Sting1 (stimulator of interferon response cGAMP interactor 1) - Rat Genome Database

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Gene: Sting1 (stimulator of interferon response cGAMP interactor 1) Rattus norvegicus
Analyze
Symbol: Sting1
Name: stimulator of interferon response cGAMP interactor 1
RGD ID: 1562552
Description: Enables 2',3'-cyclic GMP-AMP binding activity. Involved in positive regulation of type I interferon production. Predicted to be located in several cellular components, including mitochondrial outer membrane; perinuclear region of cytoplasm; and peroxisome. Predicted to be part of STING complex. Predicted to be active in autophagosome; bounding membrane of organelle; and endoplasmic reticulum membrane. Human ortholog(s) of this gene implicated in STING-associated vasculopathy with onset in infancy. Orthologous to human STING1 (stimulator of interferon response cGAMP interactor 1); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; acetamide; arsane.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: hypothetical protein LOC498840; LOC498840; mitochondrial transmembrane protein 173; RGD1562552; rSTING; similar to hypothetical protein LOC340061; Tmem173; transmembrane protein 173; uncharacterized protein LOC498840
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81827,606,196 - 27,612,544 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1827,606,196 - 27,611,947 (-)EnsemblGRCr8
mRatBN7.21827,332,119 - 27,338,371 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1827,332,119 - 27,338,335 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1827,459,541 - 27,465,793 (-)NCBIUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01828,221,584 - 28,227,830 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01827,556,463 - 27,562,709 (-)NCBIUTH_Rnor_WKY_Bbb_1.0
Dahl_SR_JrHsd1827,823,195 - 27,829,608 (-)NCBI
Lyon_Normotensive1827,405,559 - 27,411,972 (-)NCBI
Lyon_Hypertensive1827,419,895 - 27,426,308 (-)NCBI
F344_StmMcwi1827,465,149 - 27,471,401 (-)NCBI
Rnor_6.01828,529,537 - 28,535,828 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1828,529,576 - 28,535,828 (-)EnsemblRnor_6.0 Ensemblrn6Rnor6.0
Rnor_5.01828,242,119 - 28,248,371 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41828,355,029 - 28,357,171 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1827,065,352 - 27,071,596 (-)NCBICelera
Cytogenetic Map18p11NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(-)-demecolcine  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
4,4'-sulfonyldiphenol  (ISO)
4-hydroxyphenyl retinamide  (ISO)
acetamide  (EXP)
aflatoxin B1  (ISO)
aldehydo-D-glucose  (ISO)
antirheumatic drug  (ISO)
arsane  (EXP,ISO)
arsenic atom  (EXP,ISO)
arsenite(3-)  (ISO)
arsenous acid  (ISO)
aucubin  (ISO)
benzo[a]pyrene  (EXP,ISO)
beryllium sulfate  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP)
Butylbenzyl phthalate  (ISO)
cadmium atom  (ISO)
cadmium dichloride  (ISO)
cannabidiol  (ISO)
carbon nanotube  (ISO)
ceruletide  (EXP)
chloroprene  (ISO)
cisplatin  (ISO)
Cuprizon  (EXP)
cyfluthrin  (EXP,ISO)
D-glucose  (ISO)
dexamethasone  (ISO)
diarsenic trioxide  (ISO)
dibutyl phthalate  (EXP,ISO)
dioxygen  (ISO)
doxorubicin  (ISO)
endosulfan  (EXP)
ethidium  (ISO)
ethyl methanesulfonate  (ISO)
florfenicol  (ISO)
fonofos  (ISO)
formaldehyde  (ISO)
fructose  (ISO)
genistein  (ISO)
glucose  (ISO)
hexadecanoic acid  (EXP)
imidacloprid  (ISO)
indometacin  (ISO)
lipopolysaccharide  (ISO)
lycopene  (ISO)
manganese atom  (ISO)
manganese(0)  (ISO)
manganese(II) chloride  (ISO)
methyl methanesulfonate  (ISO)
microcystin-LR  (ISO)
Mitoquinone  (ISO)
N-acetyl-L-cysteine  (EXP)
nickel atom  (ISO)
nitrates  (ISO)
ozone  (ISO)
paracetamol  (ISO)
paraquat  (ISO)
parathion  (ISO)
perfluorohexanesulfonic acid  (ISO)
Phytolaccoside E  (ISO)
S-(1,2-dichlorovinyl)-L-cysteine  (ISO)
silicon dioxide  (ISO)
silver atom  (ISO)
silver(0)  (ISO)
sodium arsenite  (EXP,ISO)
sodium fluoride  (ISO)
sunitinib  (ISO)
temozolomide  (ISO)
terbufos  (ISO)
thioacetamide  (EXP)
thiram  (ISO)
titanium dioxide  (EXP,ISO)
trichloroethene  (ISO)
triclosan  (ISO)
Triptolide  (ISO)
vadimezan  (ISO)
valproic acid  (ISO)
zearalenone  (ISO)
zinc oxide  (ISO)
zoledronic acid  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

