| 1310455 | Tox | thymocyte selection-associated high mobility group box | ENCODES a protein that exhibits chromatin DNA binding (ortholog); INVOLVED IN CD4-positive, alpha-beta T cell lineage commitment (ortholog); CD4-positive, CD25-positive, alpha-beta regulatory T cell lineage commitment (ortholog); CD8-positive, alpha-beta T cell lineage commitment (ortholog); FOUND I N nucleus (ortholog); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 2,4-dinitrotoluene; 2,6-dinitrotoluene | 5 | 24672487 | 24968754 | Rat | 136 | symbol , old_gene_name , PhenoGen | gene, protein-coding, VALIDATED [RefSeq] |
| 735184 | Tox2 | TOX high mobility group box family member 2 | ENCODES a protein that exhibits RNA polymerase II-specific DNA-binding transcription factor binding; transcription coactivator activity (ortholog); INVOLVED IN female gonad development; positive regulation of transcription by RNA polymerase II; response to gonadotropin; FOUND IN nucleoplasm (ortholo g); INTERACTS WITH 4,4'-sulfonyldiphenol; alpha-Zearalanol; atrazine | 3 | 172272718 | 172400235 | Rat | 91 | symbol , PhenoGen , name | gene, protein-coding, VALIDATED [RefSeq] |
| 1311529 | Tox3 | TOX high mobility group box family member 3 | ENCODES a protein that exhibits chromatin binding (ortholog); phosphoprotein binding (ortholog); protein homodimerization activity (ortholog); INVOLVED IN calcium-mediated signaling; positive regulation of DNA-templated transcription; negative regulation of neuron apoptotic process (ortholog); ASSOC IATED WITH Breast Neoplasms (ortholog); Cleft Lip with or without Cleft Palate, Nonsyndromic, 7 (ortholog); Liver Neoplasms (ortholog); FOUND IN cytosol (ortholog); nucleoplasm (ortholog); INTERACTS WITH (+)-schisandrin B; 2,3,7,8-tetrachlorodibenzodioxine; 6-propyl-2-thiouracil | 19 | 32820957 | 32929776 | Rat | 137 | symbol , PhenoGen , name | gene, protein-coding, VALIDATED [RefSeq] |
| 708449 | Tox4 | TOX high mobility group box family member 4 | ENCODES a protein that exhibits DNA binding (inferred); INVOLVED IN positive regulation of transcription elongation by RNA polymerase II (ortholog); regulation of transcription elongation by RNA polymerase II (ortholog); RNA polymerase II promoter clearance (ortholog); FOUND IN chromatin (ortholog); chromosome, telomeric region (ortholog); PTW/PP1 phosphatase complex (ortholog); INTERACTS WITH (+)-schisandrin B; ammonium chloride; bisphenol A | 15 | 27462735 | 27476320 | Rat | 87 | symbol , PhenoGen , name | gene, protein-coding, PROVISIONAL [RefSeq] |
| 1585613 | Tox3l1 | TOX high mobility group box family member 3 like 1 | | 2 | 155710403 | 155742735 | Rat | | symbol , PhenoGen , name | gene, ncrna, VALIDATED [RefSeq] |
| 41057908 | Tox4-ps1 | TOX high mobility group box family member 4, pseudogene 1 | | 7 | 102517681 | 102592288 | Rat | | symbol , old_gene_name , PhenoGen , name | gene, pseudo, MODEL [RefSeq] |
| 2771 | Gucy2c | guanylate cyclase 2C | ENCODES a protein that exhibits guanylate cyclase activity; toxic substance binding; INVOLVED IN regulation of cell population proliferation (ortholog); response to toxic substance (ortholog); PARTICIPATES IN purine metaboli c pathway; ASSOCIATED WITH abdominal obesity-metabolic syndrome (ortholog); Colorectal Neoplasms (ortholog); congenital diarrhea 6 (ortholog); FOUND IN endoplasmic reticulum membrane (inferred); plasma membrane (inferred); INTERACTS WITH (+)-schisandrin B; 1,2-dimethylhydrazine; 1-naphthyl isothiocyanate | 4 | 171299715 | 171380296 | Rat | 117 | old_gene_name , description | gene, protein-coding, PROVISIONAL [RefSeq] |
| 1307144 | Antxr1 | ANTXR cell adhesion molecule 1 | ENCODES a protein that exhibits actin filament binding (ortholog); collagen binding (ortholog); signaling receptor activity (ortholog); INVOLVED IN actin cytoskeleton organization (ortholog); blood vessel development (ortholog); negative regulation of extracellular matrix assembly (ortholog); ASSOCI ATED WITH bladder exstrophy-epispadias-cloacal exstrophy complex (ortholog); breast cancer (ortholog); colorectal cancer (ortholog); FOUND IN cell surface (ortholog); external side of plasma membrane (ortholog); filopodium membrane (ortholog); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 6-propyl-2-thiouracil; acetamide | 4 | 121148102 | 121335549 | Rat | 196 | old_gene_name | gene, protein-coding, PROVISIONAL [RefSeq] |
| 1561294 | Antxr2 | ANTXR cell adhesion molecule 2 | ENCODES a protein that exhibits metal ion binding (inferred); signaling receptor activity (inferred); INVOLVED IN collagen fibril organization (ortholog); single fertilization (ortholog); uterus development (ortholog); ASSOCIATED WITH anthrax disease; ankylosing spondylitis (ortholog); congenital my opathy 1A (ortholog); FOUND IN cell surface (ortholog); external side of plasma membrane (ortholog); membrane (ortholog); INTERACTS WITH 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine; 6-propyl-2-thiouracil | 14 | 11845774 | 11986166 | Rat | 162 | old_gene_name | gene, protein-coding, VALIDATED [RefSeq] |
| 2526 | Hbegf | heparin-binding EGF-like growth factor | ENCODES a protein that exhibits epidermal growth factor receptor binding; growth factor activity; heparin binding (ortholog); INVOLVED IN epidermal growth factor receptor signaling pathway; negative regulation of glycoprotein biosynthetic process; positive regulation of cell growth; PARTICIPATES IN epidermal growth factor/neuregulin signaling pathway; gonadotropin-releasing hormone signaling pathway; ASSOCIATED WITH acute kidney failure; Animal Disease Models (ortholog); Cardiotoxicity (ortholog); FOUND IN cell surface (ortholog); extracellular space (ortholog); plasma membrane (ortholog); INTERACTS WITH (+)-schisandrin B; 1,2,4-trimethylbenzene; 17beta-estradiol | 18 | 28380337 | 28390220 | Rat | 413 | old_gene_name , description | gene, protein-coding, PROVISIONAL [RefSeq] |
