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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:Oxadiazon
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Accession:CHEBI:81786 term browser browse the term
Definition:An aromatic ether that has formula C15H18Cl2N2O3.
Synonyms:related_synonym: Formula=C15H18Cl2N2O3;   InChI=1S/C15H18Cl2N2O3/c1-8(2)21-12-7-11(9(16)6-10(12)17)19-14(20)22-13(18-19)15(3,4)5/h6-8H,1-5H3;   InChIKey=CHNUNORXWHYHNE-UHFFFAOYSA-N;   SMILES=CC(C)Oc1cc(c(Cl)cc1Cl)-n1nc(oc1=O)C(C)(C)C
 xref: CAS:19666-30-9;   KEGG:C18496
 xref_mesh: MESH:C012466
 xref: PPDB:496


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Oxadiazon term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Acyp2 acylphosphatase 2 affects response to substance
multiple interactions
increases expression		 ISO ACYP2 protein affects the susceptibility to oxadiazon
ACYP2 protein affects the reaction [oxadiazon inhibits the reaction [BDNF protein results in increased expression of GAP43 protein]]; ACYP2 protein affects the reaction [oxadiazon inhibits the reaction [FGF2 protein results in increased expression of GAP43 protein]]; oxadiazon results in increased expression of and results in increased activity of ACYP2 protein
oxadiazon results in increased expression of ACYP2 mRNA		 CTD PMID:30391265 NCBI chr14:104,201,894...104,371,415
Ensembl chr14:104,201,895...104,371,386 		JBrowse link
G Aldh2 aldehyde dehydrogenase 2 family member decreases expression
multiple interactions		 ISO oxadiazon results in decreased expression of ALDH2 mRNA
oxadiazon results in decreased expression of and results in decreased activity of ALDH2 protein		 CTD PMID:30391265 NCBI chr12:34,949,549...34,982,527
Ensembl chr12:34,901,219...34,982,521 		JBrowse link
G Bdnf brain-derived neurotrophic factor multiple interactions ISO ACYP2 protein affects the reaction [oxadiazon inhibits the reaction [BDNF protein results in increased expression of GAP43 protein]]; oxadiazon inhibits the reaction [BDNF protein results in increased expression of GAP43 protein] CTD PMID:30391265 NCBI chr 3:96,165,042...96,215,621
Ensembl chr 3:96,165,042...96,215,615 		JBrowse link
G Cyp19a1 cytochrome P450, family 19, subfamily a, polypeptide 1 increases activity ISO oxadiazon results in increased activity of CYP19A1 protein CTD PMID:16996190 NCBI chr 8:54,552,978...54,580,375
Ensembl chr 8:54,553,165...54,580,758 		JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 increases expression ISO oxadiazon results in increased expression of CYP1A1 mRNA CTD PMID:26710982 NCBI chr 8:58,096,021...58,102,130
Ensembl chr 8:58,096,077...58,102,125 		JBrowse link
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 increases expression ISO oxadiazon results in increased expression of CYP1A2 mRNA CTD PMID:26710982 NCBI chr 8:58,075,367...58,082,255
Ensembl chr 8:58,075,367...58,082,312 		JBrowse link
G Cyp2b3 cytochrome P450, family 2, subfamily b, polypeptide 3 multiple interactions
increases expression		 ISO NR1I3 mutant form inhibits the reaction [oxadiazon results in increased expression of CYP2B10 mRNA] CTD PMID:26710982 NCBI chr 1:81,652,762...81,732,153
Ensembl chr 1:81,652,787...81,732,143 		JBrowse link
G Cyp3a2 cytochrome P450, family 3, subfamily a, polypeptide 2 increases expression ISO oxadiazon results in increased expression of CYP3A4 mRNA CTD PMID:16565514 NCBI chr12:9,207,978...9,230,064
Ensembl chr12:9,015,383...9,285,008 		JBrowse link
G Esr1 estrogen receptor 1 multiple interactions ISO oxadiazon binds to and results in increased activity of ESR1 protein CTD PMID:33049310 NCBI chr 1:41,106,335...41,499,104
Ensembl chr 1:41,210,475...41,495,002 		JBrowse link
G Esr2 estrogen receptor 2 multiple interactions ISO oxadiazon binds to and results in increased activity of ESR2 protein CTD PMID:33049310 NCBI chr 6:94,858,438...94,909,630
Ensembl chr 6:94,809,547...94,908,919 		JBrowse link
G Fgf2 fibroblast growth factor 2 multiple interactions ISO ACYP2 protein affects the reaction [oxadiazon inhibits the reaction [FGF2 protein results in increased expression of GAP43 protein]]; oxadiazon inhibits the reaction [FGF2 protein results in increased expression of GAP43 protein] CTD PMID:30391265 NCBI chr 2:120,236,328...120,290,673
Ensembl chr 2:120,236,328...120,291,221 		JBrowse link
