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ONTOLOGY REPORT - ANNOTATIONS

Term:positive regulation of alpha-beta T cell differentiation
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Accession:GO:0046638 term browser browse the term
Definition:Any process that activates or increases the frequency, rate or extent of alpha-beta T cell differentiation.
Comment:Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'.
Synonyms:exact_synonym: positive regulation of alpha-beta T lymphocyte differentiation;   up regulation of alpha-beta T cell differentiation;   upregulation of alpha-beta T cell differentiation
 narrow_synonym: activation of alpha-beta T cell differentiation;   stimulation of alpha-beta T cell differentiation
 related_synonym: positive regulation of alpha-beta T cell development


show annotations for term's descendants           Sort by:
positive regulation of alpha-beta T cell differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ada adenosine deaminase acts_upstream_of_or_within IMP (PMID:11067867), (PMID:16670300)
(PMID:11067867), (PMID:12163459), (PMID:16670300)		 MGI PMID:11067867 PMID:12163459 PMID:16670300 NCBI chr 2:163,565,703...163,592,154
Ensembl chr 2:163,568,504...163,592,159 		JBrowse link
G Gli3 GLI-Kruppel family member GLI3 involved_in IMP (MGI:3695957|PMID:15855276) BHF-UCL PMID:15855276 MGI:3695957 NCBI chr13:15,638,308...15,904,611
Ensembl chr13:15,637,820...15,904,611 		JBrowse link
G Ihh Indian hedgehog involved_in IMP (MGI:3836494|PMID:19109233) BHF-UCL PMID:19109233 MGI:3836494 NCBI chr 1:74,984,474...74,990,831
Ensembl chr 1:74,984,474...74,990,831 		JBrowse link
G Itpkb inositol 1,4,5-trisphosphate 3-kinase B acts_upstream_of_or_within IMP (PMID:15064401) MGI PMID:15064401 NCBI chr 1:180,156,655...180,252,367
Ensembl chr 1:180,158,050...180,252,367 		JBrowse link
G Nkap NFKB activating protein involved_in ISO MGI GO_REF:0000119 MGI:4834177 NCBI chr  X:36,390,416...36,414,399
Ensembl chr  X:36,390,448...36,414,399 		JBrowse link
G Pnp purine-nucleoside phosphorylase acts_upstream_of_or_within ISO
IMP		 (PMID:9122228)
(PMID:10859343), (PMID:16964310)		 MGI PMID:9122228 PMID:10859343 PMID:16964310 GO_REF:0000008 NCBI chr14:51,181,760...51,190,869
Ensembl chr14:51,168,539...51,190,869 		JBrowse link
G Pnp2 purine-nucleoside phosphorylase 2 acts_upstream_of_or_within ISO (PMID:16964310) MGI PMID:16964310 NCBI chr14:51,193,598...51,202,206
Ensembl chr14:51,193,449...51,202,206 		JBrowse link
G Rhoa ras homolog family member A involved_in IMP (MGI:5640904|PMID:25398325) CACAO PMID:25398325 MGI:5640904 NCBI chr 9:108,183,359...108,215,142
Ensembl chr 9:108,183,328...108,215,133 		JBrowse link
G Shh sonic hedgehog involved_in IMP (MGI:3029054|PMID:14764698) BHF-UCL PMID:14764698 MGI:3029054 NCBI chr 5:28,661,838...28,672,099
Ensembl chr 5:28,661,813...28,672,254 		JBrowse link
G Syk spleen tyrosine kinase acts_upstream_of_or_within IGI (PMID:9275205) MGI PMID:9275205 NCBI chr13:52,736,670...52,802,828
Ensembl chr13:52,737,209...52,802,828 		JBrowse link
G Zap70 zeta-chain (TCR) associated protein kinase acts_upstream_of_or_within IMP
IGI		 (PMID:9208839)
(PMID:9275205)
(PMID:7630421)		 MGI PMID:7630421 PMID:9208839 PMID:9275205 NCBI chr 1:36,800,912...36,821,899
Ensembl chr 1:36,800,879...36,821,899 		JBrowse link
