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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:quinapril hydrochloride
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Accession:CHEBI:8714 term browser browse the term
Definition:A hydrochloride resulting from the reaction of equimolar amounts of quinapril and hydrogen chloride. A prodrug for quinaprilat hydrochloride (by hydrolysis of the ethyl ester to the corresponding carboxylic acid), it is used as an angiotensin-converting enzyme inhibitor (ACE inhibitor) for the treatment of hypertension and congestive heart failure.
Synonyms:exact_synonym: (3S)-2-[(2S)-2-{[(2S)-1-ethoxy-1-oxo-4-phenylbutan-2-yl]amino}propanoyl]-1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid hydrochloride;   (3S)-2-{(2S)-2-[(1S)-1-ethoxycarbonyl-3-phenylpropylamino]propanoyl}-1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid hydrochloride;   (3S)-2-{N-[(2S)-1-ethoxy-1-oxo-4-phenylbutan-2-yl]-L-alanyl}-1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid hydrochloride
 related_synonym: Accupril;   Accuprin;   Accupro;   Acequin;   Acuitel;   CI-906;   Formula=C25H30N2O5.HCl;   Formula=C25H31ClN2O5;   Hemokvin;   InChI=1S/C25H30N2O5.ClH/c1-3-32-25(31)21(14-13-18-9-5-4-6-10-18)26-17(2)23(28)27-16-20-12-8-7-11-19(20)15-22(27)24(29)30;/h4-12,17,21-22,26H,3,13-16H2,1-2H3,(H,29,30);1H/t17-,21-,22-;/m0./s1;   InChIKey=IBBLRJGOOANPTQ-JKVLGAQCSA-N;   Korec;   Quinazil;   SMILES=C1C2=C(C[C@H](N1C([C@@H](N[C@H](C(OCC)=O)CCC=3C=CC=CC3)C)=O)C(O)=O)C=CC=C2.Cl
 xref: Beilstein:5699760;   CAS:82586-55-8;   Drug_Central:2340;   KEGG:C07340;   KEGG:D00459
 xref_mesh: MESH:C041125
 xref: PMID:12749406;   PMID:16193811;   PMID:24081473;   PMID:29310224;   PMID:8959644;   Patent:US7482361;   Patent:WO2004087671


show annotations for term's descendants           Sort by:
quinapril hydrochloride term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ace angiotensin I converting enzyme decreases activity EXP
ISO		 Quinapril results in decreased activity of ACE protein CTD PMID:8227822 PMID:15728788 NCBI chr10:90,910,316...90,930,437
Ensembl chr10:90,910,316...90,931,131 		JBrowse link
G Adm adrenomedullin decreases expression EXP Quinapril results in decreased expression of ADM protein CTD PMID:10334802 NCBI chr 1:164,745,484...164,747,655
Ensembl chr 1:164,745,466...164,747,654 		JBrowse link
G Agt angiotensinogen decreases activity
multiple interactions		 EXP Quinapril results in decreased activity of AGT protein
Quinapril inhibits the reaction [Isoproterenol results in increased expression of AGT protein]; Quinapril promotes the reaction [Isoproterenol results in increased expression of AGT protein]		 CTD PMID:11709406 PMID:15728788 NCBI chr19:52,529,139...52,549,618
Ensembl chr19:52,529,185...52,540,977 		JBrowse link
G Cxcl10 C-X-C motif chemokine ligand 10 decreases expression EXP Quinapril results in decreased expression of CXCL10 CTD PMID:15831368 NCBI chr14:15,704,772...15,706,969
Ensembl chr14:15,704,758...15,706,975 		JBrowse link
G Cyp2j4 cytochrome P450, family 2, subfamily j, polypeptide 4 decreases activity ISO Quinapril results in decreased activity of CYP2J2 protein CTD PMID:30965050 NCBI chr 5:111,179,981...111,207,490
Ensembl chr 5:111,178,703...111,244,794 		JBrowse link
G Edn1 endothelin 1 decreases expression ISO Quinapril results in decreased expression of EDN1; Quinapril results in decreased expression of EDN1 protein CTD PMID:12149661 PMID:12425201 NCBI chr17:22,454,924...22,460,812
Ensembl chr17:22,454,420...22,460,885 		JBrowse link
G F2 coagulation factor II, thrombin decreases activity ISO Quinapril results in decreased activity of F2 protein CTD PMID:16907931 NCBI chr 3:77,596,196...77,609,486
Ensembl chr 3:77,596,198...77,609,486 		JBrowse link
G F5 coagulation factor V decreases activity ISO Quinapril results in decreased activity of F5 protein CTD PMID:16907931 NCBI chr13:76,513,509...76,583,106
Ensembl chr13:76,513,255...76,582,317 		JBrowse link
