FMO2 (flavin containing dimethylaniline monoxygenase 2) - Rat Genome Database

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Gene: FMO2 (flavin containing dimethylaniline monoxygenase 2) Homo sapiens
Analyze
Symbol: FMO2
Name: flavin containing dimethylaniline monoxygenase 2
RGD ID: 733627
HGNC Page HGNC:3770
Description: Enables N,N-dimethylaniline monooxygenase activity. Involved in several processes, including NADPH oxidation; toxin metabolic process; and xenobiotic metabolic process. Located in membrane.
Type: protein-coding
RefSeq Status: REVIEWED
Previously known as: dimethylaniline monooxygenase [N-oxide-forming] 2; dimethylaniline oxidase 2; flavin containing monooxygenase 2; flavin containing monooxygenase 2 (non-functional); flavin-containing monooxygenase 2; FLJ40826; FMO 1B1; FMO 2; FMO, pulmonary; FMO1B1; pulmonary flavin-containing monooxygenase 2
RGD Orthologs
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381171,185,208 - 171,212,686 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1171,185,249 - 171,212,686 (+)EnsemblGRCh38hg38GRCh38
GRCh371171,154,347 - 171,181,825 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361169,421,012 - 169,448,446 (+)NCBINCBI36Build 36hg18NCBI36
Build 341167,886,045 - 167,913,480NCBI
Celera1144,264,292 - 144,291,650 (+)NCBICelera
Cytogenetic Map1q24.3NCBI
HuRef1142,377,885 - 142,405,234 (+)NCBIHuRef
CHM1_11172,576,521 - 172,603,952 (+)NCBICHM1_1
T2T-CHM13v2.01170,541,589 - 170,568,989 (+)NCBIT2T-CHM13v2.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-schisandrin B  (ISO)
(2,4,5-trichlorophenoxy)acetic acid  (ISO)
1,1-dichloroethene  (ISO)
1,2-dimethylhydrazine  (ISO)
2,2',4,4',5,5'-hexachlorobiphenyl  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2-hydroxypropanoic acid  (EXP)
3-methylcholanthrene  (ISO)
4-(ethoxymethylene)-2-phenyloxazol-5-one  (ISO)
4-hydroxyphenyl retinamide  (ISO)
6-propyl-2-thiouracil  (ISO)
aldrin  (ISO)
all-trans-retinoic acid  (ISO)
amitrole  (ISO)
ammonium chloride  (ISO)
arsane  (EXP,ISO)
arsenic atom  (EXP,ISO)
azathioprine  (ISO)
Bardoxolone methyl  (ISO)
Benoxacor  (ISO)
benzo[a]pyrene  (EXP,ISO)
benzydamine  (EXP)
beta-D-glucan  (ISO)
beta-naphthoflavone  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (ISO)
Bisphenol B  (ISO)
bromobenzene  (ISO)
buta-1,3-diene  (ISO)
calcitriol  (EXP)
carnosic acid  (ISO)
CGP 52608  (EXP)
chloroprene  (ISO)
chlorpyrifos  (ISO)
choline  (ISO)
ciguatoxin CTX1B  (ISO)
clofibrate  (ISO)
cobalt dichloride  (ISO)
copper(II) sulfate  (ISO)
crocidolite asbestos  (ISO)
cyclosporin A  (EXP,ISO)
cypermethrin  (ISO)
dibenz[a,h]anthracene  (ISO)
dibenzofurans  (ISO)
dioxygen  (ISO)
diuron  (ISO)
doxorubicin  (EXP)
endosulfan  (ISO)
Erionite  (ISO)
ethanol  (ISO)
ethionamide  (EXP)
Ethylenethiourea  (EXP)
folic acid  (ISO)
furan  (ISO)
isoprenaline  (ISO)
L-methionine  (ISO)
lead diacetate  (ISO)
lutein  (ISO)
manganese(II) chloride  (ISO)
methamphetamine  (ISO)
methimazole  (EXP,ISO)
methotrexate  (ISO)
mono(2-ethylhexyl) phthalate  (ISO)
monosodium L-glutamate  (ISO)
N,N-diethyl-m-toluamide  (ISO)
N-nitrosodiethylamine  (ISO)
nickel atom  (EXP)
ozone  (ISO)
paracetamol  (ISO)
paraquat  (ISO)
parathion  (ISO)
pentachlorophenol  (ISO)
pentane-2,3-dione  (ISO)
perfluorohexanesulfonic acid  (ISO)
permethrin  (ISO)
phenethyl caffeate  (ISO)
phenformin  (ISO)
phenobarbital  (ISO)
pirinixic acid  (ISO)
potassium dichromate  (ISO)
prednisolone  (ISO)
propranolol  (EXP)
Pyridostigmine bromide  (ISO)
rac-lactic acid  (EXP)
resveratrol  (EXP)
rotenone  (ISO)
SCH 23390  (ISO)
sevoflurane  (ISO)
silicon dioxide  (EXP,ISO)
silver atom  (ISO)
silver(0)  (ISO)
sodium arsenate  (EXP,ISO)
sodium arsenite  (EXP,ISO)
sodium fluoride  (ISO)
streptozocin  (ISO)
sulfadimethoxine  (ISO)
tacrolimus hydrate  (ISO)
testosterone  (ISO)
testosterone enanthate  (EXP)
tetrachloroethene  (ISO)
tetrachloromethane  (ISO)