| 1563190 | Antxrl1 | ANTXR like 1 | ENCODES a protein that exhibits metal ion binding (inferred); signaling receptor activity (inferred); FOUND IN membrane (inferred); INTERACTS WITH atrazine; bisphenol A; 1,2-dimethylhydrazine (ortholog) | 16 | 9369046 | 9393569 | Rat | 19 | old_gene_name | gene, protein-coding, VALIDATED [RefSeq] |
| 6500283 | Antxrl2 | ANTXR like 2 | ENCODES a protein that exhibits metal ion binding (inferred); signaling receptor activity (inferred); FOUND IN membrane (inferred) | 16 | 9306293 | 9338559 | Rat | 7 | old_gene_name | gene, protein-coding, MODEL [RefSeq] |
| 1596785 | Antxrl3 | ANTXR like 3 | ENCODES a protein that exhibits metal ion binding (inferred); signaling receptor activity (inferred); FOUND IN membrane (inferred) | 16 | 9337985 | 9364423 | Rat | 7 | old_gene_name | gene, protein-coding, VALIDATED [RefSeq] |
| 1310963 | Nlrp1a | NLR family, pyrin domain containing 1A | ENCODES a protein that exhibits scaffold protein binding; ATP binding (ortholog); ATP hydrolysis activity (ortholog); INVOLVED IN negative regulation of cellular defense response; positive regulation of pyroptotic inflammatory response; antiviral innate immune response (ortholog); PARTICIPATES IN in terleukin-1 signaling pathway; NOD-like receptor signaling pathway; ASSOCIATED WITH Autoinflammation with Arthritis and Dyskeratosis (ortholog); genetic disease (ortholog); Multiple Self-healing Palmoplantar Carcinoma (ortholog); FOUND IN neuronal cell body; protein-containing complex; canonical inflammasome complex (ortholog); INTERACTS WITH 17beta-estradiol; 17beta-estradiol 3-benzoate; 2,3,7,8-tetrachlorodibenzodioxine | 10 | 56277134 | 56332229 | Rat | 176 | old_gene_name | gene, protein-coding, VALIDATED [RefSeq] |
| 708448 | Phax | phosphorylated adaptor for RNA export | ENCODES a protein that exhibits toxic substance binding; mRNA cap binding complex binding (ortholog); INVOLVED IN RNA stabilization (ortholog); snRNA export from nucleus (ortholog); PARTICIPATES IN RNA transport pathway; ASSOCIATED WITH Hirschsprung's disease (o rtholog); FOUND IN neuronal cell body; cytoplasm (ortholog); nucleoplasm (ortholog); INTERACTS WITH 2,4-dinitrotoluene; 2,6-dinitrotoluene; ammonium chloride | 18 | 52251231 | 52267916 | Rat | 84 | old_gene_name , description | gene, protein-coding, VALIDATED [RefSeq] |
| 1304634 | Dph2 | diphthamide biosynthesis 2 | ENCODES a protein that exhibits 2-(3-amino-3-carboxypropyl)histidine synthase activity (ortholog); 4 iron, 4 sulfur cluster binding (ortholog); INVOLVED IN protein histidyl modification to diphthamide (ortholog); ASSOCIATED WITH Developmental Disabilities (ortholog); diphthamide deficiency syndrome (ortholog); diphthamide deficiency syndrome 2 (ortholog); FOUND IN 2-(3-amino-3-carboxypropyl)histidine synthase complex (ortholog); cytosol (ortholog); perinuclear region of cytoplasm (ortholog); INTERACTS WITH 3-chloropropane-1,2-diol; bisphenol A; cobalt dichloride | 5 | 136713868 | 136716828 | Rat | 90 | old_gene_name | gene, protein-coding, PROVISIONAL [RefSeq] |
| 1311123 | Slc47a1 | solute carrier family 47 member 1 | ENCODES a protein that exhibits amide transmembrane transporter activity; polyspecific organic cation:proton antiporter activity; xenobiotic transmembrane transporter activity; INVOLVED IN monoatomic cation transmembrane transport; monoatomic cation transport; organic cation transport; PARTICIPATES IN cisplatin response pathway; metformin pharmacokinetics pathway; ASSOCIATED WITH kidney disease (ortholog); FOUND IN plasma membrane; vesicle; apical plasma membrane (ortholog); INTERACTS WITH 17beta-estradiol; 17beta-estradiol 3-benzoate; alpha-Zearalanol | 10 | 46533580 | 46590128 | Rat | 310 | old_gene_name | gene, protein-coding, PROVISIONAL [RefSeq] |
| 1562382 | Slc47a2 | solute carrier family 47 member 2 | ENCODES a protein that exhibits antiporter activity (ortholog); polyspecific organic cation:proton antiporter activity (ortholog); transmembrane transporter activity (ortholog); INVOLVED IN organic cation transport (ortholog); PARTICIPATES IN metformin pharmacokinetics pathway; FOUND IN plasma membr ane (ortholog); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; bisphenol A; Cuprizon | 10 | 46490262 | 46532954 | Rat | 133 | old_gene_name | gene, protein-coding, INFERRED [RefSeq] |
| 619755 | Rac1 | Rac family small GTPase 1 | ENCODES a protein that exhibits ATPase binding; GTP binding; GTPase activity; INVOLVED IN actin cytoskeleton organization; actin filament organization; bone resorption; PARTICIPATES IN Rho/Rac/Cdc42 mediated signaling pathway; Arf family mediated signaling pathway; azathioprine pharmacodynamics path way; ASSOCIATED WITH congestive heart failure; Left Ventricular Hypertrophy; autosomal dominant intellectual developmental disorder 48 (ortholog); FOUND IN cytosol; GABA-ergic synapse; Golgi membrane; INTERACTS WITH 11-deoxycorticosterone; 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine | 12 | 16150411 | 16170864 | Rat | 639 | old_gene_name | gene, protein-coding, PROVISIONAL [RefSeq] |
| 1307568 | Rac2 | Rac family small GTPase 2 | ENCODES a protein that exhibits GTP binding (ortholog); GTPase activity (ortholog); protein kinase regulator activity (ortholog); INVOLVED IN actin cytoskeleton organization; bone resorption; actin filament organization (ortholog); PARTICIPATES IN B cell receptor signaling pathway; ceramide signalin g pathway; chemokine mediated signaling pathway; ASSOCIATED WITH acute myeloid leukemia (ortholog); Chronic Periodontitis (ortholog); Disease Progression (ortholog); FOUND IN actin filament (ortholog); cytoplasm (ortholog); cytosol (ortholog); INTERACTS WITH 17beta-estradiol; 17beta-estradiol 3-benzoate; 2,3,7,8-tetrachlorodibenzodioxine | 7 | 111981825 | 112009201 | Rat | 274 | old_gene_name | gene, protein-coding, PROVISIONAL [RefSeq] |
