Slc12a1 (solute carrier family 12, member 1) - Rat Genome Database

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Gene: Slc12a1 (solute carrier family 12, member 1) Mus musculus
Analyze
Symbol: Slc12a1
Name: solute carrier family 12, member 1
RGD ID: 11297
MGI Page MGI
Description: Enables sodium:potassium:chloride symporter activity. Acts upstream of or within kidney development and urea transmembrane transport. Located in apical plasma membrane. Is expressed in several structures, including alimentary system and urinary system. Used to study Bartter disease type 1. Human ortholog(s) of this gene implicated in Bartter disease and Bartter disease type 1. Orthologous to human SLC12A1 (solute carrier family 12 member 1).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: AI788571; BSC1; bumetanide-sensitive cotransporter type 1; bumetanide-sensitive sodium-(potassium)-chloride cotransporter 2; D630042G03Rik; kidney-specific Na-K-Cl symporter; mBSC; mBSC1; Nkcc; Nkcc2; solute carrier family 12 member 1; ureh; urehr3
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm392124,994,430 - 125,071,922 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl2124,994,425 - 125,071,922 (+)EnsemblGRCm39 Ensembl
GRCm382125,152,510 - 125,230,002 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl2125,152,505 - 125,230,002 (+)EnsemblGRCm38mm10GRCm38
MGSCv372124,978,336 - 125,055,738 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv362124,844,041 - 124,921,440 (+)NCBIMGSCv36mm8
Celera2126,402,848 - 126,480,313 (+)NCBICelera
Cytogenetic Map2F1NCBI
cM Map261.23NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
abnormal blood homeostasis  (IAGP)
abnormal bone structure  (IAGP)
abnormal circulating magnesium level  (IAGP)
abnormal fluid regulation  (IAGP)
abnormal kidney morphology  (IAGP)
abnormal kidney physiology  (IAGP)
abnormal mineral level  (IAGP)
abnormal renal reabsorption  (IAGP)
abnormal renal tubule morphology  (IAGP)
abnormal renal water reabsorption  (IAGP)
abnormal tubuloglomerular feedback response  (IAGP)
abnormal urine homeostasis  (IAGP)
abnormal urine urea nitrogen level  (IAGP)
alkalosis  (IAGP)
decreased bone mineral density  (IAGP)
decreased circulating chloride level  (IAGP)
decreased circulating creatinine level  (IAGP)
decreased circulating glucose level  (IAGP)
decreased circulating renin level  (IAGP)
decreased mean systemic arterial blood pressure  (IAGP)
decreased skin turgor  (IAGP)
decreased systemic arterial systolic blood pressure  (IAGP)
decreased tubuloglomerular feedback response  (IAGP)
decreased urine creatinine level  (IAGP)
decreased urine osmolality  (IAGP)
decreased urine sodium level  (IAGP)
decreased urine uric acid level  (IAGP)
hydronephrosis  (IAGP)
increased blood urea nitrogen level  (IAGP)
increased circulating alkaline phosphatase level  (IAGP)
increased circulating atrial natriuretic factor  (IAGP)
increased circulating calcium level  (IAGP)
increased circulating chloride level  (IAGP)
increased circulating creatinine level  (IAGP)
increased circulating magnesium level  (IAGP)
increased circulating renin level  (IAGP)
increased circulating sodium level  (IAGP)
increased circulating total protein level  (IAGP)
increased creatinine clearance  (IAGP)
increased hematocrit  (IAGP)
increased renin activity  (IAGP)
increased tubuloglomerular feedback response  (IAGP)
increased urine calcium level  (IAGP)
increased urine creatinine level  (IAGP)
increased urine magnesium level  (IAGP)
increased urine osmolality  (IAGP)
increased urine potassium level  (IAGP)
increased urine prostaglandin level  (IAGP)
increased urine sodium level  (IAGP)
kidney failure  (IAGP)
kidney papillary atrophy  (IAGP)
metabolic acidosis  (IAGP)
nephrocalcinosis  (IAGP)
polydipsia  (IAGP)
polyuria  (IAGP)
postnatal growth retardation  (IAGP)
postnatal lethality, complete penetrance  (IAGP)
pyelitis  (IAGP)
pyelonephritis  (IAGP)
weight loss  (IAGP)
References

References - curated
# Reference Title Reference Citation
1. Molecular cloning, primary structure, and characterization of two members of the mammalian electroneutral sodium-(potassium)-chloride cotransporter family expressed in kidney. Gamba G, etal., J Biol Chem 1994 Jul 1;269(26):17713-22.
