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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:anti-estrogen
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Accession:CHEBI:50751 term browser browse the term
Definition:A drug which acts to reduce estrogenic activity in the body, either by reducing the amount of estrogen or by reducing the activity of whatever estrogen is present.
Synonyms:related_synonym: anti-estrogenic agent;   anti-estrogenic drug;   anti-oestrogen;   anti-oestrogenic agent;   anti-oestrogenic drug;   antiestrogen;   antiestrogenic agent;   antiestrogenic drug;   antioestrogen;   antioestrogenic agent;   antioestrogenic drug
 xref: Wikipedia:Antiestrogen


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danazol term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb11 ATP binding cassette subfamily B member 11 decreases activity ISO Danazol results in decreased activity of ABCB11 protein CTD PMID:23956101 NCBI chr 3:54,016,854...54,112,797
Ensembl chr 3:54,017,127...54,112,730 		JBrowse link
G Ace2 angiotensin converting enzyme 2 decreases expression ISO
EXP		 Danazol results in decreased expression of ACE2 mRNA CTD PMID:32808185 NCBI chr  X:30,293,597...30,340,961
Ensembl chr  X:30,293,589...30,340,977 		JBrowse link
G Ar androgen receptor increases activity
multiple interactions		 ISO Danazol results in increased activity of AR protein
Danazol binds to and results in decreased activity of AR protein; Danazol binds to and results in increased activity of AR protein		 CTD PMID:12730620 PMID:21543282 PMID:25752796 NCBI chr  X:63,104,771...63,273,934
Ensembl chr  X:63,104,771...63,273,925 		JBrowse link
G C3 complement C3 increases expression ISO Danazol results in increased expression of C3 protein CTD PMID:4014294 NCBI chr 9:2,087,437...2,114,366
Ensembl chr 9:2,087,437...2,114,429 		JBrowse link
G Cdkn1a cyclin-dependent kinase inhibitor 1A increases expression ISO Danazol results in increased expression of CDKN1A protein CTD PMID:27358234 NCBI chr20:7,149,177...7,159,727
Ensembl chr20:7,149,217...7,159,585 		JBrowse link
G Cfb complement factor B increases expression ISO Danazol results in increased expression of CFB protein CTD PMID:4014294 NCBI chr20:3,970,643...3,976,510
Ensembl chr20:3,951,474...3,976,505 		JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 decreases activity ISO Danazol results in decreased activity of CYP1A1 protein CTD PMID:33814510 NCBI chr 8:58,096,021...58,102,130
Ensembl chr 8:58,096,077...58,102,125 		JBrowse link
G Cyp2j4 cytochrome P450, family 2, subfamily j, polypeptide 4 decreases activity ISO Danazol results in decreased activity of CYP2J2 protein CTD PMID:29689254 PMID:30965050 NCBI chr 5:111,179,981...111,207,490
Ensembl chr 5:111,178,703...111,244,794 		JBrowse link
G Esr1 estrogen receptor 1 multiple interactions ISO Danazol binds to and results in increased activity of ESR1 protein CTD PMID:25752796 NCBI chr 1:41,106,335...41,499,104
Ensembl chr 1:41,210,475...41,495,002 		JBrowse link
G Fshb follicle stimulating hormone subunit beta decreases expression EXP Danazol results in decreased expression of FSHB protein CTD PMID:3088269 NCBI chr 3:93,548,560...93,552,370
Ensembl chr 3:93,548,560...93,552,370 		JBrowse link
G Hsd11b2 hydroxysteroid 11-beta dehydrogenase 2 decreases activity
multiple interactions		 ISO Danazol results in decreased activity of HSD11B2 protein
Danazol inhibits the reaction [HSD11B2 protein results in decreased activity of Glucocorticoids]		 CTD PMID:22273746 NCBI chr19:33,397,656...33,402,899
Ensembl chr19:33,397,656...33,402,899 		JBrowse link
G Il10 interleukin 10 multiple interactions EXP [peginterferon alfa-2a co-treated with Ribavirin co-treated with Danazol] results in decreased expression of IL10 mRNA CTD PMID:18007553 NCBI chr13:42,472,625...42,477,308
Ensembl chr13:42,472,839...42,477,313 		JBrowse link
G Il6 interleukin 6 multiple interactions EXP [peginterferon alfa-2a co-treated with Ribavirin co-treated with Danazol] results in decreased expression of IL6 mRNA CTD PMID:18007553 NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178 		JBrowse link
G Lhb luteinizing hormone subunit beta decreases expression EXP Danazol results in decreased expression of LHB protein CTD PMID:3088269 NCBI chr 1:95,898,269...95,901,973
