CHEBI ONTOLOGY - ANNOTATIONS
The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/ . The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/ ). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term: Dimethyl phthalate
Accession: CHEBI:4609
browse the term
Definition: A phthalate ester that has formula C10H10O4.
Synonyms: related_synonym: Formula=C10H10O4; InChI=1S/C10H10O4/c1-13-9(11)7-5-3-4-6-8(7)10(12)14-2/h3-6H,1-2H3; InChIKey=NIQCNGHVCWTJSM-UHFFFAOYSA-N; SMILES=COC(=O)c1ccccc1C(=O)OC
xref: CAS:131-11-3; Drug_Central:4771; KEGG:C11233
xref_mesh: MESH:C024629
xref: PPDB:2989; VSDB:2989
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Afp
alpha-fetoprotein
affects binding
EXP
dimethyl phthalate binds to AFP protein
CTD
PMID:23013281 PMID:25349334
NCBI chr14:17,573,412...17,591,476
Ensembl chr14:17,573,412...17,591,480
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Ar
androgen receptor
multiple interactions
ISO
dimethyl phthalate analog inhibits the reaction [Dihydrotestosterone binds to and results in increased activity of AR protein]; dimethyl phthalate inhibits the reaction [Dihydrotestosterone results in increased activity of AR protein]
CTD
PMID:20943248 PMID:28571686
NCBI chr X:63,104,771...63,273,934
Ensembl chr X:63,104,771...63,273,925
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Bak1
BCL2-antagonist/killer 1
increases expression
EXP
dimethyl phthalate results in increased expression of BAK1 mRNA
CTD
PMID:35598668
NCBI chr20:5,100,480...5,109,669
Ensembl chr20:5,100,480...5,109,264
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Bax
BCL2 associated X, apoptosis regulator
increases expression
EXP
dimethyl phthalate results in increased expression of BAX mRNA
CTD
PMID:35598668
NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368
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Bcl2
BCL2, apoptosis regulator
increases expression
EXP
dimethyl phthalate results in increased expression of BCL2 mRNA
CTD
PMID:35598668
NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743 Ensembl chr13:22,684,989...22,853,743
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Bid
BH3 interacting domain death agonist
increases expression
EXP
dimethyl phthalate results in increased expression of BID mRNA
CTD
PMID:35598668
NCBI chr 4:154,113,198...154,136,353
Ensembl chr 4:154,113,198...154,134,720
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Casp2
caspase 2
increases expression
EXP
dimethyl phthalate results in increased expression of CASP2 mRNA
CTD
PMID:35598668
NCBI chr 4:71,149,632...71,167,388
Ensembl chr 4:71,149,669...71,167,379
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Casp3
caspase 3
increases expression
EXP
dimethyl phthalate results in increased expression of CASP3 mRNA
CTD
PMID:35598668
NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
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Casp7
caspase 7
increases expression
EXP
dimethyl phthalate results in increased expression of CASP7 mRNA
CTD
PMID:35598668
NCBI chr 1:255,437,438...255,476,737
Ensembl chr 1:255,437,172...255,476,729
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Casp8
caspase 8
increases expression
EXP
dimethyl phthalate results in increased expression of CASP8 mRNA
CTD
PMID:35598668
NCBI chr 9:60,263,863...60,312,542
Ensembl chr 9:60,264,075...60,312,542
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Cyp11a1
cytochrome P450, family 11, subfamily a, polypeptide 1
increases expression
EXP
dimethyl phthalate results in increased expression of CYP11A1 mRNA
CTD
PMID:26472102
NCBI chr 8:58,422,807...58,434,342
Ensembl chr 8:58,404,669...58,434,338
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Cyp1a2
cytochrome P450, family 1, subfamily a, polypeptide 2
decreases activity
EXP
dimethyl phthalate results in decreased activity of CYP1A2 protein
CTD
PMID:27432241
NCBI chr 8:58,075,367...58,082,255
Ensembl chr 8:58,075,367...58,082,312
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Cyp2b1
cytochrome P450, family 2, subfamily b, polypeptide 1
decreases activity
EXP
dimethyl phthalate results in decreased activity of CYP2B1 protein
CTD
PMID:27432241
NCBI chr 1:81,518,387...81,544,999
Ensembl chr 1:81,518,408...81,542,052
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Fadd
Fas associated via death domain
increases expression
EXP
dimethyl phthalate results in increased expression of FADD mRNA
CTD
PMID:35598668
NCBI chr 1:199,743,200...199,745,746
Ensembl chr 1:199,739,994...199,745,653
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Fas
