Mir135b (microRNA 135b) - Rat Genome Database

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Gene: Mir135b (microRNA 135b) Rattus norvegicus
Analyze
Symbol: Mir135b
Name: microRNA 135b
RGD ID: 2325610
Description: Predicted to enable mRNA 3'-UTR binding activity and mRNA base-pairing translational repressor activity. Predicted to be involved in several processes, including miRNA-mediated post-transcriptional gene silencing; positive regulation of cell migration; and positive regulation of cell population proliferation. Predicted to act upstream of or within canonical Wnt signaling pathway. Orthologous to human MIR135B (microRNA 135b); INTERACTS WITH cisplatin; nitrofen; 17beta-estradiol (ortholog).
Type: ncrna (Ensembl: miRNA)
RefSeq Status: PROVISIONAL
Previously known as: microRNA mir-135b; rno-mir-135b
RGD Orthologs
Human
Mouse
Dog
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81346,191,018 - 46,191,114 (+)NCBIGRCr8
mRatBN7.21343,638,857 - 43,638,953 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1343,638,857 - 43,638,953 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1346,245,884 - 46,245,980 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01347,534,033 - 47,534,129 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01344,795,219 - 44,795,315 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01348,976,986 - 48,977,082 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1348,976,986 - 48,977,082 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01354,046,530 - 54,046,626 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Celera1343,975,159 - 43,975,255 (+)NCBICelera
Cytogenetic Map13q13NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:14691248   PMID:16381832   PMID:17604727   PMID:20403161   PMID:27048518   PMID:32491925   PMID:33596573  


Genomics

Comparative Map Data
Mir135b
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81346,191,018 - 46,191,114 (+)NCBIGRCr8
mRatBN7.21343,638,857 - 43,638,953 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1343,638,857 - 43,638,953 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1346,245,884 - 46,245,980 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01347,534,033 - 47,534,129 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01344,795,219 - 44,795,315 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01348,976,986 - 48,977,082 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1348,976,986 - 48,977,082 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01354,046,530 - 54,046,626 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Celera1343,975,159 - 43,975,255 (+)NCBICelera
Cytogenetic Map13q13NCBI
MIR135B
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381205,448,302 - 205,448,398 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1205,448,302 - 205,448,398 (-)EnsemblGRCh38hg38GRCh38
GRCh371205,417,430 - 205,417,526 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361203,684,052 - 203,684,148 (-)NCBINCBI36Build 36hg18NCBI36
Celera1178,552,602 - 178,552,698 (-)NCBICelera
Cytogenetic Map1q32.1NCBI
HuRef1176,582,827 - 176,582,923 (-)NCBIHuRef
CHM1_11206,840,703 - 206,840,799 (-)NCBICHM1_1
T2T-CHM13v2.01204,712,643 - 204,712,739 (-)NCBIT2T-CHM13v2.0
Mir135b
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391132,125,826 - 132,125,922 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1132,125,826 - 132,125,922 (+)EnsemblGRCm39 Ensembl
GRCm381132,198,088 - 132,198,184 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1132,198,088 - 132,198,184 (+)EnsemblGRCm38mm10GRCm38
MGSCv371134,094,665 - 134,094,761 (+)NCBIGRCm37MGSCv37mm9NCBIm37
Celera1134,805,071 - 134,805,167 (+)NCBICelera
Cytogenetic Map1E4NCBI
cM Map157.24NCBI
MIR135B
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1381,926,558 - 1,926,646 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl381,926,558 - 1,926,646 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha382,020,079 - 2,020,167 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0381,923,382 - 1,923,470 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl381,923,382 - 1,923,470 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1381,918,834 - 1,918,922 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0382,310,347 - 2,310,435 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0382,510,395 - 2,510,483 (-)NCBIUU_Cfam_GSD_1.0

miRNA Target Status

Confirmed Targets
Gene TargetMature miRNAMethod NameResult TypeData TypeSupport TypePMID
Syt17rno-miR-135b-5pMirtarbaseexternal_infoqRT-PCRNon-Functional MTI (Weak)18667155

