Annotation (Toggle Detail/Summary View) | ||||||||||||||||||||||||||||||||||||||||||||||||||||||
Gene-Chemical Interaction AnnotationsGene-Chemical Interaction Annotations
Gene-Chemical Interaction AnnotationsTerm | Qualifier | Evidence | With | Reference | Notes | Source | Original Reference(s) | 2,2',4,4',5,5'-hexachlorobiphenyl | multiple interactions | ISO | RGD:732455 | 6480464 | Tetrachlorodibenzodioxin inhibits the reaction [2,4,5,2',4',5'-hexachlorobiphenyl results in increased expression of PLA2G6 mRNA] | CTD | PMID:21851831 | 2,2',4,4',5,5'-hexachlorobiphenyl | increases expression | ISO | RGD:732455 | 6480464 | 2,4,5,2',4',5'-hexachlorobiphenyl results in increased expression of PLA2G6 mRNA | CTD | PMID:21851831 | 2,3,7,8-tetrachlorodibenzodioxine | decreases expression | ISO | RGD:732455 | 6480464 | Tetrachlorodibenzodioxin results in decreased expression of PLA2G6 mRNA | CTD | PMID:19465110 | 2,3,7,8-tetrachlorodibenzodioxine | affects expression | ISO | RGD:732455 | 6480464 | Tetrachlorodibenzodioxin affects the expression of PLA2G6 mRNA | CTD | PMID:21570461 | 2,3,7,8-tetrachlorodibenzodioxine | multiple interactions | ISO | RGD:732455 | 6480464 | Tetrachlorodibenzodioxin inhibits the reaction [2,4,5,2',4',5'-hexachlorobiphenyl results in increased expression of PLA2G6 mRNA] | CTD | PMID:21851831 | 2,6-dinitrotoluene | affects expression | EXP | | 6480464 | 2,6-dinitrotoluene affects the expression of PLA2G6 mRNA | CTD | PMID:21346803 | 3,3',5-triiodo-L-thyronine | increases expression | EXP | | 6480464 | Triiodothyronine results in increased expression of PLA2G6 mRNA | CTD | PMID:15953391 | 3,4-methylenedioxymethamphetamine | increases expression | ISO | RGD:732455 | 6480464 | N-Methyl-3,4-methylenedioxyamphetamine results in increased expression of PLA2G6 mRNA | CTD | PMID:20188158 | 4-vinylcyclohexene dioxide | affects expression | ISO | RGD:732455 | 6480464 | 4-vinyl-1-cyclohexene dioxide affects the expression of PLA2G6 mRNA | CTD | PMID:20829426 | acetylsalicylic acid | increases expression | ISO | RGD:732454 | 6480464 | Aspirin results in increased expression of PLA2G6 mRNA | CTD | PMID:11906190 | ammonium chloride | affects expression | EXP | | 6480464 | Ammonium Chloride affects the expression of PLA2G6 mRNA | CTD | PMID:16483693 | arachidonic acid | multiple interactions | EXP | | 6480464 | PLA2G6 protein promotes the reaction [2,2',4,6-tetrachlorobiphenyl results in increased secretion of Arachidonic Acid] | CTD | PMID:16120751 | benzene | decreases expression | EXP | | 6480464 | Benzene results in decreased expression of PLA2G6 mRNA | CTD | PMID:17905399 | benzo[a]pyrene | increases expression | ISO | RGD:732455 | 6480464 | Benzo(a)pyrene results in increased expression of PLA2G6 mRNA | CTD | PMID:21715664 | bis(2-ethylhexyl) phthalate | increases expression | ISO | RGD:732455 | 6480464 | Diethylhexyl Phthalate results in increased expression of PLA2G6 mRNA | CTD | PMID:19850644 | C60 fullerene | increases expression | EXP | | 6480464 | fullerene C60 results in increased expression of PLA2G6 mRNA | CTD | PMID:19167457 | calcium atom | multiple interactions | EXP | | 6480464 | 6-(bromomethylene)tetrahydro-3-(1-naphthaleneyl)-2H-pyran-2-one inhibits the reaction [[Lipopolysaccharides results in increased expression of and results in increased activity of PLA2G6 protein] which results in increased susceptibility to Calcium] | CTD | PMID:21178110 | calcium atom | increases activity | EXP | | 6480464 | Calcium deficiency results in increased