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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1598328
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Ngf
Name: nerve growth factor
Acc ID: CHEBI:27899
Term: cisplatin
Definition: A diamminedichloroplatinum compound in which the two ammine ligands and two chloro ligands are oriented in a cis planar configuration around the central platinum ion. An anticancer drug that interacts with, and forms cross-links between, DNA and proteins, it is used as a neoplasm inhibitor to treat solid tumours, primarily of the testis and ovary. Commonly but incorrectly described as an alkylating agent due to its mechanism of action (but it lacks alkyl groups).
Chemical ID: MESH:D002945
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Ngfdecreases expressionEXP 6480464CTDCisplatin results in decreased expression of NGF proteinPMID:14654561 PMID:21865574
Ngfdecreases response to substanceEXP 6480464CTDNGF protein results in decreased susceptibility to CisplatinPMID:10553948 PMID:9622663
Ngfmultiple interactionsEXP 6480464CTDAcetylcarnitine inhibits the reaction [Cisplatin results in decreased expression of NGF protein]; Tretinoin inhibits the reaction [Cisplatin results in decreased expression of NGF protein]PMID:14654561 PMID:21865574
Ngfdecreases expressionISONGF (Homo sapiens)6480464CTDCisplatin results in decreased expression of NGF mRNAPMID:27392435
Ngfmultiple interactionsISONGF (Homo sapiens)6480464CTDCisplatin promotes the reaction [jinfukang results in decreased expression of NGF mRNA]; jinfukang promotes the reaction [Cisplatin results in decreased expression of NGF mRNA]PMID:27392435
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