Klhl25 (kelch-like 25) - Rat Genome Database

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Gene: Klhl25 (kelch-like 25) Mus musculus
Analyze
Symbol: Klhl25
Name: kelch-like 25
RGD ID: 1321935
MGI Page MGI
Description: Enables ubiquitin ligase-substrate adaptor activity. Involved in positive regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation; positive regulation of fatty acid oxidation; and ubiquitin-dependent protein catabolic process. Part of Cul3-RING ubiquitin ligase complex. Is expressed in central nervous system; nervous system; peripheral nervous system; and retina. Orthologous to human KLHL25 (kelch like family member 25).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: 2810402K13Rik; BC027373; ectoderm-neural cortex protein 2; ectoderm-neural cortex-1; Enc-1; ENC-2; kelch-like protein 25; MGC36331
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39775,498,086 - 75,523,881 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl775,498,058 - 75,523,879 (+)EnsemblGRCm39 Ensembl
GRCm38775,848,338 - 75,874,133 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl775,848,310 - 75,874,131 (+)EnsemblGRCm38mm10GRCm38
MGSCv37782,993,224 - 83,019,016 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36775,721,910 - 75,741,004 (+)NCBIMGSCv36mm8
Celera773,298,548 - 73,327,582 (+)NCBICelera
Cytogenetic Map7D1NCBI
cM Map743.81NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
References

References - curated
# Reference Title Reference Citation
1. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
2. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:10349636   PMID:10932192   PMID:11042159   PMID:11076861   PMID:11217851   PMID:12466851   PMID:12477932   PMID:15226823   PMID:15489334   PMID:15747579   PMID:15782199   PMID:16141072  
PMID:16141073   PMID:18799693   PMID:21873635   PMID:31541165   PMID:32541003   PMID:34491895  