| 1590052 | Rac3 | Rac family small GTPase 3 | ENCODES a protein that exhibits calcium-dependent protein binding (ortholog); GTPase activity (ortholog); INVOLVED IN actin cytoskeleton organization (ortholog); cell projection assembly (ortholog); cerebral cortex GABAergic interneuron development (ortholog); ASSOCIATED WITH acute myeloid leukemia (ortholog); basal cell carcinoma (ortholog); Desbuquois dysplasia (ortholog); FOUND IN growth cone; cell periphery (ortholog); endomembrane system (ortholog); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 2,3,7,8-Tetrachlorodibenzofuran; 3-chloropropane-1,2-diol | 10 | 106501133 | 106503569 | Rat | 158 | old_gene_name | gene, protein-coding, VALIDATED [RefSeq] |
| 3521 | Art2b | ADP-ribosyltransferase 2b | ENCODES a protein that exhibits hydrolase activity, acting on glycosyl bonds (ortholog); NAD+-protein-arginine ADP-ribosyltransferase activity (ortholog); INVOLVED IN NAD+ catabolic process (ortholog); FOUND IN external side of plasma membrane (ortholog); INTERACTS WITH 2,2',4,4'-Tetrabromodiphenyl ether; 2,3,7,8-tetrachlorodibenzodioxine; 3H-1,2-dithiole-3-thione | 1 | 165368623 | 165386280 | Rat | 32 | old_gene_name | gene, protein-coding, PROVISIONAL [RefSeq] |
| 628834 | Art5 | ADP-ribosyltransferase 5 | ENCODES a protein that exhibits NAD+ nucleosidase activity (ortholog); NAD+-protein-arginine ADP-ribosyltransferase activity (ortholog); FOUND IN membrane (ortholog); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 6-propyl-2-thiouracil; acrylamide | 1 | 165885344 | 165895306 | Rat | 60 | old_gene_name | gene, protein-coding, VALIDATED [RefSeq] |
| 2053 | Parp1 | poly (ADP-ribose) polymerase 1 | ENCODES a protein that exhibits enzyme binding; histone deacetylase binding; NAD binding; INVOLVED IN carbohydrate biosynthetic process; cellular response to amyloid-beta; cellular response to nerve growth factor stimulus; PARTICIPATES IN ADP-ribosylation pathway, mono and poly-ribosylation; base ex cision repair pathway; ASSOCIATED WITH Binge Drinking; borna disease; Carotid Artery Injuries; FOUND IN nucleus; chromatin (ortholog); cytoplasm (ortholog); INTERACTS WITH (+)-pilocarpine; (+)-sesamin; (-)-anisomycin | 13 | 94839484 | 94871295 | Rat | 2342 | old_gene_name | gene, protein-coding, PROVISIONAL [RefSeq] |
| 1306243 | Parp16 | poly (ADP-ribose) polymerase family, member 16 | ENCODES a protein that exhibits kinase binding (ortholog); NAD+ poly-ADP-ribosyltransferase activity (ortholog); NAD+-protein mono-ADP-ribosyltransferase activity (ortholog); INVOLVED IN cellular response to leukemia inhibitory factor (ortholog); endoplasmic reticulum unfolded protein response (orth olog); IRE1-mediated unfolded protein response (ortholog); PARTICIPATES IN ADP-ribosylation pathway, mono and poly-ribosylation; FOUND IN endoplasmic reticulum (ortholog); endoplasmic reticulum tubular network (ortholog); nuclear envelope (ortholog); INTERACTS WITH (+)-schisandrin B; 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine | 8 | 74626399 | 74644610 | Rat | 123 | old_gene_name | gene, protein-coding, VALIDATED [RefSeq] |
| 628694 | Zc3hav1 | zinc finger CCCH-type containing, antiviral 1 | ENCODES a protein that exhibits identical protein binding; RNA binding; NAD+ binding (ortholog); INVOLVED IN cellular response to virus; negative regulation of viral genome replication; positive regulation of mRNA catabolic process; PARTICIPATES IN ADP-ribosylation pathway, mono and poly-ribosylatio n; FOUND IN cytoplasm (ortholog); cytosol (ortholog); INTERACTS WITH 2,2',5,5'-tetrachlorobiphenyl; 2,3,7,8-tetrachlorodibenzodioxine; 3-chloropropane-1,2-diol | 4 | 67979055 | 68029353 | Rat | 162 | old_gene_name | gene, protein-coding, VALIDATED [RefSeq] |
| 621583 | A4galt | alpha 1,4-galactosyltransferase | ENCODES a protein that exhibits galactosyltransferase activity; lactosylceramide 4-alpha-galactosyltransferase activity (ortholog); toxic substance binding (ortholog); INVOLVED IN globoside biosynthetic process (ortholog); plasma membrane organization (ortholog) ; PARTICIPATES IN globoside metabolic pathway; ASSOCIATED WITH Burkitt lymphoma (ortholog); Caffey disease (ortholog); NOR POLYAGGLUTINATION SYNDROME (ortholog); FOUND IN membrane (ortholog); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; ammonium chloride; bis(2-ethylhexyl) phthalate | 7 | 116248571 | 116272917 | Rat | 76 | description | gene, protein-coding, VALIDATED [RefSeq] |
| 620724 | Abtb2 | ankyrin repeat and BTB domain containing 2 | ENCODES a protein that exhibits protein heterodimerization activity (inferred); INVOLVED IN cellular response to toxic substance (ortholog); FOUND IN nucleoplasm (ortholog); INTERACTS WITH 1-naphthyl isothiocyanate; 2,3,7,8-tetrachlorodibenzodioxine; 2,4-dinitro toluene | 3 | 110409672 | 110563488 | Rat | 118 | description | gene, protein-coding, VALIDATED [RefSeq] |
| 1596307 | Aqp10 | aquaporin 10 | ENCODES a protein that exhibits glycerol channel activity (ortholog); water channel activity (ortholog); INVOLVED IN glycerol transmembrane transport (ortholog); protein homotetramerization (ortholog); response to toxic substance (ortholog); PARTICIPATES IN wate r transport pathway; FOUND IN apical plasma membrane (ortholog); plasma membrane (ortholog); INTERACTS WITH all-trans-retinoic acid (ortholog); ammonium hexachloroplatinate (ortholog); arsane (ortholog) | 2 | 177699717 | 177704620 | Rat | 62 | description | gene, protein-coding, MODEL [RefSeq] |
| 2318374 | Arhgap33 | Rho GTPase activating protein 33 | ENCODES a protein that exhibits GTPase activator activity (ortholog); protein kinase binding (ortholog); INVOLVED IN regulation of dendritic spine morphogenesis; response to toxic substance; regulation of postsynapse assembly (ortholog); ASSOCIATED WITH autism s pectrum disorder (ortholog); disease of mental health (ortholog); temporal lobe epilepsy (ortholog); FOUND IN dendritic spine; glutamatergic synapse; postsynaptic density; INTERACTS WITH 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine; 2,6-dinitrotoluene | 1 | 94903566 | 94917074 | Rat | 80 | description | gene, protein-coding, VALIDATED [RefSeq] |
