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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:2-Hydroxy-6-(8,11,14-pentadecatrienyl)benzoic acid
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Accession:CHEBI:174627 term browser browse the term
Synonyms:exact_synonym: 2-hydroxy-6-[(8E,11E)-pentadeca-8,11,14-trienyl]benzoic acid
 related_synonym: Formula=C22H30O3;   InChI=1S/C22H30O3/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-16-19-17-15-18-20(23)21(19)22(24)25/h2,4-5,7-8,15,17-18,23H,1,3,6,9-14,16H2,(H,24,25)/b5-4+,8-7+;   InChIKey=QUVGEKPNSCFQIR-AOSYACOCSA-N;   SMILES=OC=1C(=C(CCCCCCC/C=C/C/C=C/CC=C)C=CC1)C(O)=O
 xref: CAS:18654-18-7;   Chemspider:4534900;   HMDB:HMDB0031059
 xref_mesh: MESH:C088115



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2-Hydroxy-6-(8,11,14-pentadecatrienyl)benzoic acid term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bcl2 BCL2, apoptosis regulator multiple interactions ISO anacardic acid inhibits the reaction [TNF protein results in increased expression of BCL2 protein] CTD PMID:18349320 NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743
Ensembl chr13:22,684,989...22,853,743
JBrowse link
G Bcl2l1 Bcl2-like 1 multiple interactions ISO anacardic acid inhibits the reaction [TNF protein results in increased expression of BCL2L1 protein] CTD PMID:18349320 NCBI chr 3:141,253,508...141,304,582
Ensembl chr 3:141,253,523...141,303,479
JBrowse link
G Bdnf brain-derived neurotrophic factor multiple interactions ISO anacardic acid inhibits the reaction [Dronabinol results in increased expression of BDNF mRNA] CTD PMID:28481360 NCBI chr 3:96,165,042...96,215,621
Ensembl chr 3:96,165,042...96,215,615
JBrowse link
G Birc3 baculoviral IAP repeat-containing 3 multiple interactions ISO anacardic acid inhibits the reaction [TNF protein results in increased expression of BIRC3 protein] CTD PMID:18349320 NCBI chr 8:5,000,844...5,028,470
Ensembl chr 8:5,000,845...5,015,802
JBrowse link
G Birc5 baculoviral IAP repeat-containing 5 multiple interactions ISO anacardic acid inhibits the reaction [TNF protein results in increased expression of BIRC5 protein] CTD PMID:18349320 NCBI chr10:103,072,530...103,081,382
Ensembl chr10:103,073,408...103,081,380
JBrowse link
G Casp3 caspase 3 multiple interactions ISO [anacardic acid inhibits the reaction [Sodium Fluoride results in increased acetylation of TRP53 protein]] which results in decreased cleavage of CASP3 protein
[anacardic acid co-treated with TNF protein] results in increased cleavage of CASP3 protein
CTD PMID:18349320 PMID:31927229 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
JBrowse link
G Casp8 caspase 8 multiple interactions ISO [anacardic acid co-treated with TNF protein] results in increased cleavage of CASP8 protein CTD PMID:18349320 NCBI chr 9:60,263,863...60,312,542
Ensembl chr 9:60,264,075...60,312,542
JBrowse link
G Casp9 caspase 9 multiple interactions ISO [anacardic acid co-treated with TNF protein] results in increased cleavage of CASP9 protein CTD PMID:18349320 NCBI chr 5:154,108,872...154,126,628
Ensembl chr 5:154,109,046...154,126,626
JBrowse link
G Ccnd1 cyclin D1 multiple interactions ISO anacardic acid inhibits the reaction [TNF protein results in increased expression of CCND1 protein] CTD PMID:18349320 NCBI chr 1:200,089,002...200,098,524
Ensembl chr 1:200,089,002...200,098,602
JBrowse link
G Cflar CASP8 and FADD-like apoptosis regulator multiple interactions ISO anacardic acid inhibits the reaction [TNF protein results in increased expression of CFLAR protein] CTD PMID:18349320 NCBI chr 9:60,185,338...60,236,173
Ensembl chr 9:60,185,452...60,237,034
JBrowse link
G Crebbp CREB binding protein decreases activity ISO anacardic acid results in decreased activity of CREBBP protein CTD PMID:31927229 NCBI chr10:11,335,551...11,461,888
Ensembl chr10:11,335,953...11,461,888
JBrowse link
G Egf epidermal growth factor decreases response to substance ISO anacardic acid results in decreased susceptibility to EGF protein CTD PMID:18349320 NCBI chr 2:218,219,408...218,302,359
Ensembl chr 2:218,219,415...218,302,064
JBrowse link
G Ep300 E1A binding protein p300 multiple interactions
decreases expression
decreases activity
affects activity
EXP
ISO
anacardic acid inhibits the reaction [Phenylephrine results in increased expression of EP300 protein]
anacardic acid results in decreased expression of EP300 protein
anacardic acid results in decreased activity of EP300 protein
anacardic acid affects the activity of EP300 protein
CTD PMID:18349320 PMID:23297412 PMID:31927229 NCBI chr 7:113,108,476...113,178,529