Genomics

Comparative Map Data
Klhl25
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39775,498,086 - 75,523,881 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl775,498,058 - 75,523,879 (+)EnsemblGRCm39 Ensembl
GRCm38775,848,338 - 75,874,133 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl775,848,310 - 75,874,131 (+)EnsemblGRCm38mm10GRCm38
MGSCv37782,993,224 - 83,019,016 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36775,721,910 - 75,741,004 (+)NCBIMGSCv36mm8
Celera773,298,548 - 73,327,582 (+)NCBICelera
Cytogenetic Map7D1NCBI
cM Map743.81NCBI
KLHL25
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381585,759,326 - 85,794,925 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1585,759,326 - 85,794,925 (-)EnsemblGRCh38hg38GRCh38
GRCh371586,302,557 - 86,338,156 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361584,103,561 - 84,139,193 (-)NCBINCBI36Build 36hg18NCBI36
Celera1562,702,507 - 62,738,117 (-)NCBICelera
Cytogenetic Map15q25.3NCBI
HuRef1562,365,689 - 62,401,305 (-)NCBIHuRef
CHM1_11586,144,000 - 86,179,590 (-)NCBICHM1_1
T2T-CHM13v2.01583,511,457 - 83,547,035 (-)NCBIT2T-CHM13v2.0
Klhl25
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81139,134,655 - 139,159,898 (+)NCBIGRCr8
mRatBN7.21129,724,894 - 129,750,142 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1129,722,026 - 129,750,227 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1137,630,051 - 137,655,206 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01144,800,323 - 144,825,478 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01137,689,819 - 137,714,976 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01137,333,880 - 137,359,107 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1137,333,881 - 137,359,072 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01138,322,710 - 138,355,032 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41131,540,949 - 131,566,141 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11131,636,985 - 131,638,938 (+)NCBI
Celera1121,829,642 - 121,854,834 (+)NCBICelera
Cytogenetic Map1q31NCBI
Klhl25
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0NW_00495541618,965,966 - 18,991,099 (+)NCBIChiLan1.0ChiLan1.0
KLHL25
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21675,302,695 - 75,340,844 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11579,007,350 - 79,045,503 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01564,448,130 - 64,486,254 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11583,661,360 - 83,671,886 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1583,670,090 - 83,671,859 (-)Ensemblpanpan1.1panPan2
KLHL25
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1349,339,576 - 49,375,473 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl349,348,982 - 49,351,663 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha351,978,492 - 52,014,269 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0349,760,167 - 49,795,982 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl349,760,169 - 49,795,968 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1349,258,177 - 49,293,852 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0349,486,578 - 49,522,306 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0349,832,848 - 49,868,610 (-)NCBIUU_Cfam_GSD_1.0
Klhl25
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024408640134,301,314 - 134,334,028 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493648312,000,514 - 12,009,705 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493648312,001,111 - 12,033,158 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
KLHL25
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl788,262,385 - 88,264,691 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1788,249,009 - 88,291,958 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2794,609,175 - 94,657,162 (-)NCBISscrofa10.2Sscrofa10.2susScr3
KLHL25
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1294,376,292 - 4,412,778 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl294,385,011 - 4,386,780 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366605942,604,595 - 42,640,945 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Klhl25
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462476813,110,912 - 13,121,206 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462476813,112,589 - 13,134,855 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Klhl25
849 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:1040
Count of miRNA genes:375
Interacting mature miRNAs:420
Transcripts:ENSMUST00000092073, ENSMUST00000171155
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1300722Sle3_msystemic lupus erythmatosus susceptibility 3 (mouse)Not determined7351172887142720Mouse
25314307Mlh1fc2_mMLH1 foci count 2 (mouse)76502999133501729Mouse
12792978Fbmd3_mfemoral bone mineral density 3, females only (mouse)77050288142367832Mouse
10412199Sst2_msusceptibility to tuberculosis 2 (mouse)Not determined718728794119485380Mouse
1301158Eae4_msusceptibility to experimental allergic encephalomyelitis 4 (mouse)Not determined719147398141919804Mouse
4141805Sle19_msystematic lupus erythematosus susceptibility 19 (mouse)Not determined3003248581135653Mouse
26884404Huml1_mhumerus length 1, 5 week (mouse)730199425108999207Mouse
1301514Rigs1_mradiation induced gastroschisis 1 (mouse)Not determined73628001592394346Mouse
1301082Bbaa16_mB.burgdorferi-associated arthritis 16 (mouse)Not determined736280015116416877Mouse
25314303Vmm4_mvariable multisystem mineralization 4, kidney (mouse)73729942587049208Mouse
1300791Abbp3_mA/J and C57BL/6 blood pressure 3 (mouse)Not determined739673887103510010Mouse
10043926Bw1n_mbody weight 1 in NSY (mouse)Not determined745161966118693530Mouse
12880417V125Dq5_mvitamin D active form serum level QTL 5 (mouse)74524974879249748Mouse
1302141Fcsa6_mfemoral cross-sectional area 6 (mouse)Not determined74838446182384607Mouse
11532741Tbrs5_mtuberculosis resistance 5 (mouse)74915922783235415Mouse
1357752Tabw_mtally ho asscoiated body weight (mouse)Not determined74919327883193390Mouse
10053685Eae43_mexperimental allergic encephalomyelitis susceptibility 43 (mouse)Not determined75112495485125093Mouse
10054064Bwq11_mbody weight QTL 11 (mouse)Not determined75112495485125093Mouse
13208555Lgth10_mbody length 10 (mouse)751649748125599172Mouse
12880418V125Dq6_mvitamin D active form serum level QTL 6 (mouse)75214974886149748Mouse
27226751Femd5_mfemur midshaft diameter 5, 10 week (mouse)753249748143153737Mouse
25823170Hrsq7_mhost response to SARS QTL 7, log titer (mouse)754819589116822815Mouse
11565101Tsve1_mvariable short tail (Tsv) enhancer 1 (mouse)75588950887142720Mouse
27226778Femd11_mfemur midshaft diameter 11, 16 week (mouse)756949748134001729Mouse
1300952Hcs1_mhepatocarcinogenesis susceptibility 1 (mouse)Not determined75732612191326352Mouse
1301465Egrm3_mearly growth rate (mouse)Not determined75732612191326352Mouse
1301663Skull9_mskull morphology 9 (mouse)Not determined75732612191326352Mouse
26884408Bzwq13_mbi-zygomatic width QTL 13, 16 week (mouse)761749748121399223Mouse
27095916Scvln15_msacral vertebrae length 2, 16 week (mouse)761749748123699223Mouse
25314305Vmm6_mvariable multisystem mineralization 6, eye (mouse)761849748102749207Mouse
1301383Aem2_manti-erythrocyte autoantibody modifier 2 (mouse)Not determined76413542498135653Mouse
26884381Bzwq2_mbi-zygomatic width QTL 2, 5 week (mouse)76524974896949207Mouse
26884440Sklq4_mskull length QTL 4, 5 week (mouse)765249748126499172Mouse
13506750Tbthq2_mtrabecular bone thickness QTL 2 (mouse)76565974877549748Mouse
11553865Stmm1c_mskin tumor modifier of MSM 1c (mouse)76578898699788986Mouse
11553866Stmm1d_mskin tumor modifier of MSM 1d (mouse)76578898699788986Mouse
27095937Ulnl7_mulna length 7, 10 week (mouse)76644974898349207Mouse
12801463Rta1_mretinal aging 1 (mouse)76716802789089989Mouse
1301826Pgia3_mproteoglycan induced arthritis 3 (mouse)Not determined767290094101290240Mouse
1301784Ses2_msalmonella enteritidis susceptibility 2 (mouse)Not determined767290094101290240Mouse
1300620Pgia21_mproteoglycan induced arthritis 21 (mouse)Not determined767290094101290240Mouse
26884418Bzwq7_mbi-zygomatic width QTL 7, 10 week (mouse)767849748105449207Mouse
27226715Metcl3_mmetatarsal-calcaneal length 3, 5 week (mouse)767849748119499223Mouse
26884444Sklq8_mskull length QTL 8, 10 week (mouse)767849748124199223Mouse
26884451Sklq14_mskull length QTL 14, 16 week (mouse)767849748124999172Mouse
1300654Bomd1_mbone mineral density 1 (mouse)Not determined768365595102365702Mouse
27095907Scvln4_msacral vertebrae length 2, 5 week (mouse)769949748120499223Mouse
1301155Bpq7_mblood pressure QTL 7 (mouse)Not determined770143137104143379Mouse
10043973Obq29_mobesity QTL 29 (mouse)Not determined772263372106263372Mouse
4142319Powg_mpost-ovarectomy weight gain (mouse)Not determined7285710592582163Mouse
27095910Pglq13_mpelvic girdle length QTL 13, 16 week (mouse)773049748125699172Mouse
27095933Ulnl3_mulna length 3, 5 week (mouse)773149748143153737Mouse
13513914Heal52_mwound healing/ regeneration 52 (mouse)77355037278591455Mouse
11553869Stmm2b_mskin tumor modifier of MSM 2a (mouse)773725965107725965Mouse
4142212Png1_mPostnatal growth 1 (mouse)Not determined7432612192394346Mouse
27226745Metcl9_mmetatarsal-calcaneal length 9, 10 week (mouse)774849748122199223Mouse
27226781Tibl3_mtibia length 3, 5 week (mouse)774849748122199223Mouse
1301566Adip3_madiposity 3 (mouse)Not determined775394215109394346Mouse

