Related Links

Diabetes Disease Portal – Related Links

RGD Pages Related to Diabetes:

Phenotypes and Models: Phenotypes in Rat Models of Diabetes

RGD Interactive Pathway Suite Networks and Pathway Suites

Balancing Blood Pressure Regulatory Mechanisms Pathway Suite Network Network includes:
	Mechanisms Mediating and Pertinent to Decreased Blood Pressure Pathway Suite Suite includes:		Mechanisms Mediating and Pertinent to Increased Blood Pressure Pathway Suite Suite includes:
		Kallikrein-kinin cascade pathway Kinin signaling pathway Angiotensin II signaling pathway via AT2 receptor		Angiotensin II signaling pathway via AT1 receptor Aldosterone signaling pathway Aldosterone biosynthetic pathway Cholesterol biosynthetic pathway Sterol regulatory element-binding protein signaling pathway Losartan drug pathway Statin drug pathway
	Mechanisms Mediating and Pertinent to Both Increased and Decreased Blood Pressure Pathway Suite Suite includes:
		Renin-angiotensin cascade pathway Angiotensin II signaling pathway Protein kinase C (PKC) signaling pathway Calcium transport pathway Calcium/calcium-mediated signaling pathway

Glucose Homeostasis Pathway Suite Network Network includes:
	Pathway Suite for the Metabolism of Glucose and Related Molecules Pathways Suite includes:		Pathway Suite for the Glucose Homeostasis-related Regulatory and Signaling Pathways Suite includes:
		Glycolysis pathway Pyruvate metabolic pathway Pentose phosphate pathway Hexosamine biosynthetic pathway Glycogen biosynthetic pathway Gluconeogenesis pathway Glycogen degradation pathway		Insulin secretion pathway Insulin responsive facilitated sugar transporter mediated glucose transport pathway Insulin signaling pathway Glucagon signaling pathway

Gene Expression and Regulation Pathway Suite Network Network includes:
	Transcription and Transcription-Coupled Events Pathway Suite Suite includes:		Epigenetic Regulation/Control and Chromatin Modification/Remodeling Pathway Suite Suite includes:
		RNA polymerase I transcription pathway RNA polymerase II transcription pathway		Chromatin remodeling pathway DNA modification pathway Histone modification pathway RNA polymerase III transcription pathway Spliceosomal pathway
	RNA maturation, Transport and Surveillance (QC) and Protein Translation Pathway Suite Suite includes:
		Spliceosomal pathway mRNA nuclear export pathway Ribosome biogenesis pathway Translation pathway

Individual Pathway Suites
	Type 2 Diabetes Pathway Suite Suite includes:		Energy Homeostasis Suite Suite includes:
		Type 2 diabetes mellitus pathway Insulin secretion pathway Insulin signaling pathway Insulin responsive facilitated sugar transporter mediated glucose transport pathway Altered insulin secretion pathway Altered insulin signaling pathway Anti-diabetic drug pathway Metformin drug pathway		Citric acid cycle pathway Insulin signaling pathway Leptin system pathway Melanocortin system pathway mTOR signaling pathway Adenosine monophosphate-activated protein kinase (AMPK) signaling pathway
	Beta Adrenergic Receptor Pathway Suite Suite includes:		Calcium Homeostasis Pathway Suite Suite includes:
		Epinephrine biosynthetic pathway Epinephrine signaling via beta adrenergic receptors Adrenergic beta receptor agonist and beta-blocker pharmacodynamics pathway		Calcium transport pathway Calcium/calcium-mediated signaling pathway Calcium signaling pathway via the calcium-sensing receptor Parathyroid hormone signaling pathway Calcium/calmodulin dependent kinase 2 signaling pathway

Databases and Websites:

T1DBase

The National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
      NIDDK – National Diabetes Information Clearinghouse (NDIC)
      NIDDK – National Diabetes Education Program
      NIDDK – The Weight-control Information Network

U. S. National Library of Medicine Genetics Home Reference
Health Conditions A-Z
Endocrine system (hormones)

National Organization for Rare Disorders
Rare Disease Information A-Z

The Diabetes Research Institute

American Diabetes Association: Research

The Juvenile Diabetes Research Foundation International (JDRF)

Centers for Disease Control and Prevention – Diabetes Public Health Resource

The Joslin Diabetes Center: Research

OMIM Home Page
OMIM – Type 1 Diabetes/IDDM
OMIM – Type 2 Diabetes/NIDDM
OMIM – Maturity Onset Diabetes of the Young/MODY
OMIM – Permanent Neonatal Diabetes Mellitus
OMIM – Insulin
OMIM – Obesity
OMIM – Abdominal Obesity-Metabolic Syndrome
OMIM – Hypertension

GeneCards Home Page

The Human Gene Mutation Database

NCBI – Genes and Disease Home Page
Genes and Disease – Type 1 Diabetes
Genes and Disease – Obesity

Genetic Association Database Home Page

The Attie Lab Diabetes Database – a searchable microarray gene expression database in a mouse model of Type 2 Diabetes

Healthline: Type 2 Diabetes Page

Review Articles:

Type 1 Diabetes:

Genetics of type 1A diabetes. Concanno, Rich and Nepom, N Engl J Med. 2009 Apr 16;360(16):1646-54.

