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General

Strain: SS-Chr 3^BN/Mcwi
Symbol:	SS-Chr 3^BN/Mcwi
Strain:	SS-Chr 3^BN
Substrain:	Mcwi
Ontology ID:	RS:0000803
Also known as:	SS-3BN/Mcwi; SS-3^BN/Mcwi;SS-Chr 3BN/Mcwi; SS-Chr 3BN/Mcwi
Type:	consomic
Source:	PhysGen
Origin:	A SS genomic background with a BN chromosome 3 introgressed.
Coat Color:	Albino
Last Known Status:	Live Animals; Cryopreserved Sperm

Annotation (Toggle Annotation Detail/Summary View)

Phenotype Annotations

Mammalian Phenotype

Term	Qualifier	Evidence	With	Reference	Notes	Source	Original Reference(s)
decreased incidence of tumors by chemical induction	induced	IDA		4143380	as compared to SS/JrHsdMcwi under DMBA induction	RGD
increased incidence of tumors by chemical induction	induced	IDA		4143380	as compared to SS/JrHsdMcwi under DMBA induction	RGD

Phenotype Values via Phenominer

Related Phenotype Data for Term "SS-Chr 3BN/Mcwi" (RS:0000803)

Rat Strains:

SS-Chr 3BN/Mcwi

Clinical Measurements:

absolute change in blood pH
absolute change in body temperature
absolute change in partial pressure of blood carbon dioxide
absolute change in partial pressure of blood oxygen
acetylcholine-induced blood vessel dilation expressed as percent of force at maximum constriction
arterial blood flow rate
blood eosinophil count
blood hemoglobin level
blood lymphocyte count
blood monocyte count
blood neutrophil count
blood pH
body temperature
body weight
calculated pulmonary vascular resistance normalized to body weight
concentration of acetylcholine at which the reduction in force during dilation of a blood vessel is half the maximum value (EC50)
concentration of phenylephrine at which the force of blood vessel contraction is half the maximum value (EC50)
creatinine clearance
dose of methacholine at which pulmonary conductance is half its pretreatment value (ED50)
FAPGG metabolism-surface area product
fractional change in blood vessel diameter per unit change in intravascular pressure
heart contraction pressure
heart effluent lactate dehydrogenase activity level normalized to heart weight
heart left ventricle infarction weight as percentage of total heart left ventricle weight
heart rate
heart right ventricle weight to left ventricle weight ratio
heart weight as percentage of body weight
heart wet weight
hematocrit
left ventricular developed pressure
left ventricular diastolic blood pressure
left ventricular systolic blood pressure
logarithm of the concentration of acetylcholine at which the reduction in force during dilation of a blood vessel is half the maximum value (Log EC50)
logarithm of the concentration of phenylephrine at which the force of blood vessel contraction is half the maximum value (Log EC50)
lung dry weight to body weight ratio
maximum contractile force per wet weight of aorta
mean arterial blood pressure
mean corpuscular hemoglobin concentration
mean corpuscular hemoglobin level
mean corpuscular volume
methylene blue metabolism-surface area product after auto-oxidation
methylene blue metabolism-surface area product without auto-oxidation
methylene blue to FAPGG metabolism-surface area product ratio
minute ventilation (VE)
partial pressure of blood carbon dioxide (Pco2)
partial pressure of blood oxygen (Po2)
percent change in arterial blood flow rate
percent change in heart rate
percent change in left ventricular developed pressure
percent change in left ventricular systolic blood pressure
percent change in respiration rate
percent change in tidal volume
percent change in ventilation
percentage of study population developing mammary tumors during a period of time
plasma anion gap
plasma creatinine level
plasma renin activity level
post-insult time to mammary tumor formation
red blood cell count
respiration rate
serum alanine aminotransferase activity level
serum albumin level
serum alkaline phosphatase activity level
serum aspartate aminotransferase activity level
serum bicarbonate level
serum calcium level
serum chloride level
serum globulin level
serum glucose level
serum phosphate level
serum potassium level
serum sodium level
serum total cholesterol level
serum total protein level
serum urea nitrogen level
tidal volume
time to onset of heart contraction
time to peak heart contraction
total serum bilirubin level
total white blood cell count
urine albumin excretion rate
urine potassium excretion rate
urine sodium excretion rate
urine total protein excretion rate

Experimental Conditions:

7,12-dimethyltetraphene (DMBA)
acetylcholine
air carbon dioxide content
air oxygen content
controlled oxygen content Kreb's solution perfusate
controlled sodium content diet
drug dose time series
FAPGG
Kreb's solution perfusate
methacholine
methylene blue
naive control condition
perfusate suspended
phenylephrine
potassium ion
sample resting period

Measurement Methods:

automated blood cell counting method
automated blood gas analysis using a Bayer analyzer
automated plasma creatinine analysis
automated urine total protein analysis
balloon tipped catheter with pressure transducer in isolated perfused heart
digital rectal thermometry
digital scale post excision weight measurement
flame atomic emission spectrometry
fluid-filled catheter with pressure transducer in isolated perfused lung
isolated perfused heart effluent collection
isolated perfused lung vascular effluent collection
manual palpation method
microhematocrit tube assay with visual assessment
radioimmunoassay
standard blood chemistry panel
stop flow air displacement plethysmography
urine creatinine analysis
vascular fluid filled catheter
whole body digital scale
wire myography using a Digi-Med tissue force analysis system with force transducer

