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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:metoclopramide
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Accession:CHEBI:107736 term browser browse the term
Definition:A member of the class of benzamides resulting from the formal condensation of 4-amino-5-chloro-2-methoxybenzoic acid with the primary amino group of N,N-diethylethane-1,2-diamine.
Synonyms:related_synonym: 2-methoxy-4-amino-5-chloro-N,N-(dimethylaminoethyl)benzamide;   2-methoxy-5-chloroprocainamide;   4-amino-5-chloro-2-methoxy-N-(beta-diethylaminoethyl)benzamide;   4-amino-5-chloro-N-(2-(diethylamino)ethyl)-2-methoxybenzamide;   4-amino-5-chloro-N-(2-(diethylamino)ethyl)-o-anisamide;   Elieten;   Formula=C14H22ClN3O2;   InChI=1S/C14H22ClN3O2/c1-4-18(5-2)7-6-17-14(19)10-8-11(15)12(16)9-13(10)20-3/h8-9H,4-7,16H2,1-3H3,(H,17,19);   InChIKey=TTWJBBZEZQICBI-UHFFFAOYSA-N;   Reliveran;   SMILES=CCN(CC)CCNC(=O)c1cc(Cl)c(N)cc1OC;   metoclopramida;   metoclopramidum
 alt_id: CHEBI:6898
 xref: CAS:364-62-5;   DrugBank:DB01233;   Drug_Central:1782;   HMDB:HMDB0015363;   KEGG:C07868;   KEGG:D00726;   LINCS:LSM-3689
 xref_mesh: MESH:D008787
 xref: Patent:BE620543;   Patent:US3177252;   Reaxys:1884366;   VSDB:1821;   Wikipedia:Metoclopramide
 cyclic_relationship: is_conjugate_base_of CHEBI:61170


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metoclopramide term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb1a ATP binding cassette subfamily B member 1A affects response to substance ISO ABCB1A protein affects the susceptibility to Metoclopramide CTD PMID:15502009 NCBI chr 4:25,357,467...25,529,941
Ensembl chr 4:25,158,362...25,442,709 		JBrowse link
G Abcb1b ATP-binding cassette, sub-family B member 1B affects response to substance ISO ABCB1B protein affects the susceptibility to Metoclopramide CTD PMID:15502009 NCBI chr 4:25,242,761...25,325,194
Ensembl chr 4:25,242,798...25,325,199 		JBrowse link
G Ache acetylcholinesterase multiple interactions ISO Metoclopramide binds to and results in decreased activity of ACHE protein; Metoclopramide inhibits the reaction [mipafox binds to and results in decreased activity of ACHE protein]; Metoclopramide inhibits the reaction [mipafox results in decreased activity of ACHE protein]; Metoclopramide inhibits the reaction [Paraoxon binds to and results in decreased activity of ACHE protein]; Metoclopramide inhibits the reaction [Paraoxon results in decreased activity of ACHE protein] CTD PMID:12518340 PMID:14635269 PMID:15052610 PMID:16193528 NCBI chr12:19,406,133...19,413,713
Ensembl chr12:19,407,360...19,413,651 		JBrowse link
G Aldh1a2 aldehyde dehydrogenase 1 family, member A2 decreases expression ISO Metoclopramide results in decreased expression of ALDH1A2 mRNA CTD PMID:31711903 NCBI chr 8:71,877,850...71,957,107
Ensembl chr 8:71,877,850...71,957,107 		JBrowse link
G Amy2a3 amylase 2a3 multiple interactions EXP Metoclopramide inhibits the reaction [Apomorphine results in increased secretion of and results in increased activity of AMY1A protein] CTD PMID:21173550 NCBI chr 2:201,317,916...201,326,487
Ensembl chr 2:201,317,920...201,326,532 		JBrowse link
G Ar androgen receptor affects expression
multiple interactions
increases expression		 EXP Metoclopramide affects the expression of AR protein
[Metoclopramide results in decreased abundance of Testosterone] which results in decreased expression of AR protein
Metoclopramide results in increased expression of AR protein		 CTD PMID:14655152 PMID:16529173 PMID:16584088 NCBI chr  X:63,104,771...63,273,934
Ensembl chr  X:63,104,771...63,273,925 		JBrowse link
G Avp arginine vasopressin multiple interactions ISO Metoclopramide inhibits the reaction [Apomorphine results in increased expression of AVP protein] CTD PMID:16575035 NCBI chr 3:117,793,447...117,805,091
Ensembl chr 3:117,793,457...117,795,425 		JBrowse link
G Bche butyrylcholinesterase multiple interactions ISO Metoclopramide inhibits the reaction [mipafox binds to and results in decreased activity of BCHE protein]; Metoclopramide inhibits the reaction [Paraoxon binds to and results in decreased activity of BCHE protein] CTD PMID:12518340 PMID:15052610 NCBI chr 2:158,308,674...158,401,148
Ensembl chr 2:158,307,584...158,401,148 		JBrowse link