References

References - curated
# Reference Title Reference Citation
1. Sterile Lung Inflammation Induced by Silica Exacerbates Mycobacterium tuberculosis Infection via STING-Dependent Type 2 Immunity. Benmerzoug S, etal., Cell Rep. 2019 May 28;27(9):2649-2664.e5. doi: 10.1016/j.celrep.2019.04.110.
2. Brucella abortus Triggers a cGAS-Independent STING Pathway To Induce Host Protection That Involves Guanylate-Binding Proteins and Inflammasome Activation. Costa Franco MM, etal., J Immunol. 2018 Jan 15;200(2):607-622. doi: 10.4049/jimmunol.1700725. Epub 2017 Dec 4.
3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
4. Brucella abortus Cyclic Dinucleotides Trigger STING-Dependent Unfolded Protein Response That Favors Bacterial Replication. Guimarães ES, etal., J Immunol. 2019 May 1;202(9):2671-2681. doi: 10.4049/jimmunol.1801233. Epub 2019 Mar 20.
5. STING/MPYS mediates host defense against Listeria monocytogenes infection by regulating Ly6C(hi) monocyte migration. Jin L, etal., J Immunol. 2013 Mar 15;190(6):2835-43. doi: 10.4049/jimmunol.1201788. Epub 2013 Feb 1.
6. Nontypeable Haemophilus influenzae DNA stimulates type I interferon expression via STING signaling pathway. Lu C, etal., Biochim Biophys Acta Mol Cell Res. 2018 Apr;1865(4):665-673. doi: 10.1016/j.bbamcr.2018.01.011. Epub 2018 Feb 5.
7. The cGAS/STING Pathway Is Important for Dendritic Cell Activation but Is Not Essential to Induce Protective Immunity against Mycobacterium tuberculosis Infection. Marinho FV, etal., J Innate Immun. 2018;10(3):239-252. doi: 10.1159/000488952. Epub 2018 May 23.
8. STING is required for host defense against neuropathological West Nile virus infection. McGuckin Wuertz K, etal., PLoS Pathog. 2019 Aug 15;15(8):e1007899. doi: 10.1371/journal.ppat.1007899. eCollection 2019 Aug.
9. Upregulation of innate antiviral restricting factor expression in the cord blood and decidual tissue of HIV-infected mothers. Pereira NZ, etal., PLoS One. 2013 Dec 18;8(12):e84917. doi: 10.1371/journal.pone.0084917. eCollection 2013.
10. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
11. Herpesvirus-Associated Lymphadenitis Distorts Fibroblastic Reticular Cell Microarchitecture and Attenuates CD8 T Cell Responses to Neurotropic Infection in Mice Lacking the STING-IFNα/β Defense Pathways. Royer DJ, etal., J Immunol. 2016 Sep 15;197(6):2338-52. doi: 10.4049/jimmunol.1600574. Epub 2016 Aug 10.