| 621325 | As3mt | arsenite methyltransferase | ENCODES a protein that exhibits arsenite methyltransferase activity; INVOLVED IN arsonoacetate metabolic process; response to arsenic-containing substance; toxin metabolic process; PARTICIPATES IN homocysteine metabolic pathway; methionine cycle/metabolic pathwa y; ASSOCIATED WITH Arsenic Poisoning (ortholog); attention deficit hyperactivity disorder (ortholog); Birth Weight (ortholog); FOUND IN cytosol; INTERACTS WITH 1,4-dithiothreitol; 17beta-estradiol; 17beta-estradiol 3-benzoate | 1 | 255536879 | 255569245 | Rat | 246 | description | gene, protein-coding, VALIDATED [RefSeq] |
| 2163 | Ass1 | argininosuccinate synthase 1 | ENCODES a protein that exhibits argininosuccinate synthase activity; toxic substance binding; amino acid binding (ortholog); INVOLVED IN acute-phase response; argininosuccinate metabolic process; cellular response to amine stimulus; PARTICIPATES IN urea cycle pa thway; AGAT deficiency pathway; arginine and proline metabolic pathway; ASSOCIATED WITH Acute-Phase Reaction; Drug-Related Side Effects and Adverse Reactions; Endotoxemia; FOUND IN cell body fiber; mitochondrial outer membrane; neuronal cell body; INTERACTS WITH 17alpha-ethynylestradiol; 17beta-estradiol; 17beta-estradiol 3-benzoate | 3 | 35144765 | 35194632 | Rat | 431 | description | gene, protein-coding, PROVISIONAL [RefSeq] |
| 1304668 | Blmh | bleomycin hydrolase | ENCODES a protein that exhibits aminopeptidase activity (ortholog); identical protein binding (ortholog); peptidase activity (ortholog); INVOLVED IN response to toxic substance (ortholog); response to xenobiotic stimulus (ortholog); ASSOCIATED WITH Alzheimer's d isease 1 (ortholog); FOUND IN cytoplasm (ortholog); cytosol (ortholog); INTERACTS WITH (+)-schisandrin B; 2,4-dinitrotoluene; 2,6-dinitrotoluene | 10 | 62270170 | 62313349 | Rat | 107 | description | gene, protein-coding, VALIDATED [RefSeq] |
| 69069 | Ccl5 | C-C motif chemokine ligand 5 | ENCODES a protein that exhibits chemokine activity; heparin binding; CCR1 chemokine receptor binding (ortholog); INVOLVED IN cellular response to alkyl hydroperoxide; cellular response to amino acid stimulus; cellular response to cytokine stimulus; PARTICIPATES IN syndecan signaling pathway; Chagas disease pathway; chemokine mediated signaling pathway; ASSOCIATED WITH alcoholic hepatitis; allergic conjunctivitis; Animal Toxoplasmosis; FOUND IN extracellular space; cytoplasm (ortholog); membrane (ortholog); INTERACTS WITH 1-naphthyl isothiocyanate; 17alpha-ethynylestradiol; 17beta-estradiol | 10 | 68820330 | 68824906 | Rat | 907 | description | gene, protein-coding, VALIDATED [RefSeq] |
| 1561104 | Cd209d | CD209d molecule | ENCODES a protein that exhibits cell adhesion receptor activity (ortholog); D-mannose binding (ortholog); identical protein binding (ortholog); INVOLVED IN B cell adhesion (ortholog); defense response to bacterium (ortholog); dendritic cell migration (ortholog); ASSOCIATED WITH acquired immunodefici ency syndrome (ortholog); Animal Toxoplasmosis (ortholog); aspergillosis (ortholog); FOUND IN external side of plasma membrane (ortholog); plasma membrane (ortholog); INTERACTS WITH alpha-Zearalanol; bisphenol A; pravastatin | 12 | 6689002 | 6695452 | Rat | 87 | description | gene, protein-coding, PROVISIONAL [RefSeq] |
| 619745 | Cdh13 | cadherin 13 | ENCODES a protein that exhibits adiponectin binding (ortholog); cadherin binding (ortholog); identical protein binding (ortholog); INVOLVED IN cellular response to toxic substance; cellular response to xenobiotic stimulus; calcium-dependent cell-cell adhesion (o rtholog); ASSOCIATED WITH abnormal cue-induced reinstatement of an extinguished operant behavior for a cocaine reinforcer; saccharin preference; ASSOCIATED WITH coronary restenosis; Lung Neoplasms; substance-related disorder; FOUND IN GABA-ergic synapse; perinuclear region of cytoplasm; synapse; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 2,3,7,8-Tetrachlorodibenzofuran; 2-acetamidofluorene | 19 | 63258251 | 64296122 | Rat | 281 | description | gene, protein-coding, PROVISIONAL [RefSeq] |
| 620860 | Crispld2 | cysteine-rich secretory protein LCCL domain containing 2 | ENCODES a protein that exhibits glycosaminoglycan binding (ortholog); heparin binding (ortholog); INVOLVED IN lung development; extracellular matrix organization (ortholog); face morphogenesis (ortholog); ASSOCIATED WITH liver disease (ortholog); lung disease (ortholog); tox ;'>toxic encephalopathy (ortholog); FOUND IN extracellular matrix (ortholog); transport vesicle (ortholog); INTERACTS WITH 1,2,4-trimethylbenzene; 17alpha-ethynylestradiol; 2,3,7,8-tetrachlorodibenzodioxine | 19 | 64961764 | 65020099 | Rat | 172 | description | gene, protein-coding, VALIDATED [RefSeq] |
| 2476 | Cyp2f4 | cytochrome P450, family 2, subfamily f, polypeptide 4 | ENCODES a protein that exhibits monooxygenase activity; oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen (ortholog); INVOLVED IN trichloroethylene metabolic proc ess; naphthalene catabolic process (ortholog); response to toxic substance (ortholog); PARTICIPATES IN phase I biotransformation pathway via cytochrome P450; ASSOCIATED WITH autism spectrum disorder (ortholog); Experimental Liver Neoplasms (ortholog); FOUND IN endoplasmic reticulum membrane (inferred); INTERACTS WITH (+)-schisandrin B; 1,1-dichloroethene; 1-nitronaphthalene | 1 | 91543768 | 91557553 | Rat | 206 | description | gene, protein-coding, VALIDATED [RefSeq] |
| 621227 | Daxx | death-domain associated protein | ENCODES a protein that exhibits JUN kinase binding; kinesin binding; nuclear androgen receptor binding; INVOLVED IN cellular response to hydrogen peroxide; cellular response to tumor necrosis factor; cellular response to type II interferon; PARTICIPATES IN aldosterone signaling pathway; histone modi fication pathway; p53 signaling pathway; ASSOCIATED WITH Brain Hypoxia-Ischemia; Heavy Metal Toxicity; transient cerebral ischemia; FOUND IN cell body; cell cortex; microtubule; INTERACTS WITH 2,4-dinitrotoluene; 4,4'-sulfonyldiphenol; acetamide | 20 | 4971973 | 4978062 | Rat | 317 | description | gene, protein-coding, VALIDATED [RefSeq] |