thiourea  (EXP)
titanium dioxide  (ISO)
tremolite asbestos  (ISO)
trifluoperazine  (EXP)
trimellitic anhydride  (ISO)
valproic acid  (EXP,ISO)
vancomycin  (ISO)
vinclozolin  (ISO)
zinc atom  (ISO)
zinc(0)  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

Phenotype Annotations     Click to see Annotation Detail View

Human Phenotype
References

References - curated
# Reference Title Reference Citation
1. GOAs Human GO annotations GOA_HUMAN data from the GO Consortium
2. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
3. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:1417778   PMID:1542660   PMID:7720101   PMID:8128486   PMID:8311461   PMID:8749308   PMID:8786146   PMID:8889548   PMID:9804831   PMID:11042094   PMID:11744609   PMID:12214664  
PMID:12477932   PMID:12527699   PMID:14702039   PMID:15144220   PMID:15155844   PMID:15294458   PMID:15355885   PMID:15489334   PMID:15864117   PMID:15922018   PMID:16183778   PMID:16344560  
PMID:16428471   PMID:16710414   PMID:18234543   PMID:18423897   PMID:18794725   PMID:18930751   PMID:18948378   PMID:19420133   PMID:19898482   PMID:20173083   PMID:20529763   PMID:21873635  
PMID:22344438   PMID:22830265   PMID:24561181   PMID:25807282   PMID:28514442   PMID:28981537   PMID:30381441   PMID:32461654   PMID:32487729   PMID:33961781   PMID:36114029   PMID:37800598  
PMID:37963835  


Genomics

Comparative Map Data
FMO2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381171,185,208 - 171,212,686 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1171,185,249 - 171,212,686 (+)EnsemblGRCh38hg38GRCh38
GRCh371171,154,347 - 171,181,825 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361169,421,012 - 169,448,446 (+)NCBINCBI36Build 36hg18NCBI36
Build 341167,886,045 - 167,913,480NCBI
Celera1144,264,292 - 144,291,650 (+)NCBICelera
Cytogenetic Map1q24.3NCBI
HuRef1142,377,885 - 142,405,234 (+)NCBIHuRef
CHM1_11172,576,521 - 172,603,952 (+)NCBICHM1_1
T2T-CHM13v2.01170,541,589 - 170,568,989 (+)NCBIT2T-CHM13v2.0
Fmo2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391162,701,886 - 162,726,327 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1162,701,886 - 162,726,295 (-)EnsemblGRCm39 Ensembl
GRCm381162,874,317 - 162,898,758 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1162,874,317 - 162,898,726 (-)EnsemblGRCm38mm10GRCm38
MGSCv371164,805,178 - 164,828,843 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361164,711,722 - 164,735,387 (-)NCBIMGSCv36mm8
Celera1165,312,096 - 165,335,970 (-)NCBICelera
Cytogenetic Map1H2.1NCBI
cM Map170.34NCBI
Fmo2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81377,755,131 - 77,777,597 (-)NCBIGRCr8
mRatBN7.21375,221,149 - 75,244,377 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1375,224,402 - 75,244,308 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1377,802,394 - 77,822,279 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01379,102,940 - 79,122,817 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01376,362,801 - 76,382,681 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01380,752,526 - 80,775,264 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1380,755,058 - 80,775,264 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01385,646,484 - 85,669,947 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41378,546,315 - 78,592,870 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11378,560,558 - 78,607,024 (-)NCBI
Celera1374,961,570 - 74,981,614 (-)NCBICelera
Cytogenetic Map13q22NCBI
Fmo2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495540611,851,637 - 11,876,843 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495540611,851,694 - 11,875,314 (+)NCBIChiLan1.0ChiLan1.0