12. The cGAS/STING Pathway Detects Streptococcus pneumoniae but Appears Dispensable for Antipneumococcal Defense in Mice and Humans. Ruiz-Moreno JS, etal., Infect Immun. 2018 Feb 20;86(3). pii: IAI.00849-17. doi: 10.1128/IAI.00849-17. Print 2018 Mar.
13. The N-ethyl-N-nitrosourea-induced Goldenticket mouse mutant reveals an essential function of Sting in the in vivo interferon response to Listeria monocytogenes and cyclic dinucleotides. Sauer JD, etal., Infect Immun. 2011 Feb;79(2):688-94. doi: 10.1128/IAI.00999-10. Epub 2010 Nov 22.
14. The role of the adaptor molecule STING during Schistosoma mansoni infection. Souza C, etal., Sci Rep. 2020 May 13;10(1):7901. doi: 10.1038/s41598-020-64788-6.
15. STING induces early IFN-β in the liver and constrains myeloid cell-mediated dissemination of murine cytomegalovirus. Tegtmeyer PK, etal., Nat Commun. 2019 Jun 27;10(1):2830. doi: 10.1038/s41467-019-10863-0.
16. Lack of immunological DNA sensing in hepatocytes facilitates hepatitis B virus infection. Thomsen MK, etal., Hepatology. 2016 Sep;64(3):746-59. doi: 10.1002/hep.28685. Epub 2016 Jul 26.
17. The GRA15 protein from Toxoplasma gondii enhances host defense responses by activating the interferon stimulator STING. Wang P, etal., J Biol Chem. 2019 Nov 8;294(45):16494-16508. doi: 10.1074/jbc.RA119.009172. Epub 2019 Aug 15.
18. Methylation status of the stimulator of interferon genes promoter in patients with chronic hepatitis B. Wu CS, etal., Medicine (Baltimore). 2018 Dec;97(52):e13904. doi: 10.1097/MD.0000000000013904.
19. Rat and human STINGs profile similarly towards anticancer/antiviral compounds. Zhang H, etal., Sci Rep. 2015 Dec 16;5:18035. doi: 10.1038/srep18035.
Additional References at PubMed
PMID:18818105   PMID:19433799   PMID:19776740   PMID:19926846   PMID:21074459   PMID:21892174   PMID:21947006   PMID:22387590   PMID:22394562   PMID:22705373   PMID:22728658   PMID:22728659  
PMID:22728660   PMID:22745163   PMID:23160154   PMID:23258412   PMID:23542348   PMID:23747010   PMID:24560620   PMID:25254379   PMID:26300263   PMID:28069950   PMID:29056340   PMID:29694889  
PMID:30119996   PMID:30405246   PMID:30568238   PMID:30842659   PMID:30842662   PMID:32253733   PMID:34477314   PMID:35926582   PMID:36878046   PMID:38518595   PMID:38725841   PMID:39002476  