Ensembl chr 1:95,900,984...95,901,972
Ensembl chr 1:95,900,984...95,901,972 		JBrowse link
G Nfkb1 nuclear factor kappa B subunit 1 multiple interactions ISO Danazol inhibits the reaction [[Estradiol co-treated with TNF protein] results in increased activity of NFKB1 protein] CTD PMID:15866594 NCBI chr 2:224,016,214...224,132,135
Ensembl chr 2:224,016,214...224,110,404 		JBrowse link
G Pgr progesterone receptor multiple interactions ISO Danazol binds to and results in decreased activity of PGR protein; Danazol binds to and results in increased activity of PGR protein CTD PMID:25752796 NCBI chr 8:6,072,673...6,131,552
Ensembl chr 8:6,072,673...6,131,344 		JBrowse link
G Prl prolactin multiple interactions ISO Danazol inhibits the reaction [Penicillamine results in increased expression of PRL] CTD PMID:4087275 NCBI chr17:37,859,999...37,870,062
Ensembl chr17:37,860,007...37,870,062 		JBrowse link
G Serping1 serpin family G member 1 increases expression ISO Danazol results in increased expression of SERPING1 protein CTD PMID:4014294 NCBI chr 3:69,842,726...69,852,583
Ensembl chr 3:69,842,739...69,852,034 		JBrowse link
G Sts steroid sulfatase decreases activity ISO Danazol results in decreased activity of STS protein CTD PMID:11600235 NCBI chr  X:42,225,131...42,233,403
Ensembl chr  X:42,225,372...42,233,402 		JBrowse link
G Tmprss2 transmembrane serine protease 2 increases expression EXP Danazol results in increased expression of TMPRSS2 mRNA CTD PMID:32808185 NCBI chr11:36,934,306...36,973,779
Ensembl chr11:36,934,306...36,973,715 		JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO
EXP		 Danazol inhibits the reaction [[Estradiol co-treated with TNF protein] results in increased activity of NFKB1 protein]; Danazol inhibits the reaction [[Estradiol co-treated with TNF protein] results in increased expression of CXCL8 mRNA]; Danazol inhibits the reaction [[Estradiol co-treated with TNF protein] results in increased expression of CXCL8 protein]
[peginterferon alfa-2a co-treated with Ribavirin co-treated with Danazol] results in decreased expression of TNF mRNA		 CTD PMID:15866594 PMID:18007553 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629 		JBrowse link
ICI-164384 term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Egf epidermal growth factor multiple interactions ISO ICI 164384 inhibits the reaction [EGF protein promotes the reaction [Estradiol results in increased expression of OLFM4 mRNA]] CTD PMID:21048224 NCBI chr 2:218,219,408...218,302,359
Ensembl chr 2:218,219,415...218,302,064 		JBrowse link
G Egfr epidermal growth factor receptor multiple interactions ISO ICI 164384 inhibits the reaction [[Estradiol co-treated with EGFR protein] results in increased expression of SIAH2 mRNA] CTD PMID:18629630 NCBI chr14:91,176,979...91,349,722
Ensembl chr14:91,177,067...91,344,382 		JBrowse link
G Esr1 estrogen receptor 1 affects binding
multiple interactions		 ISO ICI 164384 binds to ESR1 protein
[ICI 164384 binds to and results in increased activity of ESR1 protein] which results in increased expression of HSPB1 mRNA; ICI 164384 binds to and results in increased activity of ESR1 protein		 CTD PMID:11162928 PMID:11174852 PMID:19913605 NCBI chr 1:41,106,335...41,499,104
Ensembl chr 1:41,210,475...41,495,002 		JBrowse link
G Esr2 estrogen receptor 2 affects binding EXP ICI 164384 binds to ESR2 protein CTD PMID:19913605 NCBI chr 6:94,858,438...94,909,630
Ensembl chr 6:94,809,547...94,908,919 		JBrowse link
G Hspb1 heat shock protein family B (small) member 1 multiple interactions ISO [ICI 164384 binds to and results in increased activity of ESR1 protein] which results in increased expression of HSPB1 mRNA CTD PMID:11174852 NCBI chr12:20,794,014...20,795,675
Ensembl chr12:20,794,028...20,795,743 		JBrowse link
G Mapk1 mitogen activated protein kinase 1 multiple interactions ISO ICI 164384 inhibits the reaction [Methylmercury Compounds results in increased activity of MAPK1 protein] CTD PMID:15712295 NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616 		JBrowse link
