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Pathways
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PATHWAY ONTOLOGY - ANNOTATIONS

The Pathway Ontology (PW), is currently being developed at the Rat Genome Database. For more information about this vocabulary, please see Petri et al. The rat genome database pathway portal. Database (Oxford). 2011 Apr 8;2011:bar010. Print 2011 or contact us (http://rgd.mcw.edu/contact/index.shtml).
Term:chlorothiazide pharmacodynamics pathway
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Accession:PW:0002188 term browser browse the term
Definition:The pathway of chlorothiazide-target interaction and of the biochemical or physiological responses to drug. The drug reduces sodium reabsorption in the distal convoluted tubule of kidney nephron. Genetic variations can cause differences in the response of the organism to the drug.
Synonyms:related_synonym: SMP:00078


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chlorothiazide pharmacodynamics pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Aqp1 aquaporin 1 ISO SMPDB SMP:00078 NCBI chr 6:55,313,284...55,325,540
Ensembl chr 6:55,313,417...55,325,540 		JBrowse link
G Aqp2 aquaporin 2 ISO SMPDB SMP:00078 NCBI chr15:99,476,937...99,482,426
Ensembl chr15:99,476,936...99,482,428 		JBrowse link
G Aqp3 aquaporin 3 ISO SMPDB SMP:00078 NCBI chr 4:41,092,724...41,098,183
Ensembl chr 4:41,092,722...41,098,183 		JBrowse link
G Atp1a1 ATPase, Na+/K+ transporting, alpha 1 polypeptide ISO SMPDB SMP:00078 NCBI chr 3:101,483,535...101,512,023
Ensembl chr 3:101,483,535...101,512,000 		JBrowse link
G Atp1a2 ATPase, Na+/K+ transporting, alpha 2 polypeptide ISO SMPDB SMP:00078 NCBI chr 1:172,099,276...172,125,631
Ensembl chr 1:172,099,276...172,125,631 		JBrowse link
G Atp1a3 ATPase, Na+/K+ transporting, alpha 3 polypeptide ISO SMPDB SMP:00078 NCBI chr 7:24,677,592...24,705,338
Ensembl chr 7:24,677,592...24,705,383 		JBrowse link
G Atp1a4 ATPase, Na+/K+ transporting, alpha 4 polypeptide ISO SMPDB SMP:00078 NCBI chr 1:172,051,075...172,085,991
Ensembl chr 1:172,051,080...172,085,981 		JBrowse link
G Atp1b1 ATPase, Na+/K+ transporting, beta 1 polypeptide ISO SMPDB SMP:00078 NCBI chr 1:164,264,668...164,285,924
Ensembl chr 1:164,264,678...164,285,924 		JBrowse link
G Atp1b2 ATPase, Na+/K+ transporting, beta 2 polypeptide ISO SMPDB SMP:00078 NCBI chr11:69,490,554...69,496,786
Ensembl chr11:69,490,562...69,496,768 		JBrowse link
G Atp1b3 ATPase, Na+/K+ transporting, beta 3 polypeptide ISO SMPDB SMP:00078 NCBI chr 9:96,214,708...96,246,368
Ensembl chr 9:96,214,708...96,246,495 		JBrowse link
G Atp1b4 ATPase Na+/K+ transporting, beta 4 polypeptide ISO SMPDB SMP:00078 NCBI chr  X:37,404,999...37,425,661
Ensembl chr  X:37,405,061...37,425,646 		JBrowse link
G Clcnka chloride channel, voltage-sensitive Ka ISO SMPDB SMP:00078 NCBI chr 4:141,111,922...141,126,017
Ensembl chr 4:141,111,921...141,126,035 		JBrowse link
G Fxyd2 FXYD domain-containing ion transport regulator 2 ISO SMPDB SMP:00078 NCBI chr 9:45,311,007...45,321,576
Ensembl chr 9:45,310,967...45,321,576 		JBrowse link
G Nr3c2 nuclear receptor subfamily 3, group C, member 2 ISO SMPDB SMP:00078 NCBI chr 8:77,626,422...77,971,641
Ensembl chr 8:77,626,070...77,971,641 		JBrowse link
G Scnn1a sodium channel, nonvoltage-gated 1 alpha ISO SMPDB SMP:00078 NCBI chr 6:125,286,657...125,321,906
Ensembl chr 6:125,297,622...125,321,906 		JBrowse link