Ensembl chr 7:113,106,247...113,136,088
Ensembl chr 7:113,106,247...113,136,088
JBrowse link
G Hmox1 heme oxygenase 1 multiple interactions EXP anacardic acid promotes the reaction [manganese chloride results in increased expression of HMOX1 mRNA] CTD PMID:29054681 NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079
JBrowse link
G Icam1 intercellular adhesion molecule 1 multiple interactions ISO anacardic acid inhibits the reaction [TNF protein results in increased expression of ICAM1 protein] CTD PMID:18349320 NCBI chr 8:19,553,063...19,565,438
Ensembl chr 8:19,553,645...19,565,438
JBrowse link
G Ifnl1 interferon, lambda 1 multiple interactions ISO anacardic acid inhibits the reaction [mono-(2-ethylhexyl)phthalate results in increased expression of IFNL1 mRNA] CTD PMID:37611859 NCBI chr 1:83,798,651...83,800,297
Ensembl chr 1:83,798,703...83,800,235
JBrowse link
G Il1b interleukin 1 beta decreases response to substance ISO anacardic acid results in decreased susceptibility to IL1B protein CTD PMID:18349320 NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415
JBrowse link
G Il33 interleukin 33 multiple interactions ISO anacardic acid inhibits the reaction [Diethylhexyl Phthalate results in increased expression of IL33 mRNA]; anacardic acid inhibits the reaction [mono-(2-ethylhexyl)phthalate results in increased expression of IL33 mRNA] CTD PMID:37545493 NCBI chr 1:227,701,964...227,736,374
Ensembl chr 1:227,721,435...227,736,373
JBrowse link
G Itgam integrin subunit alpha M multiple interactions ISO anacardic acid inhibits the reaction [Tretinoin results in increased expression of ITGAM] CTD PMID:24819975 NCBI chr 1:182,659,047...182,709,501
Ensembl chr 1:182,659,000...182,709,503
JBrowse link
G Kat2b lysine acetyltransferase 2B decreases activity ISO anacardic acid results in decreased activity of KAT2B protein CTD PMID:31927229 NCBI chr 9:6,562,525...6,667,064
Ensembl chr 9:6,562,288...6,667,064
JBrowse link
G Kl Klotho multiple interactions ISO anacardic acid inhibits the reaction [Dronabinol results in increased expression of KL mRNA] CTD PMID:28481360 NCBI chr12:490,402...531,417
Ensembl chr12:490,399...530,080
JBrowse link
G Map3k14 mitogen-activated protein kinase kinase kinase 14 decreases activity ISO anacardic acid results in decreased activity of MAP3K14 protein CTD PMID:18349320 NCBI chr10:88,165,349...88,215,558
Ensembl chr10:88,165,351...88,215,523
JBrowse link
G Map3k7 mitogen activated protein kinase kinase kinase 7 decreases activity ISO anacardic acid results in decreased activity of MAP3K7 protein CTD PMID:18349320 NCBI chr 5:46,356,973...46,415,597
Ensembl chr 5:46,357,931...46,415,597
JBrowse link
G Mmp2 matrix metallopeptidase 2 multiple interactions ISO anacardic acid binds to and results in decreased activity of MMP2 protein CTD PMID:22745359 NCBI chr19:14,154,657...14,182,870
Ensembl chr19:14,154,657...14,182,870
JBrowse link
G Mmp9 matrix metallopeptidase 9 multiple interactions ISO anacardic acid inhibits the reaction [TNF protein results in increased expression of MMP9 protein]
anacardic acid binds to and results in decreased activity of MMP9 protein
CTD PMID:18349320 PMID:22745359 NCBI chr 3:153,684,158...153,692,118
Ensembl chr 3:153,683,858...153,692,120
JBrowse link
G Myc MYC proto-oncogene, bHLH transcription factor multiple interactions ISO anacardic acid inhibits the reaction [TNF protein results in increased expression of MYC protein] CTD PMID:18349320 NCBI chr 7:93,593,705...93,598,633
Ensembl chr 7:93,593,705...93,598,630
JBrowse link
G Myh7 myosin heavy chain 7 multiple interactions EXP anacardic acid inhibits the reaction [Phenylephrine results in increased expression of MYH7 mRNA] CTD PMID:15593114 NCBI chr15:28,446,550...28,469,888
Ensembl chr15:28,446,550...28,468,217
JBrowse link
G Nfe2l2 NFE2 like bZIP transcription factor 2 increases expression
multiple interactions
EXP anacardic acid results in increased expression of NFE2L2 mRNA
[anacardic acid results in increased susceptibility to manganese chloride] which results in increased expression of NFE2L2 mRNA; anacardic acid inhibits the reaction [manganese chloride results in increased activity of NFE2L2 protein]; manganese chloride promotes the reaction [anacardic acid results in increased expression of NFE2L2 mRNA]
CTD PMID:29054681 NCBI chr 3:60,594,239...60,621,712
Ensembl chr 3:60,594,242...60,621,737
JBrowse link
G Nfkb1 nuclear factor kappa B subunit 1 multiple interactions ISO anacardic acid inhibits the reaction [TNF protein results in increased activity of [RELA protein binds to NFKB1 protein]] CTD PMID:18349320 NCBI chr 2:224,016,214...224,132,135