FMO2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2178,546,007 - 78,571,989 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1178,220,208 - 78,246,185 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01146,678,858 - 146,704,831 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11150,393,061 - 150,417,295 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1150,393,061 - 150,417,295 (+)Ensemblpanpan1.1panPan2
FMO2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1727,634,624 - 27,659,111 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl727,634,900 - 27,659,037 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha727,152,733 - 27,180,010 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0727,433,314 - 27,460,596 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl727,436,373 - 27,460,628 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1727,283,755 - 27,311,025 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0727,318,505 - 27,345,815 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0727,560,543 - 27,588,031 (-)NCBIUU_Cfam_GSD_1.0
Fmo2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440934498,038,620 - 98,063,536 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493648115,885,280 - 15,910,267 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493648115,885,375 - 15,910,216 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
FMO2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl963,812,492 - 63,852,085 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1963,812,016 - 63,857,608 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2970,088,134 - 70,125,384 (+)NCBISscrofa10.2Sscrofa10.2susScr3
FMO2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12557,869,866 - 57,892,359 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2557,866,555 - 57,892,193 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366605559,514,501 - 59,537,091 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Fmo2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462477110,390,472 - 10,422,524 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462477110,391,267 - 10,422,314 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in FMO2
24 total Variants

Clinical Variants
Name Type Condition(s) Position(s) Clinical significance
GRCh38/hg38 1q23.1-25.1(chr1:157747246-176021247)x3 copy number gain See cases [RCV000051854] Chr1:157747246..176021247 [GRCh38]
Chr1:157717036..175990383 [GRCh37]
Chr1:155983660..174257006 [NCBI36]
Chr1:1q23.1-25.1
pathogenic
GRCh38/hg38 1q23.3-25.2(chr1:164922655-180061589)x3 copy number gain See cases [RCV000051856] Chr1:164922655..180061589 [GRCh38]
Chr1:164891892..180030724 [GRCh37]
Chr1:163158516..178297347 [NCBI36]
Chr1:1q23.3-25.2
pathogenic
GRCh38/hg38 1q24.2-25.1(chr1:168314822-175299299)x1 copy number loss See cases [RCV000053918] Chr1:168314822..175299299 [GRCh38]
Chr1:168284060..175268435 [GRCh37]
Chr1:166550684..173535058 [NCBI36]
Chr1:1q24.2-25.1
pathogenic
GRCh38/hg38 1q23.3-25.1(chr1:161740907-173965154)x1 copy number loss See cases [RCV000053914] Chr1:161740907..173965154 [GRCh38]
Chr1:161710697..173934292 [GRCh37]
Chr1:159977321..172200915 [NCBI36]
Chr1:1q23.3-25.1
pathogenic
GRCh38/hg38 1q23.3-24.3(chr1:164036599-171252077)x1 copy number loss Developmental Delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000053916]|Developmental delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000053916]|See cases [RCV000053916] Chr1:164036599..171252077 [GRCh38]
Chr1:164005836..171221216 [GRCh37]
Chr1:162272460..169487840 [NCBI36]
Chr1:1q23.3-24.3
pathogenic
GRCh38/hg38 1q24.1-25.1(chr1:166762832-175327423)x1 copy number loss See cases [RCV000053917] Chr1:166762832..175327423 [GRCh38]
Chr1:166732069..175296559 [GRCh37]
Chr1:164998693..173563182 [NCBI36]
Chr1:1q24.1-25.1
pathogenic
NM_001460.4(FMO2):c.718C>T (p.Arg240Cys) single nucleotide variant Malignant melanoma [RCV000059990] Chr1:171203955 [GRCh38]
Chr1:171173094 [GRCh37]
Chr1:169439718 [NCBI36]
Chr1:1q24.3
not provided
GRCh38/hg38 1q24.3-31.1(chr1:171039975-186875957)x3 copy number gain See cases [RCV000134876] Chr1:171039975..186875957 [GRCh38]
Chr1:171009116..186845089 [GRCh37]
Chr1:169275740..185111712 [NCBI36]
Chr1:1q24.3-31.1
pathogenic
GRCh38/hg38 1q24.2-25.2(chr1:169218236-178075834)x1 copy number loss See cases [RCV000137128] Chr1:169218236..178075834 [GRCh38]
Chr1:169187474..178044969 [GRCh37]
Chr1:167454098..176311592 [NCBI36]
Chr1:1q24.2-25.2
pathogenic
GRCh38/hg38 1q24.3-31.2(chr1:170929720-191065409)x1 copy number loss See cases [RCV000142369] Chr1:170929720..191065409 [GRCh38]
Chr1:170898861..191034539 [GRCh37]
Chr1:169165485..189301162 [NCBI36]
Chr1:1q24.3-31.2
pathogenic
GRCh38/hg38 1q23.3-25.1(chr1:163382523-175877022)x1 copy number loss See cases [RCV000143292] Chr1:163382523..175877022 [GRCh38]
Chr1:163352313..175846158 [GRCh37]
Chr1:161618937..174112781 [NCBI36]
Chr1:1q23.3-25.1
pathogenic
GRCh38/hg38 1q24.2-31.1(chr1:170036068-187555148)x1 copy number loss See cases [RCV000143688] Chr1:170036068..187555148 [GRCh38]
Chr1:170005209..187524280 [GRCh37]
Chr1:168271833..185790903 [NCBI36]
Chr1:1q24.2-31.1
pathogenic
GRCh38/hg38 1q21.2-25.2(chr1:149854269-180267197)x3 copy number gain See cases [RCV000143515] Chr1:149854269..180267197 [GRCh38]
Chr1:149825831..180236332 [GRCh37]
Chr1:148092455..178502955 [NCBI36]
Chr1:1q21.2-25.2
pathogenic
GRCh37/hg19 1q23.2-25.1(chr1:160369890-175796325) copy number loss not provided [RCV000767779] Chr1:160369890..175796325 [GRCh37]
Chr1:1q23.2-25.1
pathogenic
GRCh37/hg19 1q24.2-25.3(chr1:169423492-180367623) copy number gain not provided [RCV000767621] Chr1:169423492..180367623 [GRCh37]
Chr1:1q24.2-25.3
pathogenic
NM_001460.5(FMO2):c.1260T>A (p.Phe420Leu) single nucleotide variant Inborn genetic diseases [RCV003203508] Chr1:171208797 [GRCh38]
Chr1:171177936 [GRCh37]
Chr1:1q24.3
uncertain significance
NM_001460.5(FMO2):c.1012C>T (p.Leu338Phe) single nucleotide variant Inborn genetic diseases [RCV003209143] Chr1:171205463 [GRCh38]
Chr1:171174602 [GRCh37]
Chr1:1q24.3
uncertain significance
GRCh37/hg19 1q23.3-25.3(chr1:161676893-184071723)x1 copy number loss See cases [RCV000447098] Chr1:161676893..184071723 [GRCh37]
Chr1:1q23.3-25.3
pathogenic
GRCh37/hg19 1q24.2-25.3(chr1:169873155-181823980)x1 copy number loss See cases [RCV000447593] Chr1:169873155..181823980 [GRCh37]
Chr1:1q24.2-25.3
pathogenic
NM_001460.5(FMO2):c.337del (p.Ser112_Val113insTer) deletion not specified [RCV000455208] Chr1:171196664 [GRCh38]
Chr1:171165803 [GRCh37]
Chr1:1q24.3
benign
GRCh37/hg19 1p36.33-q44(chr1:849467-249224684)x3 copy number gain See cases [RCV000510383] Chr1:849467..249224684 [GRCh37]
Chr1:1p36.33-q44
pathogenic
GRCh37/hg19 1p36.33-q44(chr1:849467-249224684) copy number gain See cases [RCV000510926] Chr1:849467..249224684 [GRCh37]
Chr1:1p36.33-q44
pathogenic
Single allele deletion 1q24q25 microdeletion syndrome [RCV000754969] Chr1:169095250..175778910 [GRCh37]
Chr1:1q24.2-25.1
pathogenic
GRCh37/hg19 1p36.33-q44(chr1:47851-249228449)x3 copy number gain not provided [RCV000736295] Chr1:47851..249228449 [GRCh37]
Chr1:1p36.33-q44
pathogenic
GRCh37/hg19 1p36.33-q44(chr1:82154-249218992)x3 copy number gain not provided [RCV000736305] Chr1:82154..249218992 [GRCh37]
Chr1:1p36.33-q44
pathogenic
GRCh37/hg19 1q23.2-25.2(chr1:159815642-177026983)x1 copy number loss not provided [RCV000736717] Chr1:159815642..177026983 [GRCh37]
Chr1:1q23.2-25.2
pathogenic
NM_001460.5(FMO2):c.1476A>G (p.Lys492=) single nucleotide variant not provided [RCV000948572] Chr1:171209013 [GRCh38]
Chr1:171178152 [GRCh37]
Chr1:1q24.3
likely benign
NM_001460.5(FMO2):c.1414C>T (p.Gln472Ter) single nucleotide variant not provided [RCV000948204] Chr1:171208951 [GRCh38]
Chr1:171178090 [GRCh37]
Chr1:1q24.3
benign
NM_001460.5(FMO2):c.1588dup (p.Cys530fs) duplication not provided [RCV000946525] Chr1:171209118..171209119 [GRCh38]
Chr1:171178257..171178258 [GRCh37]
Chr1:1q24.3
benign