Genome-wide association studies in type 1 diabetes. Grant and Hakonarson, Curr Diab Rep. 2009 Apr;9(2):157-63.

An update on preventive and regenerative therapies in diabetes mellitus. Reimann et al, Pharmacol Ther. 2009 Mar;121(3):317-31.

Gene therapy in type 1 diabetes. Bagley et al, Crit Rev Immunol. 2008;28(4):301-24.

Gene-gene interactions in the NOD mouse model of type 1 diabetes. Ridgway et al, Adv Immunol. 2008;100:151-75.

The genetic basis for type 1 diabetes. Mehers and Gillespie, Br Med Bull. 2008;88(1):115-29.

Autoimmune mechanisms in type 1 diabetes. Knip and Siljander, Autoimmun Rev. 2008 Jul;7(7):550-7.

Regulation of type 1 diabetes by NKT cells. Novak et al, Int Rev Immunol. 2007 Jan-Apr;26(1-2):49-72.

Genetics of type 1 diabetes mellitus. Bartsocas and Gerasimidi-Vazeou, Pediatr Endocrinol Rev. 2006 Aug;3 Suppl 3:508-13.

Type 2 Diabetes:

Testosterone in obesity, metabolic syndrome and type 2 diabetes. Stanworth and Jones, Front Horm Res. 2009;37:74-90.

Gene-environment interaction and the metabolic syndrome. Adamo and Tesson, Novartis Found Symp. 2008;293:103-19; discussion 119-27.

Metabolic syndrome: from epidemiology to systems biology. Lusis, Attie and Reue, Nat Rev Genet. 2008 Nov;9(11):819-30.

Type 2 diabetes: where we are today: an overview of disease burden, current treatments, and treatment strategies. Campbell, J Am Pharm Assoc (2003). 2009 Sep-Oct;49 Suppl 1:S3-9.

Fate of the beta-cell in the pathophysiology of type 2 diabetes. Campbell, J Am Pharm Assoc (2003). 2009 Sep-Oct;49 Suppl 1:S10-5.

Genetic dissection of type 2 diabetes. Ridderstråle and Groop, Mol Cell Endocrinol. 2009 Jan 15;297(1-2):10-7.

Agreement among type 2 diabetes linkage studies but a poor correlation with results from genome-wide association studies. Lillioja and Wilton, Diabetologia. 2009 Jun;52(6):1061-74.

Genetic determinants and molecular pathways in the pathogenesis of Type 2 diabetes. Jin and Patti, Clin Sci (Lond). 2009 Jan;116(2):99-111.

Insulin action and insulin resistance: diseases involving defects in insulin receptors, signal transduction, and the glucose transport effector system. Hunter and Garvey, Am J Med. 1998 Oct;105(4):331-45.

Genetics of type 2 diabetes mellitus. Malecki, Diabetes Res Clin Pract. 2005 Jun;68 Suppl1:S10-21.

The cellular fate of glucose and its relevance in type 2 diabetes. Bouché et al, Endocr Rev. 2004 Oct;25(5):807-30.

Alterations of insulin signaling in type 2 diabetes: a review of the current evidence from humans. Fröjdö, Vidal and Pirola, Biochim Biophys Acta. 2009 Feb;1792(2):83-92.

Novel aspects of the molecular mechanisms controlling insulin secretion. Eliasson et al, J Physiol. 2008 Jul 15;586(14):3313-24.

MicroRNAs in diabetes: tiny players in big disease. Pandey et al, Cell Physiol Biochem. 2009;23(4-6):221-32.

Role of microRNAs in diabetes. Tang, Tang and Ozcan, Biochim Biophys Acta. 2008 Nov;1779(11):697-701.

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Diabetes Disease Portal – Related Links

RGD Pages Related to Diabetes:

RGD Interactive Pathway Suite Networks and Pathway Suites

Databases and Websites:

Review Articles:

Type 1 Diabetes:

Type 2 Diabetes: