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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:isopropyl salicylate
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Accession:CHEBI:38703 term browser browse the term
Definition:A benzoate ester that is the isopropyl ester of salicylic acid.
Synonyms:exact_synonym: propan-2-yl 2-hydroxybenzoate
 related_synonym: 1-methylethyl 2-hydroxybenzoate;   Formula=C10H12O3;   InChI=1S/C10H12O3/c1-7(2)13-10(12)8-5-3-4-6-9(8)11/h3-7,11H,1-2H3;   InChIKey=YEULQIJMIOWCHB-UHFFFAOYSA-N;   Iso-propyl salicylate;   Isopropyl o-hydroxybenzoate;   SMILES=CC(C)OC(=O)c1ccccc1O;   Salicylic acid, isopropyl ester
 xref: Beilstein:2615569;   CAS:607-85-2;   PMID:1650428;   PMID:19996699;   Reaxys:2615569


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isocarbophos term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ache acetylcholinesterase decreases activity ISO
EXP		 isocarbophos metabolite results in decreased activity of ACHE protein
isocarbophos results in decreased activity of ACHE protein		 CTD PMID:24752505 PMID:26818681 PMID:33844597 NCBI chr12:19,406,133...19,413,713
Ensembl chr12:19,407,360...19,413,651 		JBrowse link
G Bax BCL2 associated X, apoptosis regulator increases expression ISO isocarbophos analog results in increased expression of BAX protein CTD PMID:20688129 NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368 		JBrowse link
G Bcl2 BCL2, apoptosis regulator decreases expression ISO isocarbophos analog results in decreased expression of BCL2 protein CTD PMID:20688129 NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743
Ensembl chr13:22,684,989...22,853,743 		JBrowse link
G Casp3 caspase 3 increases cleavage EXP isocarbophos results in increased cleavage of CASP3 protein CTD PMID:26818681 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648 		JBrowse link
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 multiple interactions ISO CYP1A2 protein results in increased metabolism of and results in decreased sulfation of and affects the activity of isocarbophos CTD PMID:24752505 NCBI chr 8:58,075,367...58,082,255
Ensembl chr 8:58,075,367...58,082,312 		JBrowse link
G Cyp2c6 cytochrome P450, family 2, subfamily C, polypeptide 6 multiple interactions ISO CYP2C19 protein results in increased metabolism of and results in decreased sulfation of and affects the activity of isocarbophos CTD PMID:24752505 NCBI chr 1:237,938,521...237,976,238
Ensembl chr 1:237,693,094...238,057,596 		JBrowse link
G Cyp2d4 cytochrome P450, family 2, subfamily d, polypeptide 4 multiple interactions ISO CYP2D6 protein results in increased metabolism of and results in decreased sulfation of and affects the activity of isocarbophos CTD PMID:24752505 NCBI chr 7:113,882,584...113,891,754
Ensembl chr 7:113,881,618...113,891,759 		JBrowse link
G Cyp3a2 cytochrome P450, family 3, subfamily a, polypeptide 2 multiple interactions ISO CYP3A4 protein results in increased metabolism of and results in decreased sulfation of and affects the activity of isocarbophos CTD PMID:24752505 NCBI chr12:9,207,978...9,230,064
Ensembl chr12:9,015,383...9,285,008 		JBrowse link
G Gja1 gap junction protein, alpha 1 increases expression EXP isocarbophos results in increased expression of GJA1 protein CTD PMID:26818681 NCBI chr20:35,756,007...35,768,481
Ensembl chr20:35,755,991...35,768,582 		JBrowse link
G Icam1 intercellular adhesion molecule 1 increases expression EXP isocarbophos results in increased expression of ICAM1 protein CTD PMID:26818681 NCBI chr 8:19,553,063...19,565,438
Ensembl chr 8:19,553,645...19,565,438 		JBrowse link
G Mapk1 mitogen activated protein kinase 1 increases phosphorylation
multiple interactions		 ISO isocarbophos analog results in increased phosphorylation of MAPK1 protein
manganese(III)-tetrakis(4-benzoic acid)porphyrin inhibits the reaction [isocarbophos analog results in increased phosphorylation of MAPK1 protein]		 CTD PMID:20688129 NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616 		JBrowse link
G Mapk3 mitogen activated protein kinase 3 increases phosphorylation
multiple interactions		 ISO isocarbophos analog results in increased phosphorylation of MAPK3 protein
manganese(III)-tetrakis(4-benzoic acid)porphyrin inhibits the reaction [isocarbophos analog results in increased phosphorylation of MAPK3 protein]		 CTD PMID:20688129 NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863 		JBrowse link
G Tp53 tumor protein p53 affects activity ISO isocarbophos affects the activity of TP53 protein; isocarbophos metabolite affects the activity of TP53 protein CTD PMID:35435491 NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524 		JBrowse link
G Vcam1 vascular cell adhesion molecule 1 increases expression EXP isocarbophos results in increased expression of VCAM1 protein CTD PMID:26818681 NCBI chr 2:204,038,120...204,057,852
Ensembl chr 2:204,038,114...204,057,958 		JBrowse link
isofenphos term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ar androgen receptor multiple interactions ISO Dihydrotestosterone inhibits the reaction [isofenphos results in increased activity of AR protein] CTD PMID:15064155 NCBI chr  X:63,104,771...63,273,934
Ensembl chr  X:63,104,771...63,273,925 		JBrowse link
G Cyp3a2 cytochrome P450, family 3, subfamily a, polypeptide 2 increases expression ISO isofenphos results in increased expression of CYP3A4 mRNA CTD PMID:17293382 NCBI chr12:9,207,978...9,230,064
Ensembl chr12:9,015,383...9,285,008 		JBrowse link
G Esr1 estrogen receptor 1 increases activity ISO isofenphos results in increased activity of ESR1 protein CTD PMID:15064155 NCBI chr 1:41,106,335...41,499,104
Ensembl chr 1:41,210,475...41,495,002 		JBrowse link
G Nr1i2 nuclear receptor subfamily 1, group I, member 2 multiple interactions ISO isofenphos binds to and results in increased activity of NR1I2 protein; isofenphos metabolite binds to and results in increased activity of NR1I2 protein CTD PMID:21115097 NCBI chr11:62,460,213...62,496,665
Ensembl chr11:62,460,213...62,496,658 		JBrowse link
G Nr1i3 nuclear receptor subfamily 1, group I, member 3 increases activity ISO isofenphos results in increased activity of NR1I3 protein CTD PMID:28927721 NCBI chr13:83,632,940...83,638,193
Ensembl chr13:83,632,899...83,637,906 		JBrowse link
G Tp53 tumor protein p53 affects activity ISO isofenphos metabolite affects the activity of TP53 protein CTD PMID:35435491 NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19808
    role 19784
      biological role 19782
        antimicrobial agent 18141
          antifungal agent 16834
            salicylic acid 1542
              isopropyl salicylate 18
                isocarbophos 14
                isofenphos 6
Path 2
Term Annotations click to browse term
  CHEBI ontology 19808
    subatomic particle 19806
      composite particle 19806
        hadron 19806
          baryon 19806
            nucleon 19806
              atomic nucleus 19806
                atom 19806
                  main group element atom 19756
                    p-block element atom 19756
                      carbon group element atom 19705
                        carbon atom 19702
                          organic molecular entity 19702
                            heteroorganic entity 19460
                              organochalcogen compound 19224
                                organooxygen compound 19141
                                  carbon oxoacid 18612
                                    carboxylic acid 18609
                                      monocarboxylic acid 17984
                                        fatty acid 16792
                                          fatty acid derivative 8960
                                            fatty alcohol 6103
                                              secondary fatty alcohol 788
                                                propan-2-ol 788
                                                  isopropyl ester 773
                                                    isopropyl salicylate 18
                                                      isocarbophos 14
                                                      isofenphos 6
paths to the root