| 1308072 | Dhx15 | DEAH-box helicase 15 | ENCODES a protein that exhibits double-stranded RNA binding (ortholog); RNA binding (ortholog); RNA helicase activity (ortholog); INVOLVED IN response to alkaloid; response to toxic substance; antiviral innate immune response (ortholog); PARTICIPATES IN ribosome biogenesis pathway; spliceosome pathway; ASSOCIATED WITH acute myeloid leukemia (ortholog); basal cell carcinoma (ortholog); epilepsy (ortholog); FOUND IN nuclear speck (ortholog); U12-type spliceosomal complex (ortholog); U2-type post-mRNA release spliceosomal complex (ortholog); INTERACTS WITH 17alpha-ethynylestradiol; 2,3,7,8-tetrachlorodibenzodioxine; bisphenol A | 14 | 62999886 | 63037829 | Rat | 131 | description | gene, protein-coding, PROVISIONAL [RefSeq] |
| 1306518 | Fbxw4 | F-box and WD repeat domain containing 4 | INVOLVED IN cartilage development (ortholog); embryonic digit morphogenesis (ortholog); limb development (ortholog); ASSOCIATED WITH Desbuquois dysplasia (ortholog); split hand-foot malformation (ortholog); split hand-foot malformation 3 (ortholog); INTERACTS WITH bisphenol A; flutamide; T-2 tox tyle='font-weight:700;'>toxin | 1 | 254375921 | 254465173 | Rat | 56 | description | gene, protein-coding, PROVISIONAL [RefSeq] |
| 61845 | Gfer | growth factor, augmenter of liver regeneration | ENCODES a protein that exhibits flavin-dependent sulfhydryl oxidase activity; flavin adenine dinucleotide binding (ortholog); protein-disulfide reductase activity (ortholog); INVOLVED IN cellular response to actinomycin D; cellular response to lipopolysaccharide; cellular response to tox nt-weight:700;'>toxic substance; PARTICIPATES IN intermembrane space assembly pathway of mitochondrial protein import; mitochondrial iron-sulfur cluster export pathway; ASSOCIATED WITH acute kidney failure; Chemical and Drug Induced Liver Injury; cryptorchidism; FOUND IN extracellular space; cytosol (ortholog); mitochondrion (ortholog); INTERACTS WITH 1,2,4-trimethylbenzene; 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine | 10 | 14223023 | 14225736 | Rat | 135 | description | gene, protein-coding, VALIDATED [RefSeq] |
| 1309970 | Gsta4 | glutathione S-transferase alpha 4 | ENCODES a protein that exhibits toxic substance binding; glutathione transferase activity (ortholog); identical protein binding (ortholog); INVOLVED IN cellular response to lithium ion; response to herbicide; response to nicotine; PARTICIPATES IN glutathione con jugation pathway; glutathione metabolic pathway; phase I biotransformation pathway via cytochrome P450; ASSOCIATED WITH Experimental Diabetes Mellitus; Experimental Liver Cirrhosis; Liver Injury; FOUND IN cytosol (ortholog); mitochondrion (ortholog); INTERACTS WITH (+)-schisandrin B; (E)-4-hydroxynon-2-enal; (S)-nicotine | 8 | 87947247 | 87964490 | Rat | 422 | description | gene, protein-coding, PROVISIONAL [RefSeq] |
| 2758 | Gstp1 | glutathione S-transferase pi 1 | ENCODES a protein that exhibits protein kinase binding; toxic substance binding; dinitrosyl-iron complex binding (ortholog); INVOLVED IN animal organ regeneration; cellular response to cell-matrix adhesion; cellular response to epidermal growth factor stimulus; PARTICIPATES IN glutathione conjugation pathway; paracetamol pharmacokinetics pathway; glutathione metabolic pathway; ASSOCIATED WITH Cholangiofibrosis; cholestasis; Chronic Cerebral Hypoperfusion; FOUND IN cytosol (ortholog); mitochondrion (ortholog); protein-containing complex (ortholog); INTERACTS WITH (3,4-dihydroxyphenyl)acetic acid; (E)-4-hydroxynon-2-enal; (R)-lipoic acid | 1 | 210767237 | 210770242 | Rat | 1183 | description | gene, protein-coding, VALIDATED [RefSeq] |
| 619989 | Ido1 | indoleamine 2,3-dioxygenase 1 | ENCODES a protein that exhibits amino acid binding; indoleamine 2,3-dioxygenase activity; oxygen binding; INVOLVED IN L-tryptophan catabolic process to L-kynurenine; inflammatory response (ortholog); kynurenic acid biosynthetic process (ortholog); PARTICIPATES IN tryptophan metabolic pathway; kynure nine metabolic pathway; sleeping sickness pathway; ASSOCIATED WITH acquired immunodeficiency syndrome (ortholog); Acute Lung Injury (ortholog); Animal Toxoplasmosis (ortholog); FOUND IN cytoplasm (ortholog); smooth muscle contractile fiber (ortholog); stereocilium bundle (ortholog); INTERACTS WITH ammonium chloride; atrazine; bisphenol A | 16 | 74133259 | 74145328 | Rat | 254 | description | gene, protein-coding, VALIDATED [RefSeq] |
| 12879433 | Ift140em1Kyo | intraflagellar transport 140; CRISPR/Cas9 induced mutant 1, Kyo | This allele was established by CRISPR/Cas9 system at Kyoto University and introduced to the Institute of Environmental Toxicology. Background strain: Jcl:Wistar. This line 1 (em1) has 2-bp insertion (c.23_24insGG) in the exon 1 of Ift140 (intraflagellar transpor t 140) gene. | | | | Rat | | description | gene, allele |
| 12879435 | Ift140em2Kyo | intraflagellar transport 140; CRISPR/Cas9 induced mutant 2, Kyo | This allele was established by CRISPR/Cas9 system at Kyoto University and introduced to the Institute of Environmental Toxicology. Background strain: Jcl:Wistar. This line 2 (em2) has 2-bp deletion (c.23_24del) in the exon 1 of Ift140 (intraflagellar transport 1 40) gene. | | | | Rat | | description | gene, allele |
| 1306896 | Igtp | interferon gamma induced GTPase | ENCODES a protein that exhibits GTP binding (inferred); hydrolase activity (inferred); nucleotide binding (inferred); PARTICIPATES IN toxoplasmosis pathway; FOUND IN membrane (inferred); INTERACTS WITH (+)-schisandrin B; 17beta-estradiol; 17beta-estradiol 3-benz oate | 10 | 42875047 | 42882866 | Rat | 59 | description | gene, protein-coding, PROVISIONAL [RefSeq] |