2. Electronic Transfer of Homolog Data MGD and Homologene mouse data transfer
3. MGDs mouse GO annotations MGD data from the GO Consortium
4. MGD IEA MGD IEA
5. Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Okazaki Y, etal., Nature. 2002 Dec 5;420(6915):563-73.
6. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
7. Mouse chromosomal location of three epithelial sodium channel subunit genes and an apical sodium chloride cotransporter gene. Pathak BG, etal., Genomics 1996 Apr 1;33(1):124-7.
8. SMPDB Annotation Import Pipeline Pipeline to import SMPDB annotations from SMPDB into RGD
9. Mouse MP Annotation Import Pipeline RGD automated import pipeline
10. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
11. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
12. Bartter's syndrome, hypokalaemic alkalosis with hypercalciuria, is caused by mutations in the Na-K-2Cl cotransporter NKCC2. Simon DB, etal., Nat Genet. 1996 Jun;13(2):183-8.
Additional References at PubMed
PMID:7573490   PMID:8589530   PMID:8617512   PMID:8621642   PMID:8663127   PMID:9107691   PMID:10070158   PMID:10070159   PMID:10349636   PMID:10779555   PMID:11042159   PMID:11076861  
PMID:11217851   PMID:11423561   PMID:11790783   PMID:11856763   PMID:12386165   PMID:12477932   PMID:14681479   PMID:15489334   PMID:15550389   PMID:15563565   PMID:16141072   PMID:16141073  
PMID:16275913   PMID:16319116   PMID:16602821   PMID:16807402   PMID:16814616   PMID:16816365   PMID:16926446   PMID:17036046   PMID:17079272   PMID:17186942   PMID:17215439   PMID:17264314  
PMID:17314325   PMID:17341212   PMID:17438304   PMID:17848580   PMID:18391953   PMID:18485340   PMID:18495801   PMID:19000842   PMID:19323993   PMID:19487454   PMID:19535327   PMID:19855135  
PMID:20215348   PMID:20219826   PMID:20385770   PMID:20944551   PMID:20978075   PMID:21131289   PMID:21205824   PMID:21228109   PMID:21267068   PMID:21321328   PMID:21354128   PMID:21511694  
PMID:21737451   PMID:21873635   PMID:21907141   PMID:21972418   PMID:22218592   PMID:22388656   PMID:22510988   PMID:22511595   PMID:23104236   PMID:23105100   PMID:23269645   PMID:23362348  
PMID:23362349   PMID:23555292   PMID:23684652   PMID:23946287   PMID:24133122   PMID:24782621   PMID:24808538   PMID:25084970   PMID:25409434   PMID:25993027   PMID:26207612   PMID:26279573  
PMID:26400961   PMID:26712462   PMID:26721884   PMID:27551042   PMID:27633993   PMID:28237360   PMID:28334964   PMID:28527294   PMID:28760814   PMID:28847650   PMID:29113990   PMID:29158444  
PMID:29412704   PMID:29449453   PMID:29459093   PMID:29541861   PMID:29596840   PMID:29679048   PMID:29735631   PMID:29993276   PMID:30046000   PMID:31365295   PMID:31685872   PMID:31813248  
PMID:32035616   PMID:32504627   PMID:32715478   PMID:33197428   PMID:33315499   PMID:33737325   PMID:34320496   PMID:34499620   PMID:35037469   PMID:35341793   PMID:35581939   PMID:35877077  
PMID:35918150   PMID:36522157   PMID:36527791   PMID:36892908   PMID:37881876  


Genomics

Comparative Map Data
Slc12a1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm392124,994,430 - 125,071,922 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl2124,994,425 - 125,071,922 (+)EnsemblGRCm39 Ensembl
GRCm382125,152,510 - 125,230,002 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl2125,152,505 - 125,230,002 (+)EnsemblGRCm38mm10GRCm38
MGSCv372124,978,336 - 125,055,738 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv362124,844,041 - 124,921,440 (+)NCBIMGSCv36mm8
Celera2126,402,848 - 126,480,313 (+)NCBICelera
Cytogenetic Map2F1NCBI
cM Map261.23NCBI
SLC12A1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381548,206,302 - 48,304,078 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1548,178,438 - 48,304,078 (+)EnsemblGRCh38hg38GRCh38
GRCh371548,498,499 - 48,596,275 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361546,285,790 - 46,383,567 (+)NCBINCBI36Build 36hg18NCBI36
Build 341546,287,189 - 46,382,417NCBI
Celera1525,391,005 - 25,488,781 (+)NCBICelera
