RGD Reference Report - Chromosome substitution reveals the genetic basis of Dahl salt-sensitive hypertension and renal disease. - Rat Genome Database

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Chromosome substitution reveals the genetic basis of Dahl salt-sensitive hypertension and renal disease.

Authors: Mattson, DL  Dwinell, MR  Greene, AS  Kwitek, AE  Roman, RJ  Jacob, HJ  Cowley AW, JR 
Citation: Mattson DL, etal., Am J Physiol Renal Physiol. 2008 Sep;295(3):F837-42. Epub 2008 Jul 23.
RGD ID: 2300225
Pubmed: PMID:18653478   (View Abstract at PubMed)
PMCID: PMC2536867   (View Article at PubMed Central)
DOI: DOI:10.1152/ajprenal.90341.2008   (Journal Full-text)

This study examined the genetic basis of hypertension and renal disease in Dahl SS/Mcwi (Dahl Salt-Sensitive) rats using a complete chromosome substitution panel of consomic rats in which each of the 20 autosomes and the X and Y chromosomes were individually transferred from the Brown Norway (BN) rat onto the Dahl SS/Mcwi genetic background. Male and female rats of each of the two parental and 22 consomic strains (10-12 rats/group) were fed a high-salt (8.0% NaCl) diet for 3 wk. Mean arterial blood pressure rose by 60 mmHg and urinary protein and albumin excretion increased 3- and 20-fold, respectively, in male SS/Mcwi rats compared with BN controls. Substitution of chromosomes 1, 5, 7, 8, 13, or 18 from the BN onto the SS/Mcwi background attenuated the development of hypertension, proteinuria, and albuminuria in male rats. In female rats, substitution of chromosomes 1 and 5 also decreased blood pressure, protein excretion, and albumin excretion. These studies also identified several chromosomes in male (6, 11, Y) and female (4, 6, 11, 19, 20) rats that reduced albuminuria without altering blood pressure. These data indicate that genes contributing to salt-sensitive hypertension are found on multiple chromosomes of the Dahl SS/Mcwi rat. Furthermore, this consomic rat panel provides a stable genetic platform that can facilitate further gene mapping by either linkage studies or the breeding of congenic and subcongenic rats.



Disease Annotations    Click to see Annotation Detail View
RGD Manual Disease Annotations    Click to see Annotation Detail View

  
Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
SS-Chr 12BN/McwiRatAlbuminuria inducedIAGPcontrolled sodium content dietcompared to SS/JrHsdMcwiRGD 
SS-Chr 17BN/McwiRatAlbuminuria inducedIAGPcontrolled sodium content dietcompared to SS/JrHsdMcwiRGD 
SS.BN-(D12Arb13-D12Rat79)/McwiRatAlbuminuria sexual_dimorphismIAGPcontrolled sodium content dietcompared to male SS/JrHsdMcwi��RGD 
BN/NHsdMcwiRatglomerulosclerosis MODEL: controlIAGPcontrolled sodium content dietcompared to male SS/JrHsdMcwiRGD 
SS/JrHsdMcwiRatglomerulosclerosis MODEL: inducedIAGPcontrolled sodium content dietcompared to male BN/NHsdMcwiRGD 

