RN7SK (RNA component of 7SK nuclear ribonucleoprotein) - Rat Genome Database

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Gene: RN7SK (RNA component of 7SK nuclear ribonucleoprotein) Homo sapiens
Analyze
Symbol: RN7SK (Ensembl: 7SK)
Name: RNA component of 7SK nuclear ribonucleoprotein (Ensembl:7SK RNA)
RGD ID: 1345130
HGNC Page HGNC:10037
Description: Predicted to be involved in negative regulation of transcription elongation by RNA polymerase II. Part of 7SK snRNP; INTERACTS WITH 2-hydroxypropanoic acid; 2-methylcholine; 3,3',5,5'-tetrabromobisphenol A.
Type: snrna (Ensembl: misc_RNA)
RefSeq Status: PROVISIONAL
Previously known as: 7SK; RNA, 7SK small nuclear; rna, 7sk, nuclear
RGD Orthologs
Mouse
Alliance Orthologs
More Info more info ...
Related Pseudogenes: RN7SKP1   RN7SKP100   RN7SKP101   RN7SKP102   RN7SKP103   RN7SKP104   RN7SKP105   RN7SKP106   RN7SKP107   RN7SKP108   RN7SKP109   RN7SKP11   RN7SKP110   RN7SKP111   RN7SKP112   RN7SKP113   RN7SKP114   RN7SKP115   RN7SKP116   RN7SKP117   RN7SKP118   RN7SKP119   RN7SKP12   RN7SKP120   RN7SKP121   RN7SKP122   RN7SKP123   RN7SKP124   RN7SKP125   RN7SKP126   RN7SKP127   RN7SKP128   RN7SKP129   RN7SKP13   RN7SKP130   RN7SKP131   RN7SKP132   RN7SKP133   RN7SKP134   RN7SKP135   RN7SKP136   RN7SKP137   RN7SKP139   RN7SKP14   RN7SKP140   RN7SKP141   RN7SKP142   RN7SKP143   RN7SKP144   RN7SKP145   RN7SKP146   RN7SKP147   RN7SKP148   RN7SKP149   RN7SKP15   RN7SKP150   RN7SKP151   RN7SKP152   RN7SKP153   RN7SKP154   RN7SKP155   RN7SKP156   RN7SKP157   RN7SKP158   RN7SKP159   RN7SKP16   RN7SKP160   RN7SKP161   RN7SKP162   RN7SKP163   RN7SKP164   RN7SKP165   RN7SKP166   RN7SKP167   RN7SKP168   RN7SKP169   RN7SKP17   RN7SKP170   RN7SKP171   RN7SKP172   RN7SKP173   RN7SKP174   RN7SKP175   RN7SKP176   RN7SKP177   RN7SKP178   RN7SKP179   RN7SKP18   RN7SKP180   RN7SKP181   RN7SKP182   RN7SKP183   RN7SKP184   RN7SKP185   RN7SKP186   RN7SKP187   RN7SKP188   RN7SKP189   RN7SKP19   RN7SKP190   RN7SKP191   RN7SKP192   RN7SKP193   RN7SKP194   RN7SKP195   RN7SKP196   RN7SKP197   RN7SKP198   RN7SKP199   RN7SKP20   RN7SKP200   RN7SKP202   RN7SKP203   RN7SKP204   RN7SKP205   RN7SKP206   RN7SKP207   RN7SKP208   RN7SKP209   RN7SKP21   RN7SKP210   RN7SKP211   RN7SKP212   RN7SKP213   RN7SKP214   RN7SKP216   RN7SKP217   RN7SKP218   RN7SKP219   RN7SKP22   RN7SKP220   RN7SKP221   RN7SKP222   RN7SKP223   RN7SKP224   RN7SKP225   RN7SKP226   