Cytogenetic Map15q21.1NCBI
HuRef1525,331,539 - 25,429,297 (+)NCBIHuRef
CHM1_11548,616,680 - 48,714,374 (+)NCBICHM1_1
T2T-CHM13v2.01546,014,393 - 46,112,359 (+)NCBIT2T-CHM13v2.0
Slc12a1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr83132,859,581 - 132,936,354 (+)NCBIGRCr8
mRatBN7.23112,406,140 - 112,482,913 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl3112,406,140 - 112,482,899 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx3116,266,766 - 116,343,349 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.03124,862,282 - 124,938,867 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.03122,522,644 - 122,599,228 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.03117,421,531 - 117,498,372 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl3117,421,604 - 117,498,367 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.03123,945,362 - 124,022,090 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.43112,455,897 - 112,534,752 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.13112,361,400 - 112,440,311 (+)NCBI
Celera3111,264,326 - 111,339,676 (+)NCBICelera
Cytogenetic Map3q36NCBI
Slc12a1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554095,597,033 - 5,680,009 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554095,597,033 - 5,680,009 (-)NCBIChiLan1.0ChiLan1.0
SLC12A1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21637,446,971 - 37,544,617 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11541,628,311 - 41,725,989 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01527,155,331 - 27,252,995 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11545,479,583 - 45,577,084 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1545,479,583 - 45,577,084 (+)Ensemblpanpan1.1panPan2
SLC12A1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.13014,458,373 - 14,548,870 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl3014,459,606 - 14,547,694 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha3014,381,456 - 14,470,305 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.03014,593,665 - 14,682,546 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl3014,593,691 - 14,681,371 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.13014,516,360 - 14,605,436 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.03014,631,905 - 14,720,735 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.03014,743,702 - 14,832,801 (+)NCBIUU_Cfam_GSD_1.0
Slc12a1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440864092,716,292 - 92,799,975 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493647110,564,535 - 10,646,977 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493647110,564,530 - 10,648,124 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
SLC12A1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1123,481,369 - 123,571,630 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11123,481,892 - 123,571,655 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21137,511,070 - 137,604,350 (-)NCBISscrofa10.2Sscrofa10.2susScr3
SLC12A1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12634,974,947 - 35,077,241 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2634,976,126 - 35,075,186 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666048106,034,886 - 106,153,601 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Slc12a1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462473111,403,675 - 11,484,982 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462473111,403,936 - 11,486,244 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Slc12a1
2769 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:866
Count of miRNA genes:268
Interacting mature miRNAs:296
Transcripts:ENSMUST00000028630, ENSMUST00000110494, ENSMUST00000110495, ENSMUST00000147095
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1302174Dssc2_mdextran sodium sulfate induced colitis QTL2 (mouse)Not determined224224632148700377Mouse
4141854T2dm2sa_mtype 2 diabetes mellitus 2 in SMXA RI mice (mouse)Not determined229307947148374934Mouse
