2q34NCBI
NGF
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381115,285,917 - 115,338,249 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1115,285,904 - 115,338,770 (-)Ensemblhg38GRCh38
GRCh371115,828,538 - 115,880,870 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361115,630,060 - 115,682,380 (-)NCBIBuild 36Build 36hg18NCBI36
Build 341115,540,580 - 115,592,899NCBI
Celera1114,057,456 - 114,109,776 (-)NCBICelera
Cytogenetic Map1p13.2NCBI
HuRef1113,686,915 - 113,739,240 (-)NCBIHuRef
CHM1_11115,943,440 - 115,995,752 (-)NCBICHM1_1
T2T-CHM13v2.01115,297,082 - 115,349,408 (-)NCBIT2T-CHM13v2.0
Ngf
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm393102,377,235 - 102,428,329 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl3102,377,235 - 102,428,329 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm383102,469,919 - 102,521,013 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl3102,469,919 - 102,521,013 (+)Ensemblmm10GRCm38
MGSCv373102,273,851 - 102,324,936 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv363102,598,989 - 102,650,066 (+)NCBIMGSCv36mm8
Celera3104,674,123 - 104,724,621 (+)NCBICelera
Cytogenetic Map3F2.2NCBI
cM Map345.25NCBI
Ngf
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495543518,581,808 - 18,601,059 (-)Ensembl
ChiLan1.0NW_00495543518,581,889 - 18,633,330 (-)NCBIChiLan1.0ChiLan1.0
NGF
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21107,940,198 - 107,992,897 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11107,539,320 - 107,592,441 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0187,223,597 - 87,276,759 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11122,272,750 - 122,325,909 (+)NCBIPanPan1.1PanPan1.1panPan2
NGF
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11752,900,647 - 52,901,607 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1752,900,647 - 52,901,607 (-)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha1752,550,068 - 52,550,845 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.01753,781,750 - 53,834,593 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1753,781,750 - 53,782,527 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11752,820,833 - 52,821,610 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01752,855,816 - 52,856,593 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01753,428,944 - 53,429,721 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Ngf
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440505813,803,009 - 13,853,189 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936627635,788 - 645,364 (-)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_004936627635,784 - 641,290 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
NGF
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl4105,256,749 - 105,307,837 (+)EnsemblsusScr11Sscrofa11.1
Sscrofa11.14105,256,691 - 105,307,843 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.24115,436,784 - 115,446,393 (+)NCBISscrofa10.2Sscrofa10.2susScr3
NGF
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12018,361,795 - 18,413,987 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2018,413,108 - 18,413,833 (+)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366603821,083,578 - 21,157,325 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Ngf
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462477211,010,845 - 11,070,017 (-)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_00462477211,009,765 - 11,070,050 (-)NCBIHetGla 1.0HetGla 1.0hetGla2
Ngf
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v1355,574,695 - 55,627,455 (-)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Ngf
348 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:39
Count of miRNA genes:37
Interacting mature miRNAs:39
Transcripts:ENSRNOT00000022200
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1358356Srcrt1Stress Responsive Cort QTL13.66blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)2163997722225110681Rat
1578648Bss11Bone structure and strength QTL 114.7femur morphology trait (VT:0000559)femoral neck cortical cross-sectional area (CMO:0001702)2169358774214358774Rat
1331734Bp204Blood pressure QTL 2043.61192arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)2170656145239614549Rat
