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ONTOLOGY REPORT - ANNOTATIONS

Term:miRNA-mediated gene silencing by mRNA destabilization
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Accession:GO:0035279 term browser browse the term
Definition:An RNA interference pathway in which microRNAs (miRNAs) direct the cleavage of target mRNAs. Once incorporated into a RNA-induced silencing complex (RISC), a miRNA base pairing with near-perfect complementarity to the target mRNA will typically direct targeted endonucleolytic cleavage of the mRNA. Many plant miRNAs downregulate gene expression through this mechanism.
Synonyms:exact_synonym: gene silencing by miRNA, mRNA cleavage;   mRNA cleavage involved in gene silencing by miRNA;   mRNA cleavage involved in gene silencing by microRNA;   miRNA-mediated gene silencing, mRNA cleavage
 broad_synonym: gene silencing by mRNA cleavage
 related_synonym: deadenylation involved in gene silencing by miRNA;   miRNA-mediated gene silencing by mRNA deadenylation


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miRNA-mediated gene silencing by mRNA destabilization term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ago1 argonaute RISC component 1 NOT|involved_in ISO (PMID:15260970) RGD PMID:15260970 NCBI chr 5:138,722,111...138,757,118
Ensembl chr 5:138,722,111...138,773,546 		JBrowse link
G Ago2 argonaute RISC catalytic component 2 involved_in ISO
ISS
IEA		 (PMID:15260970), (PMID:17524464), (PMID:18771919)
(MGI:5616320|PMID:16357216)
GO_REF:0000024
GO_REF:0000104		 RGD
UniProt		 PMID:15260970 PMID:16357216 PMID:17524464 PMID:18771919 GO_REF:0000024 GO_REF:0000104 MGI:5616320 NCBI chr 7:105,018,202...105,105,118
Ensembl chr 7:105,029,120...105,104,974 		JBrowse link
G Ago3 argonaute RISC catalytic component 3 NOT|involved_in ISO (PMID:15260970) RGD PMID:15260970 NCBI chr 5:138,632,367...138,714,230
Ensembl chr 5:138,639,569...138,714,230 		JBrowse link
G Ago4 argonaute RISC component 4 NOT|involved_in ISO (PMID:15260970) RGD PMID:15260970 NCBI chr 5:138,780,446...138,825,898
Ensembl chr 5:138,783,069...138,825,632 		JBrowse link
G Cnot6 CCR4-NOT transcription complex, subunit 6 involved_in ISO
ISS		 (PMID:20065043)
GO_REF:0000024		 RGD
UniProt		 PMID:20065043 GO_REF:0000024 NCBI chr10:33,978,785...34,031,025
Ensembl chr10:33,980,831...34,031,025 		JBrowse link
G Cnot7 CCR4-NOT transcription complex, subunit 7 involved_in ISO (PMID:20065043) RGD PMID:20065043 NCBI chr16:51,775,416...51,794,581
Ensembl chr16:51,775,412...51,794,576 		JBrowse link
G Cnot8 CCR4-NOT transcription complex, subunit 8 involved_in ISO (PMID:20065043) RGD PMID:20065043 NCBI chr10:42,281,614...42,294,740
Ensembl chr10:42,281,722...42,294,730 		JBrowse link
G Mir1 microRNA 1 involved_in ISO (PMID:23499676), (PMID:25802280) RGD PMID:23499676 PMID:25802280 NCBI chr18:1,887,537...1,887,623 JBrowse link
G Mir100 microRNA 100 involved_in ISO (PMID:22684006) RGD PMID:22684006 NCBI chr 8:41,901,225...41,901,304