RN7SKP227   RN7SKP228   RN7SKP229   RN7SKP23   RN7SKP230   RN7SKP231   RN7SKP232   RN7SKP233   RN7SKP234   RN7SKP235   RN7SKP236   RN7SKP237   RN7SKP238   RN7SKP239   RN7SKP24   RN7SKP240   RN7SKP241   RN7SKP242   RN7SKP243   RN7SKP244   RN7SKP245   RN7SKP246   RN7SKP247   RN7SKP248   RN7SKP249   RN7SKP25   RN7SKP250   RN7SKP251   RN7SKP252   RN7SKP253   RN7SKP254   RN7SKP255   RN7SKP256   RN7SKP257   RN7SKP258   RN7SKP259   RN7SKP26   RN7SKP260   RN7SKP261   RN7SKP262   RN7SKP263   RN7SKP264   RN7SKP265   RN7SKP266   RN7SKP267   RN7SKP268   RN7SKP269   RN7SKP27   RN7SKP270   RN7SKP271   RN7SKP272   RN7SKP273   RN7SKP275   RN7SKP276   RN7SKP277   RN7SKP278   RN7SKP279   RN7SKP28   RN7SKP280   RN7SKP281   RN7SKP282   RN7SKP283   RN7SKP284   RN7SKP285   RN7SKP286   RN7SKP287   RN7SKP288   RN7SKP289   RN7SKP29   RN7SKP290   RN7SKP291   RN7SKP292   RN7SKP293   RN7SKP294   RN7SKP295   RN7SKP296   RN7SKP297   RN7SKP298   RN7SKP299   RN7SKP30   RN7SKP31   RN7SKP32   RN7SKP33   RN7SKP34   RN7SKP35   RN7SKP36   RN7SKP37   RN7SKP38   RN7SKP39   RN7SKP4   RN7SKP40   RN7SKP42   RN7SKP43   RN7SKP44   RN7SKP45   RN7SKP46   RN7SKP47   RN7SKP48   RN7SKP49   RN7SKP50   RN7SKP51   RN7SKP52   RN7SKP53   RN7SKP54   RN7SKP55   RN7SKP56   RN7SKP57   RN7SKP58   RN7SKP59   RN7SKP60   RN7SKP61   RN7SKP62   RN7SKP63   RN7SKP64   RN7SKP65   RN7SKP66   RN7SKP67   RN7SKP68   RN7SKP69   RN7SKP7   RN7SKP70   RN7SKP71   RN7SKP72   RN7SKP73   RN7SKP74   RN7SKP75   RN7SKP76   RN7SKP77   RN7SKP78   RN7SKP79   RN7SKP8   RN7SKP80   RN7SKP81   RN7SKP82   RN7SKP83   RN7SKP85   RN7SKP86   RN7SKP87   RN7SKP88   RN7SKP89   RN7SKP90   RN7SKP91   RN7SKP92   RN7SKP93   RN7SKP94   RN7SKP95   RN7SKP96   RN7SKP97   RN7SKP98   RN7SKP99  
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38652,995,620 - 52,995,951 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl652,995,621 - 52,995,948 (+)EnsemblGRCh38hg38GRCh38
GRCh38.p14 Ensembl652,995,620 - 52,995,950 (+)EnsemblGRCh38hg38GRCh38
GRCh37652,860,418 - 52,860,749 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36652,968,377 - 52,968,708 (+)NCBINCBI36Build 36hg18NCBI36
Celera654,522,192 - 54,522,523 (+)NCBICelera
Cytogenetic Map6p12.2NCBI
HuRef652,691,896 - 52,692,227 (+)NCBIHuRef
CHM1_1652,862,181 - 52,862,512 (+)NCBICHM1_1
T2T-CHM13v2.0652,835,189 - 52,835,520 (+)NCBIT2T-CHM13v2.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
7SK snRNP  (IDA)