G Fos Fos proto-oncogene, AP-1 transcription factor subunit increases expression EXP Quinapril results in increased expression of FOS mRNA CTD PMID:8539265 NCBI chr 6:105,121,170...105,124,036
Ensembl chr 6:105,121,170...105,124,036 		JBrowse link
G Il6 interleukin 6 multiple interactions EXP [Tacrolimus co-treated with Quinapril] results in decreased expression of IL6 protein; [Tacrolimus co-treated with Quinapril] results in increased expression of IL6 protein CTD PMID:16549154 NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178 		JBrowse link
G Myc MYC proto-oncogene, bHLH transcription factor increases expression EXP Quinapril results in increased expression of MYC mRNA CTD PMID:8539265 NCBI chr 7:93,593,705...93,598,633
Ensembl chr 7:93,593,705...93,598,630 		JBrowse link
G Nos3 nitric oxide synthase 3 affects expression EXP Quinapril affects the expression of NOS3 mRNA CTD PMID:12176110 NCBI chr 4:10,793,834...10,814,170
Ensembl chr 4:10,793,834...10,814,166 		JBrowse link
G Nppa natriuretic peptide A increases expression
increases secretion		 EXP Quinapril results in increased expression of NPPA mRNA; Quinapril results in increased expression of NPPA protein
Quinapril results in increased secretion of NPPA protein		 CTD PMID:14639023 NCBI chr 5:158,429,042...158,430,351
Ensembl chr 5:158,429,042...158,430,351 		JBrowse link
G Pthlh parathyroid hormone-like hormone multiple interactions EXP Quinapril inhibits the reaction [Folic Acid results in increased expression of PTHLH mRNA]; Quinapril inhibits the reaction [Folic Acid results in increased expression of PTHLH protein] CTD PMID:15728788 NCBI chr 4:180,188,792...180,199,847
Ensembl chr 4:180,188,792...180,199,847 		JBrowse link
G Ren renin multiple interactions
increases expression		 EXP Quinapril promotes the reaction [Isoproterenol results in increased expression of REN protein]
Quinapril results in increased expression of REN protein		 CTD PMID:10334802 PMID:11709406 NCBI chr13:44,796,260...44,807,491
Ensembl chr13:44,796,091...44,807,489 		JBrowse link
G Slc15a1 solute carrier family 15 member 1 multiple interactions ISO Quinapril inhibits the reaction [SLC15A1 protein results in increased uptake of glycylsarcosine] CTD PMID:18713951 NCBI chr15:98,537,641...98,582,544
Ensembl chr15:98,537,641...98,582,545 		JBrowse link
G Slc15a2 solute carrier family 15 member 2 multiple interactions EXP
ISO		 Quinapril inhibits the reaction [SLC15A2 protein results in increased uptake of glycylsarcosine] CTD PMID:18713951 NCBI chr11:64,014,182...64,043,228
Ensembl chr11:64,014,182...64,043,225 		JBrowse link
G Tgfb1 transforming growth factor, beta 1 multiple interactions EXP [Tacrolimus co-treated with Quinapril] results in increased expression of TGFB1 protein CTD PMID:16549154 NCBI chr 1:81,196,532...81,212,848
Ensembl chr 1:81,196,532...81,212,847 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19808
    role 19784
      application 19627
        pharmaceutical 19468
          drug 19468
            cardiovascular drug 8613
              antihypertensive agent 1943
                quinapril hydrochloride 18
Path 2
Term Annotations click to browse term
  CHEBI ontology 19808
    subatomic particle 19806
      composite particle 19806
        hadron 19806
          baryon 19806
            nucleon 19806
              atomic nucleus 19806
                atom 19806
                  main group element atom 19756
                    main group molecular entity 19756
                      s-block molecular entity 19595
                        hydrogen molecular entity 19582
                          hydrides 19095
                            inorganic hydride 18093
                              pnictogen hydride 18082
                                nitrogen hydride 17989
                                  ammonium 8298
                                    ammonium ion derivative 8293
                                      quinapril(1+) 18
                                        quinapril hydrochloride 18
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