Klhl25 (kelch like family member 25) - Rat Genome Database

Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models   new Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources
Gene: Klhl25 (kelch like family member 25) Chinchilla lanigera
Analyze
Symbol: Klhl25
Name: kelch like family member 25
RGD ID: 8796143
Description: ENCODES a protein that exhibits ubiquitin-like ligase-substrate adaptor activity (ortholog); INVOLVED IN negative regulation of fatty acid biosynthetic process (ortholog); positive regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation (ortholog); positive regulation of fatty acid oxidation (ortholog); ASSOCIATED WITH Bloom syndrome (ortholog); colorectal cancer (ortholog); genetic disease (ortholog); FOUND IN Cul3-RING ubiquitin ligase complex (ortholog); cytoplasm (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: kelch-like family member 25; kelch-like protein 25
RGD Orthologs
Human
Mouse
Rat
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: ChiLan1.0 - Chinchilla ChiLan1.0 Assembly
NCBI Annotation Information: Annotation category: partial on reference assembly
Position:
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0NW_00495541618,965,966 - 18,991,099 (+)NCBIChiLan1.0ChiLan1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Transitive Annotation Pipeline Automated assignment of GO, PW and RDO ISO annotations across species
Additional References at PubMed
PMID:22301074  


Genomics

Comparative Map Data
Klhl25
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0NW_00495541618,965,966 - 18,991,099 (+)NCBIChiLan1.0ChiLan1.0
KLHL25
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381585,759,326 - 85,794,925 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1585,759,326 - 85,794,925 (-)EnsemblGRCh38hg38GRCh38
GRCh371586,302,557 - 86,338,156 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361584,103,561 - 84,139,193 (-)NCBINCBI36Build 36hg18NCBI36
Celera1562,702,507 - 62,738,117 (-)NCBICelera
Cytogenetic Map15q25.3NCBI
HuRef1562,365,689 - 62,401,305 (-)NCBIHuRef
CHM1_11586,144,000 - 86,179,590 (-)NCBICHM1_1
T2T-CHM13v2.01583,511,457 - 83,547,035 (-)NCBIT2T-CHM13v2.0
Klhl25
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39775,498,086 - 75,523,881 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl775,498,058 - 75,523,879 (+)EnsemblGRCm39 Ensembl
GRCm38775,848,338 - 75,874,133 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl775,848,310 - 75,874,131 (+)EnsemblGRCm38mm10GRCm38
MGSCv37782,993,224 - 83,019,016 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36775,721,910 - 75,741,004 (+)NCBIMGSCv36mm8
Celera773,298,548 - 73,327,582 (+)NCBICelera
Cytogenetic Map7D1NCBI
cM Map743.81NCBI
Klhl25
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81139,134,655 - 139,159,898 (+)NCBIGRCr8
mRatBN7.21129,724,894 - 129,750,142 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1129,722,026 - 129,750,227 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1137,630,051 - 137,655,206 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01144,800,323 - 144,825,478 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01137,689,819 - 137,714,976 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01137,333,880 - 137,359,107 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1137,333,881 - 137,359,072 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01138,322,710 - 138,355,032 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41131,540,949 - 131,566,141 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11131,636,985 - 131,638,938 (+)NCBI
Celera1121,829,642 - 121,854,834 (+)NCBICelera
Cytogenetic Map1q31NCBI
KLHL25
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21675,302,695 - 75,340,844 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11579,007,350 - 79,045,503 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01564,448,130 - 64,486,254 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11583,661,360 - 83,671,886 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1583,670,090 - 83,671,859 (-)Ensemblpanpan1.1panPan2
KLHL25
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1349,339,576 - 49,375,473 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl349,348,982 - 49,351,663 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha351,978,492 - 52,014,269 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0349,760,167 - 49,795,982 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl349,760,169 - 49,795,968 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1349,258,177 - 49,293,852 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0349,486,578 - 49,522,306 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0349,832,848 - 49,868,610 (-)NCBIUU_Cfam_GSD_1.0
Klhl25
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024408640134,301,314 - 134,334,028 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493648312,000,514 - 12,009,705 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493648312,001,111 - 12,033,158 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
KLHL25
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl788,262,385 - 88,264,691 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1788,249,009 - 88,291,958 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2794,609,175 - 94,657,162 (-)NCBISscrofa10.2Sscrofa10.2susScr3
KLHL25
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1294,376,292 - 4,412,778 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl294,385,011 - 4,386,780 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366605942,604,595 - 42,640,945 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Klhl25
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462476813,110,912 - 13,121,206 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462476813,112,589 - 13,134,855 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Expression


Sequence


Reference Sequences
RefSeq Acc Id: XM_013512646   ⟹   XP_013368100
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0NW_00495541618,965,966 - 18,991,099 (+)NCBI
Sequence:
Protein Sequences
Protein RefSeqs XP_013368100 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSCLAP00000017860.1
Reference Protein Sequences
RefSeq Acc Id: XP_013368100   ⟸   XM_013512646
- UniProtKB: A0A8C2YRG7 (UniProtKB/TrEMBL)
- Sequence:
Protein Domains
BTB


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCLAG00000012252 UniProtKB/TrEMBL
Ensembl Transcript ENSCLAT00000018038.1 UniProtKB/TrEMBL
Gene3D-CATH 1.25.40.420 UniProtKB/TrEMBL
  Kelch-type beta propeller UniProtKB/TrEMBL
InterPro BACK UniProtKB/TrEMBL
  BTB-kelch_protein UniProtKB/TrEMBL
  BTB/POZ_dom UniProtKB/TrEMBL
  Kelch-typ_b-propeller UniProtKB/TrEMBL
  Kelch_1 UniProtKB/TrEMBL
  SKP1/BTB/POZ_sf UniProtKB/TrEMBL
NCBI Gene Klhl25 ENTREZGENE
PANTHER KELCH PROTEIN UniProtKB/TrEMBL
  KELCH-LIKE PROTEIN 20 UniProtKB/TrEMBL
Pfam BACK UniProtKB/TrEMBL
  BTB UniProtKB/TrEMBL
  Kelch_1 UniProtKB/TrEMBL
PIRSF Kelch-like_protein_gigaxonin UniProtKB/TrEMBL
PROSITE BTB UniProtKB/TrEMBL
SMART BACK UniProtKB/TrEMBL
  BTB UniProtKB/TrEMBL
  Kelch UniProtKB/TrEMBL
Superfamily-SCOP Kelch motif UniProtKB/TrEMBL
  POZ domain UniProtKB/TrEMBL
UniProt A0A8C2YRG7 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-08-16 Klhl25  kelch like family member 25    kelch-like family member 25  Symbol and/or name change 5135510 APPROVED