631566Bp90Blood pressure QTL 900.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2149957381221199885Rat
1298074Bp164Blood pressure QTL 1640.003arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)244537979205135428Rat
1354648Bp239Blood pressure QTL 2390.001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)267845370229470703Rat
1354649Kidm17Kidney mass QTL 172.9kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)283465462229820014Rat
10755499Bp389Blood pressure QTL 3892.61arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)220695736231474293Rat
1298076Bp166Blood pressure QTL 1660.0009arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2138595962205135428Rat
1581576Pur7Proteinuria QTL 70.0001urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)280396178220931218Rat
152025245Scl81Serum cholesterol level QTL 813.49blood cholesterol amount (VT:0000180)2124537199209621565Rat
1581578Cm49Cardiac mass QTL 494.90.01heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)2145807215220931416Rat
61458Bp10Blood pressure QTL 103.42arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2191709311217961898Rat
631198Cm22Cardiac mass QTL 224.30.0008heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)278269809208420281Rat
1554319Bmd2Bone mineral density QTL 213.40.0001lumbar vertebra area (VT:0010570)lumbar vertebra cross-sectional area (CMO:0001689)2122597372215234002Rat
12879836Kidm61Kidney mass QTL 610.001kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)2154723085199723085Rat
1581569Uae32Urinary albumin excretion QTL 320.0001urine protein amount (VT:0005160)urine albumin excretion rate (CMO:0000757)280396178220931218Rat
12879837Am2Aortic mass QTL 20.001aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)2154723085199723085Rat
10043139Iddm55Insulin dependent diabetes mellitus QTL 553.10.0001blood glucose amount (VT:0000188)age at onset/diagnosis of type 1 diabetes mellitus (CMO:0001140)2150313808195313808Rat
12879838Cm86Cardiac mass QTL 860.002heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)2154723085199723085Rat
1302793Bw16Body weight QTL 1650.0001body mass (VT:0001259)body weight (CMO:0000012)2159440891205135267Rat
12879839Cm85Cardiac mass QTL 850.001heart mass (VT:0007028)heart wet weight to body weight ratio (CMO:0002408)2154723085199723085Rat
1549833Bp257Blood pressure QTL 2570.003arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)2170652929215652929Rat
1358900Bw48Body weight QTL 484.88body mass (VT:0001259)body weight (CMO:0000012)2159440891220931218Rat
4889834Pur24Proteinuria QTL 245.80.014urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)2171994826205135428Rat
1359031Bp275Blood pressure QTL 275arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)2188565047233565047Rat
1581499Esta2Estrogen-induced thymic atrophy QTL 2thymus mass (VT:0004954)thymus wet weight (CMO:0000855)2192287802229609668Rat
1331760Bp206Blood pressure QTL 2063.62454arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)24265106205135428Rat
12879840Bw179Body weight QTL 1790.005body mass (VT:0001259)body weight (CMO:0000012)2154723085199723085Rat
9589044Scfw1Subcutaneous fat weight QTL 15.80.001subcutaneous adipose mass (VT:1000472)abdominal subcutaneous fat pad weight (CMO:0002069)2184856304229856304Rat
8694435Bw166Body weight QTL 16614.080.001retroperitoneal fat pad mass (VT:0010430)retroperitoneal fat pad weight to body weight ratio (CMO:0000635)2184856304229856304Rat
1359032Hrtrt18Heart rate QTL 18heart pumping trait (VT:2000009)heart rate (CMO:0000002)2159440760195313808Rat
2301966Bp322Blood pressure QTL 3223.58arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2144882354205135428Rat
1298083Bp158Blood pressure QTL 1582.62arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2191709311217961898Rat
1298080Bp163Blood pressure QTL 1630.02arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)267845182205135428Rat
1357991Ael2Aortic elastin QTL 24.20.000071aorta elastin amount (VT:0003905)aortic elastin2169227906214227906Rat
8662832Vetf7Vascular elastic tissue fragility QTL 73.5aorta elastin amount (VT:0003905)aorta wall extracellular elastin dry weight to aorta wall dry weight ratio (CMO:0002002)283400752223709938Rat