Ensembl chr 8:41,901,225...41,901,304 		JBrowse link
G Mir106a microRNA 106a involved_in ISO (PMID:22912877), (PMID:26265888), (PMID:27325313) RGD PMID:22912877 PMID:26265888 PMID:27325313 NCBI chr  X:132,422,584...132,422,661
Ensembl chr  X:132,422,584...132,422,661 		JBrowse link
G Mir106b microRNA 106b involved_in ISO (PMID:27325313) RGD PMID:27325313 NCBI chr12:17,043,344...17,043,425
Ensembl chr12:17,043,344...17,043,425 		JBrowse link
G Mir125a microRNA 125a involved_in ISO (PMID:30670152) RGD PMID:30670152 NCBI chr 1:58,677,626...58,677,710
Ensembl chr 1:58,677,626...58,677,710 		JBrowse link
G Mir125b1 microRNA 125b-1 involved_in ISO (PMID:28214897) RGD PMID:28214897 NCBI chr 8:41,952,966...41,953,052
Ensembl chr 8:41,952,966...41,953,052 		JBrowse link
G Mir125b2 microRNA 125b-2 involved_in ISO (PMID:28214897) RGD PMID:28214897 NCBI chr11:16,245,620...16,245,707 JBrowse link
G Mir128-1 microRNA 128-1 involved_in ISO (PMID:33058756) RGD PMID:33058756 NCBI chr13:39,699,449...39,699,530
Ensembl chr13:39,699,449...39,699,530 		JBrowse link
G Mir128-2 microRNA 128-2 involved_in ISO (PMID:33058756) RGD PMID:33058756 NCBI chr 8:112,085,467...112,085,550
Ensembl chr 8:112,085,467...112,085,550 		JBrowse link
G Mir130a microRNA 130a involved_in ISO (PMID:30741461) RGD PMID:30741461 NCBI chr 3:69,822,542...69,822,629
Ensembl chr 3:69,822,542...69,822,629 		JBrowse link
G Mir130b microRNA 130b involved_in ISO (PMID:24040078) RGD PMID:24040078 NCBI chr11:83,880,163...83,880,244
Ensembl chr11:83,880,163...83,880,244 		JBrowse link
G Mir133a1 microRNA 133a-1 involved_in ISO (PMID:32205184) RGD PMID:32205184 NCBI chr18:1,885,082...1,885,168 JBrowse link
G Mir135b microRNA 135b involved_in ISO (PMID:27793001) RGD PMID:27793001 NCBI chr13:43,638,857...43,638,953
Ensembl chr13:43,638,857...43,638,953 		JBrowse link
G Mir137 microRNA 137 involved_in ISO (PMID:23275153) RGD PMID:23275153 NCBI chr 2:206,480,881...206,480,982
Ensembl chr 2:206,480,884...206,480,985 		JBrowse link
G Mir140 microRNA 140 involved_in ISO (PMID:24928442) RGD PMID:24928442 NCBI chr19:35,465,577...35,465,675
Ensembl chr19:35,465,577...35,465,675 		JBrowse link
G Mir142 microRNA 142 involved_in ISO (PMID:24558198), (PMID:26572508), (PMID:31168355) RGD PMID:24558198 PMID:26572508 PMID:31168355 NCBI chr10:72,557,864...72,557,950
Ensembl chr10:72,557,857...72,557,967 		JBrowse link
G Mir145 microRNA 145 involved_in ISO (PMID:25323858), (PMID:25704091), (PMID:29883722) RGD PMID:25323858 PMID:25704091 PMID:29883722 NCBI chr18:55,099,640...55,099,727
Ensembl chr18:55,099,640...55,099,727 		JBrowse link
G Mir146a microRNA 146a involved_in ISO (PMID:30779466) RGD PMID:30779466 NCBI chr10:27,848,516...27,848,610
Ensembl chr10:27,848,516...27,848,610 		JBrowse link
G Mir151 microRNA 151 involved_in ISO (PMID:20305651) RGD PMID:20305651 NCBI chr 7:105,172,377...105,172,473 JBrowse link
