Mir9-3 (microRNA 9-3) - Rat Genome Database

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Gene: Mir9-3 (microRNA 9-3) Rattus norvegicus
Analyze
Symbol: Mir9-3
Name: microRNA 9-3
RGD ID: 2325463
Description: Predicted to enable mRNA 3'-UTR binding activity; mRNA base-pairing translational repressor activity; and single-stranded RNA binding activity. Predicted to be involved in several processes, including miRNA-mediated post-transcriptional gene silencing; negative regulation of cholesterol efflux; and negative regulation of signal transduction. Predicted to act upstream of or within several processes, including cellular hyperosmotic salinity response; cellular response to ethanol; and neuron differentiation. Predicted to be located in cytoplasm and nucleus. Human ortholog(s) of this gene implicated in lung squamous cell carcinoma. Orthologous to human MIR9-3 (microRNA 9-3); INTERACTS WITH (S)-colchicine (ortholog); 5-azacytidine (ortholog); arsane (ortholog).
Type: ncrna
RefSeq Status: PROVISIONAL
Previously known as: Mir9a-3; rno-mir-9-3; rno-mir-9a-3
RGD Orthologs
Human
Mouse
Dog
Pig
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81142,849,400 - 142,849,489 (+)NCBIGRCr8
mRatBN7.21133,440,049 - 133,440,138 (+)NCBImRatBN7.2mRatBN7.2
UTH_Rnor_SHR_Utx1141,349,605 - 141,349,694 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01148,518,995 - 148,519,084 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01141,436,720 - 141,436,809 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01141,229,353 - 141,229,442 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.01142,191,179 - 142,191,268 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Celera1125,503,266 - 125,503,355 (+)NCBICelera
Cytogenetic Map1q31NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
cytoplasm  (ISO)
nucleus  (ISO)

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Genome-wide miRNA expression profiling identifies miR-9-3 and miR-193a as targets for DNA methylation in non-small cell lung cancers. Heller G, etal., Clin Cancer Res. 2012 Mar 15;18(6):1619-29. doi: 10.1158/1078-0432.CCR-11-2450. Epub 2012 Jan 26.
2. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
3. Demethylation of miR-9-3 and miR-193a genes suppresses proliferation and promotes apoptosis in non-small cell lung cancer cell lines. Wang J, etal., Cell Physiol Biochem. 2013;32(6):1707-19. doi: 10.1159/000356605. Epub 2013 Dec 13.
Additional References at PubMed
PMID:14691248   PMID:15345052   PMID:16381832   PMID:17028171   PMID:17604727   PMID:17805466   PMID:18842901   PMID:19091803   PMID:20403161   PMID:20439489   PMID:24615545   PMID:25858512  
PMID:25937343   PMID:31298359   PMID:31978557   PMID:33737500  


Genomics

Comparative Map Data
Mir9-3
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81142,849,400 - 142,849,489 (+)NCBIGRCr8
mRatBN7.21133,440,049 - 133,440,138 (+)NCBImRatBN7.2mRatBN7.2
UTH_Rnor_SHR_Utx1141,349,605 - 141,349,694 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01148,518,995 - 148,519,084 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01141,436,720 - 141,436,809 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01141,229,353 - 141,229,442 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.01142,191,179 - 142,191,268 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Celera1125,503,266 - 125,503,355 (+)NCBICelera
Cytogenetic Map1q31NCBI
MIR9-3
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381589,368,017 - 89,368,106 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1589,368,017 - 89,368,106 (+)EnsemblGRCh38hg38GRCh38
GRCh371589,911,248 - 89,911,337 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361587,712,251 - 87,712,340 (+)NCBINCBI36Build 36hg18NCBI36
Celera1566,313,666 - 66,313,755 (+)NCBICelera
Cytogenetic Map15q26.1NCBI
HuRef1566,024,059 - 66,024,148 (+)NCBIHuRef
CHM1_11589,752,292 - 89,752,381 (+)NCBICHM1_1
T2T-CHM13v2.01587,124,074 - 87,124,163 (+)NCBIT2T-CHM13v2.0
Mir9-3
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39779,155,012 - 79,155,101 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl779,155,012 - 79,155,101 (+)EnsemblGRCm39 Ensembl
GRCm38779,505,264 - 79,505,353 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl779,505,264 - 79,505,353 (+)EnsemblGRCm38mm10GRCm38
MGSCv37786,650,150 - 86,650,239 (+)NCBIGRCm37MGSCv37mm9NCBIm37
Celera776,909,037 - 76,909,126 (+)NCBICelera
Cytogenetic Map7D2NCBI
cM Map745.06NCBI
MIR9-3
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1352,410,840 - 52,410,900 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl352,410,825 - 52,410,914 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha355,045,186 - 55,045,246 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0352,827,742 - 52,827,802 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl352,827,727 - 52,827,816 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1352,350,533 - 52,350,593 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0352,560,740 - 52,560,800 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0352,900,537 - 52,900,597 (+)NCBIUU_Cfam_GSD_1.0
MIR9-3
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl754,948,447 - 54,948,536 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1754,948,452 - 54,948,532 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2759,924,193 - 59,924,273 (+)NCBISscrofa10.2Sscrofa10.2susScr3