1331745Bp203Blood pressure QTL 2034.377arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)2192287802221089121Rat
1298085Bp165Blood pressure QTL 1650.0006arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)244537979205135428Rat
8694194Abfw1Abdominal fat weight QTL 111.70.001visceral adipose mass (VT:0010063)abdominal fat pad weight to body weight ratio (CMO:0000095)2184856304229856304Rat
61366Iddm3Insulin dependent diabetes mellitus QTL 34.7blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)2192287802237287802Rat
1578671Bmd10Bone mineral density QTL 105.4femur mineral mass (VT:0010011)compact volumetric bone mineral density (CMO:0001730)2175931416220931416Rat
1641891Alcrsp17Alcohol response QTL 17response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)2151869660251712708Rat
724534Uae6Urinary albumin excretion QTL 610urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)280396034220931416Rat
61374Edpm2Estrogen-dependent pituitary mass QTL 24.420.86pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)278269809205135428Rat
2300189Bmd48Bone mineral density QTL 485.80.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)2182024327227024327Rat
8662843Vetf9Vascular elastic tissue fragility QTL 92.05thoracic aorta molecular composition trait (VT:0010568)aorta wall extracellular elastin dry weight to aorta wall extracellular collagen weight ratio (CMO:0002003)2159440760228950743Rat
2301408Kidm36Kidney mass QTL 360.002kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)2184482291229482291Rat
1331794Bp202Blood pressure QTL 2023.66819arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2143344967251712708Rat
71113Cari2Carrageenan-induced inflammation QTL 22.70.009hypodermis integrity trait (VT:0010550)inflammatory exudate volume (CMO:0001429)2143746578205135428Rat
1331805Cm29Cardiac mass QTL 293.50746heart mass (VT:0007028)heart wet weight (CMO:0000069)2143344967251712708Rat
634308Sach6Saccharin preference QTL 64.9taste sensitivity trait (VT:0001986)saccharin intake volume to total fluid intake volume ratio (CMO:0001601)2114384617215381366Rat
1598805Memor8Memory QTL 83exploratory behavior trait (VT:0010471)average horizontal distance between subject and target during voluntary locomotion in an experimental apparatus (CMO:0002674)2150096616195096616Rat
1358917Cm42Cardiac mass QTL 422.82heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)227148328206613235Rat
724568Uae13Urinary albumin excretion QTL 134.4urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)2145306936212705578Rat
7488929Bp366Blood pressure QTL 3660.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)2187663373195783351Rat
1358913Cm41Cardiac mass QTL 412.73heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)227148328206613235Rat
1300165Rf9Renal function QTL 93.28kidney glomerulus integrity trait (VT:0010546)index of glomerular damage (CMO:0001135)2113746222205135428Rat
738013Alc15Alcohol consumption QTL 154.10.00022consumption behavior trait (VT:0002069)ethanol drink intake rate to body weight ratio (CMO:0001616)2186850607231850607Rat
61398Bp50Blood pressure QTL 504.4arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2192287802237287802Rat
631507Bp105Blood pressure QTL 1050.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)2114384617215381366Rat
1641925Alcrsp2Alcohol response QTL 2response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)2151869660223841096Rat
1354609Niddm62Non-insulin dependent diabetes mellitus QTL 624.720.000006insulin secretion trait (VT:0003564)plasma insulin level (CMO:0000342)2117415288205135428Rat
1598833Bp295Blood pressure QTL 2953.5arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2150096616195096616Rat
61417Cia10Collagen induced arthritis QTL 103.4joint integrity trait (VT:0010548)experimental arthritis severity measurement (CMO:0001459)2182635347227635347Rat
1354622Kidm16Kidney mass QTL 163kidney mass (VT:0002707)left kidney wet weight (CMO:0000083)283465462225110681Rat
631266Bp132Blood pressure QTL 1320.0005arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)247856345205135428Rat
631522Bp74Blood pressure QTL 740.05arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2175008837220008837Rat