NM_001460.5(FMO2):c.396C>T (p.Asn132=) single nucleotide variant not provided [RCV000898040] Chr1:171196723 [GRCh38]
Chr1:171165862 [GRCh37]
Chr1:1q24.3
likely benign
GRCh37/hg19 1q24.2-24.3(chr1:170862952-171480090)x3 copy number gain not provided [RCV000847458] Chr1:170862952..171480090 [GRCh37]
Chr1:1q24.2-24.3
uncertain significance
GRCh37/hg19 1q24.2-25.1(chr1:167430471-174635618)x1 copy number loss not provided [RCV001005149] Chr1:167430471..174635618 [GRCh37]
Chr1:1q24.2-25.1
pathogenic
NM_001460.5(FMO2):c.724A>G (p.Met242Val) single nucleotide variant Inborn genetic diseases [RCV003260328] Chr1:171203961 [GRCh38]
Chr1:171173100 [GRCh37]
Chr1:1q24.3
uncertain significance
NM_001460.5(FMO2):c.521G>A (p.Arg174His) single nucleotide variant not provided [RCV000881318] Chr1:171199382 [GRCh38]
Chr1:171168521 [GRCh37]
Chr1:1q24.3
likely benign
NM_001460.5(FMO2):c.1204G>A (p.Glu402Lys) single nucleotide variant not provided [RCV000888316] Chr1:171207738 [GRCh38]
Chr1:171176877 [GRCh37]
Chr1:1q24.3
likely benign
NM_001460.5(FMO2):c.497T>C (p.Phe166Ser) single nucleotide variant not provided [RCV000954219] Chr1:171199358 [GRCh38]
Chr1:171168497 [GRCh37]
Chr1:1q24.3
likely benign
NM_001460.5(FMO2):c.719G>A (p.Arg240His) single nucleotide variant Inborn genetic diseases [RCV003305345] Chr1:171203956 [GRCh38]
Chr1:171173095 [GRCh37]
Chr1:1q24.3
uncertain significance
GRCh37/hg19 1q24.3(chr1:171048831-171338651)x1 copy number loss not provided [RCV001005152] Chr1:171048831..171338651 [GRCh37]
Chr1:1q24.3
uncertain significance
NC_000001.10:g.(?_130980840)_(248900000_?)dup duplication Gastrointestinal stromal tumor [RCV001300221]|Parathyroid carcinoma [RCV001341077] Chr1:130980840..248900000 [GRCh37]
Chr1:1q12-44
uncertain significance
GRCh37/hg19 1q23.3-24.3(chr1:162330810-171532331) copy number loss not specified [RCV002053680] Chr1:162330810..171532331 [GRCh37]
Chr1:1q23.3-24.3
pathogenic
GRCh37/hg19 1q24.2-24.3(chr1:167391422-171843613) copy number loss not specified [RCV002053691] Chr1:167391422..171843613 [GRCh37]
Chr1:1q24.2-24.3
pathogenic
GRCh37/hg19 1q24.2-25.3(chr1:169873155-181823980) copy number loss not specified [RCV002053713] Chr1:169873155..181823980 [GRCh37]
Chr1:1q24.2-25.3
pathogenic
NM_001460.5(FMO2):c.1381G>A (p.Val461Met) single nucleotide variant Inborn genetic diseases [RCV003279399] Chr1:171208918 [GRCh38]
Chr1:171178057 [GRCh37]
Chr1:1q24.3
uncertain significance
NM_001460.5(FMO2):c.397G>A (p.Gly133Ser) single nucleotide variant Inborn genetic diseases [RCV002793352] Chr1:171196724 [GRCh38]
Chr1:171165863 [GRCh37]
Chr1:1q24.3
uncertain significance
NM_001460.5(FMO2):c.1315C>T (p.Leu439Phe) single nucleotide variant Inborn genetic diseases [RCV002691982] Chr1:171208852 [GRCh38]
Chr1:171177991 [GRCh37]
Chr1:1q24.3
uncertain significance
NM_001460.5(FMO2):c.1250T>A (p.Ile417Asn) single nucleotide variant Inborn genetic diseases [RCV002821400] Chr1:171207784 [GRCh38]
Chr1:171176923 [GRCh37]
Chr1:1q24.3
uncertain significance
NM_001460.5(FMO2):c.1175T>G (p.Val392Gly) single nucleotide variant Inborn genetic diseases [RCV002761778] Chr1:171205626 [GRCh38]
Chr1:171174765 [GRCh37]
Chr1:1q24.3
uncertain significance
NM_001460.5(FMO2):c.571G>A (p.Gly191Arg) single nucleotide variant Inborn genetic diseases [RCV002911216] Chr1:171199432 [GRCh38]
Chr1:171168571 [GRCh37]
Chr1:1q24.3
uncertain significance
NM_001460.5(FMO2):c.1318G>A (p.Ala440Thr) single nucleotide variant Inborn genetic diseases [RCV002924205] Chr1:171208855 [GRCh38]
Chr1:171177994 [GRCh37]
Chr1:1q24.3
uncertain significance
NM_001460.5(FMO2):c.401A>T (p.Lys134Met) single nucleotide variant Inborn genetic diseases [RCV002697842] Chr1:171196728 [GRCh38]
Chr1:171165867 [GRCh37]
Chr1:1q24.3
uncertain significance
NM_001460.5(FMO2):c.629T>C (p.Val210Ala) single nucleotide variant Inborn genetic diseases [RCV002669689] Chr1:171203866 [GRCh38]
Chr1:171173005 [GRCh37]
Chr1:1q24.3
uncertain significance