G Mir16 microRNA 16 involved_in ISO (PMID:24418124) RGD PMID:24418124 NCBI chr 2:153,245,349...153,245,443
Ensembl chr 2:153,245,349...153,245,443 		JBrowse link
G Mir181a2 microRNA 181a-2 involved_in ISO (PMID:22714950), (PMID:25535255) RGD PMID:22714950 PMID:25535255 NCBI chr 3:22,615,845...22,615,961
Ensembl chr 3:22,615,845...22,615,961 		JBrowse link
G Mir181b1 microRNA 181b-1 involved_in ISO (PMID:25535255) RGD PMID:25535255 NCBI chr13:49,485,688...49,485,797
Ensembl chr13:49,485,688...49,485,797 		JBrowse link
G Mir181b2 microRNA 181b-2 involved_in ISO (PMID:25535255) RGD PMID:25535255 NCBI chr 3:22,616,948...22,617,035
Ensembl chr 3:22,616,948...22,617,035 		JBrowse link
G Mir181c microRNA 181c involved_in ISO (PMID:25535255) RGD PMID:25535255 NCBI chr19:23,983,523...23,983,628
Ensembl chr19:23,983,523...23,983,628 		JBrowse link
G Mir181d microRNA 181d involved_in ISO (PMID:25535255) RGD PMID:25535255 NCBI chr19:23,983,706...23,983,788
Ensembl chr19:23,983,706...23,983,788 		JBrowse link
G Mir185 microRNA 185 involved_in ISO (PMID:23459944), (PMID:23951060), (PMID:26316588), (PMID:29053187) RGD PMID:23459944 PMID:23951060 PMID:26316588 PMID:29053187 NCBI chr11:82,664,716...82,664,795
Ensembl chr11:82,664,716...82,664,795 		JBrowse link
G Mir18a microRNA 18a involved_in ISO (PMID:28131417), (PMID:29988076), (PMID:34937502) RGD PMID:28131417 PMID:29988076 PMID:34937502 NCBI chr15:92,180,765...92,180,860
Ensembl chr15:92,180,765...92,180,860 		JBrowse link
G Mir190b microRNA 190b involved_in ISO (PMID:32039833) RGD PMID:32039833 NCBI chr 2:175,514,800...175,514,877
Ensembl chr 2:175,514,800...175,514,877 		JBrowse link
G Mir191 microRNA 191 involved_in ISO (PMID:31874245) RGD PMID:31874245 NCBI chr 8:109,264,098...109,264,188 JBrowse link
G Mir192 microRNA 192 involved_in ISO (PMID:28483554) RGD PMID:28483554 NCBI chr 1:203,564,946...203,565,055
Ensembl chr 1:203,564,946...203,565,055 		JBrowse link
G Mir193a microRNA 193a involved_in ISO (PMID:29725386) RGD PMID:29725386 NCBI chr10:64,672,343...64,672,454
Ensembl chr10:64,672,343...64,672,454 		JBrowse link
G Mir195 microRNA 195 involved_in ISO (PMID:31921616) RGD PMID:31921616 NCBI chr10:54,951,838...54,951,924
Ensembl chr10:54,951,838...54,951,924 		JBrowse link
G Mir196a microRNA 196a acts_upstream_of_or_within ISO (PMID:15105502), (PMID:15361871) RGD PMID:15105502 PMID:15361871 NCBI chr 7:134,110,400...134,110,509
Ensembl chr 7:134,110,400...134,110,509 		JBrowse link
G Mir196b microRNA 196b acts_upstream_of_or_within ISO (PMID:15105502) RGD PMID:15105502 NCBI chr 4:81,330,487...81,330,571
Ensembl chr 4:81,330,487...81,330,571 		JBrowse link
G Mir196c microRNA 196c acts_upstream_of_or_within ISO (PMID:15105502), (PMID:15361871) RGD PMID:15105502 PMID:15361871 NCBI chr10:81,231,006...81,231,085
Ensembl chr10:81,231,006...81,231,085 		JBrowse link
G Mir19a microRNA 19a involved_in ISO (PMID:27098600), (PMID:29130787) RGD PMID:27098600 PMID:29130787 NCBI chr15:92,180,912...92,180,993