G Mapk3 mitogen activated protein kinase 3 multiple interactions ISO ICI 164384 inhibits the reaction [Methylmercury Compounds results in increased activity of MAPK3 protein] CTD PMID:15712295 NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863 		JBrowse link
G Olfm4 olfactomedin 4 multiple interactions ISO ICI 164384 inhibits the reaction [EGF protein promotes the reaction [Estradiol results in increased expression of OLFM4 mRNA]] CTD PMID:21048224 NCBI chr15:55,385,100...55,429,687
Ensembl chr15:55,407,148...55,429,681 		JBrowse link
G Pgr progesterone receptor multiple interactions ISO ICI 164384 inhibits the reaction [beta-hexachlorocyclohexane results in increased expression of PGR mRNA]; ICI 164384 inhibits the reaction [Cadmium results in increased expression of PGR protein]; ICI 164384 inhibits the reaction [Endosulfan results in increased expression of PGR mRNA]; ICI 164384 inhibits the reaction [Estradiol results in increased expression of PGR mRNA]; ICI 164384 inhibits the reaction [Heptachlor Epoxide results in increased expression of PGR mRNA] CTD PMID:8207012 PMID:16242299 NCBI chr 8:6,072,673...6,131,552
Ensembl chr 8:6,072,673...6,131,344 		JBrowse link
G Prl prolactin multiple interactions ISO ICI 164384 inhibits the reaction [beta-hexachlorocyclohexane results in increased expression of PRL mRNA]; ICI 164384 inhibits the reaction [Estradiol results in increased expression of PRL mRNA]; ICI 164384 inhibits the reaction [o,p'-DDT results in increased expression of PRL mRNA] CTD PMID:8968093 NCBI chr17:37,859,999...37,870,062
Ensembl chr17:37,860,007...37,870,062 		JBrowse link
G Siah2 siah E3 ubiquitin protein ligase 2 multiple interactions
affects response to substance
decreases expression		 ISO ICI 164384 inhibits the reaction [[Estradiol co-treated with EGFR protein] results in increased expression of SIAH2 mRNA]
SIAH2 protein affects the susceptibility to ICI 164384
ICI 164384 results in decreased expression of SIAH2 mRNA		 CTD PMID:18629630 NCBI chr 2:142,913,924...142,931,752
Ensembl chr 2:142,914,003...142,931,950 		JBrowse link
G Tff1 trefoil factor 1 multiple interactions ISO ICI 164384 inhibits the reaction [beta-hexachlorocyclohexane results in increased expression of TFF1 mRNA]; ICI 164384 inhibits the reaction [Endosulfan results in increased expression of TFF1 mRNA]; ICI 164384 inhibits the reaction [Estradiol results in increased expression of TFF1 mRNA]; ICI 164384 inhibits the reaction [Heptachlor Epoxide results in increased expression of TFF1 mRNA]; ICI 164384 inhibits the reaction [o,p'-DDT results in increased expression of TFF1 mRNA]; ICI 164384 inhibits the reaction [phenothrin results in increased expression of TFF1 mRNA] CTD PMID:8968093 PMID:10064545 PMID:16242299 NCBI chr20:9,235,736...9,239,597
Ensembl chr20:9,235,736...9,239,597 		JBrowse link
G Tp53 tumor protein p53 multiple interactions ISO ICI 164384 inhibits the reaction [bisphenol A results in increased expression of TP53 protein]; ICI 164384 inhibits the reaction [Estradiol results in increased expression of TP53 protein] CTD PMID:31681507 NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524 		JBrowse link
leuprolide term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Akt1 AKT serine/threonine kinase 1 multiple interactions ISO Leuprolide inhibits the reaction [IGF1 protein results in increased phosphorylation of AKT1 protein] CTD PMID:17143537 NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921 		JBrowse link
G Bax BCL2 associated X, apoptosis regulator increases expression ISO Leuprolide results in increased expression of BAX protein CTD PMID:15965100 NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368 		JBrowse link
G Bcl2 BCL2, apoptosis regulator increases expression EXP Leuprolide results in increased expression of BCL2 mRNA CTD PMID:18829022 NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743
Ensembl chr13:22,684,989...22,853,743 		JBrowse link
G Casp3 caspase 3 increases expression ISO Leuprolide results in increased expression of CASP3 protein CTD PMID:15965100 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648 		JBrowse link
G Casp9 caspase 9 increases expression ISO Leuprolide results in increased expression of CASP9 protein CTD PMID:15965100 NCBI chr 5:154,108,872...154,126,628
Ensembl chr 5:154,109,046...154,126,626 		JBrowse link
