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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:doramapimod
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Accession:CHEBI:40953 term browser browse the term
Definition:A member of the class of pyrazoles that is an immunomodulator used for treatment of rheumatoid arthritis, Crohn's disease and psoriasis.
Synonyms:exact_synonym: N-[3-tert-butyl-1-(4-methylphenyl)-1H-pyrazol-5-yl]-N'-{4-[2-(morpholin-4-yl)ethoxy]naphthalen-1-yl}urea
 related_synonym: 1-(3-(1,1-Dimethylethyl)-1-(4-methylphenyl)-1H-pyrazol-5-yl)-3-(4-(2-(morpholin-4-yl)ethoxy)naphthalen-1-yl)urea;   1-[3-tert-butyl-1-(4-methylphenyl)-1H-pyrazol-5-yl]-3-[4-(2-morpholin-4-ylethoxy)naphthalen-1-yl]urea;   BIRB 796;   Formula=C31H37N5O3;   InChI=1S/C31H37N5O3/c1-22-9-11-23(12-10-22)36-29(21-28(34-36)31(2,3)4)33-30(37)32-26-13-14-27(25-8-6-5-7-24(25)26)39-20-17-35-15-18-38-19-16-35/h5-14,21H,15-20H2,1-4H3,(H2,32,33,37);   InChIKey=MVCOAUNKQVWQHZ-UHFFFAOYSA-N;   SMILES=C(=O)(NC=1N(N=C(C1)C(C)(C)C)C=2C=CC(=CC2)C)NC=3C4=C(C=CC=C4)C(=CC3)OCCN5CCOCC5
 alt_id: MESH:C452139
 xref: CAS:285983-48-4;   KEGG:D03736;   LINCS:LSM-1170
 xref_mesh: MESH:C452139
 xref: PDBeChem:B96;   PMID:11896401;   PMID:19244237;   PMID:20655210;   PMID:23685672;   PMID:25358442;   PMID:25589935;   PMID:26044359;   PMID:26232862;   Reaxys:9170597


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doramapimod term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcc2 ATP binding cassette subfamily C member 2 increases expression ISO doramapimod results in increased expression of ABCC2 mRNA CTD PMID:21328587 NCBI chr 1:242,664,657...242,723,239
Ensembl chr 1:242,664,657...242,723,238 		JBrowse link
G Actg2 actin gamma 2, smooth muscle increases expression EXP doramapimod results in increased expression of ACTG2 mRNA CTD PMID:24303162 NCBI chr 4:116,021,832...116,046,475
Ensembl chr 4:116,021,832...116,046,465 		JBrowse link
G Adh7 alcohol dehydrogenase 7 (class IV), mu or sigma polypeptide increases expression EXP doramapimod results in increased expression of ADH7 mRNA CTD PMID:24303162 NCBI chr 2:226,748,724...226,763,183
Ensembl chr 2:226,741,788...226,763,182 		JBrowse link
G Ahsg alpha-2-HS-glycoprotein decreases expression ISO doramapimod results in decreased expression of AHSG mRNA CTD PMID:21328587 NCBI chr11:78,121,388...78,127,998
Ensembl chr11:78,117,918...78,145,999 		JBrowse link
G Ak5 adenylate kinase 5 increases expression EXP doramapimod results in increased expression of AK5 mRNA CTD PMID:24303162 NCBI chr 2:241,397,297...241,581,483
Ensembl chr 2:241,397,297...241,581,458 		JBrowse link
G Akr1b7 aldo-keto reductase family 1, member B7 increases expression ISO doramapimod results in increased expression of AKR1B7 mRNA CTD PMID:21328587 NCBI chr 4:63,053,560...63,100,934
Ensembl chr 4:63,076,800...63,089,502 		JBrowse link
G Apoa4 apolipoprotein A4 decreases expression ISO doramapimod results in decreased expression of APOA4 mRNA CTD PMID:21328587 NCBI chr 8:46,539,083...46,541,464
Ensembl chr 8:46,539,082...46,541,469 		JBrowse link
G C1qa complement C1q A chain decreases expression ISO doramapimod results in decreased expression of C1QA mRNA CTD PMID:21328587 NCBI chr 5:149,133,635...149,136,482
Ensembl chr 5:149,133,636...149,136,534 		JBrowse link
