Rab11a (RAB11a, member RAS oncogene family) - Rat Genome Database

Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Behavioral & Substance Use Disorder Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources
Advanced Search (OLGA)
Gene: Rab11a (RAB11a, member RAS oncogene family) Rattus norvegicus
Analyze
Symbol: Rab11a
Name: RAB11a, member RAS oncogene family
RGD ID: 619762
Description: Enables GTP binding activity and GTPase activity. Involved in several processes, including endosomal transport; positive regulation of protein localization to plasma membrane; and regulation of long-term neuronal synaptic plasticity. Located in recycling endosome. Is active in Schaffer collateral - CA1 synapse; cytoplasmic vesicle; and glutamatergic synapse. Orthologous to human RAB11A (RAB11A, member RAS oncogene family); PARTICIPATES IN autophagy pathway; eicosanoid signaling pathway; insulin responsive facilitative sugar transporter mediated glucose transport pathway; INTERACTS WITH 17alpha-ethynylestradiol; 2,3,7,8-tetrachlorodibenzodioxine; 2,6-dinitrotoluene.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: 24KG; rab-11; ras-related protein Rab-11A
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8874,118,922 - 74,141,760 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl874,118,922 - 74,141,837 (-)EnsemblGRCr8
mRatBN7.2865,223,698 - 65,246,461 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl865,222,949 - 65,246,525 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx870,737,827 - 70,760,586 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0869,010,409 - 69,033,168 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0866,880,396 - 66,903,155 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0870,192,975 - 70,215,719 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl870,192,975 - 70,215,719 (-)Ensemblrn6Rnor6.0
Rnor_5.0869,896,587 - 69,919,171 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4868,931,925 - 68,979,514 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera864,627,832 - 64,650,008 (-)NCBICelera
RGSC_v3.1868,950,978 - 68,998,568 (-)NCBI
Cytogenetic Map8q24NCBI
JBrowse:




Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
1,2-dimethylhydrazine  (ISO)
17alpha-ethynylestradiol  (EXP,ISO)
17beta-estradiol  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,6-dimethoxyphenol  (ISO)
2,6-dinitrotoluene  (EXP)
2-hydroxypropanoic acid  (ISO)
3H-1,2-dithiole-3-thione  (EXP)
4,4'-sulfonyldiphenol  (EXP,ISO)
4-hydroxynon-2-enal  (ISO)
5-fluorouracil  (ISO)
6-propyl-2-thiouracil  (EXP)
aflatoxin B1  (ISO)
all-trans-retinoic acid  (ISO)
ammonium chloride  (EXP)
amphetamine  (EXP)
antirheumatic drug  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
atrazine  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (EXP)
Butylbenzyl phthalate  (ISO)
cadmium dichloride  (EXP)
caffeine  (ISO)
captan  (ISO)
carbon nanotube  (ISO)
chlorpyrifos  (ISO)
clofibrate  (ISO)
cobalt dichloride  (EXP)
doxorubicin  (ISO)
epoxiconazole  (ISO)
ethanol  (EXP,ISO)
fipronil  (EXP)
flutamide  (EXP)
folic acid  (ISO)
folpet  (ISO)
furfural  (ISO)
gold atom  (ISO)
gold(0)  (ISO)
haloperidol  (EXP)
Maduramicin  (EXP)
melittin  (ISO)
metformin  (ISO)
methylparaben  (ISO)
mono(2-ethylhexyl) phthalate  (ISO)
N-methyl-4-phenylpyridinium  (ISO)
nimesulide  (EXP)
nitrates  (ISO)
Nivalenol  (ISO)
paracetamol  (ISO)
paraquat  (EXP)
perfluorooctane-1-sulfonic acid  (ISO)
phenethyl isothiocyanate  (EXP)
