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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1598328
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Ngf
Name: nerve growth factor
Acc ID: CHEBI:31539
Term: epalrestat
Definition: A monocarboxylic acid that is 1,3-thiazolidine which is substituted on the nitrogen by a carboxymethyl group, at positions 2 and 4 by thioxo and oxo groups, respectively, and at position 5 by a 2-methyl-3-phenylprop-2-en-1-ylidene group. It is an inhibitor of aldose reductase (which catalyses the conversion of glucose to sorbitol) and is used for the treatment of some diabetic complications, including neuropathy.
Chemical ID: MESH:C038131
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Ngfincreases expressionEXP 6480464CTDepalrestat results in increased expression of NGF proteinPMID:9628756
Ngfincreases secretionEXP 6480464CTDepalrestat results in increased secretion of NGF proteinPMID:9628756
Ngfmultiple interactionsEXP 6480464CTDepalrestat inhibits the reaction [Streptozocin results in decreased expression of NGF protein]PMID:9628756
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