Ensembl chr 2:224,016,214...224,110,404
JBrowse link
G Nfkbia NFKB inhibitor alpha multiple interactions ISO anacardic acid inhibits the reaction [TNF protein results in increased degradation of NFKBIA protein]; anacardic acid inhibits the reaction [TNF protein results in increased phosphorylation of NFKBIA protein] CTD PMID:18349320 NCBI chr 6:72,858,713...72,861,941
Ensembl chr 6:72,858,712...72,861,941
JBrowse link
G Prkcd protein kinase C, delta multiple interactions EXP anacardic acid inhibits the reaction [Paraquat results in increased cleavage of and results in increased activity of PRKCD protein] CTD PMID:21777615 NCBI chr16:5,769,217...5,799,380
Ensembl chr16:5,769,215...5,799,352
JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 multiple interactions ISO anacardic acid inhibits the reaction [TNF protein results in increased expression of PTGS2 mRNA]; anacardic acid inhibits the reaction [TNF protein results in increased expression of PTGS2 protein] CTD PMID:18349320 NCBI chr13:62,163,936...62,172,193
Ensembl chr13:62,163,932...62,172,188
JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions ISO anacardic acid inhibits the reaction [TNF protein affects the localization of RELA protein]; anacardic acid inhibits the reaction [TNF protein results in increased acetylation of RELA protein]; anacardic acid inhibits the reaction [TNF protein results in increased activity of [RELA protein binds to NFKB1 protein]] CTD PMID:18349320 NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484
JBrowse link
G Runx2 RUNX family transcription factor 2 multiple interactions ISO anacardic acid inhibits the reaction [Tretinoin results in increased expression of RUNX2 mRNA] CTD PMID:24819975 NCBI chr 9:16,167,504...16,492,826
Ensembl chr 9:16,167,482...16,492,167
JBrowse link
G Sp7 Sp7 transcription factor multiple interactions ISO anacardic acid inhibits the reaction [Tretinoin results in increased expression of SP7 mRNA] CTD PMID:24819975 NCBI chr 7:133,484,609...133,494,788
Ensembl chr 7:133,484,609...133,494,847
JBrowse link
G Spp1 secreted phosphoprotein 1 multiple interactions ISO anacardic acid inhibits the reaction [Tretinoin results in increased expression of SPP1 mRNA] CTD PMID:24819975 NCBI chr14:5,308,885...5,315,120
Ensembl chr14:5,308,885...5,315,162
JBrowse link
G Syn1 synapsin I multiple interactions ISO anacardic acid affects the reaction [Dronabinol affects the expression of SYN1 protein] CTD PMID:28481360 NCBI chr  X:1,172,208...1,227,400
Ensembl chr  X:1,172,208...1,227,396
JBrowse link
G Tnf tumor necrosis factor multiple interactions
decreases response to substance
ISO [anacardic acid co-treated with TNF protein] results in increased cleavage of CASP3 protein; [anacardic acid co-treated with TNF protein] results in increased cleavage of CASP8 protein; [anacardic acid co-treated with TNF protein] results in increased cleavage of CASP9 protein; anacardic acid inhibits the reaction [4-octylphenol results in increased expression of and results in increased secretion of TNF protein]; anacardic acid inhibits the reaction [nonylphenol results in increased expression of and results in increased secretion of TNF protein]; anacardic acid inhibits the reaction [nonylphenol results in increased expression of TNF]; anacardic acid inhibits the reaction [TNF protein affects the localization of RELA protein]; anacardic acid inhibits the reaction [TNF protein results in increased acetylation of RELA protein]; anacardic acid inhibits the reaction [TNF protein results in increased activity of [RELA protein binds to NFKB1 protein]]; anacardic acid inhibits the reaction [TNF protein results in increased degradation of NFKBIA protein]; anacardic acid inhibits the reaction [TNF protein results in increased expression of BCL2 protein]; anacardic acid inhibits the reaction [TNF protein results in increased expression of BCL2L1 protein]; anacardic acid inhibits the reaction [TNF protein results in increased expression of BIRC3 protein]; anacardic acid inhibits the reaction [TNF protein results in increased expression of BIRC5 protein]; anacardic acid inhibits the reaction [TNF protein results in increased expression of CCND1 protein]; anacardic acid inhibits the reaction [TNF protein results in increased expression of CFLAR protein]; anacardic acid inhibits the reaction [TNF protein results in increased expression of ICAM1 protein]; anacardic acid inhibits the reaction [TNF protein results in increased expression of MMP9 protein]; anacardic acid inhibits the reaction [TNF protein results in increased expression of MYC protein]; anacardic acid inhibits the reaction [TNF protein results in increased expression of PTGS2 mRNA]; anacardic acid inhibits the reaction [TNF protein results in increased expression of PTGS2 protein]; anacardic acid inhibits the reaction [TNF protein results in increased expression of VEGFA protein]; anacardic acid inhibits the reaction [TNF protein results in increased expression of XIAP protein]; anacardic acid inhibits the reaction [TNF protein results in increased phosphorylation of NFKBIA protein]