Genomics

Comparative Map Data
Sting1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81827,606,196 - 27,612,544 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1827,606,196 - 27,611,947 (-)EnsemblGRCr8
mRatBN7.21827,332,119 - 27,338,371 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1827,332,119 - 27,338,335 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1827,459,541 - 27,465,793 (-)NCBIUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01828,221,584 - 28,227,830 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01827,556,463 - 27,562,709 (-)NCBIUTH_Rnor_WKY_Bbb_1.0
Dahl_SR_JrHsd1827,823,195 - 27,829,608 (-)NCBI
Lyon_Normotensive1827,405,559 - 27,411,972 (-)NCBI
Lyon_Hypertensive1827,419,895 - 27,426,308 (-)NCBI
F344_StmMcwi1827,465,149 - 27,471,401 (-)NCBI
Rnor_6.01828,529,537 - 28,535,828 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1828,529,576 - 28,535,828 (-)EnsemblRnor_6.0 Ensemblrn6Rnor6.0
Rnor_5.01828,242,119 - 28,248,371 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41828,355,029 - 28,357,171 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1827,065,352 - 27,071,596 (-)NCBICelera
Cytogenetic Map18p11NCBI
STING1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh385139,475,533 - 139,482,758 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl5139,475,528 - 139,482,935 (-)EnsemblGRCh38.p14 Ensemblhg38GRCh38
GRCh375138,855,118 - 138,862,343 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 365138,835,733 - 138,842,476 (-)NCBIBuild 36Build 36hg18NCBI36
Celera5134,930,158 - 134,937,391 (-)NCBICelera
Cytogenetic Map5q31.2NCBI
HuRef5133,997,951 - 134,005,182 (-)NCBIHuRef
CHM1_15138,287,678 - 138,294,915 (-)NCBICHM1_1
T2T-CHM13v2.05140,000,594 - 140,007,823 (-)NCBIT2T-CHM13v2.0
Sting1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391835,866,731 - 35,873,607 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1835,866,732 - 35,873,607 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm381835,733,678 - 35,740,554 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1835,733,679 - 35,740,554 (-)EnsemblGRCm38.p6 Ensemblmm10GRCm38
MGSCv371835,893,332 - 35,900,208 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv361835,859,652 - 35,866,528 (-)NCBIMGSCv36mm8
Celera1836,189,779 - 36,196,655 (-)NCBICelera
Cytogenetic Map18B2NCBI
cM Map1819.23NCBI
Sting1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554181,083,613 - 1,100,448 (+)EnsemblChiLan1.0 Ensembl
ChiLan1.0NW_0049554181,091,022 - 1,097,064 (+)NCBIChiLan1.0ChiLan1.0
STING1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v24134,741,514 - 134,750,786 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan15132,881,061 - 132,890,364 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v05134,845,689 - 134,852,938 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.15140,967,399 - 140,989,653 (-)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl5140,967,399 - 140,973,846 (-)EnsemblPanPan1.1 EnsemblpanPan2panpan1.1
STING1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1234,783,947 - 34,792,204 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl234,784,232 - 34,789,072 (-)EnsemblCanFam3.1 EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha231,886,015 - 31,894,282 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.0235,237,857 - 35,246,124 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl235,217,688 - 35,243,000 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1232,290,300 - 32,298,567 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0233,156,814 - 33,165,081 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0233,908,726 - 33,916,993 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Sting1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mIctTri1.hap11119,866,080 - 119,873,298 (-)NCBImIctTri1.hap1
HiC_Itri_2NW_024407213153,048,662 - 153,055,631 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365318,555,637 - 8,562,885 (-)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049365318,555,966 - 8,562,829 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
STING1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl2141,358,993 - 141,367,198 (-)EnsemblSscrofa11.1 EnsemblsusScr11Sscrofa11.1
Sscrofa11.12141,359,402 - 141,367,222 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.22147,169,469 - 147,177,263 (-)NCBISscrofa10.2Sscrofa10.2susScr3
STING1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mChlSab1.0.hap12342,669,557 - 42,677,366 (+)NCBImChlSab1.0.hap1
Vero_WHO_p1.0NW_02366603435,727,193 - 35,734,956 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
ChlSab1.12342,153,576 - 42,160,903 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2342,153,026 - 42,160,907 (-)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Sting1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462474332,277,197 - 32,283,346 (-)NCBIHetGla 1.0HetGla 1.0hetGla2
HetGla_female_1.0 EnsemblNW_00462474332,273,385 - 32,283,235 (-)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
Sting1
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v1158,632,773 - 8,639,865 (+)NCBIRrattus_CSIRO_v1Rrattus_CSIRO_v1