positive regulation of CD4-positive, alpha-beta T cell differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cd83 CD83 antigen acts_upstream_of_or_within IMP (PMID:15322158) MGI PMID:15322158 NCBI chr13:43,938,661...43,956,608
Ensembl chr13:43,938,251...43,956,608 		JBrowse link
G Foxp3 forkhead box P3 acts_upstream_of_or_within IDA (PMID:17028180) MGI PMID:17028180 NCBI chr  X:7,445,915...7,461,482
Ensembl chr  X:7,439,883...7,461,484 		JBrowse link
G Nckap1l NCK associated protein 1 like involved_in IMP (MGI:3818191|PMID:19015308) UniProt PMID:19015308 MGI:3818191 NCBI chr15:103,362,219...103,411,288
Ensembl chr15:103,362,221...103,407,237 		JBrowse link
G Sash3 SAM and SH3 domain containing 3 acts_upstream_of_or_within IMP (PMID:16227612) MGI PMID:16227612 NCBI chr  X:47,235,313...47,250,442
Ensembl chr  X:47,235,313...47,250,442 		JBrowse link
G Socs1 suppressor of cytokine signaling 1 involved_in IMP (MGI:6140589|PMID:24880459) UniProt PMID:24880459 MGI:6140589 NCBI chr16:10,601,672...10,603,400
Ensembl chr16:10,600,104...10,603,400 		JBrowse link
G Tnfsf4 tumor necrosis factor (ligand) superfamily, member 4 involved_in IDA (MGI:4819294|PMID:20639485) BHF-UCL PMID:20639485 MGI:4819294 NCBI chr 1:161,223,009...161,245,777
Ensembl chr 1:161,222,980...161,245,981 		JBrowse link
G Zbtb7b zinc finger and BTB domain containing 7B involved_in IMP (MGI:6140589|PMID:24880459) UniProt PMID:24880459 MGI:6140589 NCBI chr 3:89,284,953...89,300,976
Ensembl chr 3:89,284,951...89,302,083 		JBrowse link
positive regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Foxp3 forkhead box P3 involved_in
acts_upstream_of_or_within		 TAS
IMP		 (MGI:3795336|PMID:18368049)
(PMID:16301745), (PMID:18573908)
(PMID:12612578)
(PMID:16275384)		 UniProt
MGI		 PMID:12612578 PMID:16275384 PMID:16301745 PMID:18368049 PMID:18573908 MGI:3795336 NCBI chr  X:7,445,915...7,461,482
Ensembl chr  X:7,439,883...7,461,484 		JBrowse link
G Gimap3 GTPase, IMAP family member 3 involved_in ISO MGI GO_REF:0000096 MGI:4417868 NCBI chr 6:48,741,398...48,747,785
Ensembl chr 6:48,741,398...48,747,785 		JBrowse link
G Gimap5 GTPase, IMAP family member 5 involved_in ISO RGD
MGI		 PMID:15778366 GO_REF:0000096 MGI:4417868 RGD:2303772 NCBI chr 6:48,723,131...48,731,134
Ensembl chr 6:48,723,131...48,731,144 		JBrowse link
G H2-Ea histocompatibility 2, class II antigen E alpha involved_in ISO MGI GO_REF:0000119 MGI:4834177 NCBI chr17:34,560,926...34,563,619
Ensembl chr17:34,560,926...34,563,618 		JBrowse link
G H2-Eb1 histocompatibility 2, class II antigen E beta involved_in ISO (PMID:28467828) UniProt PMID:28467828 NCBI chr17:34,524,841...34,535,648
Ensembl chr17:34,524,841...34,535,648 		JBrowse link
G Il2rg interleukin 2 receptor, gamma chain acts_upstream_of_or_within IMP (PMID:16227984) MGI PMID:16227984 NCBI chr  X:100,307,991...100,311,861
Ensembl chr  X:100,307,984...100,311,861 		JBrowse link
G Klhl25 kelch-like 25 involved_in IDA
ISO		 (MGI:6765767|PMID:34491895) UniProt
MGI		 PMID:34491895 GO_REF:0000119 MGI:4834177 MGI:6765767 NCBI chr 7:75,498,086...75,523,881
Ensembl chr 7:75,498,058...75,523,879 		JBrowse link
positive regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation involved in immune response term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ifng interferon gamma involved_in ISO MGI GO_REF:0000119 MGI:4834177 NCBI chr10:118,276,951...118,281,799
