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Pathways
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PATHWAY ONTOLOGY - ANNOTATIONS

The Pathway Ontology (PW), is currently being developed at the Rat Genome Database. For more information about this vocabulary, please see Petri et al. The rat genome database pathway portal. Database (Oxford). 2011 Apr 8;2011:bar010. Print 2011 or contact us (http://rgd.mcw.edu/contact/index.shtml).
Term:insulin-like growth factor signaling pathway
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Accession:PW:0000238 term browser browse the term
Definition:Insulin-like growth factor signaling plays important roles in cell growth and proliferation. Produced primarily by the liver in response to stimulation by growth hormone (GH), the proteins activate cognate receptors to prompt intracellular signaling pathways and cell growth in a variety of tissues. Deregulation of the pathway has been associated with various conditions, including cancer.
Synonyms:related_synonym: insulin-like growth factor receptor signaling pathway

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insulin-like growth factor signaling pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Akt1 AKT serine/threonine kinase 1 ISO PID PID:200100 NCBI chrNW_004955538:3,208,711...3,224,386
Ensembl chrNW_004955538:3,208,710...3,229,904 		JBrowse link
G Bad BCL2 associated agonist of cell death ISO PID PID:200100 NCBI chrNW_004955422:20,795,585...20,809,039
Ensembl chrNW_004955422:20,795,676...20,809,245 		JBrowse link
G Bcar1 BCAR1 scaffold protein, Cas family member ISO PID PID:200100 NCBI chrNW_004955484:2,223,306...2,258,444
Ensembl chrNW_004955484:2,227,337...2,260,565 		JBrowse link
G Crk CRK proto-oncogene, adaptor protein ISO PID PID:200100 NCBI chrNW_004955481:1,705,595...1,748,363
Ensembl chrNW_004955481:1,705,520...1,734,859 		JBrowse link
G Crkl CRK like proto-oncogene, adaptor protein ISO PID PID:200100 NCBI chrNW_004955442:19,358,202...19,388,552
Ensembl chrNW_004955442:19,358,081...19,388,815 		JBrowse link
G Esr1 estrogen receptor 1 ISO RGD PMID:20042609 RGD:7242068 NCBI chrNW_004955439:9,588,631...9,953,606
Ensembl chrNW_004955439:9,588,201...9,963,353 		JBrowse link
G Grb10 growth factor receptor bound protein 10 ISO PID PID:200100 NCBI chrNW_004955456:3,405,730...3,508,967
Ensembl chrNW_004955456:3,470,330...3,509,667 		JBrowse link
G Grb2 growth factor receptor bound protein 2 ISO RGD
PID		 PMID:15272025 PID:200100 RGD:1581313 NCBI chrNW_004955553:2,186,590...2,258,964
Ensembl chrNW_004955553:2,186,590...2,259,456 		JBrowse link
G Hras HRas proto-oncogene, GTPase ISO PID PID:200100 NCBI chrNW_004955476:11,508,446...11,510,333
Ensembl chrNW_004955476:11,508,126...11,510,333 		JBrowse link
G Igf1 insulin like growth factor 1 ISO PID
RGD		 PMID:7526037 PMID:15862547 PMID:16083987 PID:200100 RGD:12904768 RGD:1580473 RGD:1626333 NCBI chrNW_004955405:37,505,830...37,582,152
Ensembl chrNW_004955405:37,512,201...37,582,152 		JBrowse link
G Igf1r insulin like growth factor 1 receptor ISO PID
RGD		 PMID:15272025 PMID:15862547 PMID:20042609 PID:200100 RGD:1581313 RGD:1626333 RGD:7242068 NCBI chrNW_004955416:26,101,090...26,382,660
Ensembl chrNW_004955416:26,102,628...26,382,666 		JBrowse link
G Igf2 insulin like growth factor 2 ISO RGD PMID:15862547 RGD:1626333 NCBI chrNW_004955422:13,880,525...13,907,963
Ensembl chrNW_004955422:13,880,471...13,888,566 		JBrowse link
G Igfals insulin like growth factor binding protein acid labile subunit ISO RGD PMID:15862547 RGD:1626333 NCBI chrNW_004955442:15,469,602...15,482,115
Ensembl chrNW_004955442:15,478,202...15,482,115 		JBrowse link
G Igfbp1 insulin like growth factor binding protein 1 ISO RGD PMID:15862547 RGD:1626333 NCBI chrNW_004955456:6,810,461...6,814,944
Ensembl chrNW_004955456:6,810,056...6,815,685 		JBrowse link
G Igfbp2 insulin like growth factor binding protein 2 ISO RGD PMID:15862547 RGD:1626333 NCBI chrNW_004955453:16,556,873...16,584,737
Ensembl chrNW_004955453:16,557,194...16,584,634 		JBrowse link
G Igfbp3 insulin like growth factor binding protein 3 ISO RGD PMID:15862547 RGD:1626333 NCBI chrNW_004955456:6,795,560...6,802,147
Ensembl chrNW_004955456:6,795,604...6,800,845 		JBrowse link
G Igfbp4 insulin like growth factor binding protein 4 ISO RGD PMID:15862547 RGD:1626333 NCBI chrNW_004955451:15,027,184...15,029,830 JBrowse link