1301344Lith1_mlithogenic gene 1 (mouse)Not determined245347635145312647Mouse
13824983Vclq1_mcurvilinear velocity QTL 1 (mouse)261830344136841920Mouse
5491197Mobq5_mmultigenic obesity QTL 5 (mouse)Not determined265269746162518926Mouse
11528549Sluc31_msusceptibility to lung cancer 31 (mouse)274524117129213005Mouse
4141155Plast2b_mplasma plant sterol 2b (mouse)Not determined284013198148522175Mouse
10412082Hylaq1_mHyperlocomotor activity related QTL 1 (mouse)Not determined284013198148667470Mouse
5491196Mobq6_mmultigenic obesity QTL 6 (mouse)Not determined285724269180896594Mouse
1301098Cd8mts3_mCD8 memory T cell subset 3 (mouse)Not determined291089974125090104Mouse
1301909Smdq2_msegregation of mitochondrial DNA QTL 2 (mouse)Not determined292778465126778607Mouse
27226761Feml18_mfemur length 18, 16 week (mouse)294230345154241920Mouse
11049569Lmr28d_mleishmaniasis resistance 28d (mouse)297123370131123532Mouse
11049568Lmr28c_mleishmaniasis resistance 28c (mouse)297123370131123532Mouse
12904935Edlmmq2_mextensor digitorum longus muscle mass QTL 2 (mouse)297210364131210364Mouse
12904954Gmmq2_mgastrocnemius muscle mass QTL 2 (mouse)297210364131210364Mouse
4141802Ignpq1_mIgA nephropathy QTL 1 (mouse)Not determined2100824060134824269Mouse
1302203Gvhd3_mgraft-versus host disease 3 (mouse)Not determined2100942930134943090Mouse
1301330Tbbmd2_mtotal body bone mineral density 2 (mouse)Not determined2100942930134943090Mouse
1302071Fembrs1_mfemur breaking strength 1 (mouse)Not determined2100942930134943090Mouse
27226788Feml13_mfemur length 13, 10 week (mouse)2102630345159941920Mouse
11041906Lmr28a_mleishmaniasis resistance 28a (mouse)2103095716129213005Mouse
11038702Ltpr2_mLeishmania tropica response 2 (mouse)2103095716167212356Mouse
1301825Pbrgcsf1_mperipheral blood stem cell response to granulocyte colony stimulating factor 1 (mouse)Not determined2106233580140233729Mouse
10043875Bw25_mbody weight QTL 25 (mouse)Not determined2107255676141255676Mouse
1301087Bbaa15_mB.burgdorferi-associated arthritis 15 (mouse)Not determined2110489658144489807Mouse
10045885Cplaq15_mcircadian period of locomotor activity 15 (mouse)Not determined2110916118154354667Mouse
1558990Skmw9_mskeletal muscle weight 9 (mouse)Not determined2111173704145173821Mouse
1300793Pcfm2_mperiosteal circumference and femur length 2 (mouse)Not determined2111173704145173821Mouse
1301905Lgth2_mbody length 2 (mouse)Not determined2111173704145173821Mouse
1301755Hrq1_mheart rate quantitative locus 1 (mouse)Not determined2111173704145173821Mouse
1301201Chab1_mcholesterol absorption 1 (mouse)Not determined2111551028145551163Mouse
1302033Nsv1_mNeuroadapted Sindbis viral RNA level 1 (mouse)Not determined2111623386145623526Mouse
1300798Actre3_mactivity response to ethanol 3 (mouse)Not determined2112024987128173821Mouse
1301415Actre4_mactivity response to ethanol 4 (mouse)Not determined2112024987128173821Mouse
11039520Ltpr2h_mLeishmania tropica response 2h (mouse)2112212746146213005Mouse
11038699Ltpr2b_mLeishmania tropica response 2b (mouse)2112212746146213005Mouse
11038700Ltpr2a_mLeishmania tropica response 2a (mouse)2112212746146213005Mouse
1301029T2dm3_mtype 2 diabetes mellitus 3 (mouse)Not determined2114288075132714157Mouse
11039521Ltpr2g_mLeishmania tropica response 2g (mouse)2115212857149212994Mouse
11038696Ltpr2f_mLeishmania tropica response 2f (mouse)2115212857149212994Mouse
1301295Prdt1_mprion disease incubation time 1 (mouse)Not determined2116077623150077741Mouse
1558881Ses7_msalmonella enteritidis susceptibility 7 (mouse)Not determined2116306330150306474Mouse
1301618Bglu1_mblood glucose level 1 (mouse)Not determined2117942930174324863Mouse
12904007Cfq7_mconditioned fear QTL 7 (mouse)2118356772125048872Mouse
12910795Pwbwq5_mpost-weaning body weight QTL 5 (mouse)2118589253160611165Mouse
12910799Pwgrq2_mpre-weaning growth rate QTL 2 (mouse)2118589253160611165Mouse
12910812Pwgrq1_mpre-weaning growth rate QTL 1 (mouse)2118589253160611165Mouse