| 1307335 | Il20ra | interleukin 20 receptor subunit alpha | ENCODES a protein that exhibits interleukin-20 binding (ortholog); INVOLVED IN cytokine-mediated signaling pathway (ortholog); positive regulation of intrinsic apoptotic signaling pathway (ortholog); regulation of bone resorption (ortholog); PARTICIPATES IN cytokine mediated signaling pathway; Jak-S tat signaling pathway; ASSOCIATED WITH Spontaneous Abortions (ortholog); toxic shock syndrome (ortholog); INTERACTS WITH 2,3,7,8-Tetrachlorodibenzofuran; 3-chloropropane-1,2-diol; bisphenol A | 1 | 16243683 | 16313229 | Rat | 63 | description | gene, protein-coding, PROVISIONAL [RefSeq] |
| 1566151 | Il20rb | interleukin 20 receptor subunit beta | ENCODES a protein that exhibits interleukin-20 binding (ortholog); INVOLVED IN homeostasis of number of cells within a tissue (ortholog); immune response-inhibiting signal transduction (ortholog); inflammatory response to antigenic stimulus (ortholog); PARTICIPATES IN cytokine mediated signaling pat hway; Jak-Stat signaling pathway; ASSOCIATED WITH toxic shock syndrome (ortholog); INTERACTS WITH alpha-Zearalanol; bisphenol A; gentamycin | 8 | 109858108 | 109896066 | Rat | 106 | description | gene, protein-coding, PROVISIONAL [RefSeq] |
| 620873 | Il23a | interleukin 23 subunit alpha | ENCODES a protein that exhibits cytokine activity (ortholog); interleukin-23 receptor binding (ortholog); INVOLVED IN cell surface receptor signaling pathway via JAK-STAT (ortholog); cell surface receptor signaling pathway via STAT (ortholog); defense response to Gram-negative bacterium (ortholog); PARTICIPATES IN interleukin-23 signaling pathway; cytokine mediated signaling pathway; Jak-Stat signaling pathway; ASSOCIATED WITH Amebic Liver Abscess (ortholog); Animal Toxoplasmosis (ortholog); atopic dermatitis (ortholog); FOUND IN extracellular space (ortholog); interleukin-23 complex (ortholog); plasma membrane (ortholog); INTERACTS WITH (+)-schisandrin B; 1-chloro-2,4-dinitrobenzene; 2,3,7,8-tetrachlorodibenzodioxine | 7 | 1306320 | 1308434 | Rat | 342 | description | gene, protein-coding, PROVISIONAL [RefSeq] |
| 2896 | Il2rb | interleukin 2 receptor subunit beta | ENCODES a protein that exhibits interleukin-2 binding; interleukin-2 receptor activity; coreceptor activity (ortholog); INVOLVED IN cytokine-mediated signaling pathway; interleukin-15-mediated signaling pathway (ortholog); interleukin-2-mediated signaling pathway (ortholog); PARTICIPATES IN interleu kin-12 signaling pathway; interleukin-2 signaling pathway; cytokine mediated signaling pathway; ASSOCIATED WITH allergic disease (ortholog); Animal Toxoplasmosis (ortholog); asthma (ortholog); FOUND IN cell surface; external side of plasma membrane (ortholog); plasma membrane (ortholog); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 6-propyl-2-thiouracil; acetamide | 7 | 111913828 | 111928537 | Rat | 184 | description | gene, protein-coding, VALIDATED [RefSeq] |
| 628829 | Kcnc2 | potassium voltage-gated channel subfamily C member 2 | ENCODES a protein that exhibits delayed rectifier potassium channel activity; transmembrane transporter binding; voltage-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential; INVOLVED IN cellular response to ammonium ion; cellular response to nitric oxide; c ellular response to toxic substance; ASSOCIATED WITH developmental and epileptic encephalopathy (ortholog); developmental and epileptic encephalopathy 103 (ortholog); epilepsy (ortholog); FOUND IN apical plasma membrane; axolemma; axon; INTERACTS WITH 1-naphthyl isothiocyanate; 2,3,7,8-Tetrachlorodibenzofuran; 3,4-methylenedioxymethamphetamine | 7 | 49586274 | 49770212 | Rat | 186 | description | gene, protein-coding, VALIDATED [RefSeq] |
| 1560601 | Kdm5c | lysine demethylase 5C | ENCODES a protein that exhibits histone H3K4 demethylase activity (ortholog); identical protein binding (ortholog); RNA polymerase II-specific DNA-binding transcription factor binding (ortholog); INVOLVED IN response to toxic substance; gene expression (ortholog ); negative regulation of DNA-templated transcription (ortholog); PARTICIPATES IN histone modification pathway; renal cell carcinoma pathway; ASSOCIATED WITH schizophrenia; Abnormal Reflexes (ortholog); autistic disorder (ortholog); FOUND IN cytoplasm (ortholog); nucleoplasm (ortholog); nucleus (ortholog); INTERACTS WITH 1-naphthyl isothiocyanate; 17alpha-ethynylestradiol; bisphenol A | X | 24821568 | 24866423 | Rat | 123 | description | gene, protein-coding, VALIDATED [RefSeq] |
| 1310787 | Lao1 | L-amino acid oxidase 1 | ENCODES a protein that exhibits L-amino-acid oxidase activity (inferred); oxidoreductase activity (inferred); toxin activity (inferred); INVOLVED IN defense response to bacterium (inferred); modulation of process of another organism (inferred); PARTICIPATES IN a lanine, aspartate and glutamate metabolic pathway; cysteine and methionine metabolic pathway; phenylalanine metabolic pathway; FOUND IN extracellular region (inferred); INTERACTS WITH bisphenol A; fenvalerate | 5 | 137859033 | 137868926 | Rat | 19 | description | gene, protein-coding, PROVISIONAL [RefSeq] |
| 1309329 | Lrp5 | LDL receptor related protein 5 | ENCODES a protein that exhibits coreceptor activity (ortholog); toxin transmembrane transporter activity (ortholog); Wnt receptor activity (ortholog); INVOLVED IN response to peptide hormone; retina vasculature morphogenesis in camera-type eye; adipose tissue de velopment (ortholog); PARTICIPATES IN altered Wnt signaling, canonical pathway; N-cadherin signaling pathway; Wnt signaling, canonical pathway; ASSOCIATED WITH abnormal femur morphology; abnormal retina blood vessel morphology; abnormal retina blood vessel pattern; ASSOCIATED WITH autosomal dominant polycystic kidney disease; Femur Head Necrosis; osteoporosis; FOUND IN plasma membrane (ortholog); receptor complex (ortholog); INTERACTS WITH 17alpha-ethynylestradiol; 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine | 1 | 210243499 | 210346886 | Rat | 322 | description | gene, protein-coding, VALIDATED [RefSeq] |
