Irs2 (insulin receptor substrate 2) - Rat Genome Database

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Gene: Irs2 (insulin receptor substrate 2) Chinchilla lanigera
Analyze
Symbol: Irs2
Name: insulin receptor substrate 2
RGD ID: 8873730
Description: ENCODES a protein that exhibits 14-3-3 protein binding (ortholog); insulin receptor binding (ortholog); phosphatidylinositol 3-kinase activator activity (ortholog); INVOLVED IN brain development (ortholog); cell migration (ortholog); cell population proliferation (ortholog); PARTICIPATES IN erythropoietin signaling pathway; insulin signaling pathway; insulin-like growth factor signaling pathway; ASSOCIATED WITH Alzheimer's disease (ortholog); Anal Atresia, Hypospadias, and Penoscrotal Inversion (ortholog); Diabetic Nephropathies (ortholog); FOUND IN cytosol (ortholog); plasma membrane (ortholog)
Type: protein-coding
RefSeq Status: MODEL
RGD Orthologs
Human
Mouse
Rat
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: ChiLan1.0 - Chinchilla ChiLan1.0 Assembly
NCBI Annotation Information: Annotation category: partial on reference assembly
Position:
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554042,531,484 - 2,555,689 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554042,531,484 - 2,555,383 (+)NCBIChiLan1.0ChiLan1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
cytosol  (ISO)
plasma membrane  (ISO)

References

References - curated
# Reference Title Reference Citation
1. Transitive Annotation Pipeline Automated assignment of GO, PW and RDO ISO annotations across species
2. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
Additional References at PubMed
PMID:30032202  


Genomics

Comparative Map Data
Irs2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554042,531,484 - 2,555,689 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554042,531,484 - 2,555,383 (+)NCBIChiLan1.0ChiLan1.0
IRS2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh3813109,752,695 - 109,786,583 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl13109,752,695 - 109,786,583 (-)EnsemblGRCh38hg38GRCh38
GRCh3713110,405,042 - 110,438,930 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 3613109,204,185 - 109,236,915 (-)NCBINCBI36Build 36hg18NCBI36
Build 3413109,204,186 - 109,236,915NCBI
Celera1391,250,464 - 91,283,200 (-)NCBICelera
Cytogenetic Map13q34NCBI
HuRef1391,005,522 - 91,037,072 (-)NCBIHuRef
CHM1_113110,375,378 - 110,407,600 (-)NCBICHM1_1
T2T-CHM13v2.013108,981,231 - 109,015,226 (-)NCBIT2T-CHM13v2.0
Irs2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39811,034,681 - 11,058,929 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl811,034,681 - 11,058,458 (-)EnsemblGRCm39 Ensembl
GRCm38810,984,681 - 11,008,929 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl810,984,681 - 11,008,458 (-)EnsemblGRCm38mm10GRCm38
MGSCv37810,986,961 - 11,008,430 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36810,986,933 - 11,008,402 (-)NCBIMGSCv36mm8
Celera811,160,160 - 11,181,560 (-)NCBICelera
Cytogenetic Map8A1.1NCBI
cM Map85.35NCBI
Irs2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81685,190,310 - 85,214,543 (+)NCBIGRCr8
mRatBN7.21678,488,249 - 78,512,482 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1678,485,045 - 78,512,482 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1683,768,627 - 83,792,860 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01687,221,312 - 87,245,545 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01682,462,691 - 82,486,908 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01683,824,515 - 83,848,569 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1683,824,430 - 83,848,684 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01683,287,185 - 83,311,239 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41683,379,987 - 83,404,220 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11683,367,312 - 83,368,308 (+)NCBI
Celera1676,286,571 - 76,310,806 (+)NCBICelera
Cytogenetic Map16q12.5NCBI
IRS2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v214111,245,626 - 111,277,310 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan113109,927,626 - 109,959,400 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01390,886,095 - 90,917,724 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.113110,013,214 - 110,044,465 (-)NCBIpanpan1.1PanPan1.1panPan2
IRS2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12258,197,016 - 58,229,026 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2258,223,387 - 58,227,535 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2257,975,030 - 58,001,643 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02258,818,940 - 58,849,512 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2258,820,310 - 58,850,432 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12258,320,760 - 58,351,271 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02258,311,744 - 58,342,617 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02258,351,225 - 58,377,896 (-)NCBIUU_Cfam_GSD_1.0
Irs2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024404945193,155,757 - 193,179,968 (-)NCBIHiC_Itri_2
SpeTri2.0NW_0049364722,772,187 - 2,796,398 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
IRS2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1176,626,179 - 76,653,881 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11176,626,158 - 76,654,639 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
IRS2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1388,045,439 - 88,076,468 (-)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366604644,755,670 - 44,786,671 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Irs2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247932,614,589 - 2,636,947 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247932,615,092 - 2,636,835 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSCLAT00000005293   ⟹   ENSCLAP00000005197
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0 EnsemblNW_0049554042,531,484 - 2,555,689 (+)Ensembl
RefSeq Acc Id: XM_013515759   ⟹   XP_013371213
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0NW_0049554042,531,484 - 2,555,383 (+)NCBI
Sequence:
Protein Sequences
Protein RefSeqs XP_013371213 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSCLAP00000005197
  ENSCLAP00000005197.1
Reference Protein Sequences
RefSeq Acc Id: XP_013371213   ⟸   XM_013515759
- Sequence:
RefSeq Acc Id: ENSCLAP00000005197   ⟸   ENSCLAT00000005293


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCLAG00000003689 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSCLAT00000005293 ENTREZGENE
  ENSCLAT00000005293.1 UniProtKB/TrEMBL
InterPro IRS UniProtKB/TrEMBL
NCBI Gene Irs2 ENTREZGENE
PANTHER INSULIN RECEPTOR SUBSTRATE 2 UniProtKB/TrEMBL
  PTHR10614 UniProtKB/TrEMBL
UniProt A0A8C2UYY6_CHILA UniProtKB/TrEMBL