G Casp3 caspase 3 multiple interactions ISO Metoclopramide inhibits the reaction [Cisplatin results in increased activity of CASP3 protein]; Metoclopramide inhibits the reaction [Etoposide results in increased activity of CASP3 protein]; Metoclopramide inhibits the reaction [Malathion results in increased activity of and results in increased cleavage of CASP3 protein]; Metoclopramide inhibits the reaction [Paclitaxel results in increased activity of CASP3 protein]; Metoclopramide inhibits the reaction [Paraoxon results in increased activity of and results in increased cleavage of CASP3 protein]; Metoclopramide inhibits the reaction [TNF protein results in increased activity of CASP3 protein] CTD PMID:29027213 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648 		JBrowse link
G Chrm3 cholinergic receptor, muscarinic 3 multiple interactions
affects binding		 EXP [Metoclopramide binds to and results in decreased activity of CHRM3 protein] which results in decreased susceptibility to Carbachol; Metoclopramide inhibits the reaction [4-diphenylacetoxy-N-methylpiperidine methobromide binds to CHRM3 protein]
Metoclopramide binds to CHRM3 protein		 CTD PMID:15105209 NCBI chr17:60,005,137...60,467,250
Ensembl chr17:60,005,202...60,467,278 		JBrowse link
G Cxcl2 C-X-C motif chemokine ligand 2 multiple interactions ISO Metoclopramide inhibits the reaction [Indomethacin results in increased expression of CXCL2 mRNA] CTD PMID:21691039 NCBI chr14:17,181,030...17,183,075
Ensembl chr14:17,181,062...17,183,075 		JBrowse link
G Cxcl3 C-X-C motif chemokine ligand 3 multiple interactions ISO Metoclopramide inhibits the reaction [Indomethacin results in increased expression of CXCL1 mRNA] CTD PMID:21691039 NCBI chr14:17,287,727...17,289,451
Ensembl chr14:17,270,146...17,289,511 		JBrowse link
G Cyp1b1 cytochrome P450, family 1, subfamily b, polypeptide 1 decreases activity ISO Metoclopramide results in decreased activity of CYP1B1 protein CTD PMID:33814510 NCBI chr 6:15,342,312...15,350,886
Ensembl chr 6:15,342,344...15,350,917 		JBrowse link
G Cyp2d4 cytochrome P450, family 2, subfamily d, polypeptide 4 affects metabolic processing ISO CYP2D6 gene polymorphism affects the metabolism of Metoclopramide CTD PMID:16702617 NCBI chr 7:113,882,584...113,891,754
Ensembl chr 7:113,881,618...113,891,759 		JBrowse link
G Drd2 dopamine receptor D2 multiple interactions
affects binding
increases expression		 ISO
EXP		 Metoclopramide binds to and results in decreased activity of DRD2 protein
Metoclopramide binds to DRD2 protein
Metoclopramide results in increased expression of DRD2 protein		 CTD PMID:1930352 PMID:9808703 PMID:11561213 PMID:12130853 PMID:12593651 More... NCBI chr 8:49,708,927...49,772,876
Ensembl chr 8:49,708,927...49,772,875 		JBrowse link
G Esr1 estrogen receptor 1 multiple interactions ISO [Metoclopramide co-treated with Estradiol] results in decreased expression of ESR1 protein CTD PMID:11786374 NCBI chr 1:41,106,335...41,499,104
Ensembl chr 1:41,210,475...41,495,002 		JBrowse link
G Gcg glucagon increases secretion ISO Metoclopramide results in increased secretion of GCG protein CTD PMID:20829521 NCBI chr 3:47,113,914...47,122,958
Ensembl chr 3:47,113,914...47,122,929 		JBrowse link
G Gip gastric inhibitory polypeptide increases secretion ISO Metoclopramide results in increased secretion of GIP protein CTD PMID:20829521 NCBI chr10:80,968,360...80,976,506
Ensembl chr10:80,968,352...80,976,503 		JBrowse link
G Htr3a 5-hydroxytryptamine receptor 3A multiple interactions
decreases activity
affects binding		 ISO
EXP		 [Dexamethasone co-treated with Metoclopramide] results in decreased activity of HTR3A protein; [Methylprednisolone co-treated with Metoclopramide] results in decreased activity of HTR3A protein; Metoclopramide binds to and results in decreased activity of HTR3A protein; Metoclopramide inhibits the reaction [GR 65630 binds to HTR3A protein]
Metoclopramide results in decreased activity of HTR3A protein
Metoclopramide binds to HTR3A protein		 CTD PMID:12130853 PMID:12593651 PMID:15329590 PMID:16041395 PMID:17201744 NCBI chr 8:49,242,018...49,254,475
Ensembl chr 8:49,242,020...49,254,389 		JBrowse link
G Ins2 insulin 2 multiple interactions
increases expression		 ISO Dopamine promotes the reaction [Metoclopramide results in increased expression of INS protein] CTD PMID:18645345 NCBI chr 1:197,843,277...197,992,522
Ensembl chr 1:197,843,281...197,864,775 		JBrowse link
G Kcnh2 potassium voltage-gated channel subfamily H member 2 decreases activity ISO Metoclopramide results in decreased activity of KCNH2 protein CTD PMID:15640612 NCBI chr 4:10,826,834...10,859,009
Ensembl chr 4:10,826,928...10,859,008 		JBrowse link