8694383Bw158Body weight QTL 1587.690.001body lean mass (VT:0010483)lean tissue morphological measurement (CMO:0002184)2184856304229856304Rat
7488927Bp365Blood pressure QTL 3650.008arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)2165453811210453811Rat
7488925Bp364Blood pressure QTL 3640.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)2163253030208253030Rat
2306901Bp337Blood pressure QTL 3370.01arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2166372086229820014Rat
1354605Rf48Renal function QTL 482.9blood creatinine amount (VT:0005328)plasma creatinine level (CMO:0000537)276328396209350714Rat

Markers in Region
RH142206  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.22189,954,674 - 189,954,867 (+)MAPPERmRatBN7.2
Rnor_6.02204,939,746 - 204,939,938NCBIRnor6.0
Rnor_5.02224,369,886 - 224,370,078UniSTSRnor5.0
RGSC_v3.42197,633,183 - 197,633,375UniSTSRGSC3.4
Celera2182,376,141 - 182,376,333UniSTS
RH 3.4 Map21294.4UniSTS
Cytogenetic Map2q34UniSTS
NGFB  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.22189,953,767 - 189,953,914 (+)MAPPERmRatBN7.2
Rnor_6.02204,938,839 - 204,938,985NCBIRnor6.0
Rnor_5.02224,368,979 - 224,369,125UniSTSRnor5.0
RGSC_v3.42197,632,276 - 197,632,422UniSTSRGSC3.4
Celera2182,375,234 - 182,375,380UniSTS
Cytogenetic Map2q34UniSTS
PMC20267P1  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.22189,953,922 - 189,954,216 (+)MAPPERmRatBN7.2
Rnor_6.02204,938,994 - 204,939,287NCBIRnor6.0
Rnor_5.02224,369,134 - 224,369,427UniSTSRnor5.0
RGSC_v3.42197,632,431 - 197,632,724UniSTSRGSC3.4
Celera2182,375,389 - 182,375,682UniSTS
Cytogenetic Map2q34UniSTS
NGFB  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.22189,953,678 - 189,953,782 (+)MAPPERmRatBN7.2
Rnor_6.02204,938,750 - 204,938,853NCBIRnor6.0
Rnor_5.02224,368,890 - 224,368,993UniSTSRnor5.0
RGSC_v3.42197,632,187 - 197,632,290UniSTSRGSC3.4
Celera2182,375,145 - 182,375,248UniSTS
Cytogenetic Map2q34UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
14 12 64 128 85 84 53 25 53 6 268 122 11 107 71 91 31 6 6

Sequence


Ensembl Acc Id: ENSRNOT00000022200   ⟹   ENSRNOP00000022200
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl2192,589,594 - 192,643,140 (+)Ensembl
mRatBN7.2 Ensembl2189,901,058 - 189,954,452 (+)Ensembl
Rnor_6.0 Ensembl2204,886,202 - 204,939,523 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000078376   ⟹   ENSRNOP00000072445
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl2204,932,159 - 204,940,453 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000094599   ⟹   ENSRNOP00000088176
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl2192,609,918 - 192,642,971 (+)Ensembl
mRatBN7.2 Ensembl2189,921,396 - 189,954,452 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000097020   ⟹   ENSRNOP00000089587
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl2192,589,582 - 192,643,219 (+)Ensembl
mRatBN7.2 Ensembl2189,901,152 - 189,954,279 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000115339   ⟹   ENSRNOP00000082212
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl2192,631,793 - 192,642,971 (+)Ensembl
mRatBN7.2 Ensembl2189,943,274 - 189,954,452 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000116899   ⟹   ENSRNOP00000097792
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl2192,589,582 - 192,643,407 (+)Ensembl
mRatBN7.2 Ensembl2189,901,499 - 189,954,446 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000153271   ⟹   ENSRNOP00000100726
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl2192,589,583 - 192,643,834 (+)Ensembl
RefSeq Acc Id: NM_001277055   ⟹   NP_001263984
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82192,589,580 - 192,642,971 (+)NCBI
mRatBN7.22189,901,058 - 189,954,452 (+)NCBI
Rnor_6.02204,886,202 - 204,939,523 (+)NCBI
Rnor_5.02224,316,210 - 224,369,663 (+)NCBI
Celera2182,322,945 - 182,375,918 (+)NCBI
Sequence:
RefSeq Acc Id: XM_039102402   ⟹   XP_038958330
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82192,636,116 - 192,642,969 (+)NCBI
mRatBN7.22189,947,597 - 189,954,452 (+)NCBI
RefSeq Acc Id: XM_063281907   ⟹   XP_063137977
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82192,589,586 - 192,642,969 (+)NCBI
RefSeq Acc Id: NP_001263984   ⟸   NM_001277055
