RGD Reference Report - Sex-Specific Differences in Chromosome-Dependent Regulation of Vascular Reactivity in Female Consomic Rat Strains from a SS x BN Cross. - Rat Genome Database

Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Behavioral & Substance Use Disorder Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources
Advanced Search (OLGA)

Sex-Specific Differences in Chromosome-Dependent Regulation of Vascular Reactivity in Female Consomic Rat Strains from a SS x BN Cross.

Authors: Kunert, MP  Dwinell, MR  Drenjancevic-Peric, I  Lombard, JH 
Citation: Kunert MP, etal., Am J Physiol Regul Integr Comp Physiol. 2008 May 28;.
RGD ID: 2293556
Pubmed: PMID:18509103   (View Abstract at PubMed)
PMCID: PMC2519925   (View Article at PubMed Central)
DOI: DOI:10.1152/ajpregu.00038.2008   (Journal Full-text)

High-throughput studies in the Medical College of Wisconsin Program for Genomic Applications (Physgen) were designed to link chromosomes with physiological function in consomic strains derived from a cross between Dahl salt sensitive SS/JrHsdMcwi (SS) and Brown Norway normotensive BN/NHsdMcwi (BN) rats. The specific goal of the vascular protocol was to characterize the responses of aortic rings from these strains to vasoconstrictor and vasodilator stimuli (phenylephrine, acetylcholine, sodium nitroprusside and bath hypoxia) in order to identify chromosomes that either increase or decrease vascular reactivity to these vasoactive stimuli. Because previous studies demonstrated sex-specific quantitative trait loci (QTLs) related to regulation of cardiovascular phenotypes in an F2 cross between the parental strains, males and females of each consomic strain were included in all experiments. As there were significant sex-specific differences in aortic sensitivity to vasoconstrictor and vasodilator stimuli compared to the parental SS strain, we report the results of the females separately from the males. There were also sex-specific differences in aortic ring sensitivity to these vasoactive stimuli in consomic strains that were fed a high salt diet (4% NaCl) for three weeks to evaluate salt-induced changes in vascular reactivity. Differences in genetic architecture could contribute to sex-specific differences in the development and expression of cardiovascular diseases via differential regulation and expression of genes. Our findings are the first to link physiological traits with specific chromosomes in female SS rats, and support the idea that sex is an important environmental variable that plays a role in the expression and regulation of genes. Key words: phenylephrine, acetylcholine, sodium nitroprusside, hypoxia, vascular reactivity.



Objects referenced in this article
Strain BN/NHsdMcwi null Rattus norvegicus
Strain SS-Chr 10BN/Mcwi null Rattus norvegicus
Strain SS-Chr 11BN/Mcwi null Rattus norvegicus
Strain SS-Chr 12BN/Mcwi null Rattus norvegicus
Strain SS-Chr 13BN/Mcwi null Rattus norvegicus
Strain SS-Chr 14BN/Mcwi null Rattus norvegicus
Strain SS-Chr 15BN/Mcwi null Rattus norvegicus
Strain SS-Chr 16BN/Mcwi null Rattus norvegicus
Strain SS-Chr 17BN/Mcwi null Rattus norvegicus
Strain SS-Chr 18BN/Mcwi null Rattus norvegicus
Strain SS-Chr 19BN/Mcwi null Rattus norvegicus
Strain SS-Chr 1BN/Mcwi null Rattus norvegicus
Strain SS-Chr 20BN/Mcwi null Rattus norvegicus
Strain SS-Chr 2BN/Mcwi null Rattus norvegicus
Strain SS-Chr 3BN/Mcwi null Rattus norvegicus
Strain SS-Chr 4BN/Mcwi null Rattus norvegicus
Strain SS-Chr 5BN/Mcwi null Rattus norvegicus
Strain SS-Chr 6BN/Mcwi null Rattus norvegicus
Strain SS-Chr 7BN/Mcwi null Rattus norvegicus
Strain SS-Chr 8BN/Mcwi null Rattus norvegicus
Strain SS-Chr 9BN/Mcwi null Rattus norvegicus
Strain SS-Chr XBN/Mcwi null Rattus norvegicus
Strain SS/JrHsdMcwi null Rattus norvegicus

Additional Information