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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:dydrogesterone
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Accession:CHEBI:31527 term browser browse the term
Definition:A 3-oxo Delta(4)-steroid that has formula C21H28O2.
Synonyms:exact_synonym: 9beta,10alpha-pregna-4,6-diene-3,20-dione
 related_synonym: 10alpha-Isopregnenone;   6-Dehydro-retro-progesterone;   Formula=C21H28O2;   Hydrogesterone;   Hydrogestrone;   InChI=1S/C21H28O2/c1-13(22)17-6-7-18-16-5-4-14-12-15(23)8-10-20(14,2)19(16)9-11-21(17,18)3/h4-5,12,16-19H,6-11H2,1-3H3/t16-,17+,18-,19+,20+,21+/m0/s1;   InChIKey=JGMOKGBVKVMRFX-HQZYFCCVSA-N;   Isopregnenone;   Retro-6-dehydroprogesterone;   SMILES=[H][C@@]12CC[C@H](C(C)=O)[C@@]1(C)CC[C@]1([H])[C@@]2([H])C=CC2=CC(=O)CC[C@@]12C;   delta(6)-Retroprogesterone;   delta(sup 6)-Retroprogesterone;   didrogesterona;   dydrogesteronum
 xref: Beilstein:3121425;   CAS:152-62-5;   DrugBank:DB00378;   Drug_Central:975;   KEGG:D01217
 xref_mesh: MESH:D004394
 xref: Wikipedia:Dydrogesterone


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dydrogesterone term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Akr1c1 aldo-keto reductase family 1, member C1 increases expression
increases metabolic processing
decreases activity
decreases expression		 ISO Dydrogesterone results in increased expression of AKR1C1 mRNA
AKR1C1 protein results in increased metabolism of Dydrogesterone
Dydrogesterone results in decreased activity of AKR1C1 protein
Dydrogesterone results in decreased expression of AKR1C1 mRNA		 CTD PMID:21182831 PMID:23183084 NCBI chr17:65,810,474...65,837,385
Ensembl chr17:65,810,475...65,837,326 		JBrowse link
G Akr1c2 aldo-keto reductase family 1, member C2 decreases activity
decreases expression		 ISO Dydrogesterone results in decreased activity of AKR1C2 protein
Dydrogesterone results in decreased expression of AKR1C2 mRNA		 CTD PMID:22245609 PMID:23183084 NCBI chr17:65,759,778...65,808,013
Ensembl chr17:65,759,788...65,775,764 		JBrowse link
G Akr1c3 aldo-keto reductase family 1, member C3 decreases activity
decreases expression		 ISO Dydrogesterone results in decreased activity of AKR1C3 protein
Dydrogesterone results in decreased expression of AKR1C3 mRNA		 CTD PMID:21182831 PMID:23183084 NCBI chr17:66,110,970...66,127,867
Ensembl chr17:66,110,963...66,127,873 		JBrowse link
G Edn1 endothelin 1 multiple interactions ISO Dydrogesterone affects the reaction [Estradiol results in decreased expression of EDN1 protein] CTD PMID:12385860 NCBI chr17:22,454,924...22,460,812
Ensembl chr17:22,454,420...22,460,885 		JBrowse link
G Hsd17b2 hydroxysteroid (17-beta) dehydrogenase 2 decreases expression
increases expression		 ISO Dydrogesterone results in decreased expression of HSD17B2 mRNA
Dydrogesterone results in increased expression of HSD17B2 protein		 CTD PMID:23183084 NCBI chr19:45,753,576...45,825,203
Ensembl chr19:45,753,574...45,825,202 		JBrowse link
G Ifng interferon gamma decreases expression
multiple interactions		 ISO Dydrogesterone results in decreased expression of IFNG protein
Mifepristone inhibits the reaction [Dydrogesterone results in decreased expression of IFNG protein]		 CTD PMID:16045524 NCBI chr 7:53,903,339...53,907,375
Ensembl chr 7:53,903,337...53,907,375 		JBrowse link
G Il10 interleukin 10 increases expression ISO Dydrogesterone results in increased expression of IL10 protein CTD PMID:16389545 NCBI chr13:42,472,625...42,477,308
Ensembl chr13:42,472,839...42,477,313 		JBrowse link
G Il4 interleukin 4 increases expression
multiple interactions		 ISO Dydrogesterone results in increased expression of IL4 protein
Mifepristone inhibits the reaction [Dydrogesterone results in increased expression of IL4 protein]		 CTD PMID:16045524 PMID:16389545 NCBI chr10:37,771,203...37,776,750
Ensembl chr10:37,771,203...37,776,750 		JBrowse link
G Il6 interleukin 6 increases expression
multiple interactions		 ISO Dydrogesterone results in increased expression of IL6 protein
Mifepristone inhibits the reaction [Dydrogesterone results in increased expression of IL6 protein]		 CTD PMID:16045524 NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178 		JBrowse link
G Pgr progesterone receptor affects activity
decreases expression		 ISO Dydrogesterone affects the activity of PGR protein
Dydrogesterone results in decreased expression of PGR mRNA		 CTD PMID:16045524 PMID:23183084 NCBI chr 8:6,072,673...6,131,552
Ensembl chr 8:6,072,673...6,131,344 		JBrowse link
G Pibf1 progesterone immunomodulatory binding factor 1 affects expression
increases expression		 ISO Dydrogesterone affects the expression of PIBF1 protein
Dydrogesterone results in increased expression of PIBF1 protein		 CTD PMID:15760377 PMID:16045524 NCBI chr15:75,850,389...76,019,711
Ensembl chr15:75,850,624...76,019,712 		JBrowse link
G Srd5a1 steroid 5 alpha-reductase 1 decreases expression ISO Dydrogesterone results in decreased expression of SRD5A1 mRNA CTD PMID:23183084 NCBI chr 1:33,686,069...33,720,468
Ensembl chr 1:33,686,391...33,720,461 		JBrowse link
G Tacr1 tachykinin receptor 1 decreases expression ISO Dydrogesterone results in decreased expression of TACR1 protein CTD PMID:16389545 NCBI chr 4:114,920,844...115,089,733
Ensembl chr 4:114,920,844...115,089,733 		JBrowse link
G Tnf tumor necrosis factor decreases expression
multiple interactions		 ISO Dydrogesterone results in decreased expression of TNF protein
Mifepristone inhibits the reaction [Dydrogesterone results in decreased expression of TNF protein]		 CTD PMID:16045524 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19834
    chemical entity 19832
      group 19791
        organic group 18957
          3-oxo-Delta(4)-steroid group 9173
            3-oxo-Delta(4) steroid 9173
              dydrogesterone 14
Path 2
Term Annotations click to browse term
  CHEBI ontology 19834
    subatomic particle 19832
      composite particle 19832
        hadron 19832
          baryon 19832
            nucleon 19832
              atomic nucleus 19832
                atom 19832
                  main group element atom 19782
                    p-block element atom 19782
                      carbon group element atom 19731
                        carbon atom 19727
                          organic molecular entity 19727
                            heteroorganic entity 19484
                              organochalcogen compound 19248
                                organooxygen compound 19165
                                  carbonyl compound 18890
                                    ketone 17186
                                      oxo steroid 10544
                                        3-oxo steroid 9933
                                          3-oxo-Delta(4) steroid 9173
                                            dydrogesterone 14
paths to the root