G C1qb complement C1q B chain decreases expression ISO doramapimod results in decreased expression of C1QB mRNA CTD PMID:21328587 NCBI chr 5:149,118,843...149,124,394
Ensembl chr 5:149,118,846...149,124,407 		JBrowse link
G Car3 carbonic anhydrase 3 decreases expression ISO doramapimod results in decreased expression of CAR3 mRNA CTD PMID:21328587 NCBI chr 2:86,770,418...86,780,011
Ensembl chr 2:86,770,420...86,784,280 		JBrowse link
G Casp3 caspase 3 multiple interactions ISO doramapimod promotes the reaction [TNF protein results in increased activity of CASP3 protein] CTD PMID:28629242 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648 		JBrowse link
G Cd5l Cd5 molecule-like decreases expression ISO doramapimod results in decreased expression of CD5L mRNA CTD PMID:21328587 NCBI chr 2:172,791,007...172,802,018
Ensembl chr 2:172,790,934...172,829,753 		JBrowse link
G Cd74 CD74 molecule decreases expression ISO doramapimod results in decreased expression of CD74 mRNA CTD PMID:21328587 NCBI chr18:54,256,757...54,266,003
Ensembl chr18:54,256,778...54,266,003 		JBrowse link
G Ceacam1 CEA cell adhesion molecule 1 decreases expression EXP doramapimod results in decreased expression of CEACAM1 mRNA CTD PMID:24303162 NCBI chr 1:81,043,595...81,060,050
Ensembl chr 1:81,043,595...81,059,992 		JBrowse link
G Ces3a carboxylesterase 3a increases expression ISO doramapimod results in increased expression of CES3 mRNA CTD PMID:21328587 NCBI chr19:32,992,386...33,000,562 JBrowse link
G Clec1b C-type lectin domain family 1, member B decreases expression ISO doramapimod results in decreased expression of CLEC1B mRNA CTD PMID:21328587 NCBI chr 4:162,847,978...162,856,291
Ensembl chr 4:162,848,010...162,856,291 		JBrowse link
G Ctss cathepsin S decreases expression ISO doramapimod results in decreased expression of CTSS mRNA CTD PMID:21328587 NCBI chr 2:183,086,437...183,114,483
Ensembl chr 2:183,086,437...183,114,483 		JBrowse link
G Cxcl1 C-X-C motif chemokine ligand 1 multiple interactions ISO doramapimod inhibits the reaction [Lipopolysaccharides results in increased expression of CXCL1 protein] CTD PMID:14997032 NCBI chr14:17,193,364...17,195,143
Ensembl chr14:17,193,365...17,195,215 		JBrowse link
G Cxcl10 C-X-C motif chemokine ligand 10 decreases secretion ISO doramapimod results in decreased secretion of CXCL10 protein CTD PMID:17996064 NCBI chr14:15,704,772...15,706,969
Ensembl chr14:15,704,758...15,706,975 		JBrowse link
G Cxcl3 C-X-C motif chemokine ligand 3 multiple interactions ISO doramapimod inhibits the reaction [Lipopolysaccharides results in increased expression of CXCL1 protein] CTD PMID:14997032 NCBI chr14:17,287,727...17,289,451
Ensembl chr14:17,270,146...17,289,511 		JBrowse link
G Cxcr1 C-X-C motif chemokine receptor 1 multiple interactions ISO doramapimod inhibits the reaction [Lipopolysaccharides results in decreased expression of CXCR1 protein] CTD PMID:14997032 NCBI chr 9:75,766,894...75,771,079
Ensembl chr 9:75,766,770...75,771,084 		JBrowse link
G Cxcr2 C-X-C motif chemokine receptor 2 multiple interactions ISO doramapimod inhibits the reaction [Lipopolysaccharides results in decreased expression of CXCR2 protein] CTD PMID:14997032 NCBI chr 9:75,729,493...75,735,868
Ensembl chr 9:75,729,115...75,739,425 		JBrowse link
G Cyp2a3 cytochrome P450, family 2, subfamily a, polypeptide 3 increases expression ISO doramapimod results in increased expression of CYP2A4 mRNA CTD PMID:21328587 NCBI chr 1:82,171,914...82,179,980
