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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:ortho-Aminoazotoluene
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Accession:CHEBI:82285 term browser browse the term
Definition:An azobenzene that has formula C14H15N3.
Synonyms:related_synonym: C.I. Solvent Yellow 3;   Formula=C14H15N3;   InChI=1S/C14H15N3/c1-10-5-3-4-6-14(10)17-16-12-7-8-13(15)11(2)9-12/h3-9H,15H2,1-2H3/b17-16+;   InChIKey=PFRYFZZSECNQOL-WUKNDPDISA-N;   SMILES=Cc1ccccc1\\N=N\\c1ccc(N)c(C)c1
 xref: CAS:97-56-3;   KEGG:C19188
 xref_mesh: MESH:D009762


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ortho-Aminoazotoluene term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcc2 ATP binding cassette subfamily C member 2 multiple interactions
increases expression		 ISO NR1I3 gene mutant form inhibits the reaction [o-Aminoazotoluene results in increased expression of ABCC2 mRNA] CTD PMID:21672546 NCBI chr 1:242,664,657...242,723,239
Ensembl chr 1:242,664,657...242,723,238 		JBrowse link
G Abcc4 ATP binding cassette subfamily C member 4 multiple interactions
increases expression		 ISO NR1I3 gene mutant form inhibits the reaction [o-Aminoazotoluene results in increased expression of ABCC4 mRNA] CTD PMID:21672546 NCBI chr15:95,541,186...95,774,898
Ensembl chr15:95,542,315...95,774,283 		JBrowse link
G Ahr aryl hydrocarbon receptor multiple interactions ISO AHR protein affects the reaction [o-Aminoazotoluene affects the expression of CYP1A1 mRNA] CTD PMID:12700417 NCBI chr 6:52,234,089...52,271,568
Ensembl chr 6:52,234,089...52,271,568 		JBrowse link
G Bax BCL2 associated X, apoptosis regulator increases expression ISO o-Aminoazotoluene results in increased expression of BAX mRNA CTD PMID:15346788 NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368 		JBrowse link
G Ccng1 cyclin G1 increases expression ISO o-Aminoazotoluene results in increased expression of CCNG1 mRNA CTD PMID:15346788 NCBI chr10:25,176,231...25,182,604
Ensembl chr10:25,176,234...25,181,641 		JBrowse link
G Cdkn1a cyclin-dependent kinase inhibitor 1A increases expression ISO o-Aminoazotoluene results in increased expression of CDKN1A mRNA CTD PMID:15346788 NCBI chr20:7,149,177...7,159,727
Ensembl chr20:7,149,217...7,159,585 		JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 multiple interactions
increases activity
increases expression		 ISO AHR protein affects the reaction [o-Aminoazotoluene affects the expression of CYP1A1 mRNA]
o-Aminoazotoluene results in increased activity of CYP1A1 protein
o-Aminoazotoluene results in increased expression of CYP1A1 mRNA		 CTD PMID:10887293 PMID:12700417 PMID:14562683 PMID:15863256 NCBI chr 8:58,096,021...58,102,130
Ensembl chr 8:58,096,077...58,102,125 		JBrowse link
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 increases activity
increases expression		 ISO o-Aminoazotoluene results in increased activity of CYP1A2 protein
o-Aminoazotoluene results in increased expression of CYP1A2 mRNA		 CTD PMID:10887293 PMID:14562683 PMID:15863256 NCBI chr 8:58,075,367...58,082,255
Ensembl chr 8:58,075,367...58,082,312 		JBrowse link
G Cyp2b3 cytochrome P450, family 2, subfamily b, polypeptide 3 increases expression
multiple interactions		 ISO o-Aminoazotoluene results in increased expression of CYP2B10 mRNA; o-Aminoazotoluene results in increased expression of CYP2B10 protein
NR1I3 gene mutant form inhibits the reaction [o-Aminoazotoluene results in increased expression of CYP2B10 mRNA]; NR1I3 gene mutant form inhibits the reaction [o-Aminoazotoluene results in increased expression of CYP2B10 protein]		 CTD PMID:21672546 NCBI chr 1:81,652,762...81,732,153
Ensembl chr 1:81,652,787...81,732,143 		JBrowse link
G Cyp2c6 cytochrome P450, family 2, subfamily C, polypeptide 6 increases expression
multiple interactions		 ISO o-Aminoazotoluene results in increased expression of CYP2C29 mRNA
NR1I3 gene mutant form inhibits the reaction [o-Aminoazotoluene results in increased expression of CYP2C29 mRNA]		 CTD PMID:21672546 NCBI chr 1:237,938,521...237,976,238
Ensembl chr 1:237,693,094...238,057,596 		JBrowse link
G Foxa3 forkhead box A3 decreases activity ISO o-Aminoazotoluene results in decreased activity of FOXA3 protein CTD PMID:11398193 NCBI chr 1:78,662,067...78,672,321
Ensembl chr 1:78,662,431...78,672,155 		JBrowse link
