RGD Reference Report - Nerve growth factor in the developing and adult lacrimal glands of rat with and without inherited retinitis pigmentosa. - Rat Genome Database

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Nerve growth factor in the developing and adult lacrimal glands of rat with and without inherited retinitis pigmentosa.

Authors: Muzi, S  Colafrancesco, V  Sornelli, F  Mantelli, F  Lambiase, A  Aloe, L 
Citation: Muzi S, etal., Cornea. 2010 Oct;29(10):1163-8.
RGD ID: 4891133
Pubmed: PMID:20595895   (View Abstract at PubMed)
DOI: DOI:10.1097/ICO.0b013e3181d3d3f9   (Journal Full-text)

PURPOSE: In the present study, we investigated lacrimal function and presence of the neurotrophin nerve growth factor (NGF) and its receptors in the lacrimal gland (LG) of normal rats and rats with inherited retinitis pigmentosa (IRP). MATERIALS AND METHODS: After anesthesia, modified Schirmer tests were performed on IRP rats and Sprague Dawley (SD) rats to measure tear function. LGs of developing and adult IRP and SD rats were removed and used for histological, immunohistochemical, and biochemical analyses. RESULTS: The results showed that basal tear secretion is reduced in IRP rats as compared with SD rats. NGF and NGF receptors are expressed in the LG of both rat strains. In SD rats, these NGF markers are low during early life and more elevated in adult life. Conversely in rats with IRP, NGF and its receptors decreased in adult life. CONCLUSIONS: The role of NGF in maintaining ocular surface integrity is well known. The observations of this study further support the hypothesis that neurotrophins play a role in modulating tear secretion and probably in preventing the deleterious effects of dry eye. This hypothesis is presented and discussed.

RGD Manual Disease Annotations    Click to see Annotation Detail View
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
retinitis pigmentosa  ISONgf (Rattus norvegicus)4891133; 4891133protein:decreased expression:lacrimal glandRGD 
retinitis pigmentosa  IEP 4891133protein:decreased expression:lacrimal glandRGD 

Objects Annotated

Genes (Rattus norvegicus)
Ngf  (nerve growth factor)

Genes (Mus musculus)
Ngf  (nerve growth factor)

Genes (Homo sapiens)
NGF  (nerve growth factor)


Additional Information