Fas cell surface death receptor
increases expression
EXP
dimethyl phthalate results in increased expression of FAS mRNA
CTD
PMID:35598668
NCBI chr 1:231,798,963...231,832,591
Ensembl chr 1:231,798,960...231,832,591
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Faslg
Fas ligand
increases expression
EXP
dimethyl phthalate results in increased expression of FASLG mRNA
CTD
PMID:35598668
NCBI chr13:74,151,519...74,172,760
Ensembl chr13:74,154,954...74,162,215
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Ifng
interferon gamma
decreases expression
EXP
dimethyl phthalate results in decreased expression of IFNG protein
CTD
PMID:35598668
NCBI chr 7:53,903,339...53,907,375
Ensembl chr 7:53,903,337...53,907,375
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Igf1
insulin-like growth factor 1
decreases expression
EXP
dimethyl phthalate results in decreased expression of IGF1 mRNA
CTD
PMID:26472102
NCBI chr 7:22,282,895...22,361,972
Ensembl chr 7:22,282,930...22,359,296
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Il4
interleukin 4
decreases expression
EXP
dimethyl phthalate results in decreased expression of IL4 protein
CTD
PMID:35598668
NCBI chr10:37,771,203...37,776,750
Ensembl chr10:37,771,203...37,776,750
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Il6
interleukin 6
decreases expression
EXP
dimethyl phthalate results in decreased expression of IL6 protein
CTD
PMID:35598668
NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178
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Msh2
mutS homolog 2
decreases expression
EXP
dimethyl phthalate results in decreased expression of MSH2 mRNA
CTD
PMID:26472102
NCBI chr 6:6,813,793...6,872,960
Ensembl chr 6:6,813,795...6,872,938
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Myocd
myocardin
decreases expression
EXP
dimethyl phthalate results in decreased expression of MYOCD mRNA
CTD
PMID:26472102
NCBI chr10:49,833,219...49,928,806
Ensembl chr10:49,836,641...49,927,627
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Nr1i3
nuclear receptor subfamily 1, group I, member 3
affects binding
ISO
dimethyl phthalate binds to NR1I3 protein
CTD
PMID:25938866
NCBI chr13:83,632,940...83,638,193
Ensembl chr13:83,632,899...83,637,906
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Ppara
peroxisome proliferator activated receptor alpha
affects binding
ISO
dimethyl phthalate binds to PPARA protein
CTD
PMID:23843199
NCBI chr 7:116,832,405...116,900,878
Ensembl chr 7:116,832,756...116,895,346
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Ppard
peroxisome proliferator-activated receptor delta
affects binding
ISO
dimethyl phthalate binds to PPARB protein
CTD
PMID:23843199
NCBI chr20:6,298,785...6,363,970
Ensembl chr20:6,298,785...6,363,968
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Pparg
peroxisome proliferator-activated receptor gamma
affects binding
ISO
dimethyl phthalate binds to PPARG protein
CTD
PMID:23843199
NCBI chr 4:148,423,102...148,548,471
Ensembl chr 4:148,423,194...148,548,468
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Rxra
retinoid X receptor alpha
affects binding
ISO
dimethyl phthalate binds to RXRA protein
CTD
PMID:23843199
NCBI chr 3:10,989,832...11,076,366
Ensembl chr 3:10,989,832...11,073,712
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Rxrb
retinoid X receptor beta
affects binding
ISO
dimethyl phthalate binds to RXRB protein
CTD
PMID:23843199
NCBI chr20:4,816,813...4,823,267
Ensembl chr20:4,816,815...4,828,773
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Rxrg
retinoid X receptor gamma
affects binding
ISO
dimethyl phthalate binds to RXRG protein
CTD
PMID:23843199
NCBI chr13:79,743,430...79,785,173
Ensembl chr13:79,743,563...79,785,167
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Scarb1
scavenger receptor class B, member 1
decreases expression
EXP
dimethyl phthalate results in decreased expression of SCARB1 mRNA
CTD
PMID:26472102
NCBI chr12:31,296,143...31,362,649
Ensembl chr12:31,296,156...31,362,647
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Sod1
superoxide dismutase 1
decreases expression
EXP
dimethyl phthalate results in decreased expression of SOD1 protein
CTD
PMID:35598668
NCBI chr11:29,456,673...29,462,249
Ensembl chr11:29,456,558...29,462,249
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Star
steroidogenic acute regulatory protein
decreases expression
EXP
dimethyl phthalate results in decreased expression of STAR mRNA
CTD
PMID:26472102
NCBI chr16:66,267,094...66,274,368
Ensembl chr16:66,264,807...66,271,672
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