PhIP  (EXP)
pirinixic acid  (ISO)
pregnenolone 16alpha-carbonitrile  (EXP)
rac-lactic acid  (ISO)
resveratrol  (ISO)
senecionine  (ISO)
sodium arsenite  (ISO)
sodium chloride  (ISO)
Soman  (EXP)
tetrachloromethane  (ISO)
triptonide  (ISO)
valproic acid  (ISO)
vinclozolin  (EXP)
zinc atom  (ISO)
zinc(0)  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
amyloid-beta clearance by transcytosis  (IEA,ISO)
astral microtubule organization  (IEA,ISO)
early endosome to recycling endosome transport  (IEA,ISO)
establishment of protein localization to membrane  (IEA,ISO)
establishment of protein localization to organelle  (IEA,ISO)
establishment of vesicle localization  (IEA,ISO)
exocytosis  (IBA)
exosomal secretion  (IEA,ISO)
intracellular cholesterol transport  (ISS)
melanosome transport  (IBA,IEA,ISO,ISS)
mitotic metaphase chromosome alignment  (IEA,ISO)
mitotic spindle assembly  (IEA,ISO)
multivesicular body assembly  (IEA,ISO)
neuron projection development  (IEA,ISO,ISS)
neurotransmitter receptor transport, endosome to postsynaptic membrane  (IBA,IDA,IMP)
positive regulation of epithelial cell migration  (IEA,ISO)
positive regulation of G2/M transition of mitotic cell cycle  (IEA,ISO)
positive regulation of mitotic cytokinetic process  (IEA,ISO)
positive regulation of protein localization to plasma membrane  (IMP)
protein localization to cell surface  (ISO)
protein localization to cilium  (IEA,ISO,ISS)
protein localization to plasma membrane  (IEA,ISO,ISS)
protein transmembrane transport  (ISO)
protein transport  (IEA)
regulation of cilium assembly  (IEA,ISO,ISS)
regulation of cytokinesis  (IEA,ISO)
regulation of early endosome to recycling endosome transport  (IEA,ISO,ISS)
regulation of endocytic recycling  (IEA,ISO,ISS)
regulation of long-term neuronal synaptic plasticity  (IMP)
regulation of protein localization to centrosome  (IEA,ISO,ISS)
regulation of protein transport  (IMP)
regulation of vesicle-mediated transport  (IEA,ISO)
synaptic vesicle endosomal processing  (EXP,IDA,IMP)
vesicle-mediated transport  (IEA,ISO)

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Physiology and pathophysiology of the vasopressin-regulated renal water reabsorption. Boone M and Deen PM, Pflugers Arch. 2008 Sep;456(6):1005-24. Epub 2008 Apr 23.
2. Functional compartmentalization of endosomal trafficking for the synaptic delivery of AMPA receptors during long-term potentiation. Brown TC, etal., J Neurosci. 2007 Nov 28;27(48):13311-5.
3. Requirement of myosin Vb.Rab11a.Rab11-FIP2 complex in cholesterol-regulated translocation of NPC1L1 to the cell surface. Chu BB, etal., J Biol Chem. 2009 Aug 14;284(33):22481-90. doi: 10.1074/jbc.M109.034355. Epub 2009 Jun 19.
4. Positioning of AMPA Receptor-Containing Endosomes Regulates Synapse Architecture. Esteves da Silva M, etal., Cell Rep. 2015 Nov 3;13(5):933-43. doi: 10.1016/j.celrep.2015.09.062. Epub 2015 Oct 22.
5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
6. Rab proteins in endocytosis and Glut4 trafficking. Kaddai V, etal., Acta Physiol (Oxf). 2008 Jan;192(1):75-88.
7. Activity-dependent bulk endocytosis proteome reveals a key presynaptic role for the monomeric GTPase Rab11. Kokotos AC, etal., Proc Natl Acad Sci U S A. 2018 Oct 23;115(43):E10177-E10186. doi: 10.1073/pnas.1809189115. Epub 2018 Oct 9.
8. Intracellular accumulation of pIgA-R and regulators of transcytotic trafficking in cholestatic rat hepatocytes. Larkin JM, etal., Hepatology 2003 Nov;38(5):1199-209.
