SLC12A1 (solute carrier family 12 member 1) - Rat Genome Database

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Gene: SLC12A1 (solute carrier family 12 member 1) Sus scrofa
Analyze
Symbol: SLC12A1
Name: solute carrier family 12 member 1
RGD ID: 14156509
Description: ENCODES a protein that exhibits sodium:potassium:chloride symporter activity (ortholog); INVOLVED IN chloride transport (ortholog); diterpenoid metabolic process (ortholog); kidney development (ortholog); PARTICIPATES IN amiloride pharmacodynamics pathway; bendroflumethiazide pharmacodynamics pathway; bumetanide pharmacodynamics pathway; ASSOCIATED WITH Bartter disease (ortholog); Bartter disease type 1 (ortholog); Bartter disease type 3 (ortholog); FOUND IN apical plasma membrane (ortholog); cell surface (ortholog); INTERACTS WITH deoxynivalenol
Type: protein-coding
RefSeq Status: MODEL
Previously known as: solute carrier family 12 (sodium/potassium/chloride transporters), member 1
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: Sscrofa11.1 - Pig Sscrofa11.1 Assembly
Position:
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1123,481,369 - 123,571,630 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11123,481,892 - 123,571,655 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21137,511,070 - 137,604,350 (-)NCBISscrofa10.2Sscrofa10.2susScr3
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
SLC12A1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1123,481,369 - 123,571,630 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11123,481,892 - 123,571,655 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21137,511,070 - 137,604,350 (-)NCBISscrofa10.2Sscrofa10.2susScr3
SLC12A1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381548,206,302 - 48,304,078 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1548,178,438 - 48,304,078 (+)EnsemblGRCh38hg38GRCh38
GRCh371548,498,499 - 48,596,275 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361546,285,790 - 46,383,567 (+)NCBINCBI36Build 36hg18NCBI36
Build 341546,287,189 - 46,382,417NCBI
Celera1525,391,005 - 25,488,781 (+)NCBICelera
Cytogenetic Map15q21.1NCBI
HuRef1525,331,539 - 25,429,297 (+)NCBIHuRef
CHM1_11548,616,680 - 48,714,374 (+)NCBICHM1_1
T2T-CHM13v2.01546,014,393 - 46,112,359 (+)NCBIT2T-CHM13v2.0
Slc12a1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm392124,994,430 - 125,071,922 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl2124,994,425 - 125,071,922 (+)EnsemblGRCm39 Ensembl
GRCm382125,152,510 - 125,230,002 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl2125,152,505 - 125,230,002 (+)EnsemblGRCm38mm10GRCm38
MGSCv372124,978,336 - 125,055,738 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv362124,844,041 - 124,921,440 (+)NCBIMGSCv36mm8
Celera2126,402,848 - 126,480,313 (+)NCBICelera
Cytogenetic Map2F1NCBI
cM Map261.23NCBI
Slc12a1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr83132,859,581 - 132,936,354 (+)NCBIGRCr8
mRatBN7.23112,406,140 - 112,482,913 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl3112,406,140 - 112,482,899 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx3116,266,766 - 116,343,349 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.03124,862,282 - 124,938,867 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.03122,522,644 - 122,599,228 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.03117,421,531 - 117,498,372 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl3117,421,604 - 117,498,367 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.03123,945,362 - 124,022,090 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.43112,455,897 - 112,534,752 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.13112,361,400 - 112,440,311 (+)NCBI
Celera3111,264,326 - 111,339,676 (+)NCBICelera
Cytogenetic Map3q36NCBI
Slc12a1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554095,597,033 - 5,680,009 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554095,597,033 - 5,680,009 (-)NCBIChiLan1.0ChiLan1.0
SLC12A1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21637,446,971 - 37,544,617 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11541,628,311 - 41,725,989 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01527,155,331 - 27,252,995 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11545,479,583 - 45,577,084 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1545,479,583 - 45,577,084 (+)Ensemblpanpan1.1panPan2
SLC12A1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.13014,458,373 - 14,548,870 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl3014,459,606 - 14,547,694 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha3014,381,456 - 14,470,305 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.03014,593,665 - 14,682,546 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl3014,593,691 - 14,681,371 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.13014,516,360 - 14,605,436 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.03014,631,905 - 14,720,735 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.03014,743,702 - 14,832,801 (+)NCBIUU_Cfam_GSD_1.0
Slc12a1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440864092,716,292 - 92,799,975 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493647110,564,535 - 10,646,977 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493647110,564,530 - 10,648,124 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
SLC12A1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12634,974,947 - 35,077,241 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2634,976,126 - 35,075,186 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666048106,034,886 - 106,153,601 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Slc12a1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462473111,403,675 - 11,484,982 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462473111,403,936 - 11,486,244 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in SLC12A1
1860 total Variants

Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system hemolymphoid system musculoskeletal system nervous system renal system reproductive system respiratory system
High
Medium 3 3 2
Low 5 2 5 20 3 3
Below cutoff 5 2 2