G Mdm2 MDM2 proto-oncogene increases expression ISO o-Aminoazotoluene results in increased expression of MDM2 mRNA CTD PMID:15346788 NCBI chr 7:53,290,660...53,315,205
Ensembl chr 7:53,290,664...53,314,915 		JBrowse link
G Myc MYC proto-oncogene, bHLH transcription factor multiple interactions
increases expression		 ISO NR1I3 gene mutant form inhibits the reaction [o-Aminoazotoluene results in increased expression of MYC mRNA]; NR1I3 gene mutant form inhibits the reaction [o-Aminoazotoluene results in increased expression of MYC protein]
o-Aminoazotoluene results in increased expression of MYC mRNA; o-Aminoazotoluene results in increased expression of MYC protein		 CTD PMID:21672546 NCBI chr 7:93,593,705...93,598,633
Ensembl chr 7:93,593,705...93,598,630 		JBrowse link
G Nr1i3 nuclear receptor subfamily 1, group I, member 3 multiple interactions
increases response to substance
increases activity		 ISO NR1I3 gene mutant form inhibits the reaction [o-Aminoazotoluene results in increased expression of ABCC2 mRNA]; NR1I3 gene mutant form inhibits the reaction [o-Aminoazotoluene results in increased expression of ABCC4 mRNA]; NR1I3 gene mutant form inhibits the reaction [o-Aminoazotoluene results in increased expression of CYP2B10 mRNA]; NR1I3 gene mutant form inhibits the reaction [o-Aminoazotoluene results in increased expression of CYP2B10 protein]; NR1I3 gene mutant form inhibits the reaction [o-Aminoazotoluene results in increased expression of CYP2C29 mRNA]; NR1I3 gene mutant form inhibits the reaction [o-Aminoazotoluene results in increased expression of CYP3A11 mRNA]; NR1I3 gene mutant form inhibits the reaction [o-Aminoazotoluene results in increased expression of MYC mRNA]; NR1I3 gene mutant form inhibits the reaction [o-Aminoazotoluene results in increased expression of MYC protein]; NR1I3 gene mutant form inhibits the reaction [o-Aminoazotoluene results in increased expression of UGT1A1 mRNA]
NR1I3 protein results in increased susceptibility to o-Aminoazotoluene
o-Aminoazotoluene results in increased activity of NR1I3 protein		 CTD PMID:21672546 NCBI chr13:83,632,940...83,638,193
Ensembl chr13:83,632,899...83,637,906 		JBrowse link
G Tat tyrosine aminotransferase multiple interactions ISO o-Aminoazotoluene inhibits the reaction [Dexamethasone results in increased expression of TAT mRNA]; o-Aminoazotoluene inhibits the reaction [Glucocorticoids results in increased expression of TAT mRNA]; o-Aminoazotoluene inhibits the reaction [Hydrocortisone results in increased activity of TAT protein] CTD PMID:11443928 PMID:12882633 PMID:16267830 NCBI chr19:37,947,153...37,957,717
Ensembl chr19:37,947,112...37,958,031 		JBrowse link
G Tp53 tumor protein p53 increases expression ISO o-Aminoazotoluene results in increased expression of TRP53 mRNA CTD PMID:15346788 NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524 		JBrowse link
G Ugt1a1 UDP glucuronosyltransferase family 1 member A1 multiple interactions
increases expression		 ISO NR1I3 gene mutant form inhibits the reaction [o-Aminoazotoluene results in increased expression of UGT1A1 mRNA] CTD PMID:21672546 NCBI chr 9:88,801,344...88,808,465
Ensembl chr 9:88,713,184...88,808,465 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19841
    chemical entity 19839
      group 19798
        inorganic group 19393
          azo group 279
            azo compound 279
              azobenzenes 244
                ortho-Aminoazotoluene 17
Path 2
Term Annotations click to browse term
  CHEBI ontology 19841
    subatomic particle 19839
      composite particle 19839
        hadron 19839
          baryon 19839
            nucleon 19839
              atomic nucleus 19839
                atom 19839
                  main group element atom 19789
                    main group molecular entity 19789
                      s-block molecular entity 19626
                        hydrogen molecular entity 19613
                          hydrides 19120
                            inorganic hydride 18118
                              pnictogen hydride 18107
                                nitrogen hydride 18014
                                  diazene 280
                                    azo group 279
                                      azo compound 279
                                        azobenzenes 244
                                          ortho-Aminoazotoluene 17
paths to the root