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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:ethionamide
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Accession:CHEBI:4885 term browser browse the term
Definition:A thiocarboxamide that is pyridine-4-carbothioamide substituted by an ethyl group at position 2. A prodrug that undergoes metabolic activation by conversion to the corresponding S-oxide.
Synonyms:exact_synonym: 2-ethylpyridine-4-carbothioamide
 related_synonym: 2-ethyl-4-thiopyridylamide;   ETH;   ETP;   Ethinamide;   Ethioniamide;   Ethylisothiamide;   Ethyonomide;   Etionamid;   Etionamide;   Etioniamid;   Formula=C8H10N2S;   InChI=1S/C8H10N2S/c1-2-7-5-6(8(9)11)3-4-10-7/h3-5H,2H2,1H3,(H2,9,11);   InChIKey=AEOCXXJPGCBFJA-UHFFFAOYSA-N;   SMILES=CCc1cc(ccn1)C(N)=S;   Trecator;   ethionamidum;   etionamida
 xref: Beilstein:116474;   CAS:536-33-4;   DrugBank:DB00609;   Drug_Central:1083;   HMDB:HMDB0014747;   KEGG:C07665;   KEGG:D00591;   LINCS:LSM-5620
 xref_mesh: MESH:D005000
 xref: PMID:14651620;   PMID:15673755;   PMID:15850780;   Patent:GB800250;   Reaxys:116474;   Wikipedia:Ethionamide


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ethionamide term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ACE2 angiotensin converting enzyme 2 decreases expression EXP Ethionamide results in decreased expression of ACE2 mRNA CTD PMID:32808185 NCBI chr  X:15,518,197...15,607,211
Ensembl chr  X:15,494,566...15,607,236 		JBrowse link
G CCL2 C-C motif chemokine ligand 2 increases expression ISO Ethionamide results in increased expression of CCL2 mRNA; Ethionamide results in increased expression of CCL2 protein CTD PMID:25051504 NCBI chr17:34,255,285...34,257,203
Ensembl chr17:34,255,274...34,257,208 		JBrowse link
G CCL5 C-C motif chemokine ligand 5 affects expression ISO Ethionamide affects the expression of CCL5 protein CTD PMID:25051504 NCBI chr17:35,871,491...35,880,360
Ensembl chr17:35,871,491...35,880,793 		JBrowse link
G CXCL10 C-X-C motif chemokine ligand 10 decreases expression ISO Ethionamide results in decreased expression of CXCL10 protein CTD PMID:25051504 NCBI chr 4:76,021,118...76,023,497
Ensembl chr 4:76,021,118...76,023,497 		JBrowse link
G FMO2 flavin containing dimethylaniline monoxygenase 2 increases oxidation EXP FMO2 protein results in increased oxidation of Ethionamide CTD PMID:26062974 NCBI chr 1:171,185,208...171,212,686
Ensembl chr 1:171,185,249...171,212,686 		JBrowse link
G GCLM glutamate-cysteine ligase modifier subunit multiple interactions EXP Ethionamide inhibits the reaction [arsenic trioxide results in increased expression of GCLM mRNA] CTD PMID:26708503 NCBI chr 1:93,885,199...93,909,430
Ensembl chr 1:93,885,199...93,909,456 		JBrowse link
G HMOX1 heme oxygenase 1 multiple interactions EXP Ethionamide inhibits the reaction [arsenic trioxide results in increased expression of HMOX1 mRNA] CTD PMID:26708503 NCBI chr22:35,381,096...35,394,207
Ensembl chr22:35,380,361...35,394,214 		JBrowse link
G IL10 interleukin 10 decreases expression ISO Ethionamide results in decreased expression of IL10 protein CTD PMID:25051504 NCBI chr 1:206,767,602...206,772,494
Ensembl chr 1:206,767,602...206,774,541 		JBrowse link
G IL12B interleukin 12B increases expression ISO Ethionamide results in increased expression of IL12B protein CTD PMID:25051504 NCBI chr 5:159,314,780...159,330,487
Ensembl chr 5:159,314,780...159,330,863 		JBrowse link
G IL1A interleukin 1 alpha increases expression ISO Ethionamide results in increased expression of IL1A protein CTD PMID:25051504 NCBI chr 2:112,773,925...112,784,493
Ensembl chr 2:112,773,925...112,784,493 		JBrowse link
G IL1B interleukin 1 beta increases expression
affects expression		 ISO Ethionamide results in increased expression of IL1B mRNA
Ethionamide affects the expression of IL1B protein		 CTD PMID:25051504 NCBI chr 2:112,829,751...112,836,779
Ensembl chr 2:112,829,751...112,836,816 		JBrowse link
G IL6 interleukin 6 decreases expression ISO Ethionamide results in decreased expression of IL6 protein CTD PMID:25051504 NCBI chr 7:22,727,200...22,731,998
Ensembl chr 7:22,725,884...22,732,002 		JBrowse link
G KEAP1 kelch like ECH associated protein 1 multiple interactions EXP KEAP1 mRNA inhibits the reaction [Ethionamide results in increased susceptibility to arsenic trioxide] CTD PMID:26708503 NCBI chr19:10,486,125...10,503,356
Ensembl chr19:10,486,125...10,503,558 		JBrowse link
G LEP leptin decreases expression ISO Ethionamide results in decreased expression of LEP protein CTD PMID:25051504 NCBI chr 7:128,241,278...128,257,629
Ensembl chr 7:128,241,278...128,257,629 		JBrowse link
G NFE2L2 NFE2 like bZIP transcription factor 2 multiple interactions EXP NFE2L2 mRNA promotes the reaction [Ethionamide results in increased susceptibility to arsenic trioxide] CTD PMID:26708503 NCBI chr 2:177,230,303...177,264,727
Ensembl chr 2:177,218,667...177,392,756 		JBrowse link
G SRXN1 sulfiredoxin 1 multiple interactions EXP Ethionamide inhibits the reaction [arsenic trioxide results in increased expression of SRXN1 mRNA] CTD PMID:26708503 NCBI chr20:646,615...653,200
Ensembl chr20:646,615...653,200 		JBrowse link
G TNF tumor necrosis factor increases expression ISO Ethionamide results in increased expression of TNF protein CTD PMID:25051504 NCBI chr 6:31,575,565...31,578,336
Ensembl chr 6:31,575,565...31,578,336 		JBrowse link
G VEGFA vascular endothelial growth factor A increases expression ISO Ethionamide results in increased expression of VEGFA protein CTD PMID:25051504 NCBI chr 6:43,770,211...43,786,487
Ensembl chr 6:43,770,184...43,786,487 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 26040
    role 25956
      application 25177
        pro-agent 12047
          prodrug 11726
            ethionamide 18
              ethionamide S-oxide 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 26040
    subatomic particle 26015
      composite particle 26015
        hadron 26015
          baryon 26015
            nucleon 26015
              atomic nucleus 26015
                atom 26015
                  main group element atom 25840
                    p-block element atom 25840
                      carbon group element atom 25437
                        carbon atom 25395
                          organic molecular entity 25395
                            organic molecule 25223
                              organic cyclic compound 24277
                                organic heterocyclic compound 22320
                                  organic heteromonocyclic compound 19213
                                    pyridines 12190
                                      ethionamide 18
                                        ethionamide S-oxide 0
paths to the root