Ensembl chr15:92,180,912...92,180,993 		JBrowse link
G Mir19b1 microRNA 19b-1 involved_in ISO (PMID:27098600) RGD PMID:27098600 NCBI chr15:92,181,214...92,181,300
Ensembl chr15:92,181,214...92,181,300 		JBrowse link
G Mir19b2 microRNA 19b-2 involved_in ISO (PMID:27098600) RGD PMID:27098600 NCBI chr  X:132,422,072...132,422,167
Ensembl chr  X:132,422,072...132,422,167 		JBrowse link
G Mir1b microRNA 1b involved_in ISO (PMID:23499676), (PMID:25802280) RGD PMID:23499676 PMID:25802280 NCBI chr 3:167,487,117...167,487,201
Ensembl chr 3:167,487,117...167,487,201 		JBrowse link
G Mir200b microRNA 200b involved_in ISO (PMID:22522429) RGD PMID:22522429 NCBI chr 5:166,649,272...166,649,366
Ensembl chr 5:166,649,272...166,649,366 		JBrowse link
G Mir200c microRNA 200c involved_in ISO (PMID:22522429) RGD PMID:22522429 NCBI chr 4:157,523,679...157,523,747 JBrowse link
G Mir204 microRNA 204 involved_in ISO (PMID:20056717) RGD PMID:20056717 NCBI chr 1:220,316,931...220,317,040
Ensembl chr 1:220,316,931...220,317,040 		JBrowse link
G Mir206 microRNA 206 involved_in ISO (PMID:23499676) RGD PMID:23499676 NCBI chr 9:23,094,249...23,094,332
Ensembl chr 9:23,094,249...23,094,332 		JBrowse link
G Mir20a microRNA 20a involved_in ISO (PMID:29653364), (PMID:31368162) RGD PMID:29653364 PMID:31368162 NCBI chr15:92,181,084...92,181,168
Ensembl chr15:92,181,084...92,181,168 		JBrowse link
G Mir20b microRNA 20b involved_in ISO (PMID:32336590) RGD PMID:32336590 NCBI chr  X:132,422,211...132,422,282
Ensembl chr  X:132,422,211...132,422,282 		JBrowse link
G Mir210 microRNA 210 involved_in ISO (PMID:29944867) RGD PMID:29944867 NCBI chr 1:196,326,343...196,326,452
Ensembl chr 1:196,326,337...196,326,454 		JBrowse link
G Mir211 microRNA 211 involved_in ISO (PMID:21109473) RGD PMID:21109473 NCBI chr 1:117,777,539...117,777,644
Ensembl chr 1:117,777,539...117,777,644 		JBrowse link
G Mir212 microRNA 212 involved_in ISO (PMID:26693054) RGD PMID:26693054 NCBI chr10:60,023,403...60,023,513
Ensembl chr10:60,023,403...60,023,513 		JBrowse link
G Mir214 microRNA 214 involved_in ISO (PMID:30703347) RGD PMID:30703347 NCBI chr13:74,588,374...74,588,481
Ensembl chr13:74,588,372...74,588,481 		JBrowse link
G Mir223 microRNA 223 involved_in ISO (PMID:23459944), (PMID:30807577), (PMID:34637033) RGD PMID:23459944 PMID:30807577 PMID:34637033 NCBI chr  X:61,141,887...61,141,996
Ensembl chr  X:61,141,887...61,141,996 		JBrowse link
G Mir23a microRNA 23a involved_in ISO (PMID:26400397) RGD PMID:26400397 NCBI chr19:23,954,997...23,955,071
Ensembl chr19:23,954,997...23,955,071 		JBrowse link
G Mir24-2 microRNA 24-2 involved_in ISO (PMID:30378100) RGD PMID:30378100 NCBI chr19:23,954,683...23,954,790
Ensembl chr19:23,954,683...23,954,790 		JBrowse link
G Mir26b microRNA 26b involved_in ISO (PMID:25536365) RGD PMID:25536365 NCBI chr 9:75,976,596...75,976,680
Ensembl chr 9:75,976,596...75,976,680 		JBrowse link