Ensembl chr 1:82,169,949...82,179,979 		JBrowse link
G Cyss cystatin S decreases expression EXP doramapimod results in decreased expression of CYSS mRNA CTD PMID:24303162 NCBI chr 3:137,432,049...137,436,654
Ensembl chr 3:137,432,049...137,436,610 		JBrowse link
G Egr1 early growth response 1 increases expression ISO doramapimod results in increased expression of EGR1 mRNA CTD PMID:21328587 NCBI chr18:26,462,967...26,466,766
Ensembl chr18:26,462,981...26,466,766 		JBrowse link
G Fcgr2b Fc gamma receptor 2B decreases expression ISO doramapimod results in decreased expression of FCGR2B mRNA CTD PMID:21328587 NCBI chr13:83,191,253...83,207,778
Ensembl chr13:83,193,163...83,207,778 		JBrowse link
G Fgf8 fibroblast growth factor 8 decreases expression EXP doramapimod results in decreased expression of FGF8 mRNA CTD PMID:24303162 NCBI chr 1:244,584,477...244,590,578
Ensembl chr 1:244,584,652...244,590,359 		JBrowse link
G G6pc1 glucose-6-phosphatase catalytic subunit 1 decreases expression ISO doramapimod results in decreased expression of G6PC1 mRNA CTD PMID:21328587 NCBI chr10:86,307,400...86,318,766
Ensembl chr10:86,257,668...86,333,804 		JBrowse link
G Gclc glutamate-cysteine ligase, catalytic subunit increases expression ISO doramapimod results in increased expression of GCLC mRNA CTD PMID:21328587 NCBI chr 8:78,629,899...78,668,547
Ensembl chr 8:78,630,127...78,668,544 		JBrowse link
G Gpx2 glutathione peroxidase 2 increases expression ISO doramapimod results in increased expression of GPX2 mRNA CTD PMID:21328587 NCBI chr 6:95,493,589...95,496,877
Ensembl chr 6:95,493,589...95,496,877 		JBrowse link
G Grm8 glutamate metabotropic receptor 8 increases expression EXP doramapimod results in increased expression of GRM8 mRNA CTD PMID:24303162 NCBI chr 4:55,805,762...56,731,690
Ensembl chr 4:55,805,955...56,730,831 		JBrowse link
G Gstm2 glutathione S-transferase mu 2 increases expression ISO doramapimod results in increased expression of GSTM2 mRNA CTD PMID:21328587 NCBI chr 2:195,624,015...195,628,774
Ensembl chr 2:195,544,426...195,628,961 		JBrowse link
G Gstm5 glutathione S-transferase, mu 5 increases expression ISO doramapimod results in increased expression of GSTM3 mRNA CTD PMID:21328587 NCBI chr 2:195,531,599...195,534,562
Ensembl chr 2:195,531,495...195,534,553 		JBrowse link
G Hp haptoglobin decreases expression ISO doramapimod results in decreased expression of HP mRNA CTD PMID:21328587 NCBI chr19:37,539,626...37,544,178
Ensembl chr19:37,539,627...37,544,523 		JBrowse link
G Hpd 4-hydroxyphenylpyruvate dioxygenase decreases expression EXP doramapimod results in decreased expression of HPD mRNA CTD PMID:24303162 NCBI chr12:33,381,397...33,392,750
Ensembl chr12:33,381,231...33,392,766 		JBrowse link
G Icam1 intercellular adhesion molecule 1 multiple interactions ISO doramapimod inhibits the reaction [Dinitrofluorobenzene results in increased expression of ICAM1 protein] CTD PMID:19427879 NCBI chr 8:19,553,063...19,565,438
Ensembl chr 8:19,553,645...19,565,438 		JBrowse link
G Il1b interleukin 1 beta multiple interactions ISO doramapimod inhibits the reaction [Lipopolysaccharides results in increased expression of IL1B protein] CTD PMID:28629242 NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415 		JBrowse link