anacardic acid results in decreased susceptibility to TNF protein
CTD PMID:18349320 PMID:20056579 PMID:24039973 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
JBrowse link
G Tp53 tumor protein p53 multiple interactions ISO anacardic acid inhibits the reaction [[Fluorouracil results in increased acetylation of TP53 protein mutant form] which results in increased expression of UBE2C protein]; anacardic acid inhibits the reaction [Genistein promotes the reaction [trichostatin A results in increased acetylation of TP53 protein]]
[anacardic acid inhibits the reaction [Sodium Fluoride results in increased acetylation of TRP53 protein]] which results in decreased cleavage of CASP3 protein; anacardic acid inhibits the reaction [Sodium Fluoride results in increased acetylation of TRP53 protein]
CTD PMID:26768552 PMID:27129209 PMID:31927229 NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524
JBrowse link
G Tradd TNFRSF1A-associated via death domain decreases activity ISO anacardic acid results in decreased activity of TRADD protein CTD PMID:18349320 NCBI chr19:33,136,148...33,142,714
Ensembl chr19:33,136,138...33,142,638
JBrowse link
G Traf2 Tnf receptor-associated factor 2 decreases activity ISO anacardic acid results in decreased activity of TRAF2 protein CTD PMID:18349320 NCBI chr 3:8,341,950...8,366,609
Ensembl chr 3:8,341,951...8,366,538
JBrowse link
G Ube2c ubiquitin-conjugating enzyme E2C multiple interactions ISO anacardic acid inhibits the reaction [[Fluorouracil results in increased acetylation of TP53 protein mutant form] which results in increased expression of UBE2C protein] CTD PMID:27129209 NCBI chr 3:153,506,636...153,509,036
Ensembl chr 3:153,506,636...153,513,339
JBrowse link
G Vegfa vascular endothelial growth factor A multiple interactions ISO anacardic acid inhibits the reaction [TNF protein results in increased expression of VEGFA protein] CTD PMID:18349320 NCBI chr 9:14,955,300...14,970,641
Ensembl chr 9:14,955,300...14,970,641
JBrowse link
G Xiap X-linked inhibitor of apoptosis multiple interactions ISO anacardic acid inhibits the reaction [TNF protein results in increased expression of XIAP protein] CTD PMID:18349320 NCBI chr  X:120,890,537...120,938,413
Ensembl chr  X:120,897,907...120,934,700
JBrowse link

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Term Annotations click to browse term
  CHEBI ontology 19834
    role 19810
      biological role 19808
        antimicrobial agent 18166
          antifungal agent 16862
            salicylic acid 1544
              2-Hydroxy-6-(8,11,14-pentadecatrienyl)benzoic acid 44
Path 2
Term Annotations click to browse term
  CHEBI ontology 19834
    subatomic particle 19832
      composite particle 19832
        hadron 19832
          baryon 19832
            nucleon 19832
              atomic nucleus 19832
                atom 19832
                  main group element atom 19782
                    p-block element atom 19782
                      carbon group element atom 19731
                        carbon atom 19727
                          organic molecular entity 19727
                            heteroorganic entity 19484
                              organochalcogen compound 19248
                                organooxygen compound 19165
                                  carbon oxoacid 18633
                                    carboxylic acid 18630
                                      aromatic carboxylic acid 12624
                                        benzoic acids 12601
                                          benzoic acid 5330
                                            hydroxybenzoic acid 4797
                                              monohydroxybenzoic acid 2612
                                                salicylic acid 1544
                                                  2-Hydroxy-6-(8,11,14-pentadecatrienyl)benzoic acid 44
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