G Mir27a microRNA 27a involved_in ISO (PMID:25915942), (PMID:26400397) RGD PMID:25915942 PMID:26400397 NCBI chr19:23,954,831...23,954,917
Ensembl chr19:23,954,831...23,954,917 		JBrowse link
G Mir27b microRNA 27b involved_in ISO (PMID:30729664) RGD PMID:30729664 NCBI chr17:1,813,427...1,813,523
Ensembl chr17:1,813,426...1,813,529 		JBrowse link
G Mir29b1 microRNA 29b-1 involved_in ISO (PMID:26175849) RGD PMID:26175849 NCBI chr 4:59,650,987...59,651,067
Ensembl chr 4:59,650,986...59,651,067 		JBrowse link
G Mir29b2 microRNA 29b-2 involved_in ISO (PMID:26175849) RGD PMID:26175849 NCBI chr13:106,570,371...106,570,451
Ensembl chr13:106,570,367...106,570,456 		JBrowse link
G Mir30b microRNA 30b involved_in ISO (PMID:23968872) RGD PMID:23968872 NCBI chr 7:100,132,589...100,132,675
Ensembl chr 7:100,132,589...100,132,675 		JBrowse link
G Mir320a microRNA 320a involved_in ISO (PMID:32271402) RGD PMID:32271402 NCBI chr15:45,516,392...45,516,473
Ensembl chr15:45,516,392...45,516,473 		JBrowse link
G Mir322 microRNA 322 involved_in ISO (PMID:29130787) RGD PMID:29130787 NCBI chr  X:132,806,594...132,806,688
Ensembl chr  X:132,806,594...132,806,688 		JBrowse link
G Mir326 microRNA 326 involved_in ISO (PMID:24279830) RGD PMID:24279830 NCBI chr 1:153,854,029...153,854,123
Ensembl chr 1:153,854,029...153,854,123 		JBrowse link
G Mir337 microRNA 337 involved_in ISO (PMID:22723956) RGD PMID:22723956 NCBI chr 6:128,538,903...128,538,999
Ensembl chr 6:128,538,902...128,538,998 		JBrowse link
G Mir340-1 microRNA 340-1 involved_in ISO (PMID:28413603) RGD PMID:28413603 NCBI chr10:34,393,568...34,393,665
Ensembl chr10:34,393,568...34,393,665 		JBrowse link
G Mir342 microRNA 342 involved_in ISO (PMID:23951060) RGD PMID:23951060 NCBI chr 6:127,565,269...127,565,367
Ensembl chr 6:127,565,269...127,565,367 		JBrowse link
G Mir34b microRNA 34b involved_in ISO (PMID:22336710) RGD PMID:22336710 NCBI chr 8:51,410,244...51,410,327
Ensembl chr 8:51,410,244...51,410,327 		JBrowse link
G Mir3582 microRNA 3582 involved_in ISO (PMID:32205184) RGD PMID:32205184 NCBI chr18:1,885,063...1,885,180
Ensembl chr18:1,885,063...1,885,180 		JBrowse link
G Mir365b microRNA 365b involved_in ISO (PMID:30910589) RGD PMID:30910589 NCBI chr10:64,686,255...64,686,340
Ensembl chr10:64,686,252...64,686,351 		JBrowse link
G Mir423 microRNA 423 involved_in ISO (PMID:32264887) RGD PMID:32264887 NCBI chr10:61,914,142...61,914,220
Ensembl chr10:61,914,133...61,914,226 		JBrowse link
G Mir486 microRNA 486 involved_in ISO (PMID:25857263) RGD PMID:25857263
G Mir497 microRNA 497 involved_in ISO (PMID:29969696) RGD PMID:29969696 NCBI chr10:54,951,514...54,951,582
Ensembl chr10:54,951,505...54,951,584 		JBrowse link
G Mir544 microRNA 544 involved_in ISO (PMID:27186677) RGD PMID:27186677 NCBI chr 6:128,743,530...128,743,607
Ensembl chr 6:128,743,530...128,743,607 		JBrowse link
G Mir665 microRNA 665 involved_in ISO (PMID:34454184) RGD PMID:34454184 NCBI chr 6:128,539,440...128,539,533