NM_001460.5(FMO2):c.848T>A (p.Val283Glu) single nucleotide variant Inborn genetic diseases [RCV002921232] Chr1:171205299 [GRCh38]
Chr1:171174438 [GRCh37]
Chr1:1q24.3
uncertain significance
NM_001460.5(FMO2):c.1226T>C (p.Ile409Thr) single nucleotide variant Inborn genetic diseases [RCV003370081] Chr1:171207760 [GRCh38]
Chr1:171176899 [GRCh37]
Chr1:1q24.3
uncertain significance
GRCh37/hg19 1q23.3-25.1(chr1:164571371-175708060)x1 copy number loss not provided [RCV003483966] Chr1:164571371..175708060 [GRCh37]
Chr1:1q23.3-25.1
pathogenic
NM_001460.5(FMO2):c.135G>A (p.Glu45=) single nucleotide variant not provided [RCV003409244] Chr1:171193337 [GRCh38]
Chr1:171162476 [GRCh37]
Chr1:1q24.3
likely benign
GRCh37/hg19 1q24.2-31.1(chr1:167994071-187711459)x1 copy number loss not specified [RCV003987250] Chr1:167994071..187711459 [GRCh37]
Chr1:1q24.2-31.1
pathogenic
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:2722
Count of miRNA genes:991
Interacting mature miRNAs:1164
Transcripts:ENST00000209929, ENST00000441535, ENST00000462643, ENST00000483192, ENST00000488431, ENST00000489354, ENST00000493513, ENST00000529935
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

Markers in Region
G42296  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371171,167,401 - 171,167,524UniSTSGRCh37
Build 361169,434,025 - 169,434,148RGDNCBI36
Celera1144,277,310 - 144,277,433RGD
Cytogenetic Map1q24.3UniSTS
HuRef1142,390,894 - 142,391,017UniSTS
G67463  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371171,154,794 - 171,155,126UniSTSGRCh37
Build 361169,421,418 - 169,421,750RGDNCBI36
Celera1144,264,698 - 144,265,030RGD
Cytogenetic Map1q24.3UniSTS
HuRef1142,378,291 - 142,378,623UniSTS
G67464  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371171,162,376 - 171,162,812UniSTSGRCh37
Build 361169,429,000 - 169,429,436RGDNCBI36
Celera1144,272,285 - 144,272,721RGD
Cytogenetic Map1q24.3UniSTS
HuRef1142,385,869 - 142,386,305UniSTS
G67465  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371171,168,395 - 171,168,717UniSTSGRCh37
Build 361169,435,019 - 169,435,341RGDNCBI36
Celera1144,278,304 - 144,278,626RGD
Cytogenetic Map1q24.3UniSTS
HuRef1142,391,888 - 142,392,210UniSTS
G67459  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371171,172,836 - 171,173,253UniSTSGRCh37
Build 361169,439,460 - 169,439,877RGDNCBI36
Celera1144,282,746 - 144,283,163RGD
Cytogenetic Map1q24.3UniSTS
HuRef1142,396,330 - 142,396,747UniSTS
G67460  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371171,174,360 - 171,174,899UniSTSGRCh37
Build 361169,440,984 - 169,441,523RGDNCBI36
Celera1144,284,270 - 144,284,809RGD
Cytogenetic Map1q24.3UniSTS
HuRef1142,397,854 - 142,398,393UniSTS
G67461  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371171,176,720 - 171,177,017UniSTSGRCh37
Build 361169,443,344 - 169,443,641RGDNCBI36
Celera1144,286,630 - 144,286,927RGD
Cytogenetic Map1q24.3UniSTS
HuRef1142,400,214 - 142,400,511UniSTS
G67462  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371171,177,852 - 171,178,491UniSTSGRCh37
Build 361169,444,476 - 169,445,115RGDNCBI36
Celera1144,287,762 - 144,288,401RGD
Cytogenetic Map1q24.3UniSTS
HuRef1142,401,346 - 142,401,985UniSTS
SHGC-75894  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371171,181,618 - 171,181,762UniSTSGRCh37
Build 361169,448,242 - 169,448,386RGDNCBI36
Celera1144,291,446 - 144,291,590RGD
Cytogenetic Map1q24.3UniSTS
HuRef1142,405,030 - 142,405,174UniSTS
TNG Radiation Hybrid Map178460.0UniSTS
GeneMap99-GB4 RH Map1619.52UniSTS
STS-Y09267  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371171,178,090 - 171,178,288UniSTSGRCh37
Build 361169,444,714 - 169,444,912RGDNCBI36
Celera1144,288,000 - 144,288,198RGD
Cytogenetic Map1q24.3UniSTS
HuRef1142,401,584 - 142,401,782UniSTS
GeneMap99-GB4 RH Map1620.39UniSTS
FMO2_3015  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371171,177,861 - 171,178,455UniSTSGRCh37
