Igfbp1 (insulin like growth factor binding protein 1)

Gene: Igfbp1 (insulin like growth factor binding protein 1) Chinchilla lanigera

Analyze

Symbol:

Igfbp1

Name:

insulin like growth factor binding protein 1

RGD ID:

8909655

Description:

ENCODES a protein that exhibits insulin-like growth factor binding (ortholog); insulin-like growth factor I binding (ortholog); insulin-like growth factor II binding (ortholog); INVOLVED IN insulin receptor signaling pathway (ortholog); positive regulation of cell growth (ortholog); response to insulin (ortholog); PARTICIPATES IN forkhead class A signaling pathway; hypoxia inducible factor pathway; insulin-like growth factor signaling pathway; ASSOCIATED WITH acute kidney failure (ortholog); breast cancer (ortholog); Burns (ortholog); FOUND IN extracellular space (ortholog); Golgi apparatus (ortholog)

Type:

protein-coding

RefSeq Status:

MODEL

Previously known as:

insulin-like growth factor binding protein 1; insulin-like growth factor-binding protein 1

RGD Orthologs

Alliance Orthologs

More Info

more info ...

Latest Assembly:

ChiLan1.0 - Chinchilla ChiLan1.0 Assembly

Position:

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955456	6,810,056 - 6,815,685 (-)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955456	6,810,461 - 6,814,944 (-)	NCBI	ChiLan1.0	ChiLan1.0

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

acute kidney failure (ISO)

breast cancer (ISO)

Burns (ISO)

Colonic Neoplasms (ISO)

diabetic angiopathy (ISO)

Diabetic Nephropathies (ISO)

endometriosis (ISO)

Endotoxemia (ISO)

Experimental Liver Cirrhosis (ISO)

liver cirrhosis (ISO)

pleomorphic xanthoastrocytoma (ISO)

pre-malignant neoplasm (ISO)

primary biliary cholangitis (ISO)

Spontaneous Abortions (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

insulin receptor signaling pathway (ISO)

positive regulation of cell growth (ISO)

response to insulin (ISO)

response to organic cyclic compound (ISO)

tissue regeneration (ISO)

Cellular Component

extracellular space (ISO)

Golgi apparatus (ISO)

Molecular Function

insulin-like growth factor binding (ISO)

insulin-like growth factor I binding (ISO)

insulin-like growth factor II binding (ISO)

protein binding (ISO)

Molecular Pathway Annotations Click to see Annotation Detail View

forkhead class A signaling pathway (ISO)

hypoxia inducible factor pathway (ISO)

insulin-like growth factor signaling pathway (ISO)

References

References - curated

#	Reference Title	Reference Citation
1.	Transitive Annotation Pipeline	Automated assignment of GO, PW and RDO ISO annotations across species

Additional References at PubMed

PMID:22301074	PMID:30032202

Genomics

Comparative Map Data

Igfbp1
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955456	6,810,056 - 6,815,685 (-)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955456	6,810,461 - 6,814,944 (-)	NCBI	ChiLan1.0	ChiLan1.0

IGFBP1
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	7	45,888,488 - 45,893,660 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	7	45,888,360 - 45,893,660 (+)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	7	45,928,087 - 45,933,259 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	7	45,894,484 - 45,899,792 (+)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	7	45,701,326 - 45,706,499	NCBI
Celera	7	46,026,880 - 46,032,188 (+)	NCBI		Celera
Cytogenetic Map	7	p12.3	NCBI
HuRef	7	45,812,919 - 45,818,173 (+)	NCBI		HuRef
CHM1_1	7	45,932,162 - 45,937,470 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	7	46,047,763 - 46,055,379 (+)	NCBI		T2T-CHM13v2.0
CRA_TCAGchr7v2	7	45,967,292 - 45,972,600 (+)	NCBI

Igfbp1
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	11	7,147,787 - 7,152,546 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	11	7,147,782 - 7,152,546 (+)	Ensembl		GRCm39 Ensembl
GRCm38	11	7,197,787 - 7,202,546 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	11	7,197,782 - 7,202,546 (+)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	11	7,097,790 - 7,102,549 (+)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	11	7,097,785 - 7,102,539 (+)	NCBI		MGSCv36	mm8
Celera	11	7,672,987 - 7,677,746 (+)	NCBI		Celera
Cytogenetic Map	11	A1	NCBI
cM Map	11	4.75	NCBI

Igfbp1
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	14	86,261,277 - 86,266,344 (+)	NCBI		GRCr8
mRatBN7.2	14	82,047,415 - 82,052,482 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	14	82,047,415 - 82,052,482 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	14	86,448,608 - 86,453,531 (+)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	14	87,688,457 - 87,693,380 (+)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	14	84,137,002 - 84,142,071 (+)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	14	87,448,716 - 87,453,783 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	14	87,448,692 - 87,453,785 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	14	81,083,056 - 81,088,123 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	14	87,950,222 - 87,955,289 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	14	87,969,366 - 87,974,434 (+)	NCBI
Celera	14	81,092,381 - 81,126,760 (+)	NCBI		Celera
RH 3.4 Map	14	605.9	RGD
Cytogenetic Map	14	q21	NCBI