G Gap43 growth associated protein 43 multiple interactions ISO ACYP2 protein affects the reaction [oxadiazon inhibits the reaction [BDNF protein results in increased expression of GAP43 protein]]; ACYP2 protein affects the reaction [oxadiazon inhibits the reaction [FGF2 protein results in increased expression of GAP43 protein]]; oxadiazon inhibits the reaction [BDNF protein results in increased expression of GAP43 protein]; oxadiazon inhibits the reaction [FGF2 protein results in increased expression of GAP43 protein] CTD PMID:30391265 NCBI chr11:58,376,371...58,470,047
Ensembl chr11:58,376,371...58,470,045 		JBrowse link
G Gpt glutamic--pyruvic transaminase increases expression
multiple interactions		 ISO oxadiazon results in increased expression of GPT protein
NR1I3 protein affects the reaction [oxadiazon results in increased expression of GPT protein]		 CTD PMID:26710982 NCBI chr 7:108,416,646...108,419,495
Ensembl chr 7:108,416,642...108,419,494 		JBrowse link
G Nr1i2 nuclear receptor subfamily 1, group I, member 2 increases activity
multiple interactions		 ISO oxadiazon results in increased activity of NR1I2 protein
oxadiazon binds to and results in increased activity of NR1I2 protein		 CTD PMID:16565514 PMID:33049310 NCBI chr11:62,460,213...62,496,665
Ensembl chr11:62,460,213...62,496,658 		JBrowse link
G Nr1i3 nuclear receptor subfamily 1, group I, member 3 multiple interactions
affects response to substance
increases activity		 ISO NR1I3 mutant form inhibits the reaction [oxadiazon results in increased expression of CYP2B10 mRNA]; NR1I3 protein affects the reaction [oxadiazon results in increased abundance of protoporphyrin IX]; NR1I3 protein affects the reaction [oxadiazon results in increased expression of GPT protein]
NR1I3 protein affects the susceptibility to oxadiazon
oxadiazon results in increased activity of NR1I3 protein		 CTD PMID:26710982 PMID:28927721 NCBI chr13:83,632,940...83,638,193
Ensembl chr13:83,632,899...83,637,906 		JBrowse link
G Por cytochrome p450 oxidoreductase increases expression ISO oxadiazon results in increased expression of POR mRNA CTD PMID:26710982 NCBI chr12:20,951,058...20,999,198
Ensembl chr12:20,951,058...20,999,245 		JBrowse link
G Pparg peroxisome proliferator-activated receptor gamma multiple interactions ISO oxadiazon binds to and results in increased activity of PPARG protein CTD PMID:33049310 NCBI chr 4:148,423,102...148,548,471
Ensembl chr 4:148,423,194...148,548,468 		JBrowse link
G Ppox protoporphyrinogen oxidase decreases activity ISO oxadiazon results in decreased activity of PPOX protein CTD PMID:9431441 NCBI chr13:83,697,661...83,701,998
Ensembl chr13:83,664,891...83,701,805 		JBrowse link
G Rarb retinoic acid receptor, beta increases activity ISO oxadiazon results in increased activity of RARB protein CTD PMID:20143881 NCBI chr15:8,700,533...9,051,288
Ensembl chr15:8,406,492...9,051,288 		JBrowse link
G Thrb thyroid hormone receptor beta multiple interactions ISO oxadiazon binds to and results in increased activity of THRB protein CTD PMID:33049310 NCBI chr15:7,685,180...8,031,920
Ensembl chr15:7,685,180...7,882,916 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19841
    chemical entity 19839
      group 19798
        polyatomic entity 19797
          molecule 19701
            organic molecule 19686
              organic cyclic compound 19498
                organic aromatic compound 19367
                  aromatic ether 16529
                    Oxadiazon 20
Path 2
Term Annotations click to browse term
  CHEBI ontology 19841
    subatomic particle 19839
      composite particle 19839
        hadron 19839
          baryon 19839
            nucleon 19839
              atomic nucleus 19839
                atom 19839
                  main group element atom 19789
                    main group molecular entity 19789
                      p-block molecular entity 19789
                        carbon group molecular entity 19737
                          organic molecular entity 19733
                            heteroorganic entity 19492
                              organochalcogen compound 19255
                                organooxygen compound 19172
                                  ether 17284
                                    aromatic ether 16529
                                      Oxadiazon 20
paths to the root