Ensembl chr10:118,276,951...118,281,797 		JBrowse link
G Lgals9 lectin, galactose binding, soluble 9 involved_in ISO (PMID:20209097) UniProt PMID:20209097 NCBI chr11:78,853,805...78,875,750
Ensembl chr11:78,853,800...78,875,772 		JBrowse link
positive regulation of CD8-positive, alpha-beta T cell differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cbfb core binding factor beta involved_in IMP (MGI:3772948|PMID:18258917) UniProt PMID:18258917 MGI:3772948 NCBI chr 8:105,897,306...105,944,621
Ensembl chr 8:105,897,306...105,944,621 		JBrowse link
G Lilrb4a leukocyte immunoglobulin-like receptor, subfamily B, member 4A involved_in ISO MGI GO_REF:0000119 MGI:4834177 NCBI chr10:51,366,999...51,372,709
Ensembl chr10:51,367,052...51,372,707 		JBrowse link
G Lilrb4b leukocyte immunoglobulin-like receptor, subfamily B, member 4B involved_in ISO MGI GO_REF:0000119 MGI:4834177 NCBI chr10:51,356,757...51,362,417
Ensembl chr10:51,356,728...51,362,799 		JBrowse link
G Nckap1l NCK associated protein 1 like involved_in IMP (MGI:3818191|PMID:19015308) UniProt PMID:19015308 MGI:3818191 NCBI chr15:103,362,219...103,411,288
Ensembl chr15:103,362,221...103,407,237 		JBrowse link
G Runx1 runt related transcription factor 1 involved_in IDA (MGI:3772948|PMID:18258917) UniProt PMID:18258917 MGI:3772948 NCBI chr16:92,398,354...92,622,962
Ensembl chr16:92,398,354...92,623,037 		JBrowse link
G Runx3 runt related transcription factor 3 involved_in IMP (MGI:3772948|PMID:18258917) UniProt PMID:18258917 MGI:3772948 NCBI chr 4:134,847,956...134,905,301
Ensembl chr 4:134,847,963...134,905,301 		JBrowse link
positive regulation of NK T cell differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ap3b1 adaptor-related protein complex 3, beta 1 subunit acts_upstream_of_or_within IMP (PMID:14557411) MGI PMID:14557411 NCBI chr13:94,492,332...94,702,838
Ensembl chr13:94,495,468...94,702,825 		JBrowse link
G Ap3d1 adaptor-related protein complex 3, delta 1 subunit acts_upstream_of_or_within IMP (PMID:14557411) MGI PMID:14557411 NCBI chr10:80,542,790...80,578,137
Ensembl chr10:80,542,790...80,578,098 		JBrowse link
G Cd1d1 CD1d1 antigen acts_upstream_of_or_within IMP (PMID:9133426)
(PMID:10201995)		 MGI PMID:9133426 PMID:10201995 NCBI chr 3:86,903,141...86,919,665
Ensembl chr 3:86,903,141...86,906,748 		JBrowse link
G Tgfbr2 transforming growth factor, beta receptor II acts_upstream_of_or_within IMP (PMID:16973387) MGI PMID:16973387 NCBI chr 9:115,916,763...116,004,431
Ensembl chr 9:115,913,361...116,004,428 		JBrowse link
G Zbtb16 zinc finger and BTB domain containing 16 involved_in IMP (MGI:3807724|PMID:18660811) UniProt PMID:18660811 MGI:3807724 NCBI chr 9:48,563,097...48,747,525
Ensembl chr 9:48,565,597...48,747,522 		JBrowse link
positive regulation of T-helper 1 cell differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Anxa1 annexin A1 involved_in ISO MGI GO_REF:0000119 MGI:4834177 NCBI chr19:20,350,798...20,368,035
Ensembl chr19:20,350,792...20,368,308 		JBrowse link
G Ccl19 C-C motif chemokine ligand 19 involved_in IDA (MGI:3576832|PMID:15845453) BHF-UCL PMID:15845453 MGI:3576832 NCBI chr 4:42,754,525...42,756,558
Ensembl chr 4:42,754,525...42,756,577 		JBrowse link