12910814Pwbwq1_mpre-weaning body weight QTL 1 (mouse)2118589253160611165Mouse
1300712El2_mepilepsy 2 (mouse)Not determined2122207146142532135Mouse
1301294Hrtfm5_mheart failure modifier 5 (mouse)Not determined2122883015156883131Mouse
1301066Otx2m2_morthodenticle homolog 2 (Drosophila) modifier 2 (mouse)Not determined2123231973148700377Mouse
1301822Pgia2_mproteoglycan induced arthritis 2 (mouse)Not determined2123937311157937424Mouse
27226749Femd10_mfemur midshaft diameter 10, 16 week (mouse)2124441920168241920Mouse

Markers in Region
48.MMHAP61FRH12.seq  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm382125,189,066 - 125,189,288UniSTSGRCm38
MGSCv372125,014,802 - 125,015,024UniSTSGRCm37
Celera2126,439,338 - 126,439,553UniSTS
Cytogenetic Map2F1UniSTS
cM Map269.5UniSTS
Whitehead_YAC2 UniSTS
D10Mit186  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381075,681,135 - 75,681,262UniSTSGRCm38
MGSCv371075,143,880 - 75,144,007UniSTSGRCm37
Celera1076,725,825 - 76,725,952UniSTS
Cytogenetic Map10C1UniSTS
cM Map1040.0UniSTS
Whitehead Genetic1036.1UniSTS
U20973  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm382125,229,087 - 125,229,204UniSTSGRCm38
MGSCv372125,054,823 - 125,054,940UniSTSGRCm37
Celera2126,479,398 - 126,479,515UniSTS
Cytogenetic Map2F1UniSTS
cM Map269.5UniSTS
Whitehead/MRC_RH21566.08UniSTS
Whitehead/MRC_RH21565.58UniSTS
AI788571  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm382125,164,669 - 125,164,776UniSTSGRCm38
MGSCv372124,990,405 - 124,990,512UniSTSGRCm37
Celera2126,414,924 - 126,415,031UniSTS
Cytogenetic Map2F1UniSTS
cM Map269.5UniSTS
Whitehead/MRC_RH21567.1UniSTS
Slc12a1  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm382125,228,882 - 125,229,912UniSTSGRCm38
MGSCv372125,054,618 - 125,055,648UniSTSGRCm37
Celera2126,479,193 - 126,480,223UniSTS
Cytogenetic Map2F1UniSTS
cM Map269.5UniSTS
cM Map269.5UniSTS
Slc12a1  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map2F1UniSTS
Slc12a1  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm382125,229,490 - 125,229,710UniSTSGRCm38
MGSCv372125,055,226 - 125,055,446UniSTSGRCm37
Celera2126,479,801 - 126,480,021UniSTS
Cytogenetic Map2F1UniSTS
cM Map269.5UniSTS


Expression


Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001079690 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_183354 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_030248885 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_030248886 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_030248887 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_030248888 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_030248889 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_030248890 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_030248891 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_030248892 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AI527944 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AI875508 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK052750 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK085455 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK128928 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AL844547 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AL929451 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC016888 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC051100 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BY716143 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH466519 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  U20973 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  U20974 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  U20975 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  U45313 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  U61381 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  U94518 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENSMUST00000028630   ⟹   ENSMUSP00000028630
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl2124,994,520 - 125,071,922 (+)Ensembl
