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PATHWAY ONTOLOGY - ANNOTATIONS

The Pathway Ontology (PW), is currently being developed at the Rat Genome Database. For more information about this vocabulary, please see Petri et al. The rat genome database pathway portal. Database (Oxford). 2011 Apr 8;2011:bar010. Print 2011 or contact us (https://rgd.mcw.edu/rgdweb/contact/contactus.html).
Term:hexosamine biosynthetic pathway
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Accession:PW:0000559 term browser browse the term
Definition:The formation of nucleotide hexosamines, primarily UDP-N-acetylglucosamine, constitutes the final step in the hexosamine biosynthetic pathway which provides substrates for the O-linked glycosylation of proteins. Glycoproteins that are either secreted from the cell or inserted into the plasma membrane undergo N-linked glycosylation. The O-linked glycosylation of nuclear and/or cytosolic proteins confers a signaling dimension to the hexosamine biosynthetic pathway.
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hexosamine biosynthetic pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Gfpt1 glutamine fructose-6-phosphate transaminase 1 IMP
ISO 		RGD PMID:10898949 PMID:15466941 RGD:1625426, RGD:1625539 NCBI chr 4:121,054,023...121,103,799
Ensembl chr 4:121,054,045...121,103,799 		JBrowse link
G Gnpnat1 glucosamine-phosphate N-acetyltransferase 1 ISO RGD PMID:15466941 RGD:1625539 NCBI chr15:21,076,129...21,088,526
Ensembl chr15:21,076,130...21,088,423 		JBrowse link
G Gpi glucose-6-phosphate isomerase ISO RGD PMID:15466941 RGD:1625539 NCBI chr 1:95,965,389...95,996,932
Ensembl chr 1:95,965,396...95,993,261 		JBrowse link
G Oga O-GlcNAcase TAS RGD PMID:18445751 RGD:2311625 NCBI chr 1:254,547,311...254,589,596
Ensembl chr 1:254,547,311...254,582,855 		JBrowse link
G Ogt O-linked N-acetylglucosamine (GlcNAc) transferase ISO
TAS 		RGD PMID:15466941 PMID:18445751 RGD:1625539, RGD:2311625 NCBI chr  X:70,811,317...70,856,123
Ensembl chr  X:70,811,319...70,856,123 		JBrowse link
G Pgm3 phosphoglucomutase 3 ISO RGD PMID:15466941 RGD:1625539 NCBI chr 8:96,398,331...96,416,045
Ensembl chr 8:96,398,269...96,416,021 		JBrowse link
G Uap1 UDP-N-acetylglucosamine pyrophosphorylase 1 ISO RGD PMID:15466941 RGD:1625539 NCBI chr13:84,875,719...84,910,706
Ensembl chr13:84,875,719...84,910,239
Ensembl chr 6:84,875,719...84,910,239 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  pathway 6091
    classic metabolic pathway 1853
      carbohydrate metabolic pathway 526
        amino sugar metabolic pathway 50
          hexosamine metabolic pathway 7
            hexosamine biosynthetic pathway 7
Path 2
Term Annotations click to browse term
  pathway 6091
    regulatory pathway 3864
      homeostasis pathway 1772
        organic chemical homeostasis pathway 767
          glucose homeostasis pathway 344
            glucose utilization pathway 121
              glucose conversion pathway 7
                hexosamine biosynthetic pathway 7
paths to the root