G Scnn1b sodium channel, nonvoltage-gated 1 beta ISO SMPDB SMP:00078 NCBI chr 7:121,464,261...121,517,951
Ensembl chr 7:121,464,261...121,517,737 		JBrowse link
G Scnn1g sodium channel, nonvoltage-gated 1 gamma ISO SMPDB SMP:00078 NCBI chr 7:121,333,643...121,367,705
Ensembl chr 7:121,333,702...121,367,698 		JBrowse link
G Slc12a1 solute carrier family 12, member 1 ISO SMPDB SMP:00078 NCBI chr 2:124,994,430...125,071,922
Ensembl chr 2:124,994,425...125,071,922 		JBrowse link
G Slc12a3 solute carrier family 12, member 3 ISO SMPDB SMP:00078 NCBI chr 8:95,055,737...95,092,850
Ensembl chr 8:95,055,829...95,092,842 		JBrowse link
G Slc12a6 solute carrier family 12, member 6 ISO SMPDB SMP:00078 NCBI chr 2:112,096,659...112,193,508
Ensembl chr 2:112,096,170...112,193,508 		JBrowse link
G Slc14a2 solute carrier family 14 (urea transporter), member 2 ISO SMPDB SMP:00078 NCBI chr18:78,189,359...78,640,165
Ensembl chr18:78,189,363...78,640,157 		JBrowse link
G Slc1a1 solute carrier family 1 (neuronal/epithelial high affinity glutamate transporter, system Xag), member 1 ISO SMPDB SMP:00078 NCBI chr19:28,812,535...28,891,360
Ensembl chr19:28,812,449...28,891,360 		JBrowse link
G Slc22a2 solute carrier family 22 (organic cation transporter), member 2 ISO SMPDB SMP:00078 NCBI chr17:12,803,076...12,847,376
Ensembl chr17:12,803,019...12,847,375 		JBrowse link
G Slc22a6 solute carrier family 22 (organic anion transporter), member 6 ISO SMPDB SMP:00078 NCBI chr19:8,595,360...8,605,663
Ensembl chr19:8,595,403...8,605,663 		JBrowse link
G Slc38a4 solute carrier family 38, member 4 ISO SMPDB SMP:00078 NCBI chr15:96,892,701...96,953,837
Ensembl chr15:96,892,701...96,953,837 		JBrowse link
G Slc3a1 solute carrier family 3, member 1 ISO SMPDB SMP:00078 NCBI chr17:85,335,775...85,371,669
Ensembl chr17:85,335,804...85,371,664 		JBrowse link
G Slc3a2 solute carrier family 3 (activators of dibasic and neutral amino acid transport), member 2 ISO SMPDB SMP:00078 NCBI chr19:8,684,931...8,700,733
Ensembl chr19:8,684,246...8,700,733 		JBrowse link
G Slc6a20b solute carrier family 6 (neurotransmitter transporter), member 20B ISO SMPDB SMP:00078 NCBI chr 9:123,422,888...123,461,603
Ensembl chr 9:123,419,865...123,461,630 		JBrowse link
G Slc7a5 solute carrier family 7 (cationic amino acid transporter, y+ system), member 5 ISO SMPDB SMP:00078 NCBI chr 8:122,607,885...122,634,425
Ensembl chr 8:122,607,889...122,634,433 		JBrowse link
G Slc7a6 solute carrier family 7 (cationic amino acid transporter, y+ system), member 6 ISO SMPDB SMP:00078 NCBI chr 8:106,894,718...106,925,346
Ensembl chr 8:106,895,489...106,925,338 		JBrowse link
G Slc7a7 solute carrier family 7 (cationic amino acid transporter, y+ system), member 7 ISO SMPDB SMP:00078 NCBI chr14:54,606,899...54,657,525
Ensembl chr14:54,606,899...54,655,237 		JBrowse link
G Slc7a8 solute carrier family 7 (cationic amino acid transporter, y+ system), member 8 ISO SMPDB SMP:00078 NCBI chr14:54,959,672...55,019,343
Ensembl chr14:54,959,666...55,019,403 		JBrowse link
G Slc7a9 solute carrier family 7 (cationic amino acid transporter, y+ system), member 9 ISO SMPDB SMP:00078 NCBI chr 7:35,148,152...35,165,459
Ensembl chr 7:35,148,221...35,165,461 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  pathway 6072
    drug pathway 402
      cardiovascular system drug pathway 189
        diuretic drug pathway 33
          chlorothiazide drug pathway 33
            chlorothiazide pharmacodynamics pathway 33
paths to the root