Build 361169,444,485 - 169,445,079RGDNCBI36
Celera1144,287,771 - 144,288,365RGD
HuRef1142,401,355 - 142,401,949UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system sensory system visual system adipose tissue appendage entire extraembryonic component pharyngeal arch
High
Medium 1256 2064 851 163 72 8 2473 1491 728 113 390 1196 154 1194 1715 1
Low 977 190 739 362 456 354 1588 647 2177 187 857 173 12 1 10 1066 1 1
Below cutoff 69 689 88 70 869 70 124 11 748 55 96 36 7 2

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001301347 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001365900 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001426376 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001426378 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001426379 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001460 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NR_160266 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_001737072 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_007057966 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_921761 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AI821378 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK098145 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK304385 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK312877 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AL021026 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AL833218 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AY916056 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC005894 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BI766311 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BT006979 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CA312067 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH471067 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CP068277 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  DB224311 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  DB236882 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  KF459607 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  R95468 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  Y09267 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

RefSeq Acc Id: ENST00000209929   ⟹   ENSP00000209929
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1171,185,300 - 171,212,686 (+)Ensembl
RefSeq Acc Id: ENST00000462643
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1171,185,249 - 171,193,510 (+)Ensembl
RefSeq Acc Id: ENST00000483192   ⟹   ENSP00000487216
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1171,185,524 - 171,196,720 (+)Ensembl
RefSeq Acc Id: ENST00000488431
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1171,207,543 - 171,209,207 (+)Ensembl
RefSeq Acc Id: ENST00000489354
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1171,185,300 - 171,203,989 (+)Ensembl
RefSeq Acc Id: ENST00000493513
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1171,185,302 - 171,186,366 (+)Ensembl
RefSeq Acc Id: ENST00000529935   ⟹   ENSP00000487002
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1171,185,300 - 171,209,196 (+)Ensembl
RefSeq Acc Id: NM_001301347   ⟹   NP_001288276
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381171,185,300 - 171,212,686 (+)NCBI
CHM1_11172,576,480 - 172,603,952 (+)NCBI
T2T-CHM13v2.01170,541,681 - 170,568,989 (+)NCBI
Sequence:
RefSeq Acc Id: NM_001365900   ⟹   NP_001352829
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381171,185,208 - 171,212,683 (+)NCBI
T2T-CHM13v2.01170,541,589 - 170,568,986 (+)NCBI
Sequence:
RefSeq Acc Id: NM_001460   ⟹   NP_001451
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381171,185,300 - 171,212,686 (+)NCBI
GRCh371171,154,388 - 171,181,822 (+)ENTREZGENE
Build 361169,421,012 - 169,448,446 (+)NCBI Archive