G Igfbp5 insulin like growth factor binding protein 5 ISO RGD PMID:15862547 RGD:1626333 NCBI chrNW_004955453:16,530,110...16,550,733
Ensembl chrNW_004955453:16,530,110...16,550,733 		JBrowse link
G Igfbp6 insulin like growth factor binding protein 6 ISO RGD PMID:15862547 RGD:1626333 NCBI chrNW_004955458:377,929...382,109
Ensembl chrNW_004955458:377,929...382,567 		JBrowse link
G Irs1 insulin receptor substrate 1 ISO PID
RGD		 PMID:15272025 PID:200100 RGD:1581313 NCBI chrNW_004955453:7,685,715...7,742,262
Ensembl chrNW_004955453:7,685,715...7,742,262 		JBrowse link
G Irs2 insulin receptor substrate 2 ISO PID PID:200100 NCBI chrNW_004955404:2,531,484...2,555,383
Ensembl chrNW_004955404:2,531,484...2,555,689 		JBrowse link
G Nck2 NCK adaptor protein 2 ISO PID PID:200100 NCBI chrNW_004955470:10,487,962...10,593,046
Ensembl chrNW_004955470:10,487,481...10,593,046 		JBrowse link
G Pdpk1 3-phosphoinositide dependent protein kinase 1 ISO PID PID:200100 NCBI chrNW_004955442:14,685,089...14,772,870
Ensembl chrNW_004955442:14,685,153...14,772,870 		JBrowse link
G Pik3ca phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha ISO PID PID:200100 NCBI chrNW_004955420:8,355,415...8,427,024
Ensembl chrNW_004955420:8,356,353...8,427,024 		JBrowse link
G Pik3r1 phosphoinositide-3-kinase regulatory subunit 1 ISO PID PID:200100 NCBI chrNW_004955446:1,020,707...1,098,327
Ensembl chrNW_004955446:1,020,043...1,098,820 		JBrowse link
G Prkcd protein kinase C delta ISO PID PID:200100 NCBI chrNW_004955430:3,125,066...3,151,857
Ensembl chrNW_004955430:3,124,738...3,153,274 		JBrowse link
G Prkcz protein kinase C zeta ISO PID PID:200100 NCBI chrNW_004955486:8,947,579...9,021,702
Ensembl chrNW_004955486:8,947,579...9,021,702 		JBrowse link
G Prkd1 protein kinase D1 ISO PID PID:200100 NCBI chrNW_004955409:30,554,095...30,860,588
Ensembl chrNW_004955409:30,554,013...30,860,649 		JBrowse link
G Ptpn1 protein tyrosine phosphatase non-receptor type 1 ISO PID PID:200100 NCBI chrNW_004955445:7,754,313...7,819,229
Ensembl chrNW_004955445:7,754,319...7,819,275 		JBrowse link
G Ptpn11 protein tyrosine phosphatase non-receptor type 11 ISO PID PID:200100 NCBI chrNW_004955482:8,934,734...9,031,230
Ensembl chrNW_004955482:8,934,306...9,035,203 		JBrowse link
G Pxn paxillin ISO PID PID:200100 NCBI chrNW_004955455:11,387,140...11,401,178
Ensembl chrNW_004955455:11,388,378...11,403,082 		JBrowse link
G Rack1 receptor for activated C kinase 1 ISO PID PID:200100 NCBI chrNW_004955530:78,488...83,297
Ensembl chrNW_004955530:78,426...83,297 		JBrowse link
G Raf1 Raf-1 proto-oncogene, serine/threonine kinase ISO PID PID:200100 NCBI chrNW_004955429:17,980,956...18,049,723
Ensembl chrNW_004955429:18,025,932...18,049,723 		JBrowse link
G Rps6kb1 ribosomal protein S6 kinase B1 ISO PID PID:200100 NCBI chrNW_004955451:3,181,085...3,225,610 JBrowse link
G Shc1 SHC adaptor protein 1 ISO PID PID:200100 NCBI chrNW_004955545:1,468,391...1,479,209
Ensembl chrNW_004955545:1,468,391...1,476,814 		JBrowse link
G Sos1 SOS Ras/Rac guanine nucleotide exchange factor 1 ISO PID PID:200100 NCBI chrNW_004955441:6,649,895...6,724,271
Ensembl chrNW_004955441:6,646,385...6,713,028 		JBrowse link
G Ywhae tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein epsilon ISO PID PID:200100 NCBI chrNW_004955481:1,752,778...1,805,700
Ensembl chrNW_004955481:1,752,778...1,808,583 		JBrowse link
G Ywhaz tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein zeta ISO PID PID:200100 NCBI chrNW_004955417:16,047,263...16,070,506
Ensembl chrNW_004955417:16,047,263...16,072,854 		JBrowse link
altered insulin-like growth factor signaling pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Igf1 insulin like growth factor 1 ISO RGD PMID:15996002 RGD:1580474 NCBI chrNW_004955405:37,505,830...37,582,152
Ensembl chrNW_004955405:37,512,201...37,582,152 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  pathway 3930
    signaling pathway 1892
      growth factor signaling pathway 372
        insulin-like growth factor signaling pathway 38
          altered insulin-like growth factor signaling pathway 1
Path 2
Term Annotations click to browse term
  pathway 3930
    signaling pathway 1892
      hormone signaling pathway 368
        peptide and protein hormone signaling pathway 262
          insulin-like growth factor signaling pathway 38
            altered insulin-like growth factor signaling pathway 1
paths to the root