9. Overview of macroautophagy regulation in mammalian cells. Mehrpour M, etal., Cell Res. 2010 Jul;20(7):748-62. Epub 2010 Jun 15.
10. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
11. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
12. A Role of myosin Vb and Rab11-FIP2 in the aquaporin-2 shuttle. Nedvetsky PI, etal., Traffic. 2007 Feb;8(2):110-23. Epub 2006 Dec 6.
13. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
14. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
15. GOA pipeline RGD automated data pipeline
16. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
17. Molecular cloning and characterization of a ras p21-like GTP-binding protein (24KG) from rat liver. Sakurada K, etal., Biochem Biophys Res Commun 1991 Jun 28;177(3):1224-32.
18. EARP is a multisubunit tethering complex involved in endocytic recycling. Schindler C, etal., Nat Cell Biol. 2015 May;17(5):639-50. doi: 10.1038/ncb3129. Epub 2015 Mar 23.
19. A novel method to monitor insulin-stimulated GTP-loading of Rab11a in cardiomyocytes. Schwenk RW and Eckel J, Cell Signal. 2007 Apr;19(4):825-30. Epub 2006 Dec 8.
20. Hidden proteome of synaptic vesicles in the mammalian brain. Taoufiq Z, etal., Proc Natl Acad Sci U S A. 2020 Dec 29;117(52):33586-33596. doi: 10.1073/pnas.2011870117. Epub 2020 Dec 21.
21. Identification and characterization of a novel variant in the highly conserved catalytic center of Rab11a. Uhlig M, etal., Eur J Med Genet. 2006 Jan-Feb;49(1):29-36.
22. A tubular endosomal fraction from rat liver: biochemical evidence of receptor sorting by default. Verges M, etal., Proc Natl Acad Sci U S A. 1999 Aug 31;96(18):10146-51.
23. GLUT4 translocation: the last 200 nanometers. Watson RT and Pessin JE, Cell Signal. 2007 Nov;19(11):2209-17. Epub 2007 Jun 21.
24. Role of ARF6 in internalization of metal-binding proteins, metallothionein and transferrin, and cadmium-metallothionein toxicity in kidney proximal tubule cells. Wolff NA, etal., Toxicol Appl Pharmacol. 2008 Jul 1;230(1):78-85. Epub 2008 Feb 20.
25. Insulin action on glucose transporters through molecular switches, tracks and tethers. Zaid H, etal., Biochem J. 2008 Jul 15;413(2):201-15.
Additional References at PubMed
PMID:11163216   PMID:12145319   PMID:12477932   PMID:15128739   PMID:15229288   PMID:15326289   PMID:15489334   PMID:15601896   PMID:15634213   PMID:15837192   PMID:16380373   PMID:16791210  
PMID:16905101   PMID:17007872   PMID:17030804   PMID:17082457   PMID:17462998   PMID:17562788   PMID:18504258   PMID:18570918   PMID:18614015   PMID:18656450   PMID:19061864   PMID:19631257  
PMID:19706553   PMID:21255211   PMID:21291502   PMID:22139371   PMID:22573681   PMID:22613965   PMID:23389633   PMID:23533145   PMID:23612789   PMID:24006491   PMID:24035762   PMID:24561039  
PMID:24648492   PMID:26005850   PMID:26302266   PMID:27068304   PMID:27807067   PMID:28005071   PMID:28829741   PMID:30545898   PMID:32375403   PMID:37268020  


Genomics

Comparative Map Data
Rab11a
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8874,118,922 - 74,141,760 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl874,118,922 - 74,141,837 (-)EnsemblGRCr8
mRatBN7.2865,223,698 - 65,246,461 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl865,222,949 - 65,246,525 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx870,737,827 - 70,760,586 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0869,010,409 - 69,033,168 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0866,880,396 - 66,903,155 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0870,192,975 - 70,215,719 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl870,192,975 - 70,215,719 (-)Ensemblrn6Rnor6.0
Rnor_5.0869,896,587 - 69,919,171 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4868,931,925 - 68,979,514 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera864,627,832 - 64,650,008 (-)NCBICelera