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
70225Bp58Blood pressure QTL 583.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)132356093162846471Rat
10059597Bp377Blood pressure QTL 3773.420.025arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)132737458199368955Rat
2313402Anxrr24Anxiety related response QTL 24aggression-related behavior trait (VT:0015014)tameness/aggressiveness composite score (CMO:0002136)148963584144267916Rat
1578654Bss10Bone structure and strength QTL 104femur morphology trait (VT:0000559)femoral neck cortical cross-sectional area (CMO:0001702)149393172159356837Rat
634314Niddm44Non-insulin dependent diabetes mellitus QTL 44blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)149393289199050459Rat
2298545Neuinf8Neuroinflammation QTL 84.6nervous system integrity trait (VT:0010566)spinal cord beta-2 microglobulin mRNA level (CMO:0002125)157336763151090257Rat
1578780Cm52Cardiac mass QTL 523.30.0001heart mass (VT:0007028)heart wet weight (CMO:0000069)181591954219808434Rat
724529Cm16Cardiac mass QTL 162.7heart mass (VT:0007028)calculated heart weight (CMO:0000073)187580395150700247Rat
724521Uae1Urinary albumin excretion QTL 13.80.0001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)190508614173018436Rat
1358902Bw47Body weight QTL 471.67body mass (VT:0001259)body weight (CMO:0000012)190508614180359386Rat
1300153Bp171Blood pressure QTL 1713.37arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)190664883143200202Rat
2293142Bp314Blood pressure QTL 314arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)192184926137184926Rat
724567Tcas6Tongue tumor susceptibility QTL 66.85tongue integrity trait (VT:0010553)number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)192948896144267916Rat
1331793Bp200Blood pressure QTL 2003.71601arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)194494440172949803Rat
1331751Bp199Blood pressure QTL 1993.60022arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)194494440181830018Rat
1331749Hrtrt11Heart rate QTL 112.973heart pumping trait (VT:2000009)heart rate (CMO:0000002)194494440198211706Rat
70209Niddm23Non-insulin dependent diabetes mellitus QTL 232.82blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)194494440198324465Rat
731168Bp154Blood pressure QTL 1543.4arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)194642644214537671Rat
61346Rf2Renal disease susceptibility QTL 23.7urine protein amount (VT:0005160)urine protein level (CMO:0000591)199267916144267916Rat
61399Tcat1Tongue tumor resistance QTL 13.3tongue integrity trait (VT:0010553)number of squamous cell tumors of the tongue with diameter greater than 5 mm (CMO:0001879)199267916144267916Rat
8655649Arrd1Age-related retinal degeneration QTL 14.89retinal layer morphology trait (VT:0003727)percentage of study population developing retinopathy during a period of time (CMO:0002453)1100357752183970443Rat
2317833Alcrsp19Alcohol response QTL 1912.40.001response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)1100979852145979852Rat
1641897Alcrsp1Alcohol response QTL 1response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)1100979852145979852Rat
2303591Gluco41Glucose level QTL 412blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)1102168504147168504Rat
61370Mcs3Mammary carcinoma susceptibility QTL 32.15mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)1102268556147268556Rat
1354623Rf46Renal function QTL 463.8blood creatinine amount (VT:0005328)plasma creatinine level (CMO:0000537)1102813953151162766Rat
1354591Cm36Cardiac mass QTL 364.1heart left ventricle mass (VT:0007031)calculated heart weight (CMO:0000073)1102813953201278233Rat
1354615Cm32Cardiac mass QTL 325.2heart left ventricle mass (VT:0007031)heart left ventricle wet weight (CMO:0000071)1102813953201278233Rat
1354606Bp246Blood pressure QTL 2463.6arterial blood pressure trait (VT:2000000)pulse pressure (CMO:0000292)1102813953218753816Rat
9590300Scort16Serum corticosterone level QTL 164.390.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)1103111621148111621Rat
8694370Bw154Body weight QTL 1548.910.001body lean mass (VT:0010483)lean tissue morphological measurement (CMO:0002184)1103111621148111621Rat