GRCm38.p6 Ensembl2125,152,600 - 125,230,002 (+)Ensembl
RefSeq Acc Id: ENSMUST00000110494   ⟹   ENSMUSP00000106120
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl2124,994,425 - 125,071,922 (+)Ensembl
GRCm38.p6 Ensembl2125,152,505 - 125,230,002 (+)Ensembl
RefSeq Acc Id: ENSMUST00000110495   ⟹   ENSMUSP00000106121
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl2124,994,520 - 125,071,919 (+)Ensembl
GRCm38.p6 Ensembl2125,152,600 - 125,229,999 (+)Ensembl
RefSeq Acc Id: ENSMUST00000147095
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl2124,994,500 - 125,009,065 (+)Ensembl
GRCm38.p6 Ensembl2125,152,580 - 125,167,145 (+)Ensembl
RefSeq Acc Id: NM_001079690   ⟹   NP_001073158
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm392124,994,520 - 125,071,922 (+)NCBI
GRCm382125,152,600 - 125,230,002 (+)ENTREZGENE
MGSCv372124,978,336 - 125,055,738 (+)RGD
Celera2126,402,848 - 126,480,313 (+)RGD
cM Map2 ENTREZGENE
Sequence:
RefSeq Acc Id: NM_183354   ⟹   NP_899197
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm392124,994,520 - 125,071,922 (+)NCBI
GRCm382125,152,600 - 125,230,002 (+)ENTREZGENE
MGSCv372124,978,336 - 125,055,738 (+)RGD
Celera2126,402,848 - 126,480,313 (+)RGD
cM Map2 ENTREZGENE
Sequence:
RefSeq Acc Id: XM_030248885   ⟹   XP_030104745
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm392124,994,430 - 125,071,922 (+)NCBI
GRCm382125,152,510 - 125,230,002 (+)NCBI
Sequence:
RefSeq Acc Id: XM_030248886   ⟹   XP_030104746
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm392124,994,478 - 125,071,922 (+)NCBI
GRCm382125,152,558 - 125,230,002 (+)NCBI
Sequence:
RefSeq Acc Id: XM_030248887   ⟹   XP_030104747
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm392124,994,430 - 125,071,922 (+)NCBI
GRCm382125,152,510 - 125,230,002 (+)NCBI
Sequence:
RefSeq Acc Id: XM_030248888   ⟹   XP_030104748
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm392124,994,430 - 125,071,922 (+)NCBI
GRCm382125,152,510 - 125,230,002 (+)NCBI
Sequence:
RefSeq Acc Id: XM_030248889   ⟹   XP_030104749
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm392124,994,479 - 125,071,922 (+)NCBI
GRCm382125,152,559 - 125,230,002 (+)NCBI
Sequence:
RefSeq Acc Id: XM_030248890   ⟹   XP_030104750
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm392124,994,430 - 125,071,922 (+)NCBI
GRCm382125,152,510 - 125,230,002 (+)NCBI
Sequence:
RefSeq Acc Id: XM_030248891   ⟹   XP_030104751
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm392124,994,479 - 125,071,922 (+)NCBI
GRCm382125,152,559 - 125,230,002 (+)NCBI
Sequence:
RefSeq Acc Id: XM_030248892   ⟹   XP_030104752
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm392124,994,479 - 125,071,922 (+)NCBI
GRCm382125,152,559 - 125,230,002 (+)NCBI
Sequence:
Reference Protein Sequences
RefSeq Acc Id: NP_899197   ⟸   NM_183354
- Peptide Label: isoform A
- UniProtKB: Q9Z1E0 (UniProtKB/Swiss-Prot),   Q91W55 (UniProtKB/Swiss-Prot),   P55014 (UniProtKB/Swiss-Prot),   O35938 (UniProtKB/Swiss-Prot),   A2AQ50 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001073158   ⟸   NM_001079690
- Peptide Label: isoform F
- UniProtKB: Q9Z1E0 (UniProtKB/Swiss-Prot),   Q91W55 (UniProtKB/Swiss-Prot),   P55014 (UniProtKB/Swiss-Prot),   O35938 (UniProtKB/Swiss-Prot),   A2AQ51 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_030104745   ⟸   XM_030248885
- Peptide Label: isoform X1
- UniProtKB: Q9Z1E0 (UniProtKB/Swiss-Prot),   Q91W55 (UniProtKB/Swiss-Prot),   P55014 (UniProtKB/Swiss-Prot),   O35938 (UniProtKB/Swiss-Prot)
RefSeq Acc Id: XP_030104748   ⟸   XM_030248888
- Peptide Label: isoform X3
- UniProtKB: Q9Z1E0 (UniProtKB/Swiss-Prot),   Q91W55 (UniProtKB/Swiss-Prot),   P55014 (UniProtKB/Swiss-Prot),   O35938 (UniProtKB/Swiss-Prot)
RefSeq Acc Id: XP_030104750   ⟸   XM_030248890
- Peptide Label: isoform X5
- UniProtKB: Q9Z1E0 (UniProtKB/Swiss-Prot),   Q91W55 (UniProtKB/Swiss-Prot),   P55014 (UniProtKB/Swiss-Prot),   O35938 (UniProtKB/Swiss-Prot),   A2AQ52 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_030104747   ⟸   XM_030248887