RGSC_v3.1868,950,978 - 68,998,568 (-)NCBI
Cytogenetic Map8q24NCBI
RAB11A
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381565,869,491 - 65,891,989 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1565,726,054 - 65,891,989 (+)Ensemblhg38GRCh38
GRCh371566,161,829 - 66,184,327 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361563,948,850 - 63,968,846 (+)NCBIBuild 36Build 36hg18NCBI36
Build 341563,948,849 - 63,968,846NCBI
Celera1543,039,718 - 43,059,714 (+)NCBICelera
Cytogenetic Map15q22.31NCBI
HuRef1542,986,532 - 43,009,063 (+)NCBIHuRef
CHM1_11566,279,669 - 66,302,201 (+)NCBICHM1_1
T2T-CHM13v2.01563,678,915 - 63,701,413 (+)NCBIT2T-CHM13v2.0
Rab11a
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39964,622,582 - 64,645,038 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl964,622,581 - 64,645,040 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm38964,715,300 - 64,737,756 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl964,715,299 - 64,737,758 (-)Ensemblmm10GRCm38
MGSCv37964,563,107 - 64,585,563 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv36964,514,239 - 64,535,762 (-)NCBIMGSCv36mm8
Celera961,945,730 - 61,968,176 (-)NCBICelera
Cytogenetic Map9CNCBI
cM Map934.87NCBI
Rab11a
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554509,638,761 - 9,656,603 (-)Ensembl
ChiLan1.0NW_0049554509,638,761 - 9,656,291 (-)NCBIChiLan1.0ChiLan1.0
RAB11A
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21655,116,127 - 55,138,190 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11559,288,585 - 59,308,848 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01544,810,880 - 44,833,438 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11563,088,084 - 63,108,077 (+)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1563,088,084 - 63,108,077 (+)EnsemblpanPan2panpan1.1
RAB11A
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.13030,200,831 - 30,218,412 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl3030,200,831 - 30,218,411 (+)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha3030,128,206 - 30,145,797 (+)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.03030,390,944 - 30,408,531 (+)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl3030,390,701 - 30,412,317 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.13030,320,666 - 30,338,234 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.03030,383,756 - 30,401,404 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.03030,624,755 - 30,642,365 (+)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Rab11a
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024408640108,241,149 - 108,264,137 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493647126,088,852 - 26,113,433 (+)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_00493647126,089,216 - 26,111,245 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
RAB11A
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1163,858,123 - 163,891,527 (+)EnsemblsusScr11Sscrofa11.1
Sscrofa11.11163,858,254 - 163,887,741 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21181,463,316 - 181,492,724 (-)NCBISscrofa10.2Sscrofa10.2susScr3
RAB11A
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12617,682,629 - 17,702,325 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2617,682,874 - 17,702,309 (-)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_023666048123,739,221 - 123,760,752 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Rab11a
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247816,699,926 - 6,718,545 (-)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_0046247816,699,926 - 6,718,020 (-)NCBIHetGla 1.0HetGla 1.0hetGla2
Rab11a
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v1859,024,080 - 59,046,420 (-)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Rab11a
93 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:383
Count of miRNA genes:223