activity of PLA2G6 protein | CTD | PMID:17885217 | calcium(0) | multiple interactions | EXP | | 6480464 | 6-(bromomethylene)tetrahydro-3-(1-naphthaleneyl)-2H-pyran-2-one inhibits the reaction [[Lipopolysaccharides results in increased expression of and results in increased activity of PLA2G6 protein] which results in increased susceptibility to Calcium] | CTD | PMID:21178110 | calcium(0) | increases activity | EXP | | 6480464 | Calcium deficiency results in increased activity of PLA2G6 protein | CTD | PMID:17885217 | cocaine | affects expression | EXP | | 6480464 | Cocaine affects the expression of PLA2G6 mRNA | CTD | PMID:20187946 | copper atom | decreases expression | EXP | | 6480464 | Copper results in decreased expression of PLA2G6 mRNA | CTD | PMID:22465980 | copper(0) | decreases expression | EXP | | 6480464 | Copper results in decreased expression of PLA2G6 mRNA | CTD | PMID:22465980 | diazinon | decreases expression | EXP | | 6480464 | Diazinon results in decreased expression of PLA2G6 mRNA | CTD | PMID:21968025 | gold atom | multiple interactions | ISO | RGD:732455 | 6480464 | [Gold co-treated with Polyethylene Glycols] results in increased expression of PLA2G6 mRNA | CTD | PMID:19695318 | gold(0) | multiple interactions | ISO | RGD:732455 | 6480464 | [Gold co-treated with Polyethylene Glycols] results in increased expression of PLA2G6 mRNA | CTD | PMID:19695318 | hydrogen peroxide | affects expression | ISO | RGD:732454 | 6480464 | Hydrogen Peroxide affects the expression of PLA2G6 mRNA | CTD | PMID:20044591 | perfluorooctanoic acid | increases expression | ISO | RGD:732455 | 6480464 | perfluorooctanoic acid results in increased expression of PLA2G6 mRNA | CTD | PMID:17681415 | phenobarbital | multiple interactions | ISO | RGD:732455 | 6480464 | NR1I3 protein affects the reaction [Phenobarbital results in increased expression of PLA2G6 mRNA] | CTD | PMID:19482888 | phenobarbital | affects expression | ISO | RGD:732455 | 6480464 | Phenobarbital affects the expression of PLA2G6 mRNA | CTD | PMID:23091169 | phenobarbital | increases expression | ISO | RGD:732455 | 6480464 | Phenobarbital results in increased expression of PLA2G6 mRNA | CTD | PMID:19850644 PMID:19482888 | phenobarbital | multiple interactions | ISO | RGD:732455 | 6480464 | NR1I3 protein promotes the reaction [Phenobarbital results in increased expression of PLA2G6 mRNA] | CTD | PMID:19850644 | phenobarbital | increases expression | ISO | RGD:732455 | 6480464 | Phenobarbital results in increased expression of PLA2G6 mRNA | CTD | PMID:19482888 PMID:19850644 | phenylephrine | affects response to substance | EXP | | 6480464 | PLA2G6 protein affects the susceptibility to Phenylephrine | CTD | PMID:17885217 | pirinixic acid | multiple interactions | ISO | RGD:732455 | 6480464 | PPARA protein promotes the reaction [pirinixic acid results in decreased expression of PLA2G6 mRNA] | CTD | PMID:19850644 | pirinixic acid | increases expression | ISO | RGD:732455 | 6480464 | pirinixic acid results in increased expression of PLA2G6 mRNA | CTD | PMID:17426115 more ... | pirinixic acid | increases expression | ISO | RGD:732455 | 6480464 | pirinixic acid results in increased expression of PLA2G6 mRNA | CTD | PMID:20059764 more ... | pirinixic acid | increases expression | ISO | RGD:732455 | 6480464 | pirinixic acid results in increased expression of PLA2G6 mRNA | CTD | PMID:20813756 more ... | pirinixic acid | increases expression | ISO | RGD:732455 | 6480464 | pirinixic acid results in increased