Variants

.
Variants in Sting1
26 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:94
Count of miRNA genes:75
Interacting mature miRNAs:87
Transcripts:ENSRNOT00000068386
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1331733Bp233Blood pressure QTL 2333.97196arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)182507112683910656Rat
2301409Cm70Cardiac mass QTL 700.001heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)18706572852065728Rat
1358358Sradr6Stress Responsive Adrenal Weight QTL 62.49adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)182201556261600538Rat
1331735Rf44Renal function QTL 442.981urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)181564228031610627Rat
61382Bp46Blood pressure QTL 4618.8arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)181221668431644508Rat
2301413Bp318Blood pressure QTL 3180.002arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)182682218671822186Rat
12904716Am21Aortic mass QTL 210.005aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)18706572852065728Rat
1331741Bp232Blood pressure QTL 2323.59112arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)182349405785487725Rat
12904714Cm131Cardiac mass QTL 1310.002heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)18706572852065728Rat
12904715Cm132Cardiac mass QTL 1320.001heart right ventricle mass (VT:0007033)heart right ventricle weight to body weight ratio (CMO:0000914)18706572852065728Rat
6903345Bp349Blood pressure QTL 3493.9arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)18391722648917226Rat
12904668Bw188Body weight QTL 1880.03body mass (VT:0001259)body weight (CMO:0000012)182682218671822186Rat
2313082Bss85Bone structure and strength QTL 850.80.0001long bone metaphysis morphology trait (VT:0000133)tibia midshaft total cross-sectional area (CMO:0001715)181522610142690662Rat
12904669Cm125Cardiac mass QTL 1250.001heart mass (VT:0007028)heart wet weight to body weight ratio (CMO:0002408)182682218671822186Rat
6903347Bp350Blood pressure QTL 3504.4arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)18131610627Rat
12904670Cm126Cardiac mass QTL 1260.001heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)182682218671822186Rat
2312568Glom21Glomerulus QTL 2120.005kidney glomerulus morphology trait (VT:0005325)index of glomerular damage (CMO:0001135)18546045542690191Rat
6903349Bp351Blood pressure QTL 3513.5arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)18391722648917226Rat
631509Sald2Serum aldosterone level QTL 22.9blood aldosterone amount (VT:0005346)serum aldosterone level (CMO:0000487)182641582171415821Rat
6903351Bp352Blood pressure QTL 3523.3arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)18391722648917226Rat
12904677Kidm72Kidney mass QTL 720.001kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)182682218671822186Rat
1331766Bp236Blood pressure QTL 2363.022arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)18131610627Rat
12904673Cm127Cardiac mass QTL 1270.005heart right ventricle mass (VT:0007033)heart right ventricle weight to body weight ratio (CMO:0000914)182682218671822186Rat
12904675Am19Aortic mass QTL 190.001aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)182682218671822186Rat
631264Scl22Serum cholesterol level QTL 226.2blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)181221668431644508Rat
1331775Bp235Blood pressure QTL 2353.201arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)181564228031610627Rat
2325839Bp348Blood pressure QTL 3480.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)18144930869Rat
1600373Mamtr6Mammary tumor resistance QTL 6mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)181955353285493247Rat
2293708Bss46Bone structure and strength QTL 468.80.0001lumbar vertebra morphology trait (VT:0010494)lumbar vertebra cortical cross-sectional area (CMO:0001690)181206648257066482Rat
1578667Bss21Bone structure and strength QTL 213.5femur morphology trait (VT:0000559)femoral neck cortical cross-sectional area (CMO:0001702)181206648285493247Rat
2312598Bp340Blood pressure QTL 3400.05arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)18381190230809809Rat
2300180Bmd67Bone mineral density QTL 674.80.0001femur mineral mass (VT:0010011)bone mineral density (CMO:0001226)18134566578Rat
2299160Iddm35Insulin dependent diabetes mellitus QTL 352.79blood glucose amount (VT:0000188)age at onset/diagnosis of type 1 diabetes mellitus (CMO:0001140)18448264849482648Rat
1331753Bp231Blood pressure QTL 2313.643arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)18154490981Rat
1578661Bss20Bone structure and strength QTL 203.7femur morphology trait (VT:0000559)femoral neck cross-sectional area (CMO:0001697)181206648285493247Rat
11565454Kidm59Kidney mass QTL 590.001kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)18706572852065728Rat
1331754Bp230Blood pressure QTL 2304.61609arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)181564228086134022Rat
2293661Bss50Bone structure and strength QTL 504.640.0003lumbar vertebra size trait (VT:0010518)lumbar vertebra trabecular cross-sectional area (CMO:0001692)18134566578Rat
61375Bp41Blood pressure QTL 412.4blood pressure trait (VT:0000183)systolic blood pressure (CMO:0000004)18430735449307354Rat

Markers in Region
RH140265  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21827,332,418 - 27,332,634 (+)MAPPERmRatBN7.2
Rnor_6.01828,529,876 - 28,530,091NCBIRnor6.0
Rnor_5.01828,242,419 - 28,242,634UniSTSRnor5.0
RGSC_v3.41828,355,329 - 28,355,544UniSTSRGSC3.4
Celera1827,065,652 - 27,065,867UniSTS
RH 3.4 Map18380.8UniSTS
Cytogenetic Map18p11UniSTS


Expression

RNA-SEQ Expression

adipose tissue
alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
entire extraembryonic component
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
pharyngeal arch
renal system
reproductive system
respiratory system
sensory system
visual system
275 156 722 1591 4008 987 1703 108 851 493 833 153 5315 2564 445 3923 38 1370 705 908 157 155