G Cldn4 claudin 4 decreases expression ISO Leuprolide results in decreased expression of CLDN4 protein CTD PMID:21761342 NCBI chr12:21,751,638...21,753,436
Ensembl chr12:21,751,331...21,753,436 		JBrowse link
G Cldn8 claudin 8 decreases expression ISO Leuprolide results in decreased expression of CLDN8 protein CTD PMID:21761342 NCBI chr11:27,875,857...27,878,106
Ensembl chr11:27,875,692...27,878,513 		JBrowse link
G Cycs cytochrome c, somatic affects localization
increases expression		 ISO
EXP		 Leuprolide affects the localization of CYCS protein
Leuprolide results in increased expression of CYCS mRNA		 CTD PMID:15965100 PMID:18829022 NCBI chr 4:79,651,894...79,653,994
Ensembl chr 4:79,651,378...79,654,054
Ensembl chr18:79,651,378...79,654,054 		JBrowse link
G Cyp19a1 cytochrome P450, family 19, subfamily a, polypeptide 1 multiple interactions ISO [Leuprolide co-treated with Testosterone] results in decreased expression of CYP19A1 mRNA CTD PMID:16032706 NCBI chr 8:54,552,978...54,580,375
Ensembl chr 8:54,553,165...54,580,758 		JBrowse link
G Fshr follicle stimulating hormone receptor multiple interactions ISO [Leuprolide co-treated with Testosterone] results in decreased expression of FSHR mRNA CTD PMID:16032706 NCBI chr 6:5,198,825...5,406,785
Ensembl chr 6:5,198,825...5,406,785 		JBrowse link
G Igf1 insulin-like growth factor 1 multiple interactions ISO Leuprolide inhibits the reaction [IGF1 protein results in increased expression of and affects the localization of [ITGA5 protein binds to ITGB3 protein]]; Leuprolide inhibits the reaction [IGF1 protein results in increased phosphorylation of AKT1 protein] CTD PMID:17143537 NCBI chr 7:22,282,895...22,361,972
Ensembl chr 7:22,282,930...22,359,296 		JBrowse link
G Igf1r insulin-like growth factor 1 receptor multiple interactions ISO Leuprolide results in decreased expression of and results in decreased phosphorylation of IGF1R protein CTD PMID:17143537 NCBI chr 1:121,549,831...121,838,548
Ensembl chr 1:121,550,743...121,831,777 		JBrowse link
G Il6 interleukin 6 multiple interactions
decreases expression		 EXP Leuprolide inhibits the reaction [resveratrol results in decreased expression of IL6 protein]; resveratrol inhibits the reaction [Leuprolide results in decreased expression of IL6 protein] CTD PMID:25462211 NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178 		JBrowse link
G Itga5 integrin subunit alpha 5 multiple interactions ISO Leuprolide inhibits the reaction [IGF1 protein results in increased expression of and affects the localization of [ITGA5 protein binds to ITGB3 protein]] CTD PMID:17143537 NCBI chr 7:134,478,963...134,502,837
Ensembl chr 7:134,478,968...134,502,837 		JBrowse link
G Itgb3 integrin subunit beta 3 multiple interactions ISO Leuprolide inhibits the reaction [IGF1 protein results in increased expression of and affects the localization of [ITGA5 protein binds to ITGB3 protein]] CTD PMID:17143537 NCBI chr10:89,509,917...89,564,679
Ensembl chr10:89,509,989...89,564,679 		JBrowse link
G Lhb luteinizing hormone subunit beta decreases expression ISO Leuprolide results in decreased expression of LHB protein CTD PMID:10221860 NCBI chr 1:95,898,269...95,901,973
Ensembl chr 1:95,900,984...95,901,972
Ensembl chr 1:95,900,984...95,901,972 		JBrowse link
G Lhcgr luteinizing hormone/choriogonadotropin receptor multiple interactions
decreases expression		 ISO [Leuprolide co-treated with Testosterone] results in decreased expression of LHCGR mRNA
Leuprolide results in decreased expression of LHCGR mRNA		 CTD PMID:16032706 NCBI chr 6:5,661,871...5,728,109
Ensembl chr 6:5,661,871...5,724,521 		JBrowse link
G Mmp2 matrix metallopeptidase 2 multiple interactions
decreases expression		 EXP Leuprolide inhibits the reaction [Resveratrol results in decreased expression of MMP2 protein]; Resveratrol inhibits the reaction [Leuprolide results in decreased expression of MMP2 protein] CTD PMID:25462211 NCBI chr19:14,154,657...14,182,870
Ensembl chr19:14,154,657...14,182,870 		JBrowse link
G Mmp9 matrix metallopeptidase 9 decreases expression
multiple interactions		 EXP Leuprolide results in decreased expression of MMP9 protein