- Peptide Label: isoform X2
- UniProtKB: Q9Z1E0 (UniProtKB/Swiss-Prot),   Q91W55 (UniProtKB/Swiss-Prot),   P55014 (UniProtKB/Swiss-Prot),   O35938 (UniProtKB/Swiss-Prot)
RefSeq Acc Id: XP_030104746   ⟸   XM_030248886
- Peptide Label: isoform X1
- UniProtKB: Q9Z1E0 (UniProtKB/Swiss-Prot),   Q91W55 (UniProtKB/Swiss-Prot),   P55014 (UniProtKB/Swiss-Prot),   O35938 (UniProtKB/Swiss-Prot)
RefSeq Acc Id: XP_030104751   ⟸   XM_030248891
- Peptide Label: isoform X5
- UniProtKB: Q9Z1E0 (UniProtKB/Swiss-Prot),   Q91W55 (UniProtKB/Swiss-Prot),   P55014 (UniProtKB/Swiss-Prot),   O35938 (UniProtKB/Swiss-Prot),   A2AQ52 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_030104752   ⟸   XM_030248892
- Peptide Label: isoform X6
- UniProtKB: Q9Z1E0 (UniProtKB/Swiss-Prot),   Q91W55 (UniProtKB/Swiss-Prot),   P55014 (UniProtKB/Swiss-Prot),   O35938 (UniProtKB/Swiss-Prot),   A2AQ50 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_030104749   ⟸   XM_030248889
- Peptide Label: isoform X4
- UniProtKB: Q9Z1E0 (UniProtKB/Swiss-Prot),   Q91W55 (UniProtKB/Swiss-Prot),   P55014 (UniProtKB/Swiss-Prot),   O35938 (UniProtKB/Swiss-Prot),   A2AQ51 (UniProtKB/TrEMBL)
RefSeq Acc Id: ENSMUSP00000106120   ⟸   ENSMUST00000110494
RefSeq Acc Id: ENSMUSP00000106121   ⟸   ENSMUST00000110495
RefSeq Acc Id: ENSMUSP00000028630   ⟸   ENSMUST00000028630
Protein Domains
Amino acid permease N-terminal   Amino acid permease/ SLC12A   SLC12A transporter C-terminal

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P55014-F1-model_v2 AlphaFold P55014 1-1095 view protein structure

Promoters
RGD ID:6832711
Promoter ID:MM_KWN:31513
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:Kidney
Transcripts:ENSMUST00000028630,   ENSMUST00000110495,   OTTMUST00000036347,   OTTMUST00000036350
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv362124,978,186 - 124,978,686 (+)MPROMDB
RGD ID:6878566
Promoter ID:EPDNEW_M2734
Type:multiple initiation site
Name:Slc12a1_1
Description:Mus musculus solute carrier family 12, member 1 , transcriptvariant 2, mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm382125,152,600 - 125,152,660EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:103150 AgrOrtholog
Ensembl Genes ENSMUSG00000027202 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSMUST00000028630 ENTREZGENE
  ENSMUST00000028630.9 UniProtKB/TrEMBL
  ENSMUST00000110494 ENTREZGENE
  ENSMUST00000110494.9 UniProtKB/TrEMBL
  ENSMUST00000110495 ENTREZGENE
  ENSMUST00000110495.3 UniProtKB/TrEMBL
Gene3D-CATH Amino acid/polyamine transporter I UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro AA-permease/SLC12A_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  AA_permease_N UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SLC12_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Slc12a1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SLC12A1/SLC12A2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SLC12A_fam UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:20495 UniProtKB/Swiss-Prot
MGD MGI:103150 ENTREZGENE
NCBI Gene 20495 ENTREZGENE
PANTHER PTHR11827 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SOLUTE CARRIER FAMILY 12 MEMBER 1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam AA_permease UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  AA_permease_N UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SLC12 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PharmGKB SLC12A1 RGD
PhenoGen Slc12a1 PhenoGen
PRINTS NAKCLTRNSPRT UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  NAKCLTRSPRT2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A2AQ50 ENTREZGENE, UniProtKB/TrEMBL
  A2AQ51 ENTREZGENE, UniProtKB/TrEMBL
  A2AQ52 ENTREZGENE, UniProtKB/TrEMBL
  O35938 ENTREZGENE
  P55014 ENTREZGENE
  Q91W55 ENTREZGENE
  Q9Z1E0 ENTREZGENE
  S12A1_MOUSE UniProtKB/Swiss-Prot
UniProt Secondary O35938 UniProtKB/Swiss-Prot
  Q91W55 UniProtKB/Swiss-Prot
  Q9Z1E0 UniProtKB/Swiss-Prot