Sos1 (SOS Ras/Rac guanine nucleotide exchange factor 1) - Rat Genome Database

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Gene: Sos1 (SOS Ras/Rac guanine nucleotide exchange factor 1) Chinchilla lanigera
Analyze
Symbol: Sos1
Name: SOS Ras/Rac guanine nucleotide exchange factor 1
RGD ID: 8958015
Description: ENCODES a protein that exhibits epidermal growth factor receptor binding (ortholog); guanyl-nucleotide exchange factor activity (ortholog); molecular condensate scaffold activity (ortholog); INVOLVED IN B cell homeostasis (ortholog); B cell receptor signaling pathway (ortholog); blood vessel morphogenesis (ortholog); PARTICIPATES IN epidermal growth factor/neuregulin signaling pathway; erythropoietin signaling pathway; Fc epsilon receptor mediated signaling pathway; ASSOCIATED WITH arrhythmogenic right ventricular cardiomyopathy (ortholog); atrial heart septal defect (ortholog); Atrial Septal Defect, Secundum Type (ortholog); FOUND IN cytoplasm (ortholog); glutamatergic synapse (ortholog); GTPase complex (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: son of sevenless homolog 1; son of sevenless homolog 1 (Drosophila)
RGD Orthologs
Human
Mouse
Rat
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: ChiLan1.0 - Chinchilla ChiLan1.0 Assembly
NCBI Annotation Information: Annotation category: partial on reference assembly
Position:
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554416,646,385 - 6,713,028 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554416,649,895 - 6,724,271 (-)NCBIChiLan1.0ChiLan1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Transitive Annotation Pipeline Automated assignment of GO, PW and RDO ISO annotations across species
2. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
Sos1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554416,646,385 - 6,713,028 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554416,649,895 - 6,724,271 (-)NCBIChiLan1.0ChiLan1.0
SOS1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38238,981,549 - 39,124,868 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl238,962,206 - 39,124,345 (-)EnsemblGRCh38hg38GRCh38
GRCh37239,208,690 - 39,352,009 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36239,066,469 - 39,201,067 (-)NCBINCBI36Build 36hg18NCBI36
Build 34239,124,615 - 39,259,214NCBI
Celera239,049,411 - 39,188,687 (-)NCBICelera
Cytogenetic Map2p22.1NCBI
HuRef238,947,128 - 39,086,120 (-)NCBIHuRef
CHM1_1239,139,128 - 39,278,182 (-)NCBICHM1_1
T2T-CHM13v2.0238,990,066 - 39,133,839 (-)NCBIT2T-CHM13v2.0
Sos1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391780,701,181 - 80,787,882 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1780,701,180 - 80,787,882 (-)EnsemblGRCm39 Ensembl
GRCm381780,393,752 - 80,480,453 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1780,393,751 - 80,480,453 (-)EnsemblGRCm38mm10GRCm38
MGSCv371780,793,092 - 80,879,793 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361780,305,779 - 80,388,265 (-)NCBIMGSCv36mm8
Celera1784,712,016 - 84,797,777 (-)NCBICelera
Cytogenetic Map17E3NCBI
cM Map1750.67NCBI
Sos1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8620,286,117 - 20,363,350 (+)NCBIGRCr8
mRatBN7.2614,533,870 - 14,613,348 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl614,533,360 - 14,611,107 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx614,832,784 - 14,910,104 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0615,154,472 - 15,231,727 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0614,650,751 - 14,727,998 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.063,105,443 - 3,182,977 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl63,104,861 - 3,182,996 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.063,082,456 - 3,159,445 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.463,308,778 - 3,390,661 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.163,310,822 - 3,394,313 (-)NCBI
Celera614,210,655 - 14,287,471 (+)NCBICelera
Cytogenetic Map6q12NCBI
SOS1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21287,342,622 - 87,487,223 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12A87,346,597 - 87,488,030 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02A39,019,046 - 39,162,248 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12A39,773,758 - 39,911,964 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2A39,773,760 - 39,911,961 (-)Ensemblpanpan1.1panPan2