- Peptide Label: precursor
- UniProtKB: P25427 (UniProtKB/Swiss-Prot),   A6K3I9 (UniProtKB/TrEMBL),   A0A8I6A8J2 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000072445   ⟸   ENSRNOT00000078376
Ensembl Acc Id: ENSRNOP00000022200   ⟸   ENSRNOT00000022200
RefSeq Acc Id: XP_038958330   ⟸   XM_039102402
- Peptide Label: isoform X1
- UniProtKB: A0A0G2K2Z7 (UniProtKB/TrEMBL),   A0A8I6AA86 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSRNOP00000089587   ⟸   ENSRNOT00000097020
Ensembl Acc Id: ENSRNOP00000097792   ⟸   ENSRNOT00000116899
Ensembl Acc Id: ENSRNOP00000082212   ⟸   ENSRNOT00000115339
Ensembl Acc Id: ENSRNOP00000088176   ⟸   ENSRNOT00000094599
RefSeq Acc Id: XP_063137977   ⟸   XM_063281907
- Peptide Label: isoform X2
- UniProtKB: P25427 (UniProtKB/Swiss-Prot),   A0A8I6A8J2 (UniProtKB/TrEMBL),   A6K3I9 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSRNOP00000100726   ⟸   ENSRNOT00000153271
Protein Domains
Nerve growth factor-related

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P25427-F1-model_v2 AlphaFold P25427 1-241 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13691620
Promoter ID:EPDNEW_R2145
Type:single initiation site
Name:Ngf_1
Description:nerve growth factor
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.02204,886,202 - 204,886,262EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1598328 AgrOrtholog
BioCyc Gene G2FUF-51836 BioCyc
Ensembl Genes ENSRNOG00000016571 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000022200.7 UniProtKB/Swiss-Prot
  ENSRNOT00000116899 ENTREZGENE
  ENSRNOT00000116899.1 UniProtKB/Swiss-Prot
Gene3D-CATH 2.10.90.10 UniProtKB/Swiss-Prot
InterPro Cystine-knot_cytokine UniProtKB/Swiss-Prot
  Nerve_growth_factor-like UniProtKB/Swiss-Prot
  Nerve_growth_factor-rel UniProtKB/Swiss-Prot
  Nerve_growth_factor_bsu UniProtKB/Swiss-Prot
  Nerve_growth_factor_bsu_mml UniProtKB/Swiss-Prot
  Nerve_growth_factor_CS UniProtKB/Swiss-Prot
KEGG Report rno:310738 UniProtKB/Swiss-Prot
NCBI Gene 310738 ENTREZGENE
PANTHER BETA-NERVE GROWTH FACTOR UniProtKB/Swiss-Prot
  PTHR11589 UniProtKB/Swiss-Prot
Pfam NGF UniProtKB/Swiss-Prot
PharmGKB NGF RGD
PhenoGen Ngf PhenoGen
PIRSF NGF UniProtKB/Swiss-Prot
PRINTS MAMLNGFBETA UniProtKB/Swiss-Prot
  NGF UniProtKB/Swiss-Prot
  NGFBETA UniProtKB/Swiss-Prot
PROSITE NGF_1 UniProtKB/Swiss-Prot
  NGF_2 UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000016571 RatGTEx
SMART NGF UniProtKB/Swiss-Prot
Superfamily-SCOP SSF57501 UniProtKB/Swiss-Prot
UniProt A0A0G2K2Z7 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I5ZWC1_RAT UniProtKB/TrEMBL
  A0A8I6A8J2 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I6AA86 ENTREZGENE, UniProtKB/TrEMBL
  A6K3I9 ENTREZGENE, UniProtKB/TrEMBL
  NGF_RAT UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-03-17 Ngf  nerve growth factor  Ngf  nerve growth factor (beta polypeptide)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-09-24 Ngf  nerve growth factor (beta polypeptide)  Ngf  nerve growth factor  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-04-25 Ngf  nerve growth factor  Ngfb  nerve growth factor, beta  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2007-04-13   nerve growth factor, beta  Ngfb  nerve growth factor, beta (mapped)  Name updated 737654 APPROVED
2007-04-11 Ngfb  nerve growth factor, beta (mapped)  Ngfb_mapped  nerve growth factor, beta (mapped)  Data merged from RGD:3174 737654 APPROVED
2006-11-20 Ngfb  nerve growth factor, beta (mapped)      Symbol and Name status set to provisional 70820 PROVISIONAL
2005-11-17 Ngfb_mapped  nerve growth factor, beta (mapped)  Ngfb  nerve growth factor, beta  Symbol and Name updated 1556543 APPROVED
2002-06-10 Ngfb  Nerve growth factor, beta polypeptide      Symbol and Name status set to approved 70586 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_expression expressed in the CNS 1302255
gene_expression expression is not altered by 60 Hz magnetic fields (EMFs) during gestation and lactation 1302255
gene_function functions in brain development 1302255
gene_homology mouse Ngfb exhibits growth factor, receptor signaling and brain developmental functions 704405
gene_regulation developmentally regulated in the central nervous system 1302255