| 1302993 | Ly96 | lymphocyte antigen 96 | ENCODES a protein that exhibits lipopolysaccharide immune receptor activity (ortholog); INVOLVED IN cellular response to lipopolysaccharide (ortholog); detection of lipopolysaccharide (ortholog); lipopolysaccharide-mediated signaling pathway (ortholog); PARTICIPATES IN Toll-like receptor signaling p athway; toxoplasmosis pathway; ASSOCIATED WITH Bacterial Keratitis (ortholog); carcinoma (ortholog); cholestasis (ortholog); FOUND IN lipopolysaccharide receptor complex (ortholog); plasma membrane (ortholog); INTERACTS WITH 1-naphthyl isothiocyanate; 4,4'-diaminodiphenylmethane; 6-propyl-2-thiouracil | 5 | 7365536 | 7397864 | Rat | 198 | description | gene, protein-coding, PROVISIONAL [RefSeq] |
| 1359517 | Mapda | N6-Methyl-AMP deaminase | ENCODES a protein that exhibits N6-methyl-AMP deaminase activity (ortholog); INVOLVED IN toxic metabolite repair (ortholog); INTERACTS WITH (+)-schisandrin B; 17beta-estradiol; 17beta-estradiol 3-benzoate | 3 | 128555604 | 128583809 | Rat | 68 | description | gene, protein-coding, VALIDATED [RefSeq] |
| 3046 | Mapk3 | mitogen activated protein kinase 3 | ENCODES a protein that exhibits ATP binding; MAP kinase activity; scaffold protein binding; INVOLVED IN arachidonate metabolic process; cellular response to toxic substance; decidualization; PARTICIPATES IN the extracellular signal-regulated Raf/Mek/Erk signalin g pathway; ceramide signaling pathway; endothelin signaling pathway; ASSOCIATED WITH alcohol dependence; alcohol use disorder; cocaine abuse; FOUND IN caveola; cytoplasm; nucleoplasm; INTERACTS WITH (+)-catechin; (+)-dihydromyricetin; (+)-pilocarpine | 1 | 190797189 | 190803411 | Rat | 3590 | description | gene, protein-coding, VALIDATED [RefSeq] |
| 628649 | Mc2r | melanocortin 2 receptor | ENCODES a protein that exhibits corticotropin receptor activity (ortholog); INVOLVED IN placenta development; adenylate cyclase-activating G protein-coupled receptor signaling pathway (ortholog); positive regulation of glucocorticoid biosynthetic process (ortholog); PARTICIPATES IN G protein mediate d signaling pathway via Galphas family; melanocortin system pathway; ASSOCIATED WITH Acute-Phase Reaction; Disorders of Environmental Origin; toxic shock syndrome; FOUND IN plasma membrane (ortholog); INTERACTS WITH ammonium chloride; bis(2-butoxyethyl)phthalate; bisphenol A | 18 | 64279878 | 64291775 | Rat | 99 | description | gene, protein-coding, VALIDATED [RefSeq] |
| 620937 | Mlh1 | mutL homolog 1 | ENCODES a protein that exhibits chromatin binding (ortholog); enzyme activator activity (ortholog); enzyme binding (ortholog); INVOLVED IN response to hypoxia; response to toxic substance; response to xenobiotic stimulus; PARTICIPATES IN altered mismatch repair pathway; colorectal cancer pathway; endometrial cancer pathway; ASSOCIATED WITH lung carcinoma; bile duct cancer (ortholog); breast cancer (ortholog); FOUND IN synaptonemal complex; chiasma (ortholog); chromosome (ortholog); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 2,6-dinitrotoluene; 4-hydroperoxycyclophosphamide | 8 | 120074871 | 120112109 | Rat | 500 | description | gene, protein-coding, VALIDATED [RefSeq] |
| 3160 | Nefm | neurofilament medium chain | ENCODES a protein that exhibits protein-containing complex binding; signaling receptor binding; toxic substance binding; INVOLVED IN axon regeneration; cellular response to estradiol stimulus; cellular response to oxidative stress; PARTICIPATES IN amyotrophic la teral sclerosis pathway; ASSOCIATED WITH amyotrophic lateral sclerosis; congenital hypothyroidism; Experimental Diabetes Mellitus; FOUND IN axon; cytoskeleton; intermediate filament; INTERACTS WITH (-)-anisomycin; 2,5-hexanedione; 2-(3,4-dimethoxyphenyl)-5-\{[2-(3,4-dimethoxyphenyl)ethyl](methyl)amino\}-2-(propan-2-yl)pentanenitrile | 15 | 46535857 | 46541161 | Rat | 243 | description | gene, protein-coding, VALIDATED [RefSeq] |
| 3240 | P2rx1 | purinergic receptor P2X 1 | ENCODES a protein that exhibits ATP binding; extracellularly ATP-gated monoatomic cation channel activity; identical protein binding; INVOLVED IN monoatomic cation transmembrane transport; monoatomic ion transmembrane transport; neuronal action potential; PARTICIPATES IN calcium/calcium-mediated sig naling pathway; ASSOCIATED WITH toxic encephalopathy (ortholog); FOUND IN glutamatergic synapse; postsynaptic membrane; presynaptic active zone membrane; INTERACTS WITH 17beta-estradiol; acetamide; aflatoxin B1 | 10 | 58117107 | 58132167 | Rat | 169 | description | gene, protein-coding, VALIDATED [RefSeq] |
| 628670 | Ppif | peptidylprolyl isomerase F | ENCODES a protein that exhibits cyclosporin A binding; peptide binding; peptidyl-prolyl cis-trans isomerase activity; INVOLVED IN regulation of apoptotic process; regulation of mitochondrial membrane permeability; apoptotic mitochondrial changes (ortholog); PARTICIPATES IN tox 00;'>toxoplasmosis pathway; ASSOCIATED WITH COVID-19 (ortholog); intestinal disease (ortholog); Ulcer (ortholog); FOUND IN mitochondrial inner membrane; mitochondrial matrix; mitochondrial permeability transition pore complex (ortholog); INTERACTS WITH 1,1'-azobis(N,N-dimethylformamide); 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine | 16 | 1264001 | 1270722 | Rat | 255 | description | gene, protein-coding, PROVISIONAL [RefSeq] |
| 632280 | Ppp1r9a | protein phosphatase 1, regulatory subunit 9A | ENCODES a protein that exhibits actin filament binding; GTPase binding; identical protein binding; INVOLVED IN cellular response to toxic substance; excitatory postsynaptic potential; negative regulation of long-term synaptic potentiation; ASSOCIATED WITH hepato cellular carcinoma; Pain; transient cerebral ischemia; FOUND IN actin cytoskeleton; cytoskeleton; dendrite; INTERACTS WITH 1-naphthyl isothiocyanate; 17alpha-ethynylestradiol; 2,3,7,8-tetrachlorodibenzodioxine | 4 | 33936949 | 34258927 | Rat | 206 | description | gene, protein-coding, VALIDATED [RefSeq] |