Markers in Region
AI747590  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38775,873,777 - 75,873,922UniSTSGRCm38
MGSCv37783,018,663 - 83,018,808UniSTSGRCm37
Celera773,327,229 - 73,327,374UniSTS
Cytogenetic Map7D2UniSTS
Whitehead/MRC_RH7800.47UniSTS


Expression


Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001122780 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_029652 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_182782 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_011250832 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AC158297 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK012967 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK143086 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK157879 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK178730 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK183609 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK185774 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK199125 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK200369 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK201755 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK205772 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK208739 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK211871 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC011221 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC022600 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC022930 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC027373 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BP767188 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BY042513 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BY241272 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH466543 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENSMUST00000092073   ⟹   ENSMUSP00000089707
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl775,498,086 - 75,523,878 (+)Ensembl
GRCm38.p6 Ensembl775,848,338 - 75,874,130 (+)Ensembl
RefSeq Acc Id: ENSMUST00000171155   ⟹   ENSMUSP00000133175
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl775,498,058 - 75,523,879 (+)Ensembl
GRCm38.p6 Ensembl775,848,310 - 75,874,131 (+)Ensembl
RefSeq Acc Id: ENSMUST00000205612   ⟹   ENSMUSP00000146192
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl775,498,112 - 75,517,235 (+)Ensembl
GRCm38.p6 Ensembl775,848,364 - 75,867,487 (+)Ensembl
RefSeq Acc Id: ENSMUST00000205887   ⟹   ENSMUSP00000145600
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl775,498,189 - 75,515,375 (+)Ensembl
GRCm38.p6 Ensembl775,848,441 - 75,865,627 (+)Ensembl
RefSeq Acc Id: ENSMUST00000206019   ⟹   ENSMUSP00000146102
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl775,498,089 - 75,517,239 (+)Ensembl
GRCm38.p6 Ensembl775,848,341 - 75,867,491 (+)Ensembl
RefSeq Acc Id: ENSMUST00000206418
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl775,498,145 - 75,523,273 (+)Ensembl
GRCm38.p6 Ensembl775,848,397 - 75,873,525 (+)Ensembl
RefSeq Acc Id: NM_001122780   ⟹   NP_001116252
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39775,498,086 - 75,523,878 (+)NCBI
GRCm38775,848,338 - 75,874,130 (+)NCBI
MGSCv37782,993,224 - 83,019,016 (+)RGD
Celera773,298,548 - 73,327,582 (+)RGD
cM Map7 ENTREZGENE
Sequence:
RefSeq Acc Id: NM_029652   ⟹   NP_083928
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39775,498,086 - 75,523,878 (+)NCBI
GRCm38775,848,338 - 75,874,130 (+)NCBI
MGSCv37782,993,224 - 83,019,016 (+)RGD
Celera773,298,548 - 73,327,582 (+)RGD
cM Map7 ENTREZGENE
Sequence:
RefSeq Acc Id: NM_182782   ⟹   NP_877583
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39775,498,086 - 75,517,239 (+)NCBI
GRCm38775,848,338 - 75,867,491 (+)NCBI
MGSCv37782,993,224 - 83,019,016 (+)RGD
Celera773,298,548 - 73,327,582 (+)RGD
cM Map7 ENTREZGENE
Sequence:
RefSeq Acc Id: XM_011250832   ⟹   XP_011249134
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39775,498,109 - 75,523,881 (+)NCBI
GRCm38775,848,361 - 75,874,133 (+)NCBI
Sequence:
Reference Protein Sequences
RefSeq Acc Id: NP_877583   ⟸   NM_182782
- UniProtKB: Q8R2P1 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: NP_083928   ⟸   NM_029652
- UniProtKB: Q8R2P1 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: NP_001116252   ⟸   NM_001122780
- UniProtKB: Q8R2P1 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_011249134   ⟸   XM_011250832
- Peptide Label: isoform X1
- UniProtKB: Q8R2P1 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: ENSMUSP00000146102   ⟸   ENSMUST00000206019
RefSeq Acc Id: ENSMUSP00000145600   ⟸   ENSMUST00000205887
RefSeq Acc Id: ENSMUSP00000146192   ⟸   ENSMUST00000205612
RefSeq Acc Id: ENSMUSP00000133175   ⟸   ENSMUST00000171155
RefSeq Acc Id: ENSMUSP00000089707   ⟸   ENSMUST00000092073
Protein Domains
BACK   BTB

