Gene: Slc7a9 (solute carrier family 7 (cationic amino acid transporter, y+ system), member 9)
Mus musculus
Symbol:
Slc7a9
Name:
solute carrier family 7 (cationic amino acid transporter, y+ system), member 9
Description:
ENCODES a protein that exhibits amino acid transmembrane transporter activity (ortholog); INVOLVED IN amino acid transport (ortholog); ASSOCIATED WITH abnormal circulating amino acid level; abnormal renal tubule morphology; aminoaciduria; ASSOCIATED WITH Cystinuria (ortholog); FOUND IN integral to membrane (inferred); membrane (inferred); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; benzo[a]pyrene; aflatoxin B1 (ortholog)
Type:
protein-coding
RefSeq Status:
VALIDATED
Also known as:
B(0,+)-type amino acid transporter 1; b(0,+)AT; b, + amino acid transporter; b, +AT; CSNU3; glycoprotein-associated amino acid transporter b0,+AT1; glycoprotein-associated amino acid transporter b0,+AT1; OTTMUSP00000041638; OTTMUSP00000041639; OTTMUSP00000041640; solute carrier family 7 member 9
Orthologs:
Homo sapiens : SLC7A9
(solute carrier family 7 (glycoprotein-associated amino acid transporter light chain, bo,+ system), member 9)
HGNC
Rattus norvegicus : Slc7a9
(solute carrier family 7 (glycoprotein-associated amino acid transporter light chain, bo,+ system), member 9)
Latest Assembly:
Mouse Genome Assembly Build 37
Position:
Map Chr Position Strand Source Mouse Genome Assembly GRCm38 7 35,449,092 - 35,466,034 + NCBI Mouse cM Map 7 + NCBI Mouse Celera Assembly 7 30,576,728 - 30,593,652 + NCBI Mouse Genome Assembly Build 37 7 36,234,198 - 36,251,018 + NCBI Mouse Genome Assembly Build 36.1 7 36,234,198 - 36,251,018 + NCBI Mouse Cytogenetic Map 7 B2 NCBI
Model
Disease Annotations
Gene-Chemical Interaction Annotations
2,3,7,8-tetrachlorodibenzodioxine increases expression EXP 6480464 Tetrachlorodibenzodioxin results in increased expression of SLC7A9 mRNA CTD PMID:19770486 aflatoxin B1 affects expression ISO RGD:734403 6480464 Aflatoxin B1 affects the expression of SLC7A9 protein CTD PMID:20106945 ammonium chloride affects expression ISO RGD:619905 6480464 Ammonium Chloride affects the expression of SLC7A9 mRNA CTD PMID:16483693 benzo[a]pyrene increases expression EXP 6480464 Benzo(a)pyrene results in increased expression of SLC7A9 mRNA CTD PMID:19770486 cadmium atom increases expression ISO RGD:619905 6480464 Cadmium results in increased expression of SLC7A9 mRNA CTD PMID:17327699 cadmium dichloride increases expression ISO RGD:619905 6480464 Cadmium Chloride results in increased expression of SLC7A9 mRNA CTD PMID:17327699 copper(2+) sulfate decreases expression ISO RGD:734403 6480464 Copper Sulfate results in decreased expression of SLC7A9 mRNA CTD PMID:19549813 cyclosporin A decreases expression ISO RGD:734403 6480464 Cyclosporine results in decreased expression of SLC7A9 mRNA CTD PMID:20106945 L-cystine multiple interactions ISO RGD:734403 6480464 [SLC3A1 protein co-treated with SLC7A9 protein] results in increased uptake of Cystine CTD PMID:14978168 quercetin decreases expression ISO RGD:734403 6480464 Quercetin results in decreased expression of SLC7A9 mRNA CTD PMID:21632981 tetrachloromethane affects expression ISO RGD:619905 6480464 Carbon Tetrachloride affects the expression of SLC7A9 mRNA CTD PMID:12734012 tetrachloromethane decreases expression ISO RGD:619905 6480464 Carbon Tetrachloride results in decreased expression of SLC7A9 protein CTD PMID:12629582
Biological Process
amino acid transmembrane transport IEA InterPro:IPR002293 2290270 MGI:MGI:2152098 UniProtKB MGI:MGI:2152098 amino acid transport ISO UniProtKB:P82252 2290270 MGI:MGI:4417868 RGD MGI:MGI:4417868 transport IEA UniProtKB-KW:KW-0813 2290270 MGI:MGI:1354194 UniProtKB MGI:MGI:1354194
Cellular Component
integral to membrane IEA UniProtKB-KW:KW-0812 2290270 MGI:MGI:1354194 UniProtKB MGI:MGI:1354194 membrane IEA InterPro:IPR002293 2290270 MGI:MGI:2152098 UniProtKB MGI:MGI:2152098 membrane IEA UniProtKB-KW:KW-0472 2290270 MGI:MGI:1354194 UniProtKB MGI:MGI:1354194
Molecular Function
amino acid transmembrane transporter activity ISO UniProtKB:P82252 2290270 MGI:MGI:4417868 RGD MGI:MGI:4417868
1300693 Mmtg3_m modifier of mammary tumor growth 3 (mouse) Not determined 7 2580218 36580441 Mouse 1301572 Sluc30_m susceptibility to lung cancer 30 (mouse) Not determined 7 3283120 37283268 Mouse 4142339 Spmd3_m spermatogenesis defect 3 (mouse) Not determined 7 10257545 44257688 Mouse 1300758 Bomd4_m bone mineral density 4 (mouse) Not determined 7 10523163 44523313 Mouse 1558951 mdlk1_m modifier of Dlk1 (mouse) Not determined 7 11074461 45074578 Mouse 1357699 Nhdlq6_m non-HDL QTL 6 (mouse) Not determined 7 11074461 45074578 Mouse 1558893 Spir1_m Streptococcus pneumoniae infection resistance 1 (mouse) Not determined 7 11391392 45391530 Mouse 1301627 Vmbic4_m ventral midbrain iron content 4 (mouse) Not determined 7 14118079 48118215 Mouse 1301041 Prnr2_m prion resistance 2 (mouse) Not determined 7 14118079 48118215 Mouse 1558790 Mmtp1_m modifier of mammary tumor progression 1 (mouse) Not determined 7 14118079 48118215 Mouse 4141790 Hfem1_m Hfe modifier 1 (mouse) Not determined 7 14118079 48118215 Mouse 1301352 Bis4_m beta-carboline induced seizures 4 (mouse) Not determined 7 17527929 51528044 Mouse 1301622 Eae12_m susceptibility to experimental allergic encephalomyelitis 12 (mouse) Not determined 7 20365609 54365698 Mouse 1357714 Hdl38_m HDL level 38 (mouse) Not determined 7 20365609 54365698 Mouse 1301052 Bhr6_m bronchial hyperresponsiveness 6 (mouse) Not determined 7 20927844 54927961 Mouse 4141960 Rosq1_m reactive oxygen species QTL 1 (mouse) Not determined 7 30279833 64279979 Mouse 1301711 Tbrs3_m tuberculosis resistance 3 (mouse) Not determined 7 30287212 64287356 Mouse 4141204 Wtlr4_m weight loss response 4 (mouse) Not determined 7 30287212 64287356 Mouse 1301709 Bdt4_m bone density traits 4 (mouse) Not determined 7 30494518 64494662 Mouse 1357445 Dyscalc1_m dystrophic cardiac calcinosis 1 (mouse) Not determined 7 35942350 69942472 Mouse