RGD Reference Report - The metabolic cascade leading to eicosanoid precursors--desaturases, elongases, and phospholipases A2--is altered in Zucker fatty rats. - Rat Genome Database

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The metabolic cascade leading to eicosanoid precursors--desaturases, elongases, and phospholipases A2--is altered in Zucker fatty rats.

Authors: Fevre, C  Bellenger, S  Pierre, AS  Minville, M  Bellenger, J  Gresti, J  Rialland, M  Narce, M  Tessier, C 
Citation: Fevre C, etal., Biochim Biophys Acta. 2011 Jun;1811(6):409-17. Epub 2010 Dec 21.
RGD ID: 6482748
Pubmed: PMID:21172452   (View Abstract at PubMed)
DOI: DOI:10.1016/j.bbalip.2010.12.004   (Journal Full-text)

Metabolic syndrome characterized by insulin resistance and obesity is accompanied by severe lipid metabolism perturbations and chronic low-grade inflammation. However, many unresolved questions remained regarding the regulation that underlie dyslipidemia, particularly the regulation of the metabolic cascade (synthesis and release) leading to eicosanoid precursors release. This study was undertaken to investigate the regulation of desaturases/elongases and phospholipases A(2) during the establishment of metabolic syndrome. Our results showed that delta-6 desaturase as well as elongase-6 expressions were upregulated in 3-month-old Zucker fatty rats as compared to lean littermates, independently of SREBP-1c activation. We also demonstrated for the first time an increase of liver group VII phospholipase A(2) gene expression in the obese animals together with a strong specific inhibition of type IVA and VIA phospholipases A(2). These results suggest that the regulation of unsaturated fatty acids biosynthesis and signalling cascade could contribute to the development of liver lipid dysregulation related to metabolic syndrome and may be considered as new potential targets in such pathological conditions.

RGD Manual Disease Annotations    Click to see Annotation Detail View
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
Metabolic Syndrome  ISOPla2g4a (Rattus norvegicus)6482748; 6482748mRNA:decreased expression:liverRGD 
Metabolic Syndrome  ISOPla2g6 (Rattus norvegicus)6482748; 6482748mRNA:decreased expression:liverRGD 
Metabolic Syndrome  ISOPla2g7 (Rattus norvegicus)6482748; 6482748mRNA:increased expression:liverRGD 
Metabolic Syndrome  IEP 6482748; 6482748mRNA:decreased expression:liverRGD 
Metabolic Syndrome  IEP 6482748mRNA:increased expression:liverRGD 

Objects Annotated

Genes (Rattus norvegicus)
Pla2g4a  (phospholipase A2 group IVA)
Pla2g6  (phospholipase A2 group VI)
Pla2g7  (phospholipase A2 group VII)

Genes (Mus musculus)
Pla2g4a  (phospholipase A2, group IVA (cytosolic, calcium-dependent))
Pla2g6  (phospholipase A2, group VI)
Pla2g7  (phospholipase A2, group VII (platelet-activating factor acetylhydrolase, plasma))

Genes (Homo sapiens)
PLA2G4A  (phospholipase A2 group IVA)
PLA2G6  (phospholipase A2 group VI)
PLA2G7  (phospholipase A2 group VII)


Additional Information