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q8R2P1-F1-model_v2 AlphaFold Q8R2P1 1-589 view protein structure

Promoters
RGD ID:8664465
Promoter ID:EPDNEW_M10263
Type:initiation region
Name:Klhl25_1
Description:Mus musculus kelch-like 25 , transcript variant 1, mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38775,848,364 - 75,848,424EPDNEW
RGD ID:6841396
Promoter ID:MM_KWN:51191
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:3T3L1_Day2,   3T3L1_Day3,   3T3L1_Day4,   BoneMarrow_0Hour,   BoneMarrow_2Hour,   BoneMarrow_4Hour,   Brain,   ES_Cell,   Kidney,   Liver,   Lung,   MEF_B4,   MEF_B6,   Spleen
Transcripts:NM_182782,   UC009HWY.1,   UC009HXA.1
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv36782,992,961 - 82,993,461 (+)MPROMDB

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:2668031 AgrOrtholog
Ensembl Genes ENSMUSG00000055652 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Transcript ENSMUST00000092073 ENTREZGENE
  ENSMUST00000092073.11 UniProtKB/Swiss-Prot
  ENSMUST00000171155 ENTREZGENE
  ENSMUST00000171155.4 UniProtKB/Swiss-Prot
  ENSMUST00000205612.2 UniProtKB/TrEMBL
  ENSMUST00000205887.2 UniProtKB/TrEMBL
  ENSMUST00000206019 ENTREZGENE
  ENSMUST00000206019.2 UniProtKB/Swiss-Prot
Gene3D-CATH 1.25.40.420 UniProtKB/Swiss-Prot
  2.120.10.80 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro BACK UniProtKB/Swiss-Prot
  BTB-kelch_protein UniProtKB/Swiss-Prot
  BTB/POZ_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Kelch-typ_b-propeller UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Kelch_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  KLHL25 UniProtKB/Swiss-Prot
  SKP1/BTB/POZ_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:207952 UniProtKB/Swiss-Prot
MGD MGI:2668031 ENTREZGENE
NCBI Gene 207952 ENTREZGENE
PANTHER ACTIN-BINDING PROTEIN IPP UniProtKB/Swiss-Prot
  KELCH PROTEIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  KELCH-LIKE PROTEIN 20 UniProtKB/TrEMBL
  KELCH-LIKE PROTEIN DIABLO UniProtKB/TrEMBL
  LD33804P UniProtKB/TrEMBL
Pfam BACK UniProtKB/Swiss-Prot
  BTB UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Kelch_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Klhl25 PhenoGen
PIRSF Kelch-like_protein_gigaxonin UniProtKB/Swiss-Prot
PROSITE BTB UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART BACK UniProtKB/Swiss-Prot
  BTB UniProtKB/Swiss-Prot
  Kelch UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF117281 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF54695 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A0U1RNK3_MOUSE UniProtKB/TrEMBL
  A0A0U1RQ03_MOUSE UniProtKB/TrEMBL
  KLH25_MOUSE UniProtKB/Swiss-Prot, ENTREZGENE
  Q9CZ64_MOUSE UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2013-01-22 Klhl25  kelch-like 25    kelch-like 25 (Drosophila)  Symbol and/or name change 5135510 APPROVED