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:954090   PMID:1646389   PMID:1721058   PMID:2443710   PMID:6548262   PMID:8139910   PMID:11713532   PMID:11713533   PMID:12832472   PMID:14580347   PMID:14627702   PMID:15169877  
PMID:15201869   PMID:15713661   PMID:15994294   PMID:16109377   PMID:16362050   PMID:17381310   PMID:17611602   PMID:17643375   PMID:18249148   PMID:18483222   PMID:18483487   PMID:19246988  
PMID:20201073   PMID:20471949   PMID:20816986   PMID:20976203   PMID:21087998   PMID:21282977   PMID:21360054   PMID:21957495   PMID:22952229   PMID:24515107   PMID:24917669   PMID:25293881  
PMID:25753663   PMID:26209609   PMID:26324325   PMID:26725010   PMID:26878240   PMID:27752877   PMID:28254838   PMID:28431135   PMID:28820318   PMID:29037489   PMID:29117863   PMID:29845934  
PMID:29946027   PMID:30637716   PMID:32105815   PMID:34549701   PMID:34620876   PMID:36566349   PMID:38193993  


Genomics

Comparative Map Data
RN7SK
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38652,995,620 - 52,995,951 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl652,995,621 - 52,995,948 (+)EnsemblGRCh38hg38GRCh38
GRCh38.p14 Ensembl652,995,620 - 52,995,950 (+)EnsemblGRCh38hg38GRCh38
GRCh37652,860,418 - 52,860,749 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36652,968,377 - 52,968,708 (+)NCBINCBI36Build 36hg18NCBI36
Celera654,522,192 - 54,522,523 (+)NCBICelera
Cytogenetic Map6p12.2NCBI
HuRef652,691,896 - 52,692,227 (+)NCBIHuRef
CHM1_1652,862,181 - 52,862,512 (+)NCBICHM1_1
T2T-CHM13v2.0652,835,189 - 52,835,520 (+)NCBIT2T-CHM13v2.0
Rn7sk
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39978,082,584 - 78,082,915 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl978,082,585 - 78,082,915 (-)EnsemblGRCm39 Ensembl
GRCm38978,175,302 - 78,175,633 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl978,175,303 - 78,175,633 (-)EnsemblGRCm38mm10GRCm38
MGSCv37978,023,109 - 78,023,440 (-)NCBIGRCm37MGSCv37mm9NCBIm37
Celera975,352,389 - 75,352,720 (-)NCBICelera
Cytogenetic Map9E1NCBI
cM Map943.63NCBI


Clinical Variants
Name Type Condition(s) Position(s) Clinical significance
GRCh38/hg38 6p12.3-11.2(chr6:50971182-57432788)x1 copy number loss See cases [RCV000134922] Chr6:50971182..57432788 [GRCh38]
Chr6:50938895..57297586 [GRCh37]
Chr6:51046854..57405545 [NCBI36]
Chr6:6p12.3-11.2		 pathogenic
GRCh38/hg38 6p12.3-12.1(chr6:51093754-53859634)x4 copy number gain See cases [RCV000137095] Chr6:51093754..53859634 [GRCh38]
Chr6:51061467..53724432 [GRCh37]
Chr6:51169426..53832391 [NCBI36]
Chr6:6p12.3-12.1		 pathogenic
GRCh38/hg38 6p21.1-12.1(chr6:45681671-54212044)x1 copy number loss See cases [RCV000138349] Chr6:45681671..54212044 [GRCh38]
Chr6:45649408..54076842 [GRCh37]
Chr6:45757386..54184801 [NCBI36]
Chr6:6p21.1-12.1		 pathogenic|uncertain significance
GRCh37/hg19 6p25.3-q27(chr6:156975-170919482)x3 copy number gain See cases [RCV000512067] Chr6:156975..170919482 [GRCh37]
Chr6:6p25.3-q27		 pathogenic
GRCh37/hg19 6p25.3-q27(chr6:156975-170919482) copy number gain See cases [RCV000510595] Chr6:156975..170919482 [GRCh37]
Chr6:6p25.3-q27		 pathogenic
GRCh37/hg19 6p25.3-q27(chr6:108666-170980171)x3 copy number gain not provided [RCV000745403] Chr6:108666..170980171 [GRCh37]
Chr6:6p25.3-q27		 pathogenic
GRCh37/hg19 6p25.3-q27(chr6:60107-171054786)x3 copy number gain not provided [RCV000745400] Chr6:60107..171054786 [GRCh37]
Chr6:6p25.3-q27		 pathogenic
GRCh37/hg19 6p25.3-q27(chr6:165632-170919470)x3 copy number gain not provided [RCV000745404] Chr6:165632..170919470 [GRCh37]
Chr6:6p25.3-q27		 pathogenic
GRCh37/hg19 6p22.1-q14.1(chr6:29455465-81447367) copy number gain not provided [RCV000767714] Chr6:29455465..81447367 [GRCh37]
Chr6:6p22.1-q14.1		 pathogenic
GRCh37/hg19 6p12.2-12.1(chr6:52810337-53016306)x3 copy number gain not provided [RCV001005797] Chr6:52810337..53016306 [GRCh37]
Chr6:6p12.2-12.1		 uncertain significance
GRCh37/hg19 6p12.3-12.1(chr6:48626041-55575545)x1 copy number loss See cases [RCV001263045] Chr6:48626041..55575545 [GRCh37]
Chr6:6p12.3-12.1		 likely pathogenic
GRCh37/hg19 6p12.2-12.1(chr6:52657712-53622715)x3 copy number gain not provided [RCV001258723] Chr6:52657712..53622715 [GRCh37]
Chr6:6p12.2-12.1		 uncertain significance
NC_000006.11:g.(?_51930764)_(52906034_?)del deletion not provided [RCV001346439] Chr6:51930764..52906034 [GRCh37]
Chr6:6p12.2-12.1		 uncertain significance
GRCh37/hg19 6p21.1-q12(chr6:43636308-64947206)x3 copy number gain not provided [RCV002221457] Chr6:43636308..64947206 [GRCh37]
Chr6:6p21.1-q12		 likely pathogenic
GRCh37/hg19 6p12.3-12.1(chr6:50181657-55538355)x1 copy number loss not provided [RCV003485511] Chr6:50181657..55538355 [GRCh37]
Chr6:6p12.3-12.1		 pathogenic
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:121
Count of miRNA genes:120
Interacting mature miRNAs:121
Transcripts:ENST00000365328
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system sensory system appendage entire extraembryonic component
High 5 9 5 25 1 5 2 2 20 2 1 1
Medium 167 1 184 126 342 130 277 47 114 209 243 296 1 3
Low 42 3 92 87 25 87 23 11 17 77 40 76 7
Below cutoff 2 1 2 1

