Several protein classes are important for the maturation of the autophagosome and its fusion with a lysosome to form the autolysosome. They include members of the Rab family, of ESCRT and SNARE complexes and Becn1 in association with Uvrag and Rubicon. Some Rab members, like Rab5a and Rab33b, may help localize members of the conjugation systems in earlier steps; they are shown here along with Rab7a and 11a that play a role in the maturation and fusion of the autophagosome. Also of note is the fact that ESCRT and SNARE are heteromeric complexes and therefore all family members may be involved in autophagy. However, evidence is available for selected members and they are listed here. For more information, check PMIDs 20548331, 19535733 and references therein. In the case of ESCRT members, the type of ESCRT complex is indicated in brackets.The genes are listed with aliases in parentheses, full name and link to gene report pages:

Rab members
Rab5a (Rab5, Rab-5a) RAB5A, member Ras oncogene family
Rab7a (Rab7, Rab-7a) – RAB7A, member RAS oncogene family
Rab11a (Rab11, Rab-11a) – Rab11a, member RAS oncogene family
Rab33b (Rab-33B) – RAB33B, member RAS oncogene family

ESCRT members
Hgs (Hrs) – hepatocyte growth factor-regulated tyrosine kinase substrate [member of ESCRT-0 complex]
Tsg101 (VPS23, Tsg10) – tumor susceptibility 101 [member of ESCRT-I complex]
Snf8 (Vps22) – SNF8, ESCRT-II complex subunit
Chmp3 (Vps24) – charged multivesicular body protein 3 [member of ESCRT-III complex]
Chmp2b (VPS2B) – charged multivesicular body protein 2B [member of ESCRT-III complex]
Vps4a (Vps4, Skd1) – vacuolar protein sorting 4 homolog A [others, ESCRT-III disassembly]

SNARE members
Vamp3 (Vamp-3, cellubrevin) – vesicle-associated membrane protein 3
Vamp7 (Vamp-7, Sybl1) – vesicle-associated membrane protein 7