Sequence


Ensembl Acc Id: ENSRNOT00000068386   ⟹   ENSRNOP00000063348
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1827,606,196 - 27,611,947 (-)Ensembl
mRatBN7.2 Ensembl1827,332,119 - 27,338,335 (-)Ensembl
Rnor_6.0 Ensembl1828,529,576 - 28,535,828 (-)Ensembl
RefSeq Acc Id: NM_001109122   ⟹   NP_001102592
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81827,606,196 - 27,612,448 (-)NCBI
mRatBN7.21827,332,119 - 27,338,371 (-)NCBI
Dahl_SR_JrHsd1827,823,195 - 27,829,608 (-)NCBI
Lyon_Normotensive1827,405,559 - 27,411,972 (-)NCBI
Lyon_Hypertensive1827,419,895 - 27,426,308 (-)NCBI
F344_StmMcwi1827,465,149 - 27,471,401 (-)NCBI
Rnor_6.01828,529,576 - 28,535,828 (-)NCBI
Rnor_5.01828,242,119 - 28,248,371 (-)NCBI
RGSC_v3.41828,355,029 - 28,357,171 (-)RGD
Celera1827,065,352 - 27,071,596 (-)RGD
Sequence:
RefSeq Acc Id: XM_039097039   ⟹   XP_038952967
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81827,606,276 - 27,612,544 (-)NCBI
mRatBN7.21827,332,188 - 27,338,345 (-)NCBI
Protein Sequences
Protein RefSeqs NP_001102592 (Get FASTA)   NCBI Sequence Viewer  
  XP_038952967 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AEM66211 (Get FASTA)   NCBI Sequence Viewer  
  EDL76277 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000063348
  ENSRNOP00000063348.4
GenBank Protein F1M391 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_001102592   ⟸   NM_001109122
- UniProtKB: F1M391 (UniProtKB/TrEMBL),   I3P832 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000063348   ⟸   ENSRNOT00000068386
RefSeq Acc Id: XP_038952967   ⟸   XM_039097039
- Peptide Label: isoform X1
- UniProtKB: I3P832 (UniProtKB/TrEMBL)
Protein Domains
STING ligand-binding   STING transmembrane

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-F1M391-F1-model_v2 AlphaFold F1M391 1-379 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13700715
Promoter ID:EPDNEW_R11239
Type:multiple initiation site
Name:Tmem173_1
Description:transmembrane protein 173
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01828,535,782 - 28,535,842EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1562552 AgrOrtholog
BioCyc Gene G2FUF-7894 BioCyc
Ensembl Genes ENSRNOG00000042137 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000068386 ENTREZGENE
  ENSRNOT00000068386.4 UniProtKB/Swiss-Prot
Gene3D-CATH 1.20.5.5200 UniProtKB/Swiss-Prot
  3.40.50.12100 UniProtKB/Swiss-Prot
InterPro STING UniProtKB/Swiss-Prot
  STING_C_chordates UniProtKB/Swiss-Prot
  STING_C_sf UniProtKB/Swiss-Prot
  STING_LBD UniProtKB/Swiss-Prot
  STING_TM UniProtKB/Swiss-Prot
KEGG Report rno:498840 UniProtKB/Swiss-Prot
NCBI Gene 498840 ENTREZGENE
PANTHER PTHR34339 UniProtKB/Swiss-Prot
  STIMULATOR OF INTERFERON GENES PROTEIN UniProtKB/Swiss-Prot
Pfam STING_TM UniProtKB/Swiss-Prot
  TMEM173 UniProtKB/Swiss-Prot
PhenoGen Sting1 PhenoGen
RatGTEx ENSRNOG00000042137 RatGTEx
UniProt A0A8L2QV42_RAT UniProtKB/TrEMBL
  F1M391 ENTREZGENE
  I3P832 ENTREZGENE, UniProtKB/TrEMBL
  STING_RAT UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2019-09-13 Sting1  stimulator of interferon response cGAMP interactor 1  Tmem173  transmembrane protein 173  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2012-10-12 Tmem173  transmembrane protein 173  RGD1562552  similar to hypothetical protein LOC340061  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-04-30 RGD1562552  similar to hypothetical protein LOC340061   RGD1562552_predicted  similar to hypothetical protein LOC340061 (predicted)  'predicted' is removed 2292626 APPROVED
2006-03-07 RGD1562552_predicted  similar to hypothetical protein LOC340061 (predicted)  LOC498840  similar to hypothetical protein LOC340061  Symbol and Name status set to approved 1299863 APPROVED
2006-02-09 LOC498840  similar to hypothetical protein LOC340061      Symbol and Name status set to provisional 70820 PROVISIONAL