Phenotype Annotations    Click to see Annotation Detail View

Mammalian Phenotype

Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
SS-Chr 12BN/McwiRatalbuminuria sexual_dimorphismIAGPcontrolled sodium content dietin maleRGD 
BN/NHsdMcwiRatdecreased mean systemic arterial blood pressure inducedIAGPcontrolled sodium content dietcompared to male and female SS/JrHsdMcwiRGD 
SS-Chr 10BN/McwiRatdecreased mean systemic arterial blood pressure sexual_dimorphismIAGPcontrolled sodium content dietcompared to female SS/JrHsdMCWiRGD 
SS-Chr 13BN/McwiRatdecreased mean systemic arterial blood pressure sexual_dimorphismIAGPcontrolled sodium content dietcompared to male SS/JrHsdMcwiRGD 
SS-Chr 14BN/McwiRatdecreased mean systemic arterial blood pressure sexual_dimorphismIAGPcontrolled sodium content dietcompared to male SS-Chr 14BN/McwiRGD 
SS-Chr 16BN/McwiRatdecreased mean systemic arterial blood pressure inducedIAGPcontrolled sodium content dietcompared to male SS/JrHsdMcwiRGD 
SS-Chr 16BN/McwiRatdecreased mean systemic arterial blood pressure sexual_dimorphismIAGPcontrolled sodium content dietin femaleRGD 
SS-Chr 18BN/McwiRatdecreased mean systemic arterial blood pressure inducedIAGPcontrolled sodium content dietcompared to male SS/JrHsdMcwiRGD 
SS-Chr 1BN/McwiRatdecreased mean systemic arterial blood pressure inducedIAGPcontrolled sodium content dietcompared to SS/JrHsdMcwiRGD 
SS-Chr 20BN/McwiRatdecreased mean systemic arterial blood pressure inducedIAGPcontrolled sodium content dietcompared to male SS/JrHsdMcwiRGD 
SS-Chr 2BN/McwiRatdecreased mean systemic arterial blood pressure sexual_dimorphismIAGPcontrolled sodium content dietcompared to male SS-Chr 2BN/Mcwi��RGD 
SS-Chr 4BN/McwiRatdecreased mean systemic arterial blood pressure sexual_dimorphismIAGPcontrolled sodium content dietcompared to female SS/JrHsdMcwi, male SS-Chr 4BN/Mcwi��RGD 
SS-Chr 5BN/McwiRatdecreased mean systemic arterial blood pressure inducedIAGPcontrolled sodium content dietcompared to SS/JrHsdMcwiRGD 
SS-Chr 7BN/McwiRatdecreased mean systemic arterial blood pressure inducedIAGPcontrolled sodium content dietcompared to male SS/JrHsdMcwiRGD 
SS-Chr 8BN/McwiRatdecreased mean systemic arterial blood pressure inducedIAGPcontrolled sodium content dietcompared to male SS/JrHsdMcwiRGD 
SS.BN-(D8Rat163-D8Rat81)/McwiRatdecreased mean systemic arterial blood pressure sexual_dimorphismIAGPcontrolled sodium content dietcompared to male SS/JrHsdMCWiRGD 
BN/NHsdMcwiRatdecreased urine albumin level inducedIAGPcontrolled sodium content dietcompared to male and female SS/JrHsdMcwiRGD 
SS-Chr 10BN/McwiRatdecreased urine albumin level inducedIAGPcontrolled sodium content dietcompared to male SS-Chr10BN/MCWi, female SS/JrHsdMcwi��RGD 
SS-Chr 11BN/McwiRatdecreased urine albumin level inducedIAGPcontrolled sodium content dietcompared to SS/JrHsdMcwiRGD 
SS-Chr 13BN/McwiRatdecreased urine albumin level inducedIAGPcontrolled sodium content dietcompared to SS/JrHsdMcwiRGD 
SS-Chr 14BN/McwiRatdecreased urine albumin level sexual_dimorphismIAGPcontrolled sodium content dietcompared to female SS/JrHsdMcwi��RGD 
SS-Chr 16BN/McwiRatdecreased urine albumin level sexual_dimorphismIAGPcontrolled sodium content dietin femaleRGD 
SS-Chr 16BN/McwiRatdecreased urine albumin level inducedIAGPcontrolled sodium content dietcompared to SS/JrHsdMcwiRGD 
SS-Chr 17BN/McwiRatdecreased urine albumin level sexual_dimorphismIAGPcontrolled sodium content dietin femaleRGD 
SS-Chr 18BN/McwiRatdecreased urine albumin level inducedIAGPcontrolled sodium content dietcompared to SS/JrHsdMcwiRGD 
SS-Chr 19BN/McwiRatdecreased urine albumin level sexual_dimorphismIAGPcontrolled sodium content dietcompared to female SS/JrHsdMCWiRGD 
SS-Chr 1BN/McwiRatdecreased urine albumin level inducedIAGPcontrolled sodium content dietcompared to SS/JrHsdMcwiRGD 
SS-Chr 20BN/McwiRatdecreased urine albumin level inducedIAGPcontrolled sodium content dietcompared to female SS/JrHsdMcwiRGD 
SS-Chr 2BN/McwiRatdecreased urine albumin level sexual_dimorphismIAGPcontrolled sodium content dietcompared to female SS/JrHsdMcwi, male SS-Chr 2BN/Mcwi��RGD 
SS-Chr 3BN/McwiRatdecreased urine albumin level sexual_dimorphismIAGPcontrolled sodium content dietcompared to male SS-Chr 3BN/Mcwi��RGD 
SS-Chr 5BN/McwiRatdecreased urine albumin level inducedIAGPcontrolled sodium content dietcompared to SS/JrHsdMcwiRGD 
SS-Chr 6BN/McwiRatdecreased urine albumin level inducedIAGPcontrolled sodium content dietcompared to male and female SS/JrHsdMcwi�RGD 
SS-Chr 7BN/McwiRatdecreased urine albumin level inducedIAGPcontrolled sodium content dietcompared to SS/JrHsdMcwi on 8% NaCl dietRGD 
SS-Chr 8BN/McwiRatdecreased urine albumin level inducedIAGPcontrolled sodium content dietcompared to SS/JrHsdMcwiRGD 
SS-Chr 9BN/McwiRatdecreased urine albumin level sexual_dimorphismIAGPcontrolled sodium content dietcompared to male SS-Chr 9BN/Mcwi, female SS/JrHsdMCWiRGD 
SS-Chr XBN/McwiRatdecreased urine albumin level sexual_dimorphismIAGPcontrolled sodium content dietcompared to male S-Chr XBN/McwiRGD 
SS-Chr YBN/McwiRatdecreased urine albumin level inducedIAGPcontrolled sodium content dietcompared to male SS/JrHsdMcwiRGD 
SS.BN-(D12Arb13-D12Rat79)/McwiRatdecreased urine albumin level sexual_dimorphismIAGPcontrolled sodium content dietcompared to female SS/JrHsdMcwi, male SS.BN-D12Arb13-D12Rat79/McwiRGD 
SS.BN-(D8Rat163-D8Rat81)/McwiRatdecreased urine albumin level inducedIAGPcontrolled sodium content dietcompared to male and female SS/JrHsdMcwi��RGD 
SS/JrHsdMcwiRatincreased mean systemic arterial blood pressure inducedIAGPcontrolled sodium content dietcompared to BN/NHsdMcwiRGD 
SS-Chr 11BN/McwiRatsalt-sensitive hypertension inducedIAGPcontrolled sodium content diet RGD 
SS-Chr 6BN/McwiRatsalt-sensitive hypertension inducedIAGPcontrolled sodium content diet RGD 
Objects referenced in this article
Strain SS-Chr 19SHR/Rkb null Rattus norvegicus

Additional Information