expression of PLA2G6 mRNA | CTD | PMID:17426115 more ... | pirinixic acid | increases expression | ISO | RGD:732455 | 6480464 | pirinixic acid results in increased expression of PLA2G6 mRNA | CTD | PMID:17426115 more ... | pirinixic acid | increases expression | ISO | RGD:732455 | 6480464 | pirinixic acid results in increased expression of PLA2G6 mRNA | CTD | PMID:17426115 more ... | pirinixic acid | increases expression | EXP | | 6480464 | pirinixic acid results in increased expression of PLA2G6 mRNA | CTD | PMID:19162173 | pirinixic acid | multiple interactions | ISO | RGD:732455 | 6480464 | PPARA protein promotes the reaction [pirinixic acid results in increased expression of PLA2G6 mRNA] | CTD | PMID:20059764 | pirinixic acid | increases expression | ISO | RGD:732455 | 6480464 | pirinixic acid results in increased expression of PLA2G6 mRNA | CTD | PMID:19850644 more ... | propiconazole | increases expression | ISO | RGD:732455 | 6480464 | propiconazole results in increased expression of PLA2G6 mRNA | CTD | PMID:22334560 | resveratrol | increases expression | ISO | RGD:732454 | 6480464 | resveratrol results in increased expression of PLA2G6 mRNA | CTD | PMID:15767336 | thapsigargin | affects response to substance | EXP | | 6480464 | PLA2G6 protein affects the susceptibility to Thapsigargin | CTD | PMID:17885217 | thapsigargin | multiple interactions | EXP | | 6480464 | UCN protein inhibits the reaction [Thapsigargin results in increased activity of PLA2G6 protein] | CTD | PMID:17885217 | thapsigargin | increases activity | EXP | | 6480464 | Thapsigargin results in increased activity of PLA2G6 protein | CTD | PMID:17885217 | trans-resveratrol | increases expression | ISO | RGD:732454 | 6480464 | resveratrol results in increased expression of PLA2G6 mRNA | CTD | PMID:15767336 | troglitazone | decreases expression | ISO | RGD:732455 | 6480464 | troglitazone results in decreased expression of PLA2G6 mRNA | CTD | PMID:12732648 | | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Gene Ontology AnnotationsMolecular Pathway AnnotationsDisease AnnotationsGene-Chemical Interaction Annotations
|
|
|
Gene Ontology Annotations
|
|
|
|
|
|
|
Molecular Pathway Annotations
|
|
| External Database Links | |
| KEGG Pathway | alpha-Linolenic acid metabolism |
| Arachidonic acid metabolism | |
| Ether lipid metabolism | |
| Fc gamma R-mediated phagocytosis | |
| Glycerophospholipid metabolism | |
| Linoleic acid metabolism | |
| Metabolic pathways | |
| Vascular smooth muscle contraction | |
References - curated| 1. |
Bloch-Shilderman E, etal., J Pharmacol Exp Ther. 2002 Jun;301(3):953-62. |
| 2. |
Brant K, etal., Biol Reprod. 2006 May;74(5):874-80. Epub 2006 Jan 25. |
| 3. |
Fevre C, etal., Biochim Biophys Acta. 2011 Jun;1811(6):409-17. Epub 2010 Dec 21. |
| 4. |
Gilroy DW, etal., FASEB J. 2004 Mar;18(3):489-98. |
| 5. |
GOA data from the GO Consortium |
| 6. |
Khateeb S, etal., Am J Hum Genet. 2006 Nov;79(5):942-8. Epub 2006 Sep 19. |
| 7. |
Kubota Y, etal., Naunyn Schmiedebergs Arch Pharmacol. 2003 Jun;367(6):588-91. Epub 2003 May 15. |
| 8. |
Lei X, etal., J Biol Chem. 2008 Dec 12;283(50):34819-32. Epub 2008 Oct 20. |
| 9. |
Lopez-Vales R, etal., Brain. 2008 Oct;131(Pt 10):2620-31. Epub 2008 Aug 21. |
| 10. |
Lopez-Vales R, etal., FASEB J. 2011 Dec;25(12):4240-52. Epub 2011 Aug 25. |
| 11. |
Ma Z, etal., J Biol Chem 1997 Apr 25;272(17):11118-27. |
| 12. |
Ma Z, etal., J Biol Chem. 2001 Apr 20;276(16):13198-208. Epub 2001 Jan 22. |
| 13. |
MGD data from the GO Consortium |