HuRef1142,377,885 - 142,405,234 (+)ENTREZGENE
CHM1_11172,576,480 - 172,603,952 (+)NCBI
T2T-CHM13v2.01170,541,681 - 170,568,989 (+)NCBI
Sequence:
RefSeq Acc Id: NR_160266
RefSeq Status: REVIEWED
Type: NON-CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381171,185,300 - 171,212,686 (+)NCBI
T2T-CHM13v2.01170,541,681 - 170,568,989 (+)NCBI
Sequence:
RefSeq Acc Id: XR_001737072
Type: NON-CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381171,185,208 - 171,211,230 (+)NCBI
Sequence:
RefSeq Acc Id: XR_007057966
Type: NON-CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381171,185,208 - 171,212,686 (+)NCBI
RefSeq Acc Id: XR_921761
Type: NON-CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381171,185,208 - 171,211,230 (+)NCBI
Sequence:
RefSeq Acc Id: NP_001451   ⟸   NM_001460
- Peptide Label: isoform a
- UniProtKB: Q86U73 (UniProtKB/Swiss-Prot),   Q5EBX4 (UniProtKB/Swiss-Prot),   Q9BRX1 (UniProtKB/Swiss-Prot),   Q99518 (UniProtKB/Swiss-Prot),   Q5JPC7 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001288276   ⟸   NM_001301347
- Peptide Label: isoform b
- UniProtKB: B4E2Q9 (UniProtKB/TrEMBL),   Q5JPC7 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001352829   ⟸   NM_001365900
- Peptide Label: isoform c
- UniProtKB: Q5JPC7 (UniProtKB/TrEMBL)
RefSeq Acc Id: ENSP00000487216   ⟸   ENST00000483192
RefSeq Acc Id: ENSP00000209929   ⟸   ENST00000209929
RefSeq Acc Id: ENSP00000487002   ⟸   ENST00000529935

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q99518-F1-model_v2 AlphaFold Q99518 1-535 view protein structure

Promoters
RGD ID:6858102
Promoter ID:EPDNEW_H2215
Type:initiation region
Name:FMO2_1
Description:flavin containing monooxygenase 2
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh381171,185,300 - 171,185,360EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene HGNC:3770 AgrOrtholog
COSMIC FMO2 COSMIC
Ensembl Genes ENSG00000094963 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Transcript ENST00000209929 ENTREZGENE
  ENST00000209929.10 UniProtKB/Swiss-Prot
  ENST00000483192.2 UniProtKB/TrEMBL
  ENST00000529935.5 UniProtKB/TrEMBL
Gene3D-CATH 3.50.50.60 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
GTEx ENSG00000094963 GTEx
HGNC ID HGNC:3770 ENTREZGENE
Human Proteome Map FMO2 Human Proteome Map
InterPro FAD/NAD-bd_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Flavin_mOase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Flavin_mOase-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Flavin_mOase_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report hsa:2327 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
NCBI Gene 2327 ENTREZGENE
OMIM 603955 OMIM
PANTHER DIMETHYLANILINE MONOOXYGENASE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  DIMETHYLANILINE MONOOXYGENASE [N-OXIDE-FORMING] 2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam FMO-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PharmGKB PA164741534 PharmGKB
PIRSF FMO UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PRINTS FMOXYGENASE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  FMOXYGENASE2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF51905 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A0D9SFZ0_HUMAN UniProtKB/TrEMBL
  A0A0D9SG76_HUMAN UniProtKB/TrEMBL
  B4E2Q9 ENTREZGENE, UniProtKB/TrEMBL
  FMO2_HUMAN UniProtKB/Swiss-Prot
  Q5EBX4 ENTREZGENE
  Q5JPC7 ENTREZGENE, UniProtKB/TrEMBL
  Q86U73 ENTREZGENE
  Q99518 ENTREZGENE
  Q9BRX1 ENTREZGENE
UniProt Secondary Q5EBX4 UniProtKB/Swiss-Prot
  Q86U73 UniProtKB/Swiss-Prot
  Q9BRX1 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2019-04-30 FMO2  flavin containing dimethylaniline monoxygenase 2  FMO2  flavin containing monooxygenase 2  Symbol and/or name change 5135510 APPROVED
2015-11-10 FMO2  flavin containing monooxygenase 2  FMO2  flavin containing monooxygenase 2 (non-functional)  Symbol and/or name change 5135510 APPROVED