Predicted Targets
Summary Value
Count of predictions:19457
Count of gene targets:9457
Count of transcripts:10203
Interacting mature miRNAs:rno-miR-135b-3p, rno-miR-135b-5p
Prediction methods:Microtar, Miranda, Pita, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1354666Bp244Blood pressure QTL 2444.9arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)131101056920Rat
1354666Bp244Blood pressure QTL 2444.9arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)131101056920Rat
1354666Bp244Blood pressure QTL 2444.9arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)131101056920Rat
61339Bp24Blood pressure QTL 240.05arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)13599466844807491Rat
1581554Pur11Proteinuria QTL 11urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)13599483377046787Rat
1581573Uae36Urinary albumin excretion QTL 36urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)13599483377046787Rat
1581570Eae17Experimental allergic encephalomyelitis QTL 174.1nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis incidence/prevalence measurement (CMO:0001046)138897350101631289Rat
7411662Foco29Food consumption QTL 2920.80.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)13931346554313465Rat
9589141Insul28Insulin level QTL 2810.820.001blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)13931346554313465Rat
2317040Aia21Adjuvant induced arthritis QTL 212.75joint integrity trait (VT:0010548)left rear ankle joint diameter (CMO:0002149)13983154154831541Rat
2317046Aia8Adjuvant induced arthritis QTL 83.9700000286102295joint integrity trait (VT:0010548)left rear ankle joint diameter (CMO:0002149)13983154154831541Rat
1300163Cardf1Cardiac cell morphology QTL 14.18aorta morphology trait (VT:0000272)artery lesion measurement (CMO:0000975)131192944945417941Rat
2302275Gluco37Glucose level QTL 373.8blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)131192944946193066Rat
631645Bp121Blood pressure QTL 1213.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)131491565559915655Rat
9589164Gluco66Glucose level QTL 666.670.001blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)131515872260158722Rat
1331784Bp222Blood pressure QTL 2222.944arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)131769443653050594Rat
7207885Glom27Glomerulus QTL 273.9kidney glomerulus integrity trait (VT:0010546)kidney crescentic glomeruli count to kidney normal glomeruli count ratio (CMO:0002139)1320605871101339738Rat
61391Bp5Blood pressure QTL 55.6arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)132230187567301875Rat
70170Eae14Experimental allergic encephalomyelitis QTL 140.0024nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis incidence/prevalence measurement (CMO:0001046)132320344868203448Rat
6893338Cm76Cardiac mass QTL 7600.99heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)132369296968692969Rat
1558644Cm45Cardiac mass QTL 453.60.002heart mass (VT:0007028)heart wet weight (CMO:0000069)132369296968692969Rat
1354621Rf47Renal function QTL 473.7kidney renin amount (VT:0010559)kidney renin level (CMO:0002166)1330395351101056920Rat
2301962Cm72Cardiac mass QTL 724.12heart left ventricle mass (VT:0007031)heart left ventricle weight (CMO:0000776)133124133158363171Rat
70181BpQTLcluster11Blood pressure QTL cluster 116.922arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)133124133193395974Rat
70181BpQTLcluster11Blood pressure QTL cluster 116.922arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)133124133193395974Rat
70181BpQTLcluster11Blood pressure QTL cluster 116.922arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)133124133193395974Rat
70181BpQTLcluster11Blood pressure QTL cluster 116.922arterial blood pressure trait (VT:2000000)absolute change in mean arterial blood pressure (CMO:0000533)133124133193395974Rat
2303563Bw89Body weight QTL 896body mass (VT:0001259)body weight (CMO:0000012)133228447177284471Rat
61340Bp25Blood pressure QTL 254.20.004arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)133453521879535218Rat
12879477Bp401Blood pressure QTL 401arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)133726209282262092Rat
61349Bp31Blood pressure QTL 315.75arterial blood pressure trait (VT:2000000)blood pressure measurement (CMO:0000003)133737450982374509Rat
70220Bp55Blood pressure QTL 555.75arterial blood pressure trait (VT:2000000)blood pressure measurement (CMO:0000003)133737450982374509Rat
4889861Pur29Proteinuria QTL 2913.80.005urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)133741558480753406Rat
1331750Bp220Blood pressure QTL 2202.98arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)133741558482415584Rat
1549897Stresp12Stress response QTL 123.35stress-related behavior trait (VT:0010451)number of approaches toward negative stimulus before onset of defensive burying response (CMO:0001960)133843340883433408Rat
619615Bp80Blood pressure QTL 800.0354arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)133975454484754544Rat
2303032Bp328Blood pressure QTL 328arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)134118402245417941Rat
4145117Mcs27Mammary carcinoma susceptibility QTL 270.0001mammary gland integrity trait (VT:0010552)post-insult time to mammary tumor formation (CMO:0000345)134343790447841255Rat

Markers in Region
D13Rat87  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21343,637,528 - 43,637,697 (+)MAPPERmRatBN7.2
Rnor_6.01348,975,660 - 48,975,828NCBIRnor6.0
Rnor_5.01354,045,204 - 54,045,372UniSTSRnor5.0
RGSC_v3.41345,077,465 - 45,077,634RGDRGSC3.4
RGSC_v3.41345,077,466 - 45,077,634UniSTSRGSC3.4
RGSC_v3.11345,091,508 - 45,091,677RGD
Celera1343,973,833 - 43,974,001UniSTS
FHH x ACI Map1317.13RGD
FHH x ACI Map1317.13UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

nervous system reproductive system
High
Medium
Low 27 3
Below cutoff 5

Sequence

Nucleotide Sequences
RefSeq Transcripts NR_031797 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide JAXUCZ010000013 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENSRNOT00000053744
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1343,638,857 - 43,638,953 (+)Ensembl
Rnor_6.0 Ensembl1348,976,986 - 48,977,082 (+)Ensembl
RefSeq Acc Id: NR_031797
RefSeq Status: PROVISIONAL
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81346,191,018 - 46,191,114 (+)NCBI
mRatBN7.21343,638,857 - 43,638,953 (+)NCBI
Rnor_6.01348,976,986 - 48,977,082 (+)NCBI
Rnor_5.01354,046,530 - 54,046,626 (+)NCBI
Celera1343,975,159 - 43,975,255 (+)NCBI
Sequence:
Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:2325610 AgrOrtholog
BioCyc Gene G2FUF-18323 BioCyc
Ensembl Genes ENSRNOG00000035621 Ensembl, ENTREZGENE
Ensembl Transcript ENSRNOT00000053744 ENTREZGENE
miRBase MI0000645 ENTREZGENE
NCBI Gene 100313987 ENTREZGENE
PhenoGen Mir135b PhenoGen
RatGTEx ENSRNOG00000035621 RatGTEx
RNAcentral URS000001C659 RNACentral
  URS0000488C83 RNACentral
  URS000075E52B RNACentral


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2013-08-14 Mir135b  microRNA 135b  Mir135b  microRNA mir-135b  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2010-06-02 Mir135b  microRNA mir-135b      Symbol and Name status set to provisional 70820 PROVISIONAL