| 1563360 | Ptpn13 | protein tyrosine phosphatase, non-receptor type 13 | ENCODES a protein that exhibits phosphatidylinositol 3-kinase regulatory subunit binding (ortholog); protein tyrosine phosphatase activity (ortholog); INVOLVED IN cellular response to toxic substance; negative regulation of excitatory synapse assembly; negative regulation of protein phosphorylation; PARTICIPATES IN ephrin - ephrin receptor bidirectional signaling axis; ASSOCIATED WITH transient cerebral ischemia; breast cancer (ortholog); colon cancer (ortholog); FOUND IN cell body; cytoplasm (ortholog); lamellipodium (ortholog); INTERACTS WITH 17beta-estradiol; 17beta-estradiol 3-benzoate; 2,3,7,8-tetrachlorodibenzodioxine | 14 | 6412841 | 6587238 | Rat | 193 | description | gene, protein-coding, VALIDATED [RefSeq] |
| 1303020 | Rnase6 | ribonuclease A family member 6 | ENCODES a protein that exhibits RNA nuclease activity (ortholog); INVOLVED IN antibacterial humoral response (ortholog); antimicrobial humoral immune response mediated by antimicrobial peptide (ortholog); defense response to Gram-negative bacterium (ortholog); ASSOCIATED WITH liver disease (ortholog ); toxic encephalopathy (ortholog); FOUND IN cytoplasmic vesicle (ortholog); extracellular space (ortholog); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; amphetamine; bisphenol A | 15 | 26827896 | 26830807 | Rat | 88 | description | gene, protein-coding, VALIDATED [RefSeq] |
| 628815 | Slc17a3 | solute carrier family 17 member 3 | ENCODES a protein that exhibits efflux transmembrane transporter activity (ortholog); toxin transmembrane transporter activity (ortholog); transmembrane transporter activity (ortholog); INVOLVED IN organic anion transport (ortholog); urate metabolic process (ort holog); urate transport (ortholog); ASSOCIATED WITH gout (ortholog); FOUND IN apical plasma membrane (ortholog); cytoplasm (ortholog); endoplasmic reticulum membrane (ortholog); INTERACTS WITH 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine; 3-chloropropane-1,2-diol | 17 | 41698679 | 41729057 | Rat | 132 | description | gene, protein-coding, PROVISIONAL [RefSeq] |
| 628885 | Slc22a19 | solute carrier family 22, member 19 | ENCODES a protein that exhibits toxin transmembrane transporter activity (ortholog); transmembrane transporter activity (ortholog); INVOLVED IN response to molecule of fungal origin; sodium-independent organic anion transport; organic anion transport (ortholog); ASSOCIATED WITH acute kidney failure (ortholog); FOUND IN apical plasma membrane; INTERACTS WITH 17beta-estradiol; 4-methylumbelliferone sulfate; acetamide | 1 | 214339594 | 214394681 | Rat | 69 | description | gene, protein-coding, PROVISIONAL [RefSeq] |
| 1309495 | Srsf9 | serine and arginine rich splicing factor 9 | ENCODES a protein that exhibits protein domain specific binding (ortholog); INVOLVED IN response to alkaloid; response to toxic substance; negative regulation of mRNA splicing, via spliceosome (ortholog); PARTICIPATES IN spliceosome pathway; ASSOCIATED WITH Expe rimental Autoimmune Encephalomyelitis (ortholog); human immunodeficiency virus infectious disease (ortholog); urinary bladder cancer (ortholog); FOUND IN nucleoplasm (ortholog); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; amitrole; bisphenol A | 12 | 46938948 | 46945213 | Rat | 94 | description | gene, protein-coding, VALIDATED [RefSeq] |
| 3679 | St8sia1 | ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 1 | ENCODES a protein that exhibits sialyltransferase activity; alpha-N-acetylneuraminate alpha-2,8-sialyltransferase activity (ortholog); INVOLVED IN cellular response to heat (ortholog); positive regulation of cell population proliferation (ortholog); PARTICIPATES IN ganglioside metabolic pathway; glo boside metabolic pathway; lacto-series glycosphingolipid metabolic pathway; ASSOCIATED WITH liver disease (ortholog); toxic encephalopathy (ortholog); FOUND IN Golgi membrane (inferred); INTERACTS WITH acetamide; alpha-Zearalanol; ammonium chloride | 4 | 177513966 | 177651553 | Rat | 85 | description | gene, protein-coding, VALIDATED [RefSeq] |
| 1562552 | Sting1 | stimulator of interferon response cGAMP interactor 1 | ENCODES a protein that exhibits 2',3'-cyclic GMP-AMP binding; cyclic-di-GMP binding (ortholog); identical protein binding (ortholog); INVOLVED IN positive regulation of type I interferon production; activation of innate immune response (ortholog); antiviral innate immune response (ortholog); ASSOCIA TED WITH Animal Toxoplasmosis (ortholog); brucellosis (ortholog); Chediak-Higashi syndrome (ortholog); FOUND IN autophagosome (ortholog); cytoplasm (ortholog); cytosol (ortholog); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; acetamide; arsane | 18 | 27606196 | 27612544 | Rat | 310 | description | gene, protein-coding, PROVISIONAL [RefSeq] |
| 1564460 | Tlr11 | toll-like receptor 11 | INVOLVED IN response to bacterium (ortholog); PARTICIPATES IN toxoplasmosis pathway; ASSOCIATED WITH membranoproliferative glomerulonephritis (ortholog); FOUND IN membrane (inferred); INTERACTS WITH bisphenol A; 1,2,4-trichloro-5-(2,5-dichlorophenyl)benzene (ort holog); 2,2',4,4',5,5'-hexachlorobiphenyl (ortholog) | 15 | 26018987 | 26023426 | Rat | 23 | description | gene, protein-coding, VALIDATED [RefSeq] |
| 1566403 | Tmem181 | transmembrane protein 181 | ENCODES a protein that exhibits toxic substance binding (ortholog); FOUND IN membrane (inferred); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 6-propyl-2-thiouracil; amitrole | 1 | 49235923 | 49290244 | Rat | 55 | description | gene, protein-coding, PROVISIONAL [RefSeq] |