SOS1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11731,007,940 - 31,181,569 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1731,009,257 - 31,142,063 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1730,825,007 - 30,830,255 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01731,664,627 - 31,805,012 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1731,664,631 - 31,805,021 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11730,886,361 - 31,025,725 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01730,956,021 - 31,095,889 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01731,169,723 - 31,309,388 (-)NCBIUU_Cfam_GSD_1.0
Sos1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440629240,733,944 - 40,853,206 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493650812,162,547 - 12,281,820 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493650812,162,553 - 12,281,812 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
SOS1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl3101,209,641 - 101,362,723 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.13101,209,568 - 101,366,057 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.23107,318,421 - 107,466,093 (+)NCBISscrofa10.2Sscrofa10.2susScr3
SOS1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11468,259,509 - 68,404,167 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1468,259,360 - 68,399,895 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604543,577,050 - 43,723,991 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Sos1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462473820,466,117 - 20,591,910 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462473820,466,120 - 20,591,966 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSCLAT00000008485   ⟹   ENSCLAP00000008358
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0 EnsemblNW_0049554416,646,385 - 6,712,134 (-)Ensembl
RefSeq Acc Id: ENSCLAT00000008486   ⟹   ENSCLAP00000008359
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0 EnsemblNW_0049554416,650,990 - 6,713,028 (-)Ensembl
RefSeq Acc Id: XM_005391044   ⟹   XP_005391101
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0NW_0049554416,649,895 - 6,724,271 (-)NCBI
Sequence:
Protein Sequences
Protein RefSeqs XP_005391101 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSCLAP00000008358.1
  ENSCLAP00000008359
  ENSCLAP00000008359.1
Reference Protein Sequences
RefSeq Acc Id: XP_005391101   ⟸   XM_005391044
- UniProtKB: A0A8C2V673 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSCLAP00000008358   ⟸   ENSCLAT00000008485
RefSeq Acc Id: ENSCLAP00000008359   ⟸   ENSCLAT00000008486
Protein Domains
DH   N-terminal Ras-GEF   PH   Ras-GEF


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCLAG00000005852 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSCLAT00000008485.1 UniProtKB/TrEMBL
  ENSCLAT00000008486 ENTREZGENE
  ENSCLAT00000008486.1 UniProtKB/TrEMBL
Gene3D-CATH 1.10.20.10 UniProtKB/TrEMBL
  1.10.840.10 UniProtKB/TrEMBL
  1.20.900.10 UniProtKB/TrEMBL
  2.30.29.30 UniProtKB/TrEMBL
  6.10.250.3060 UniProtKB/TrEMBL
  Son of sevenless (SoS) protein Chain: S domain 1 UniProtKB/TrEMBL
InterPro DBL_dom_sf UniProtKB/TrEMBL
  DH-domain UniProtKB/TrEMBL
  Histone-fold UniProtKB/TrEMBL
  PH-like_dom_sf UniProtKB/TrEMBL
  PH_domain UniProtKB/TrEMBL
  Ras-like_GEF UniProtKB/TrEMBL
  Ras-like_Gua-exchang_fac_N UniProtKB/TrEMBL
  Ras_G-nucl-exch_fac_CS UniProtKB/TrEMBL
  Ras_GEF_dom_sf UniProtKB/TrEMBL
  RASGEF_cat_dom UniProtKB/TrEMBL
  RASGEF_cat_dom_sf UniProtKB/TrEMBL
NCBI Gene Sos1 ENTREZGENE
PANTHER PTHR23113 UniProtKB/TrEMBL
  SON OF SEVENLESS HOMOLOG 1 UniProtKB/TrEMBL
Pfam PF00169 UniProtKB/TrEMBL
  RasGEF UniProtKB/TrEMBL
  RasGEF_N UniProtKB/TrEMBL
  RhoGEF UniProtKB/TrEMBL
PROSITE DH_2 UniProtKB/TrEMBL
  PH_DOMAIN UniProtKB/TrEMBL
  RASGEF UniProtKB/TrEMBL
  RASGEF_CAT UniProtKB/TrEMBL
  RASGEF_NTER UniProtKB/TrEMBL
SMART RasGEF UniProtKB/TrEMBL
  RasGEFN UniProtKB/TrEMBL
  RhoGEF UniProtKB/TrEMBL
  SM00233 UniProtKB/TrEMBL
Superfamily-SCOP PH domain-like UniProtKB/TrEMBL
  SSF47113 UniProtKB/TrEMBL
  SSF48065 UniProtKB/TrEMBL
  SSF48366 UniProtKB/TrEMBL
UniProt A0A8C2V2G9_CHILA UniProtKB/TrEMBL
  A0A8C2V673 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-08-16 Sos1  SOS Ras/Rac guanine nucleotide exchange factor 1    son of sevenless homolog 1 (Drosophila)  Symbol and/or name change 5135510 APPROVED