G Kcnk1 potassium two pore domain channel subfamily K member 1 decreases expression EXP doramapimod results in decreased expression of KCNK1 mRNA CTD PMID:24303162 NCBI chr19:53,959,411...53,997,726
Ensembl chr19:53,959,657...53,997,724 		JBrowse link
G Lmod1 leiomodin 1 increases expression EXP doramapimod results in increased expression of LMOD1 mRNA CTD PMID:24303162 NCBI chr13:46,754,048...46,796,186
Ensembl chr13:46,754,033...46,794,900 		JBrowse link
G Mapk14 mitogen activated protein kinase 14 decreases activity ISO doramapimod results in decreased activity of MAPK14 protein CTD PMID:28629242 NCBI chr20:6,749,646...6,810,590
Ensembl chr20:6,749,670...6,810,589 		JBrowse link
G Meig1 meiosis/spermiogenesis associated 1 increases expression ISO doramapimod results in increased expression of MEIG1 mRNA CTD PMID:21328587 NCBI chr17:74,810,791...74,828,433
Ensembl chr17:74,814,632...74,828,433 		JBrowse link
G Mybpc1 myosin binding protein C1 decreases expression EXP doramapimod results in decreased expression of MYBPC1 mRNA CTD PMID:24303162 NCBI chr 7:22,930,350...23,015,981
Ensembl chr 7:22,930,350...23,015,957 		JBrowse link
G Myh11 myosin heavy chain 11 increases expression EXP doramapimod results in increased expression of MYH11 mRNA CTD PMID:24303162 NCBI chr10:743,364...838,459
Ensembl chr10:743,685...838,459 		JBrowse link
G Myh3 myosin heavy chain 3 increases expression EXP doramapimod results in increased expression of MYH3 mRNA CTD PMID:24303162 NCBI chr10:51,770,177...51,793,994
Ensembl chr10:51,770,177...51,793,992 		JBrowse link
G Nqo1 NAD(P)H quinone dehydrogenase 1 increases expression ISO doramapimod results in increased expression of NQO1 mRNA CTD PMID:21328587 NCBI chr19:35,295,633...35,310,528
Ensembl chr19:35,295,573...35,310,557 		JBrowse link
G Olr59 olfactory receptor 59 increases expression EXP doramapimod results in increased expression of OLR59 mRNA CTD PMID:24303162 NCBI chr 1:157,193,051...157,227,707
Ensembl chr 1:157,193,080...157,211,179 		JBrowse link
G Otog otogelin decreases expression EXP doramapimod results in decreased expression of OTOG mRNA CTD PMID:24303162 NCBI chr 1:96,746,336...96,815,416
Ensembl chr 1:96,746,336...96,815,415 		JBrowse link
G Pfn2 profilin 2 increases expression ISO doramapimod results in increased expression of PFN2 mRNA CTD PMID:21328587 NCBI chr 2:142,067,102...142,072,938
Ensembl chr 2:142,067,104...142,072,938 		JBrowse link
G Pon1 paraoxonase 1 decreases expression EXP doramapimod results in decreased expression of PON1 mRNA CTD PMID:24303162 NCBI chr 4:33,294,737...33,325,759
Ensembl chr 4:33,294,722...33,321,360 		JBrowse link
G Pparg peroxisome proliferator-activated receptor gamma increases expression ISO doramapimod results in increased expression of PPARG mRNA CTD PMID:21328587 NCBI chr 4:148,423,102...148,548,471
Ensembl chr 4:148,423,194...148,548,468 		JBrowse link
G Prm2 protamine 2 increases expression ISO doramapimod results in increased expression of PRM2 mRNA CTD PMID:21328587 NCBI chr10:4,876,285...4,877,026
Ensembl chr10:4,873,372...4,877,026 		JBrowse link
G Rgs4 regulator of G-protein signaling 4 increases expression EXP doramapimod results in increased expression of RGS4 mRNA CTD PMID:24303162 NCBI chr13:81,936,775...81,943,103
Ensembl chr13:81,936,775...81,943,068 		JBrowse link
G RT1-Bb RT1 class II, locus Bb decreases expression ISO doramapimod results in decreased expression of H2-AB1 mRNA CTD PMID:21328587 NCBI chr20:4,596,558...4,602,201