Phenotype Annotations

Mammalian Phenotype

decreased incidence of tumors by chemical induction (IDA)

increased incidence of tumors by chemical induction (IDA)

Experimental Data Annotations

Rat Strain

SS-Chr 3BN/Mcwi (IEA)

Phenotype Values via Phenominer

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Clinical Measurement

heart rate

left ventricular diastolic blood pressure

left ventricular systolic blood pressure

mean arterial blood pressure

body weight

body temperature

left ventricular developed pressure

red blood cell count

blood hemoglobin level

blood neutrophil count

blood lymphocyte count

blood monocyte count

blood eosinophil count

hematocrit

mean corpuscular volume

plasma anion gap

heart wet weight

heart weight as percentage of body weight

lung dry weight to body weight ratio

heart right ventricle weight to left ventricle weight ratio

plasma renin activity level

minute ventilation (VE)

arterial blood flow rate

tidal volume

partial pressure of blood carbon dioxide (Pco2)

percent change in ventilation

respiration rate

mean corpuscular hemoglobin level

mean corpuscular hemoglobin concentration

absolute change in partial pressure of blood carbon dioxide

absolute change in partial pressure of blood oxygen

absolute change in blood pH

post-insult time to mammary tumor formation

serum total cholesterol level

total white blood cell count

total serum bilirubin level

blood pH

partial pressure of blood oxygen (Po2)

serum bicarbonate level

serum chloride level

serum potassium level

serum sodium level

serum calcium level

percent change in respiration rate

percent change in tidal volume

plasma creatinine level

serum phosphate level

serum glucose level

serum albumin level

serum alanine aminotransferase activity level

serum alkaline phosphatase activity level

serum aspartate aminotransferase activity level

serum urea nitrogen level

serum total protein level

time to onset of heart contraction

time to peak heart contraction

heart contraction pressure

heart left ventricle infarction weight as percentage of total heart left ventricle weight

absolute change in body temperature

calculated pulmonary vascular resistance normalized to body weight

FAPGG metabolism-surface area product

methylene blue metabolism-surface area product without auto-oxidation

methylene blue metabolism-surface area product after auto-oxidation

methylene blue to FAPGG metabolism-surface area product ratio

dose of methacholine at which pulmonary conductance is half its pretreatment value (ED50)

fractional change in blood vessel diameter per unit change in intravascular pressure

concentration of phenylephrine at which the force of blood vessel contraction is half the maximum value (EC50)

logarithm of the concentration of phenylephrine at which the force of blood vessel contraction is half the maximum value (Log EC50)

concentration of acetylcholine at which the reduction in force during dilation of a blood vessel is half the maximum value (EC50)

logarithm of the concentration of acetylcholine at which the reduction in force during dilation of a blood vessel is half the maximum value (Log EC50)

maximum contractile force per wet weight of aorta

acetylcholine-induced blood vessel dilation expressed as percent of force at maximum constriction

percent change in heart rate

percent change in arterial blood flow rate

percent change in left ventricular developed pressure

percent change in left ventricular systolic blood pressure

urine total protein excretion rate

urine albumin excretion rate

urine sodium excretion rate

urine potassium excretion rate

creatinine clearance

heart effluent lactate dehydrogenase activity level normalized to heart weight

percentage of study population developing mammary tumors during a period of time

serum globulin level

References - curated

1.	Adamovic T, et al., Genes Chromosomes Cancer. 2010 Nov;49(11):1035-45.
2.	Kunert MP, etal., Am J Physiol Regul Integr Comp Physiol. 2008 May 28;.
3.	Kunert MP, etal., Physiol Genomics. 2006 Aug 16;26(3):218-25. Epub 2006 Jun 13.
4.	PhysGen strains
5.	RGD Automated Pipelines

RGD Disease Portals

SS-Chr 3^BN/Mcwi has been annotated in the following RGD Disease Portals.

Aging/Age-Related Disease Phenotypes

Cancer Phenotypes

Region

Additional Information

RGD Curation Notes

Note Type	Note	Reference
strain_drgs_chems	The aortic rings of animals on low-salt diet were less sensitive to phenylephrine as compared to the parental SS.	1598768
strain_other	The average weight of females is 184g and of males 267g.	629526
strain_reproduction	The average litter size is 7.1 pups and the average generation time is 51 days.	629526

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2013-08-12	SS-Chr 3^BN/Mcwi		SS-Chr 3^BN/Mcwi		Name updated	68913	APPROVED
2013-08-12	SS-Chr 3^BN/Mcwi		SS-Chr 3^BN/Mcwi		Name updated	68913	APPROVED

More on this Strain
	Strain Nomenclature
	Strain Registration

RGD Object Information
RGD ID:	1358154
Created:	2005-05-13
Species:	Rattus norvegicus
Last Modified:	2009-06-15
Status:	ACTIVE

Functional Annotation unavailable	Annotation Distribution unavailable	Genomic Variants unavailble Genomic Variants unavailable
Functional Annotation	Annotation Distribution	Genomic Variants

Protein-Protein Interactions unavailable	Genome Viewer unavailable	Damaging Variants unavailble Damaging Variants unavailable
Protein-Protein Interactions	Genome Viewer	Damaging Variants

Annotation Comparison unavailable	OLGA unavailable
Annotation Comparison	OLGA	Excel (Download)

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Description:

Strain: SS-Chr 3BN/Mcwi

Related Phenotype Data for Term "SS-Chr 3BN/Mcwi" (RS:0000803)

Strain: SS-Chr 3^BN/Mcwi