IGFBP1
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	6	50,770,502 - 50,778,799 (+)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	7	99,095,242 - 99,103,537 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	7	46,538,566 - 46,545,536 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	7	46,657,834 - 46,663,158 (+)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	7	46,658,097 - 46,662,584 (+)	Ensembl	panpan1.1		panPan2

IGFBP1
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	16	1,037,169 - 1,040,996 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	16	1,037,162 - 1,167,094 (-)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	16	1,813,131 - 1,816,855 (-)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	16	1,023,782 - 1,027,506 (-)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	16	1,023,782 - 1,153,699 (-)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	16	1,014,419 - 1,018,140 (-)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	16	950,042 - 953,757 (-)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	16	220,948 - 224,674 (+)	NCBI		UU_Cfam_GSD_1.0

Igfbp1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024405118	101,282,472 - 101,287,845 (+)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936478	20,494,203 - 20,499,001 (+)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936478	20,494,190 - 20,499,001 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

IGFBP1
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	18	50,018,487 - 50,022,799 (-)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	18	50,018,487 - 50,022,799 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	18	54,862,385 - 54,866,697 (-)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

IGFBP1
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	21	12,932,727 - 12,939,078 (-)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	21	12,932,732 - 12,937,891 (-)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666062	9,598,999 - 9,604,182 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Igfbp1
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624740	6,893,867 - 6,897,377 (-)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624740	6,893,334 - 6,897,591 (-)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Expression

Sequence

Nucleotide Sequences


RefSeq Transcripts	XM_005396640	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AGCD01046378	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	GBCQ01013594	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

RefSeq Acc Id:

ENSCLAT00000007528 ⟹ ENSCLAP00000007411

Type:

CODING

Position:

Chinchilla Assembly	Chr	Position (strand)	Source
ChiLan1.0 Ensembl	NW_004955456	6,810,056 - 6,815,685 (-)	Ensembl

RefSeq Acc Id:

XM_005396640 ⟹ XP_005396697

Type:

CODING

Position:

Chinchilla Assembly	Chr	Position (strand)	Source
ChiLan1.0	NW_004955456	6,810,461 - 6,814,944 (-)	NCBI

Sequence:

show sequence

TGCACCCCACAGGCATCGTCTGCAGCCTCTGCCACCAACCAGCCAGCATCAGACACTGAGCGCA
GCTGCCTGTCTGTGAGCATCCACCTCTGCGCCCTTGGCACCTGCGCCCGGCACTGACCACCGTC
CAGCGAGGCTGTCTGCTGCCCACCACCCTTGCCCTGGGATGCCTGAGGTCCCAGCTGCCGGCCC
TGGGCCGCTCCTGCTCTTGATGGCCATCCAGATTGCCATGGTGGCCCCTGCGCCTCAGCCATGG
CACTGTGCGCCCTGCTCCGCTGAGCGCCTGGCACTCTGCCCACCGGTGCCTGCCTCATGCCAGG
AGGTCTCCCGGTCCGCAGGCTGTGGCTGCTGCCCTGTGTGTGCCCTGCAACTCGGTGCCTCCTG
TGGCGTGGCCACTGCACGCTGTGCCCAAGGACTCAGCTGTCGTGCACTGCCTGGGGAGCCCCGG
CCCCTGCAGGCCCTCACCCGTGGCCAGGGCACCTGTGTGCTGGAGTCCACTGAGCCTGCCTCGA
GGACCGTGTCCGGTGCCGAAGGTGAAGAGGCCAAGGGCCCCCTGGCCCGCCAGCACGAGCACCC
TGAGAGTGGAGAGATGACTGAGGAACAGCTGCTGGAGAATTTCCACCTGATGGTGCCCTCCAGG
GAGGACCTGCCCGTCCTCTGGAACGCCATCAGCACCTACAACAGCATGCGCTCCCGAAACGTCG
CAGACATCAAGAAATGGAAGCCGTGCCAGCGGGAACTCTACAAAGTACTGGAGAGATTAGACAA
TGCTCGACAGAAGTCAGGGGAAGAAATCTACAAGTTTTATCTGCCAAACTGCAACAAGAATGGA
TTCTATCATAGTAAACAGTGCGAGACATCCCTGGAGGGTGAGGCGGGGCTGTGCTGGTGCGTCT
ACCCTTGGAGCGGGAAGAGGATGCCGGGGTCTGTGGACACCAGAGGGGACCCCAACTGCCAGCA
GTATTTTAACTTACAAAACTGAAAATACATGCCCTATATGTTCTTTCACGTGAAATATTTAAGT
ACATAGCATATTTATACTCTAGAGCACACACATTTTTATATATGTGCATATGTATATATACAGG
AACTAGTTTTTATACTCCACTTGATATATAAACTGGTTTGTATTTATTCACTGTAAGTTTATTT
TTTTTCTACACAGTAACTTGTGCTATAGTAATTTATATATCACAAACACTTCCTGTCACCTCTT
GTGTAAATACTTGTGTTTCTGCTCTCCGGAGCTCTTCTGTTTTTCAAGAGCATGGGTAGAGGCT
GCCCAGGAAAAGCACCAGCAAATGCAAGGCAGTGCTTTTTTAATATTTAAGGGGCAAGTAGCCT
ATATTTGAGAAAAATTTACTCTCTAGAGCTCGCAGACACACATCCGGTGGAAATCGGCAGGGCA
AGTTAAACAGTTAAACAGTTCTGGATACACAGCCTGGTGTAAGCACTAGGTGGGGTGATGTCAC
TTGCGCCCGGCAGCCGCAGCCCTTGTAAAGCCCAGTGCGGGGTGGAAACCTGCCCGGAATAAAG
TCTGCACAGTGGCCACCGAC