Leuprolide inhibits the reaction [Resveratrol results in decreased expression of MMP9 protein]; Resveratrol inhibits the reaction [Leuprolide results in decreased expression of MMP9 protein]		 CTD PMID:25462211 NCBI chr 3:153,684,158...153,692,118
Ensembl chr 3:153,683,858...153,692,120 		JBrowse link
G Slc22a2 solute carrier family 22 member 2 multiple interactions ISO Leuprolide inhibits the reaction [SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium] CTD PMID:21599003 NCBI chr 1:48,121,061...48,163,268
Ensembl chr 1:48,121,061...48,163,268 		JBrowse link
G Tnf tumor necrosis factor multiple interactions
decreases expression		 EXP Leuprolide inhibits the reaction [resveratrol results in decreased expression of TNF protein]; resveratrol inhibits the reaction [Leuprolide results in decreased expression of TNF protein] CTD PMID:25462211 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629 		JBrowse link
G Vegfa vascular endothelial growth factor A decreases expression
multiple interactions		 EXP Leuprolide results in decreased expression of VEGFA protein
Leuprolide inhibits the reaction [resveratrol results in decreased expression of VEGFA protein]; resveratrol inhibits the reaction [Leuprolide results in decreased expression of VEGFA protein]		 CTD PMID:25462211 NCBI chr 9:14,955,300...14,970,641
Ensembl chr 9:14,955,300...14,970,641 		JBrowse link
RU 58668 term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ahr aryl hydrocarbon receptor multiple interactions ISO [RU 58668 results in increased activity of AHR protein] which results in increased expression of CYP1A1 mRNA CTD PMID:19901195 NCBI chr 6:52,234,089...52,271,568
Ensembl chr 6:52,234,089...52,271,568 		JBrowse link
G Bcl2 BCL2, apoptosis regulator affects expression ISO RU 58668 affects the expression of BCL2 protein CTD PMID:15868441 NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743
Ensembl chr13:22,684,989...22,853,743 		JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 increases expression
multiple interactions		 ISO RU 58668 results in increased expression of CYP1A1 mRNA
[RU 58668 results in increased activity of AHR protein] which results in increased expression of CYP1A1 mRNA; RU 58668 inhibits the reaction [Tetrachlorodibenzodioxin results in increased activity of CYP1A1 protein]		 CTD PMID:18493746 PMID:19901195 NCBI chr 8:58,096,021...58,102,130
Ensembl chr 8:58,096,077...58,102,125 		JBrowse link
G Esr1 estrogen receptor 1 multiple interactions ISO RU 58668 inhibits the reaction [Estradiol results in increased activity of ESR1 protein]; RU 58668 promotes the reaction [fulvestrant inhibits the reaction [Genistein results in increased activity of ESR1 protein]]; RU 58668 results in decreased stability of and results in decreased expression of ESR1 protein CTD PMID:15868441 PMID:20599613 NCBI chr 1:41,106,335...41,499,104
Ensembl chr 1:41,210,475...41,495,002 		JBrowse link
G Igf1r insulin-like growth factor 1 receptor affects expression ISO RU 58668 affects the expression of IGF1R protein CTD PMID:15868441 NCBI chr 1:121,549,831...121,838,548
Ensembl chr 1:121,550,743...121,831,777 		JBrowse link
G Igfbp2 insulin-like growth factor binding protein 2 affects expression ISO RU 58668 affects the expression of IGFBP2 protein CTD PMID:15868441 NCBI chr 9:74,415,574...74,442,945
Ensembl chr 9:74,415,546...74,442,937 		JBrowse link
G Pgr progesterone receptor affects expression ISO RU 58668 affects the expression of PGR protein CTD PMID:15868441 NCBI chr 8:6,072,673...6,131,552
Ensembl chr 8:6,072,673...6,131,344 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19841
    role 19817
      application 19661
        pharmaceutical 19502
          drug 19502
            anti-estrogen 52
              9,9-bis(4-hydroxyphenyl)fluorene 0
              ICI-164384 13
              RU 58668 7
              clomiphene citrate 0
              danazol 21
              elacestrant 0
              furowanin B 0
              glyceollin III 0
              leuprolide + 22
              millewanin G 0
              millewanin H 0
              monoisopropyl phthalate 0
              monopentyl phthalate 0
              nafarelin + 0
              nafarelin acetate + 0
              nafarelin acetate hydrate 0
              tamoxifen N-oxide 0
paths to the root