Interacting mature miRNAs:270
Transcripts:ENSRNOT00000015598
Prediction methods:Microtar, Miranda, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1298065Scl16Serum cholesterol level QTL 163.8blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)83975280384752803Rat
1554321Bmd3Bone mineral density QTL 37.90.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)849849908118871671Rat
1578769Uae31Urinary albumin excretion QTL 313.30.001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)839106363103375781Rat
1298079Activ2Activity QTL 29.50.000001voluntary movement trait (VT:0003491)rearing measurement (CMO:0001515)85076395195763951Rat
11556286Cm81Cardiac mass QTL 810.01heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)83910625884106258Rat
70161Bp62Blood pressure QTL 622.90.001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)85158969999045312Rat
1578765Klgr1Kidney lesion grade QTL 13.30.0001kidney morphology trait (VT:0002135)organ lesion measurement (CMO:0000677)839106363103375781Rat
61464Niddm11Non-insulin dependent diabetes mellitus QTL 113.10.001blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)84447792689477926Rat
4889938Bss89Bone structure and strength QTL 893.8tibia size trait (VT:0100001)tibia cortical bone volume (CMO:0001725)85899169791341052Rat
1578755Pur5Proteinuria QTL 53.30.0001urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)839106258103375958Rat
2313088Bss75Bone structure and strength QTL 753.10.0001body length (VT:0001256)body length, nose to rump (CMO:0000079)83910625891341052Rat
631210Bw3Body weight QTL35.9mesenteric fat pad mass (VT:0010427)mesenteric fat pad weight to body weight ratio (CMO:0000654)861019838121662124Rat
8662823Vetf5Vascular elastic tissue fragility QTL 51.9artery integrity trait (VT:0010639)patent ductus arteriosus score (CMO:0002566)863404444108404444Rat
1358896Bp262Blood pressure QTL 2622.89arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)835464071107982864Rat
731182Uae24Urinary albumin excretion QTL 246.4urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)84754141992541419Rat
61353Bp35Blood pressure QTL 350.001arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)83910625884106258Rat
631842Inf1Infertility severity QTL 14.10.001seminal gland mass (VT:0010524)seminal vesicle wet weight (CMO:0001603)83154366176543661Rat
1359033Bp273Blood pressure QTL 273arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)83910625884106258Rat
1331769Rf39Renal function QTL 393.871urine output (VT:0003620)timed urine volume (CMO:0000260)850763951107970527Rat
61358Bp39Blood pressure QTL 392arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)84444783789447837Rat
1358906Bp253Blood pressure QTL 25340.0004arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)84961020494610204Rat
1358907Cm40Cardiac mass QTL 401.89heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)835464071107982864Rat
70197BpQTLcluster8Blood pressure QTL cluster 83.482arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)855428333127966348Rat
2316950Scl66Serum cholesterol level QTL 664.1blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)839106363114525825Rat
1582254Kidm31Kidney mass QTL 313kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)84924517894245178Rat
724540Uae8Urinary albumin excretion QTL 85urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)839106258103375958Rat
10402857Bp380Blood pressure QTL 3800.95arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)862848139107848139Rat
1358892Kidm26Kidney mass QTL 263.69kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)835464071107982864Rat
1582243Bw66Body weight QTL 663.40.0048body mass (VT:0001259)body weight (CMO:0000012)84924517894245178Rat
5684973Bss100Bone structure and strength QTL 1004.7tibia area (VT:1000281)tibia area measurement (CMO:0001382)85899169791341052Rat