hide sequence

Protein Sequences


Protein RefSeqs	XP_005396697	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSCLAP00000007411
	ENSCLAP00000007411.1

RefSeq Acc Id:

XP_005396697 ⟸ XM_005396640

- UniProtKB:

A0A8C2V333 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MPEVPAAGPGPLLLLMAIQIAMVAPAPQPWHCAPCSAERLALCPPVPASCQEVSRSAGCGCCPV
CALQLGASCGVATARCAQGLSCRALPGEPRPLQALTRGQGTCVLESTEPASRTVSGAEGEEAKG
PLARQHEHPESGEMTEEQLLENFHLMVPSREDLPVLWNAISTYNSMRSRNVADIKKWKPCQREL
YKVLERLDNARQKSGEEIYKFYLPNCNKNGFYHSKQCETSLEGEAGLCWCVYPWSGKRMPGSVD
TRGDPNCQQYFNLQN

hide sequence

RefSeq Acc Id:

ENSCLAP00000007411 ⟸ ENSCLAT00000007528

Protein Domains

IGFBP N-terminal Thyroglobulin type-1

Additional Information

External Database Links

Database	Acc Id	Source(s)
Ensembl Genes	ENSCLAG00000005212	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript	ENSCLAT00000007528	ENTREZGENE
	ENSCLAT00000007528.1	UniProtKB/TrEMBL
Gene3D-CATH	4.10.40.20	UniProtKB/TrEMBL
	4.10.800.10	UniProtKB/TrEMBL
InterPro	Growth_fac_rcpt_cys_sf	UniProtKB/TrEMBL
	IGFBP-like	UniProtKB/TrEMBL
	IGFBP1	UniProtKB/TrEMBL
	IGFBP_1-6_chordata	UniProtKB/TrEMBL
	Insulin_GF-bd_Cys-rich_CS	UniProtKB/TrEMBL
	Thyroglobulin_1	UniProtKB/TrEMBL
	Thyroglobulin_1_sf	UniProtKB/TrEMBL
NCBI Gene	Igfbp1	ENTREZGENE
PANTHER	INSULIN-LIKE GROWTH FACTOR BINDING PROTEIN	UniProtKB/TrEMBL
	INSULIN-LIKE GROWTH FACTOR-BINDING PROTEIN 1	UniProtKB/TrEMBL
Pfam	IGFBP	UniProtKB/TrEMBL
	Thyroglobulin_1	UniProtKB/TrEMBL
PRINTS	IGFBPFAMILY	UniProtKB/TrEMBL
	IGFBPFAMILY1	UniProtKB/TrEMBL
PROSITE	IGFBP_N_1	UniProtKB/TrEMBL
	IGFBP_N_2	UniProtKB/TrEMBL
	THYROGLOBULIN_1_1	UniProtKB/TrEMBL
	THYROGLOBULIN_1_2	UniProtKB/TrEMBL
SMART	SM00121	UniProtKB/TrEMBL
	SM00211	UniProtKB/TrEMBL
Superfamily-SCOP	SSF57184	UniProtKB/TrEMBL
	SSF57610	UniProtKB/TrEMBL
UniProt	A0A8C2V333	ENTREZGENE, UniProtKB/TrEMBL

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2016-08-16	Igfbp1	insulin like growth factor binding protein 1		insulin-like growth factor binding protein 1	Symbol and/or name change	5135510	APPROVED

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

Imported Disease Annotations - ClinVar

Imported Disease Annotations - CTD

RGD Manual Annotations

Imported Annotations - PID (archival)

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Imported Disease Annotations - ClinVar

Imported Disease Annotations - CTD

RGD Manual Annotations

Imported Annotations - PID (archival)