G Ccr2 C-C motif chemokine receptor 2 involved_in IC (MGI:3699670|PMID:14662900) BHF-UCL PMID:14662900 MGI:3699670 NCBI chr 9:123,901,954...123,913,594
Ensembl chr 9:123,901,987...123,913,594 		JBrowse link
G Ccr7 C-C motif chemokine receptor 7 involved_in IC (MGI:3576832|PMID:15845453) BHF-UCL PMID:15845453 MGI:3576832 NCBI chr11:99,035,025...99,045,903
Ensembl chr11:99,035,022...99,045,903 		JBrowse link
G Hlx H2.0-like homeobox acts_upstream_of_or_within IGI
IMP		 (PMID:16424184) MGI PMID:16424184 NCBI chr 1:184,459,340...184,464,690
Ensembl chr 1:184,459,337...184,464,816 		JBrowse link
G Irf1 interferon regulatory factor 1 involved_in TAS (MGI:5319622|PMID:11244049) UniProt PMID:11244049 MGI:5319622 NCBI chr11:53,660,841...53,669,200
Ensembl chr11:53,660,841...53,669,200 		JBrowse link
G Ripk2 receptor (TNFRSF)-interacting serine-threonine kinase 2 acts_upstream_of_or_within IMP (PMID:11894097) MGI PMID:11894097 NCBI chr 4:16,122,740...16,163,674
Ensembl chr 4:16,122,733...16,163,647 		JBrowse link
G Socs5 suppressor of cytokine signaling 5 involved_in IDA (MGI:3687909|PMID:12242343) UniProt PMID:12242343 MGI:3687909 NCBI chr17:87,414,707...87,445,153
Ensembl chr17:87,415,107...87,445,267 		JBrowse link
positive regulation of T-helper 17 cell differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Malt1 MALT1 paracaspase involved_in IDA (MGI:6142401|PMID:25282160) UniProt PMID:25282160 MGI:6142401 NCBI chr18:65,564,010...65,612,138
Ensembl chr18:65,564,009...65,612,138 		JBrowse link
G Mir326 microRNA 326 acts_upstream_of_or_within IDA
IMP		 (PMID:19838199) MGI PMID:19838199 NCBI chr 7:99,201,476...99,201,570
Ensembl chr 7:99,201,476...99,201,570 		JBrowse link
G Nfkbid nuclear factor of kappa light polypeptide gene enhancer in B cells inhibitor, delta involved_in IMP (MGI:6142401|PMID:25282160) UniProt PMID:25282160 MGI:6142401 NCBI chr 7:30,121,156...30,128,173
Ensembl chr 7:30,121,157...30,128,171 		JBrowse link
G Nfkbiz nuclear factor of kappa light polypeptide gene enhancer in B cells inhibitor, zeta involved_in IMP (MGI:6142401|PMID:25282160) UniProt PMID:25282160 MGI:6142401 NCBI chr16:55,631,740...55,659,018
Ensembl chr16:55,631,738...55,659,262 		JBrowse link
G Nlrp3 NLR family, pyrin domain containing 3 involved_in IMP (MGI:5689221|PMID:26098997) UniProt PMID:26098997 MGI:5689221 NCBI chr11:59,432,395...59,457,781
Ensembl chr11:59,432,394...59,457,782 		JBrowse link
positive regulation of T-helper 17 cell lineage commitment term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Brd2 bromodomain containing 2 involved_in IDA
ISO		 (MGI:6106706|PMID:28262505) UniProt
MGI		 PMID:28262505 GO_REF:0000119 MGI:4834177 MGI:6106706 NCBI chr17:34,330,993...34,341,581
Ensembl chr17:34,330,997...34,341,608 		JBrowse link
G Brd4 bromodomain containing 4 involved_in IMP (MGI:6106706|PMID:28262505) UniProt PMID:28262505 MGI:6106706 NCBI chr17:32,415,246...32,503,717
Ensembl chr17:32,415,248...32,503,696 		JBrowse link
G Ep300 E1A binding protein p300 involved_in ISO MGI GO_REF:0000119 MGI:4834177 NCBI chr15:81,470,329...81,536,273
Ensembl chr15:81,469,552...81,536,278 		JBrowse link
G Il23a interleukin 23, alpha subunit p19 involved_in IDA
IBA		 (MGI:3851279|PMID:19501566) BHF-UCL
GO_Central		 PMID:19501566 GO_REF:0000033 MGI:3851279 NCBI chr10:128,132,009...128,133,953
Ensembl chr10:128,132,008...128,134,621 		JBrowse link