| 14. |
Pipeline to import KEGG annotations from KEGG into RGD Pathway Ontology |
| 15. |
RGD automated data pipeline |
| 16. |
RGD automated import pipeline for gene-chemical interactions |
| 17. |
RGD Automated Pipelines |
| 18. |
Schaeffer EL and Gattaz WF, Psychopharmacology (Berl). 2005 Sep;181(2):392-400. Epub 2005 Oct 14. |
| 19. |
Seegers HC, etal., J Pharmacol Exp Ther. 2002 Sep;302(3):918-23. |
| 20. |
Shinzawa K, etal., J Neurosci. 2008 Feb 27;28(9):2212-20. |
| 21. |
Sina F, etal., Eur J Neurol. 2009 Jan;16(1):101-4. |
| 22. |
Smani T, etal., J Biol Chem. 2003 Apr 4;278(14):11909-15. Epub 2003 Jan 23. |
| 23. |
Song H, etal., J Biol Chem. 2010 Oct 29;285(44):33843-57. Epub 2010 Aug 23. |
| 24. |
St-Gelais F, etal., Hippocampus. 2004;14(3):319-25. |
| 25. |
Strokin M, etal., Am J Physiol Cell Physiol. 2011 Mar;300(3):C542-9. Epub 2010 Dec 22. |
| 26. |
Strokin M, etal., Hum Mol Genet. 2012 Apr 4. |
| 27. |
Tomiyama H, etal., J Hum Genet. 2011 May;56(5):401-3. Epub 2011 Mar 3. |
| 28. |
Wada H, etal., Am J Pathol. 2009 Dec;175(6):2257-63. Epub 2009 Nov 5. |
| 29. |
Wang Z, etal., J Biol Chem. 2005 Feb 25;280(8):6840-9. Epub 2004 Dec 2. |
| 30. |
Wu Y, etal., Eur J Neurol. 2009 Feb;16(2):240-5. Epub 2008 Dec 9. |
| 31. |
Xie Z, etal., J Biol Chem. 2011 Dec 30;286(52):44646-58. Epub 2011 Nov 4. |
| 32. |
Yoshino H, etal., Neurology. 2010 Oct 12;75(15):1356-61. |
References - uncurated| PubMed | 12089145 |
| 12477932 | |
| 12928445 | |
| 15052324 | |
| 15630695 | |
| 16407316 | |
| 16603590 | |
| 16854462 | |
| 17267947 | |
| 17475622 | |
| 17555549 | |
| 17666570 | |
| 17685585 | |
| 17768607 | |
| 17885217 | |
| 18171998 | |
| 18937505 | |
| 19741254 | |
| 20107037 | |
| 20118407 | |
| 20132906 | |
| 20406040 | |
| 21037228 | |
| 21094175 | |
| 21116712 | |
| 22218592 |
RGD Disease Portals| Pla2g6 has been annotated in the following RGD Disease Portals. |
|||||||
 |
| ||||||
 |
| ||||||
 |
| ||||||
 |
| ||||||
 |
| ||||||
 |
| ||||||
 |
| ||||||
Comparative Map Data| Pla2g6 (Rattus norvegicus) |
|
|||||||||||||||||||||||||||||||||||
| PLA2G6 (Homo sapiens) |
|
|||||||||||||||||||||||||||||||||||
| Pla2g6 (Mus musculus) |
|
Position Markers| BE108691 |
|
||||||||||||||||||||||||||||||
| RH141625 |
|
||||||||||||||||||||||||||||||
| BI275205 |
|
||||||||||||||||||||||||||||||
| BM382819 |
|
QTLs in Region (RGSC Genome Assembly v3.4)| The following QTLs overlap with this region. |  | Full Report | | CSV | | TAB | | Printer | | Gviewer |
Nucleotide Sequences| Nucleotide RefSeqs | NM_001005560 | (Get FASTA) | Search GEO for Microarray Profiles |
| NM_001270796 | (Get FASTA) | Search GEO for Microarray Profiles | |
| GenBank Nucleotide | AABR06052010 | (Get FASTA) | Search GEO for Microarray Profiles |
| AABR06052011 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AAHX01051741 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AAHX01051742 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AAHX01051743 | (Get FASTA) | Search GEO for Microarray Profiles | |
| BC061866 | (Get FASTA) | Search GEO for Microarray Profiles | |
| BC081916 | (Get FASTA) | Search GEO for Microarray Profiles | |
| CH473950 | (Get FASTA) | Search GEO for Microarray Profiles | |
| U51898 | (Get FASTA) | Search GEO for Microarray Profiles |
| RefSeq Acc Id: | NM_001005560 | ||||||||||||||||||||
| RefSeq Status: | PROVISIONAL | ||||||||||||||||||||
| Type: | CODING | ||||||||||||||||||||
| Protein Acc Id: | NP_001005560 | ||||||||||||||||||||
| Position: |
|