61373Mcs4Mammary carcinoma susceptibility QTL 41.1mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)84447504389475043Rat
2313057Bss76Bone structure and strength QTL 7630.0001tibia size trait (VT:0100001)tibia midshaft cross-sectional area (CMO:0001717)83910625891341052Rat
12879878Bw183Body weight QTL 1830.001body mass (VT:0001259)body weight (CMO:0000012)862848139107848139Rat
1300177Cm2Cardiac mass QTL 23.65heart mass (VT:0007028)heart weight (CMO:0000017)863141536109261840Rat
1549908Neudeg1Neurodegradation QTL 15.50nervous system integrity trait (VT:0010566)logarithm of the ratio of the lesioned side motor neuron count to contralateral side motor neuron count (CMO:0001986)858337123103337123Rat
12879879Cm99Cardiac mass QTL 990.001heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)862848139107848139Rat
2313067Bss77Bone structure and strength QTL 773.10.0001tibia size trait (VT:0100001)tibia midshaft endosteal cross-sectional area (CMO:0001716)83910625891341052Rat
1331804Cm30Cardiac mass QTL 303.77443heart mass (VT:0007028)heart wet weight (CMO:0000069)862970527107970527Rat
12879880Cm100Cardiac mass QTL 1000.001heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)862848139107848139Rat
12879881Cm101Cardiac mass QTL 1010.001heart right ventricle mass (VT:0007033)heart right ventricle weight to body weight ratio (CMO:0000914)862848139107848139Rat
12879882Am8Aortic mass QTL 80.001aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)862848139107848139Rat
12879883Kidm65Kidney mass QTL 650.001kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)862848139107848139Rat
71120Niddm21Non-insulin dependent diabetes mellitus QTL 213.73blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)866992095111992095Rat
1358912Bw51Body weight QTL 512.95body mass (VT:0001259)body weight (CMO:0000012)860248093105248093Rat
2313086Bss60Bone structure and strength QTL 604.10.0001tibia length (VT:0004357)tibia length (CMO:0000450)85899169791341052Rat
2293697Bmd39Bone mineral density QTL 39femur strength trait (VT:0010010)femur total energy absorbed before break (CMO:0001677)862848139107848139Rat
1331837Bw23Body weight QTL 234.190.00007body mass (VT:0001259)body weight (CMO:0000012)855428416107963099Rat
1331838Niddm61Non-insulin dependent diabetes mellitus QTL 613.530.0004blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)862963099107963099Rat
631650Stl6Serum triglyceride level QTL 640.0019blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)870041301121080908Rat
1581557Eae16Experimental allergic encephalomyelitis QTL 163.8nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis incidence/prevalence measurement (CMO:0001046)868690349119799881Rat
2313046Bss78Bone structure and strength QTL 783.50.0001tibia strength trait (VT:1000284)tibia total energy absorbed before break (CMO:0001736)83910625891341052Rat
2301402Bp316Blood pressure QTL 3160.005arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)862848139107848139Rat
631664Hcar3Hepatocarcinoma resistance QTL 32.90.0005liver integrity trait (VT:0010547)volume of individual liver tumorous lesion (CMO:0001078)862982864107982864Rat

Markers in Region
AI602490  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2865,225,099 - 65,225,286 (+)MAPPERmRatBN7.2
Rnor_6.0870,194,377 - 70,194,563NCBIRnor6.0
Rnor_5.0869,897,989 - 69,898,175UniSTSRnor5.0
RGSC_v3.4868,933,327 - 68,933,513UniSTSRGSC3.4
Celera864,629,234 - 64,629,420UniSTS
Cytogenetic Map8q24UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 165 91 90 59 92 59 6 356 192 11 144 81 92 31 17 17

Sequence


Ensembl Acc Id: ENSRNOT00000015598   ⟹   ENSRNOP00000015598
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl874,118,922 - 74,141,684 (-)Ensembl
mRatBN7.2 Ensembl865,223,696 - 65,246,525 (-)Ensembl
Rnor_6.0 Ensembl870,192,975 - 70,215,719 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000107918   ⟹   ENSRNOP00000078332