G Lhb luteinizing hormone subunit beta increases expression ISO Metoclopramide results in increased expression of LHB protein CTD PMID:2880862 NCBI chr 1:95,898,269...95,901,973
Ensembl chr 1:95,900,984...95,901,972
Ensembl chr 1:95,900,984...95,901,972 		JBrowse link
G Mpo myeloperoxidase multiple interactions ISO Metoclopramide inhibits the reaction [Indomethacin results in increased activity of MPO protein] CTD PMID:21691039 NCBI chr10:72,594,883...72,608,862
Ensembl chr10:72,594,661...72,604,819 		JBrowse link
G Nos2 nitric oxide synthase 2 multiple interactions ISO Metoclopramide inhibits the reaction [Indomethacin results in increased expression of NOS2 mRNA] CTD PMID:21691039 NCBI chr10:63,815,308...63,851,208
Ensembl chr10:63,815,308...63,851,210 		JBrowse link
G Parp1 poly (ADP-ribose) polymerase 1 multiple interactions ISO Metoclopramide inhibits the reaction [Malathion results in increased cleavage of PARP1 protein]; Metoclopramide inhibits the reaction [Paraoxon results in increased cleavage of PARP1 protein] CTD PMID:29027213 NCBI chr13:92,307,593...92,339,406
Ensembl chr13:92,307,586...92,339,404 		JBrowse link
G Prl prolactin multiple interactions
affects expression
increases secretion
increases expression		 ISO
EXP		 Lisuride inhibits the reaction [Metoclopramide results in increased secretion of PRL protein]; Metoclopramide results in increased expression of and results in increased secretion of PRL protein
Metoclopramide affects the expression of PRL protein
Metoclopramide results in increased expression of PRL protein		 CTD PMID:386688 PMID:1304515 PMID:1304992 PMID:2635674 PMID:3962302 More... NCBI chr17:37,859,999...37,870,062
Ensembl chr17:37,860,007...37,870,062 		JBrowse link
G Prlr prolactin receptor increases expression ISO Metoclopramide results in increased expression of PRLR mRNA; Metoclopramide results in increased expression of PRLR mRNA alternative form CTD PMID:19304288 NCBI chr 2:59,134,147...59,324,719
Ensembl chr 2:59,134,588...59,324,718 		JBrowse link
G Slc22a2 solute carrier family 22 member 2 multiple interactions ISO Metoclopramide inhibits the reaction [SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium] CTD PMID:21599003 NCBI chr 1:48,121,061...48,163,268
Ensembl chr 1:48,121,061...48,163,268 		JBrowse link
G Srd5a1 steroid 5 alpha-reductase 1 increases expression EXP Metoclopramide results in increased expression of SRD5A1 mRNA CTD PMID:18978642 NCBI chr 1:33,686,069...33,720,468
Ensembl chr 1:33,686,391...33,720,461 		JBrowse link
G Srd5a2 steroid 5 alpha-reductase 2 increases expression EXP Metoclopramide results in increased expression of SRD5A2 mRNA CTD PMID:18978642 NCBI chr 6:21,426,225...21,465,727
Ensembl chr 6:21,426,215...21,462,112 		JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO Metoclopramide inhibits the reaction [TNF protein results in increased activity of CASP3 protein] CTD PMID:29027213 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629 		JBrowse link
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  CHEBI ontology 19838
    role 19814
      biological role 19812
        xenobiotic 18738
          metoclopramide 31
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  CHEBI ontology 19838
    subatomic particle 19836
      composite particle 19836
        hadron 19836
          baryon 19836
            nucleon 19836
              atomic nucleus 19836
                atom 19836
                  main group element atom 19786
                    p-block element atom 19786
                      carbon group element atom 19734
                        carbon atom 19731
                          organic molecular entity 19731
                            heteroorganic entity 19488
                              organochalcogen compound 19251
                                organooxygen compound 19168
                                  carbon oxoacid 18637
                                    carboxylic acid 18634
                                      carboacyl group 17696
                                        univalent carboacyl group 17696
                                          carbamoyl group 17546
                                            carboxamide 17546
                                              monocarboxylic acid amide 15681
                                                arenecarboxamide 8249
                                                  benzamides 8249
                                                    metoclopramide 31
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