Sequence


Reference Sequences
RefSeq Acc Id: ENSSSCT00000005145   ⟹   ENSSSCP00000005019
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl1123,481,369 - 123,571,565 (-)Ensembl
RefSeq Acc Id: ENSSSCT00000046526   ⟹   ENSSSCP00000052263
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl1123,481,374 - 123,571,630 (-)Ensembl
RefSeq Acc Id: ENSSSCT00000059650   ⟹   ENSSSCP00000056300
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl1123,481,379 - 123,571,586 (-)Ensembl
RefSeq Acc Id: XM_001926142   ⟹   XP_001926177
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.11123,481,892 - 123,571,565 (-)NCBI
Sequence:
RefSeq Acc Id: XM_005654446   ⟹   XP_005654503
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.11123,481,892 - 123,571,655 (-)NCBI
Sequence:
Reference Protein Sequences
RefSeq Acc Id: XP_005654503   ⟸   XM_005654446
- Peptide Label: isoform X2
- UniProtKB: A0A287BI72 (UniProtKB/TrEMBL),   A0A8D0UAD2 (UniProtKB/TrEMBL),   A0A4X1SH85 (UniProtKB/TrEMBL),   A0A8D1EUQ9 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_001926177   ⟸   XM_001926142
- Peptide Label: isoform X1
- UniProtKB: F1SN65 (UniProtKB/TrEMBL),   A0A481BAR6 (UniProtKB/TrEMBL),   A0A4X1SHX8 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSSSCP00000005019   ⟸   ENSSSCT00000005145
RefSeq Acc Id: ENSSSCP00000056300   ⟸   ENSSSCT00000059650
RefSeq Acc Id: ENSSSCP00000052263   ⟸   ENSSSCT00000046526
Protein Domains
Amino acid permease N-terminal   Amino acid permease/ SLC12A   SLC12A transporter C-terminal


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSSSCG00000004659 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
  ENSSSCG00015066929 UniProtKB/TrEMBL
  ENSSSCG00025076689 UniProtKB/TrEMBL
  ENSSSCG00030012095 UniProtKB/TrEMBL
  ENSSSCG00035058688 UniProtKB/TrEMBL
  ENSSSCG00040048316 UniProtKB/TrEMBL
  ENSSSCG00045016822 UniProtKB/TrEMBL
  ENSSSCG00050051950 UniProtKB/TrEMBL
  ENSSSCG00055027087 UniProtKB/TrEMBL
  ENSSSCG00060003946 UniProtKB/TrEMBL
  ENSSSCG00065073592 UniProtKB/TrEMBL
  ENSSSCG00070001000 UniProtKB/TrEMBL
Ensembl Transcript ENSSSCT00000005145 ENTREZGENE
  ENSSSCT00000005145.5 UniProtKB/TrEMBL
  ENSSSCT00000046526.2 UniProtKB/TrEMBL
  ENSSSCT00000059650 ENTREZGENE
  ENSSSCT00000059650.1 UniProtKB/TrEMBL
  ENSSSCT00015091453.1 UniProtKB/TrEMBL
  ENSSSCT00025106592.1 UniProtKB/TrEMBL
  ENSSSCT00030016726.1 UniProtKB/TrEMBL
  ENSSSCT00035078669.1 UniProtKB/TrEMBL
  ENSSSCT00040066389.1 UniProtKB/TrEMBL
  ENSSSCT00045029128.1 UniProtKB/TrEMBL
  ENSSSCT00050070813.1 UniProtKB/TrEMBL
  ENSSSCT00055054177.1 UniProtKB/TrEMBL
  ENSSSCT00060004986.1 UniProtKB/TrEMBL
  ENSSSCT00065101592.1 UniProtKB/TrEMBL
  ENSSSCT00070001986.1 UniProtKB/TrEMBL
  ENSSSCT00070001990.1 UniProtKB/TrEMBL
Gene3D-CATH Amino acid/polyamine transporter I UniProtKB/TrEMBL
InterPro AA-permease/SLC12A_dom UniProtKB/TrEMBL
  AA_permease_N UniProtKB/TrEMBL
  Na/K/Cl_cotranspt UniProtKB/TrEMBL
  SLC12_C UniProtKB/TrEMBL
  Slc12a1 UniProtKB/TrEMBL
  SLC12A_fam UniProtKB/TrEMBL
KEGG Report ssc:100154291 UniProtKB/TrEMBL
NCBI Gene SLC12A1 ENTREZGENE
PANTHER PTHR11827 UniProtKB/TrEMBL
  SOLUTE CARRIER FAMILY 12 MEMBER 1 UniProtKB/TrEMBL
Pfam AA_permease UniProtKB/TrEMBL
  AA_permease_N UniProtKB/TrEMBL
  SLC12 UniProtKB/TrEMBL
PRINTS NAKCLTRNSPRT UniProtKB/TrEMBL
  NAKCLTRSPRT2 UniProtKB/TrEMBL
UniProt A0A287B828_PIG UniProtKB/TrEMBL
  A0A287BI72 ENTREZGENE, UniProtKB/TrEMBL
  A0A481BAR6 ENTREZGENE
  A0A4X1SH85 ENTREZGENE, UniProtKB/TrEMBL
  A0A4X1SHX8 ENTREZGENE, UniProtKB/TrEMBL
  A0A8D0UAD2 ENTREZGENE, UniProtKB/TrEMBL
  A0A8D1EUQ9 ENTREZGENE, UniProtKB/TrEMBL
  F1SN65 ENTREZGENE, UniProtKB/TrEMBL
UniProt Secondary A0A481BAR6 UniProtKB/TrEMBL
VGNC ID VGNC:92921 ENTREZGENE