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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1598328 Species: Rattus norvegicus RGD Object: Gene Symbol: Ngf Name: nerve growth factor (beta polypeptide)

Acc ID: CHEBI:10650 Term: sumatriptan Definition: A sulfonamide that consists of N,N-dimethyltryptamine bearing an additional (N-methylsulfamoyl)methyl substituent at position 5. Selective agonist for a vascular 5-HT1 receptor subtype (probably a member of the 5-HT1D family). CasRN: 103628-46-2 Chemical ID: MESH:D018170

Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.

Qualifier	Evidence	With	Reference	Source	Notes	Original Reference(s)
multiple interactions	EXP		6480464	CTD	Sumatriptan inhibits the reaction [NGF protein results in increased expression of CALCA mRNA]	PMID:12574409
multiple interactions	EXP		6480464	CTD	[Naproxen co-treated with Sumatriptan] inhibits the reaction [Capsaicin results in increased expression of NGF protein] Sumatriptan inhibits the reaction [Capsaicin results in increased expression of NGF protein]	PMID:22150557