Sequence


Reference Sequences
RefSeq Acc Id: ENST00000365328
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl652,995,620 - 52,995,950 (+)Ensembl
RefSeq Acc Id: ENST00000636484
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl652,995,621 - 52,995,948 (+)Ensembl
RefSeq Acc Id: NR_001445
RefSeq Status: PROVISIONAL
Type: NON-CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38652,995,620 - 52,995,951 (+)NCBI
GRCh37652,860,418 - 52,860,749 (+)ENTREZGENE
Build 36652,968,377 - 52,968,708 (+)NCBI Archive
HuRef652,691,896 - 52,692,227 (+)ENTREZGENE
CHM1_1652,862,181 - 52,862,512 (+)NCBI
T2T-CHM13v2.0652,835,189 - 52,835,520 (+)NCBI
Sequence:
Promoters
RGD ID:6804284
Promoter ID:HG_KWN:53864
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:CD4+TCell,   CD4+TCell_12Hour,   HeLa_S3,   K562,   Lymphoblastoid,   NB4
Transcripts:ENST00000365328,   ENST00000370959,   NM_001512,   OTTHUMT00000040945
Position:
Human AssemblyChrPosition (strand)Source
Build 36652,967,991 - 52,968,491 (-)MPROMDB

Additional Information

Database Acc Id Source(s)
AGR Gene HGNC:10037 AgrOrtholog
COSMIC RN7SK COSMIC
Ensembl Genes ENSG00000202198 Ensembl, ENTREZGENE
  ENSG00000283293 Ensembl
Ensembl Transcript ENST00000365328 ENTREZGENE
GTEx ENSG00000202198 GTEx
  ENSG00000283293 GTEx
HGNC ID HGNC:10037 ENTREZGENE
Human Proteome Map RN7SK Human Proteome Map
NCBI Gene 125050 ENTREZGENE
OMIM 606515 OMIM
PharmGKB PA34405 PharmGKB
RNAcentral URS0000734D8F RNACentral


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2019-04-02 RN7SK  RNA component of 7SK nuclear ribonucleoprotein    RNA, 7SK small nuclear  Symbol and/or name change 5135510 APPROVED