631496Bp97Blood pressure QTL 973.08arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1106047847151047847Rat
1300158Bp173Blood pressure QTL 1733.48arterial blood pressure trait (VT:2000000)blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)1115540693185145286Rat
7794788Mcs32Mammary carcinoma susceptibility QTL 322.61mammary gland integrity trait (VT:0010552)mammary tumor incidence/prevalence measurement (CMO:0000946)1115540693238914717Rat
631199Cm23Cardiac mass QTL 234.60.0004heart left ventricle mass (VT:0007031)heart left ventricle wet weight (CMO:0000071)1115585465172949803Rat
7421630Bp362Blood pressure QTL 3620.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1118608292241799120Rat
2313060Bss71Bone structure and strength QTL 712.60.0001long bone metaphysis morphology trait (VT:0000133)tibia midshaft total cross-sectional area (CMO:0001715)1118944747163944747Rat
631205Bp196Blood pressure QTL 19640.0001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1118944897199050459Rat
1598850Bp297Blood pressure QTL 2972.1arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1121006655166006655Rat
1598866Bp287Blood pressure QTL 2875.1arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1121006655166006655Rat
61442Strs1Sensitivity to stroke QTL 17.4cerebrum integrity trait (VT:0010549)post-insult time to onset of cerebrovascular lesion (CMO:0002343)1121767634166767634Rat
2293140Bp313Blood pressure QTL 313arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1121833674166833674Rat
631544Bp84Blood pressure QTL 845.6arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1123350408181759564Rat
1358189Cstrr1Cold stress response QTL 10.0001catecholamine amount (VT:0010543)urine norepinephrine level (CMO:0001629)1123350408182418476Rat
1641895Bp298Blood pressure QTL 298arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1123350408182418476Rat
1578770Stresp23Stress response QTL 23kidney sympathetic nerve activity (VT:0004050)stimulated renal sympathetic nerve activity to basal renal sympathetic nerve activity ratio (CMO:0001786)1123350408182418476Rat
631549Bp89Blood pressure QTL 895.7arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1123350581201284552Rat
631570Bp94Blood pressure QTL 940.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1123479780142990467Rat
634348Bp138Blood pressure QTL 138arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1125611501168883176Rat
9685799Bp375Blood pressure QTL 375arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1125611501170611501Rat
631654Bp107Blood pressure QTL 107arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1125611501170611501Rat
9685802Bp376Blood pressure QTL 376arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1126540680171540680Rat
738006Anxrr14Anxiety related response QTL 1440.00035locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)1130636910175636910Rat
738028Anxrr12Anxiety related response QTL 124.90.00001locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)1130636910175636910Rat
631202Gluco13Glucose level QTL 130.0001blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)1131763437159756369Rat


Expression


Sequence

Nucleotide Sequences
RefSeq Transcripts NR_031812 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide JAXUCZ010000001 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: NR_031812
RefSeq Status: PROVISIONAL
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81142,849,400 - 142,849,489 (+)NCBI
mRatBN7.21133,440,049 - 133,440,138 (+)NCBI
Rnor_6.01141,229,353 - 141,229,442 (+)NCBI
Rnor_5.01142,191,179 - 142,191,268 (+)NCBI
Celera1125,503,266 - 125,503,355 (+)NCBI
Sequence:

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:2325463 AgrOrtholog
BioCyc Gene G2FUF-58790 BioCyc
miRBase MI0000839 ENTREZGENE
NCBI Gene 100314149 ENTREZGENE
PhenoGen Mir9-3 PhenoGen
RNAcentral URS00003496BE RNACentral
  URS00004208C5 RNACentral
  URS000075C671 RNACentral


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2015-04-09 Mir9-3  microRNA 9-3  Mir9-3  microRNA mir-9-3  Name updated 61478 APPROVED
2010-06-02 Mir9-3  microRNA mir-9-3      Symbol and Name status set to provisional 70820 PROVISIONAL