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl865,222,949 - 65,239,095 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000111784   ⟹   ENSRNOP00000089588
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl874,120,468 - 74,141,756 (-)Ensembl
mRatBN7.2 Ensembl865,225,153 - 65,246,516 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000115583   ⟹   ENSRNOP00000079481
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl874,118,922 - 74,141,837 (-)Ensembl
mRatBN7.2 Ensembl865,222,949 - 65,246,445 (-)Ensembl
RefSeq Acc Id: NM_031152   ⟹   NP_112414
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8874,118,922 - 74,141,684 (-)NCBI
mRatBN7.2865,223,698 - 65,246,461 (-)NCBI
Rnor_6.0870,192,975 - 70,215,719 (-)NCBI
Rnor_5.0869,896,587 - 69,919,171 (-)NCBI
RGSC_v3.4868,931,925 - 68,979,514 (-)RGD
Celera864,627,832 - 64,650,008 (-)RGD
Sequence:
RefSeq Acc Id: XM_063266217   ⟹   XP_063122287
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8874,120,223 - 74,141,760 (-)NCBI
Protein Sequences
Protein RefSeqs NP_112414 (Get FASTA)   NCBI Sequence Viewer  
  XP_063122287 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAA42012 (Get FASTA)   NCBI Sequence Viewer  
  AAH85727 (Get FASTA)   NCBI Sequence Viewer  
  EDL95799 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000015598
  ENSRNOP00000015598.3
  ENSRNOP00000079481
GenBank Protein P62494 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_112414   ⟸   NM_031152
- UniProtKB: P62494 (UniProtKB/Swiss-Prot),   A6J5C6 (UniProtKB/TrEMBL),   A0A8I6AA65 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000015598   ⟸   ENSRNOT00000015598
Ensembl Acc Id: ENSRNOP00000078332   ⟸   ENSRNOT00000107918
Ensembl Acc Id: ENSRNOP00000079481   ⟸   ENSRNOT00000115583
Ensembl Acc Id: ENSRNOP00000089588   ⟸   ENSRNOT00000111784
RefSeq Acc Id: XP_063122287   ⟸   XM_063266217
- Peptide Label: isoform X1
- UniProtKB: A0A8I5ZN41 (UniProtKB/TrEMBL)

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P62494-F1-model_v2 AlphaFold P62494 1-216 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13696069
Promoter ID:EPDNEW_R6594
Type:initiation region
Name:Rab11a_1
Description:RAB11a, member RAS oncogene family
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0870,215,783 - 70,215,843EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:619762 AgrOrtholog
BioCyc Gene G2FUF-30098 BioCyc
Ensembl Genes ENSRNOG00000011302 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000015598 ENTREZGENE
  ENSRNOT00000015598.4 UniProtKB/Swiss-Prot
  ENSRNOT00000115583 ENTREZGENE
Gene3D-CATH 3.40.50.300 UniProtKB/Swiss-Prot
IMAGE_CLONE IMAGE:7189729 IMAGE-MGC_LOAD
InterPro P-loop_NTPase UniProtKB/Swiss-Prot
  Rab_GTPases_membrane_traffic UniProtKB/Swiss-Prot
  Small_GTP-bd_dom UniProtKB/Swiss-Prot
  Small_GTPase UniProtKB/Swiss-Prot
KEGG Report rno:81830 UniProtKB/Swiss-Prot
MGC_CLONE MGC:93374 IMAGE-MGC_LOAD
NCBI Gene 81830 ENTREZGENE
PANTHER DRAB11-RELATED UniProtKB/Swiss-Prot
Pfam Ras UniProtKB/Swiss-Prot
PhenoGen Rab11a PhenoGen
PRINTS RASTRNSFRMNG UniProtKB/Swiss-Prot
PROSITE RAB UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000011302 RatGTEx
SMART RAB UniProtKB/Swiss-Prot
  RAN UniProtKB/Swiss-Prot
  RAS UniProtKB/Swiss-Prot
  RHO UniProtKB/Swiss-Prot
Superfamily-SCOP SSF52540 UniProtKB/Swiss-Prot
UniProt A0A8I5ZN41 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I6AA65 ENTREZGENE, UniProtKB/TrEMBL
  A6J5C6 ENTREZGENE, UniProtKB/TrEMBL
  P62494 ENTREZGENE, UniProtKB/Swiss-Prot
UniProt Secondary P24410 UniProtKB/Swiss-Prot
  Q9JLX1 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2004-09-10 Rab11a  RAB11a, member RAS oncogene family      Symbol and Name status set to approved 1299863 APPROVED
2002-08-07 Rab11a  RAB11a, member RAS oncogene family      Symbol and Name status set to provisional 70820 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
gene_expression expressed in brain, liver, testis, spleen, and heart 633809