Protein Sequences| Protein RefSeqs | NP_001005560 | (Get FASTA) |
| NP_001257725 | (Get FASTA) | |
| GenBank Protein | AAC53136 | (Get FASTA) |
| AAH81916 | (Get FASTA) | |
| EDM15808 | (Get FASTA) | |
| EDM15809 | (Get FASTA) | |
| P97570 | (Get FASTA) |
Strain Sequence Variants
|
||||||||||||||||||||
|
||||||||||||||||||||
|
||||||||||||||||||||
|
||||||||||||||||||||
|
||||||||||||||||||||
|
||||||||||||||||||||
|
||||||||||||||||||||
|
||||||||||||||||||||
|
||||||||||||||||||||
|
||||||||||||||||||||
|
||||||||||||||||||||
|
||||||||||||||||||||
|
||||||||||||||||||||
|
||||||||||||||||||||
|
||||||||||||||||||||
|
||||||||||||||||||||
|
||||||||||||||||||||
|
||||||||||||||||||||
|
||||||||||||||||||||
|
||||||||||||||||||||
|
||||||||||||||||||||
|
||||||||||||||||||||
|
||||||||||||||||||||
|
||||||||||||||||||||
External Database Links| Database | Acc Id | Source(s) |
| Ensembl Genes | ENSRNOG00000012295 | ENTREZGENE, UniProtKB/Swiss-Prot |
| Ensembl Protein | ENSRNOP00000016827 | UniProtKB/Swiss-Prot |
| ENSRNOP00000017104 | ENTREZGENE, UniProtKB/Swiss-Prot | |
| Ensembl Transcript | ENSRNOT00000016827 | UniProtKB/Swiss-Prot |
| ENSRNOT00000017108 | ENTREZGENE, UniProtKB/Swiss-Prot | |
| Entrez Gene | 360426 | ENTREZGENE |
| Gene3D-CATH | ANK | UniProtKB/Swiss-Prot |
| Germonline | ENSRNOG00000012295 | UniProtKB/Swiss-Prot |
| HomoloGene Group ID | 2635 | ENTREZGENE |
| IMAGE_CLONE | IMAGE:7112407 | IMAGE-MGC_LOAD |
| InterPro | Acyl_Trfase/lysoPlipase | UniProtKB/Swiss-Prot |
| Ankyrin_rpt | UniProtKB/Swiss-Prot | |
| Ankyrin_rpt-contain_dom | UniProtKB/Swiss-Prot | |
| Patatin | UniProtKB/Swiss-Prot | |
| IPI | IPI00189942 | UniProtKB/Swiss-Prot |
| IPI00205595 | UniProtKB/Swiss-Prot | |
| KEGG Report | rno:360426 | ENTREZGENE, UniProtKB/Swiss-Prot |
| MGC_CLONE | MGC:93880 | IMAGE-MGC_LOAD |
| Pfam | Ank | UniProtKB/Swiss-Prot |
| Ank_2 | UniProtKB/Swiss-Prot | |
| Patatin | UniProtKB/Swiss-Prot | |
| PRINTS | ANKYRIN | UniProtKB/Swiss-Prot |
| PROSITE | ANK_REP_REGION | UniProtKB/Swiss-Prot |
| ANK_REPEAT | UniProtKB/Swiss-Prot | |
| SMART | ANK | UniProtKB/Swiss-Prot |
| Superfamily-SCOP | Acyl_Trfase/lysoPlipase | UniProtKB/Swiss-Prot |
| ANK | UniProtKB/Swiss-Prot | |
| UniGene | Rn.44692 | ENTREZGENE |
| UniProt | PA2G6_RAT | UniProtKB/Swiss-Prot |
Nomenclature History| Date | Current Symbol | Current Name | Previous Symbol | Previous Name | Description | Reference | Status |
|---|---|---|---|---|---|---|---|
| 2008-09-09 | Pla2g6 | phospholipase A2, group VI (cytosolic, calcium-independent) | Pla2g6 | phospholipase A2, group VI | Nomenclature updated to reflect human and mouse nomenclature | 10779 | APPROVED |
| 2005-01-20 | Pla2g6 | phospholipase A2, group VI | Symbol and Name status set to approved | 10779 | APPROVED | ||
| 2003-02-27 | Pla2g6 | phospholipase A2, group VI | Symbol and Name status set to provisional | 1724 | PROVISIONAL |
RGD Curation Notes| Note Type | Note | Reference |
|---|---|---|
| gene_domains | amino acid residues 150-414 contain a domain that is homologous to tubulin binding and integral membrane protein binding domains of ankyrin | 729507 |
| More on Pla2g6 | |
|
Entrez Gene |
|
Ensembl Gene |
| Genome Browser |
|
NCBI Map Viewer |
|
Vista |
|
Vista + UCSC |
| RGD Object Information | |
| RGD ID: | 628867 |
| Created: | 2003-02-27 |
| Species: | Rattus norvegicus |
| Last Modified: | 2013-04-16 |
| Status: | ACTIVE |
© Bioinformatics Program, HMGC at the Medical College of Wisconsin
RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.