positive regulation of T-helper 2 cell differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Il18 interleukin 18 involved_in IMP (MGI:3608083|PMID:12829194) BHF-UCL PMID:12829194 MGI:3608083 NCBI chr 9:50,466,000...50,493,141
Ensembl chr 9:50,466,127...50,493,140 		JBrowse link
G Il4ra interleukin 4 receptor, alpha acts_upstream_of_or_within IGI (PMID:16424184) MGI PMID:16424184 NCBI chr 7:125,151,443...125,178,646
Ensembl chr 7:125,151,292...125,178,646 		JBrowse link
G Il6 interleukin 6 acts_upstream_of_or_within IDA (PMID:12594267) MGI PMID:12594267 NCBI chr 5:30,218,112...30,224,973
Ensembl chr 5:30,218,112...30,224,979 		JBrowse link
G Nlrp3 NLR family, pyrin domain containing 3 involved_in IMP (MGI:5689221|PMID:26098997) UniProt PMID:26098997 MGI:5689221 NCBI chr11:59,432,395...59,457,781
Ensembl chr11:59,432,394...59,457,782 		JBrowse link
G Prkcz protein kinase C, zeta involved_in IMP (MGI:3584076|PMID:15987782) UniProt PMID:15987782 MGI:3584076 NCBI chr 4:155,344,579...155,445,856
Ensembl chr 4:155,344,586...155,445,818 		JBrowse link
G Rara retinoic acid receptor, alpha involved_in ISO MGI GO_REF:0000119 MGI:4834177 NCBI chr11:98,818,626...98,865,768
Ensembl chr11:98,818,644...98,865,768 		JBrowse link
G Tnfsf4 tumor necrosis factor (ligand) superfamily, member 4 involved_in IDA (MGI:4943387|PMID:18354165) BHF-UCL PMID:18354165 MGI:4943387 NCBI chr 1:161,223,009...161,245,777
Ensembl chr 1:161,222,980...161,245,981 		JBrowse link
positive regulation of T-helper cell differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Shb src homology 2 domain-containing transforming protein B acts_upstream_of_or_within IMP (PMID:24645804) MGI PMID:24645804 NCBI chr 4:45,423,278...45,530,804
Ensembl chr 4:45,423,278...45,532,470 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 28577
    immune system process 3144
      leukocyte activation 1139
        lymphocyte activation 931
          lymphocyte differentiation 503
            T cell differentiation 357
              positive regulation of T cell differentiation 133
                positive regulation of alpha-beta T cell differentiation 59
                  positive regulation of CD4-positive, alpha-beta T cell differentiation + 38
                  positive regulation of CD8-positive, alpha-beta T cell differentiation 6
                  positive regulation of NK T cell differentiation 5
Path 2
Term Annotations click to browse term
  biological_process 28577
    cellular process 17497
      cellular developmental process 5063
        cell differentiation 5063
          cell development 3449
            hemopoiesis 1161
              leukocyte differentiation 751
                mononuclear cell differentiation 607
                  lymphocyte differentiation 503
                    T cell differentiation 357
                      regulation of T cell differentiation 205
                        positive regulation of T cell differentiation 133
                          positive regulation of alpha-beta T cell differentiation 59
                            positive regulation of CD4-positive, alpha-beta T cell differentiation + 38
                            positive regulation of CD8-positive, alpha-beta T cell differentiation 6
                            positive regulation of NK T cell differentiation 5
paths to the root