Ensembl chr 6:128,539,440...128,539,533 		JBrowse link
G Mir708 microRNA 708 involved_in ISO (PMID:26932538) RGD PMID:26932538 NCBI chr 1:150,599,876...150,599,963
Ensembl chr 1:150,599,876...150,599,963 		JBrowse link
G Mir9-3 microRNA 9-3 involved_in ISO (PMID:26315535), (PMID:29584810) RGD PMID:26315535 PMID:29584810 NCBI chr 1:133,440,049...133,440,138 JBrowse link
G Mir93 microRNA 93 involved_in ISO (PMID:24606633), (PMID:28797104) RGD PMID:24606633 PMID:28797104 NCBI chr12:17,043,135...17,043,221
Ensembl chr12:17,043,135...17,043,221 		JBrowse link
G Mir96 microRNA 96 involved_in ISO (PMID:23459944) RGD PMID:23459944 NCBI chr 4:58,788,411...58,788,516
Ensembl chr 4:58,788,411...58,788,516 		JBrowse link
G Mir98 microRNA 98 involved_in ISO (PMID:27860183), (PMID:28251559), (PMID:30195495) RGD PMID:27860183 PMID:28251559 PMID:30195495 NCBI chr  X:20,981,235...20,981,342
Ensembl chr  X:20,981,235...20,981,342 		JBrowse link
G Mirlet7a1 microRNA let-7a-1 involved_in ISO (PMID:17671087), (PMID:30467960) RGD PMID:17671087 PMID:30467960 NCBI chr17:16,113,766...16,113,859
Ensembl chr17:16,113,768...16,113,867 		JBrowse link
G Mirlet7b microRNA let-7b involved_in ISO (PMID:29471394) RGD PMID:29471394 NCBI chr 7:116,804,186...116,804,270
Ensembl chr 7:116,804,186...116,804,270 		JBrowse link
G Mirlet7c1 microRNA let-7c-1 involved_in ISO (PMID:19841744) RGD PMID:19841744 NCBI chr11:16,201,163...16,201,256
Ensembl chr11:16,201,158...16,201,265 		JBrowse link
G Mirlet7c2 microRNA let7c-2 involved_in ISO (PMID:17671087), (PMID:30467960) RGD PMID:17671087 PMID:30467960 NCBI chr 7:116,803,771...116,803,865
Ensembl chr 7:116,803,771...116,803,865 		JBrowse link
G Mov10 Mov10 RNA helicase involved_in ISO (PMID:16289642) RGD PMID:16289642 NCBI chr 2:192,292,041...192,315,142
Ensembl chr 2:192,293,470...192,315,083 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 19692
    biological regulation 13305
      regulation of biological quality 3362
        regulation of RNA stability 265
          regulation of mRNA stability 250
            mRNA destabilization 178
              miRNA-mediated gene silencing by mRNA destabilization 89
Path 2
Term Annotations click to browse term
  biological_process 19692
    biological regulation 13305
      regulation of biological process 12902
        regulation of metabolic process 6432
          regulation of biosynthetic process 5325
            regulation of cellular biosynthetic process 5234
              regulation of macromolecule biosynthetic process 5135
                regulation of gene expression 5020
                  negative regulation of gene expression 1366
                    mRNA catabolic process 330
                      regulation of mRNA catabolic process 266
                        regulation of mRNA stability 250
                          mRNA destabilization 178
                            miRNA-mediated gene silencing by mRNA destabilization 89
paths to the root