Ensembl chr20:4,596,559...4,607,597 		JBrowse link
G Slc7a11 solute carrier family 7 member 11 increases expression ISO doramapimod results in increased expression of SLC7A11 mRNA CTD PMID:21328587 NCBI chr 2:134,382,002...134,517,622
Ensembl chr 2:133,963,107...134,517,536 		JBrowse link
G Spock2 SPARC/osteonectin, cwcv and kazal like domains proteoglycan 2 decreases expression EXP doramapimod results in decreased expression of SPOCK2 mRNA CTD PMID:24303162 NCBI chr20:28,037,334...28,064,272
Ensembl chr20:28,033,475...28,064,272 		JBrowse link
G Spsb1 splA/ryanodine receptor domain and SOCS box containing 1 decreases expression ISO doramapimod results in decreased expression of SPSB1 mRNA CTD PMID:21328587 NCBI chr 5:160,358,292...160,418,541
Ensembl chr 5:160,358,308...160,418,468 		JBrowse link
G Srxn1 sulfiredoxin 1 increases expression ISO doramapimod results in increased expression of SRXN1 mRNA CTD PMID:21328587 NCBI chr 3:140,604,490...140,610,050
Ensembl chr 3:140,599,608...140,628,448 		JBrowse link
G Stmn2 stathmin 2 increases expression EXP doramapimod results in increased expression of STMN2 mRNA CTD PMID:24303162 NCBI chr 2:93,204,690...93,252,011
Ensembl chr 2:93,204,692...93,252,011 		JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO doramapimod inhibits the reaction [Lipopolysaccharides results in increased expression of TNF protein]; doramapimod promotes the reaction [TNF protein results in increased activity of CASP3 protein] CTD PMID:28629242 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629 		JBrowse link
G Vsig4 V-set and immunoglobulin domain containing 4 decreases expression ISO doramapimod results in decreased expression of VSIG4 mRNA CTD PMID:21328587 NCBI chr  X:61,144,926...61,170,212
Ensembl chr  X:61,144,928...61,170,212 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19841
    role 19817
      biological role 19815
        immunomodulator 15058
          doramapimod 60
Path 2
Term Annotations click to browse term
  CHEBI ontology 19841
    subatomic particle 19839
      composite particle 19839
        hadron 19839
          baryon 19839
            nucleon 19839
              atomic nucleus 19839
                atom 19839
                  main group element atom 19789
                    p-block element atom 19789
                      carbon group element atom 19737
                        carbon atom 19733
                          organic molecular entity 19733
                            heteroorganic entity 19492
                              organochalcogen compound 19255
                                organooxygen compound 19172
                                  carbon oxoacid 18641
                                    carboxylic acid 18638
                                      carboacyl group 17698
                                        univalent carboacyl group 17698
                                          carbamoyl group 17548
                                            carboxamide 17548
                                              monocarboxylic acid amide 15680
                                                urea 5580
                                                  ureas 5578
                                                    doramapimod 60
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