Pi4ka (phosphatidylinositol 4-kinase alpha) - Rat Genome Database

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Pathways
Gene: Pi4ka (phosphatidylinositol 4-kinase alpha) Chinchilla lanigera
Analyze
Symbol: Pi4ka
Name: phosphatidylinositol 4-kinase alpha
RGD ID: 8866730
Description: ENCODES a protein that exhibits 1-phosphatidylinositol 4-kinase activity (ortholog); INVOLVED IN actin cytoskeleton organization (ortholog); host-mediated perturbation of viral process (ortholog); myelination in peripheral nervous system (ortholog); PARTICIPATES IN inositol metabolic pathway; phosphoinositide metabolic pathway; ASSOCIATED WITH Gastrointestinal Defects and Immunodeficiency Syndrome 2 (ortholog); genetic disease (ortholog); hereditary spastic paraplegia 84 (ortholog); FOUND IN cytoplasm (ortholog); Golgi-associated vesicle membrane (ortholog); plasma membrane (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: phosphatidylinositol 4-kinase, catalytic, alpha
RGD Orthologs
Human
Mouse
Rat
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: ChiLan1.0 - Chinchilla ChiLan1.0 Assembly
Position:
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495544219,446,955 - 19,598,725 (+)Ensembl
ChiLan1.0NW_00495544219,446,955 - 19,594,790 (+)NCBIChiLan1.0ChiLan1.0
JBrowse:




Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Transitive Annotation Pipeline Automated assignment of GO, PW and RDO ISO annotations across species
Additional References at PubMed
PMID:30032202  


Genomics

Comparative Map Data
Pi4ka
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495544219,446,955 - 19,598,725 (+)Ensembl
ChiLan1.0NW_00495544219,446,955 - 19,594,790 (+)NCBIChiLan1.0ChiLan1.0
PI4KA
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382220,707,691 - 20,858,811 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl2220,707,691 - 20,859,417 (-)Ensemblhg38GRCh38
GRCh372221,061,979 - 21,213,099 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 362219,391,979 - 19,543,070 (-)NCBIBuild 36Build 36hg18NCBI36
Build 342219,386,544 - 19,517,555NCBI
Celera224,557,005 - 4,704,409 (-)NCBICelera
Celera225,492,598 - 5,494,284 (+)NCBICelera
Cytogenetic Map22q11.21NCBI
HuRef224,329,838 - 4,481,241 (-)NCBIHuRef
CHM1_12221,062,151 - 21,213,286 (-)NCBICHM1_1
T2T-CHM13v2.02221,116,400 - 21,267,532 (-)NCBIT2T-CHM13v2.0
Pi4ka
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391617,098,215 - 17,224,178 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1617,098,215 - 17,224,178 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm381617,280,351 - 17,406,314 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1617,280,351 - 17,406,314 (-)Ensemblmm10GRCm38
MGSCv371617,280,444 - 17,406,407 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv361617,193,915 - 17,319,877 (-)NCBIMGSCv36mm8
Celera1617,853,225 - 17,979,271 (-)NCBICelera
Cytogenetic Map16A3NCBI
cM Map1610.71NCBI
Pi4ka
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81197,113,390 - 97,234,374 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1197,113,245 - 97,228,315 (+)EnsemblGRCr8
mRatBN7.21183,609,148 - 83,726,876 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1183,609,069 - 83,724,080 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1192,336,920 - 92,454,084 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01184,998,070 - 85,115,233 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01184,051,678 - 84,168,839 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Dahl_SR_JrHsd1198,977,410 - 99,092,429 (+)NCBIDahl_SR_JrHsd
Lyon_Normotensive1197,173,798 - 97,288,586 (+)NCBILyon_Normotensive
Lyon_Hypertensive1198,098,078 - 98,213,099 (+)NCBILyon_Hypertensive
F344_StmMcwi1196,903,692 - 97,018,486 (+)NCBIF344_StmMcwi
Rnor_6.01187,858,323 - 87,975,549 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1187,858,453 - 87,973,422 (+)Ensemblrn6Rnor6.0
Rnor_5.01190,914,592 - 91,028,242 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41185,610,281 - 85,726,603 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1182,373,025 - 82,486,238 (+)NCBICelera
RGSC_v3.11185,650,877 - 85,767,200 (+)NCBI
Cytogenetic Map11q23NCBI
PI4KA
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22330,414,241 - 30,565,263 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12232,963,144 - 33,114,773 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0222,931,523 - 3,082,475 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PI4KA
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12630,630,693 - 30,749,158 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2630,630,261 - 30,749,126 (+)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha2630,589,065 - 30,707,530 (+)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.02632,039,270 - 32,155,774 (+)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2632,038,805 - 32,155,769 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12630,085,016 - 30,204,201 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02629,709,699 - 29,828,234 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02630,798,988 - 30,918,013 (+)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Pi4ka
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405118140,376,969 - 140,513,432 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049366192,240,266 - 2,377,093 (-)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049366192,240,641 - 2,377,088 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
PI4KA
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1450,390,410 - 50,491,944 (-)EnsemblsusScr11Sscrofa11.1
Sscrofa11.11450,390,416 - 50,491,983 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21453,838,856 - 53,940,687 (-)NCBISscrofa10.2Sscrofa10.2susScr3
PI4KA
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1194,648,184 - 4,797,573 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl194,648,183 - 4,797,396 (-)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_0236660852,209,589 - 2,351,629 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Pi4ka
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_004624945837,864 - 1,014,684 (+)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_004624945837,877 - 1,016,041 (+)NCBIHetGla 1.0HetGla 1.0hetGla2
Pi4ka
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v142,550,135 - 2,662,882 (-)NCBIRrattus_CSIRO_v1


Expression

RNA-SEQ Expression


Sequence


Ensembl Acc Id: ENSCLAT00000024904   ⟹   ENSCLAP00000024666
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0 EnsemblNW_00495544219,446,955 - 19,598,725 (+)Ensembl
Ensembl Acc Id: ENSCLAT00000024905   ⟹   ENSCLAP00000024667
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0 EnsemblNW_00495544219,446,967 - 19,598,725 (+)Ensembl
RefSeq Acc Id: XM_005391836   ⟹   XP_005391893
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0NW_00495544219,446,955 - 19,594,790 (+)NCBI
Sequence:
RefSeq Acc Id: XM_005391837   ⟹   XP_005391894
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0NW_00495544219,473,379 - 19,594,790 (+)NCBI
Sequence:
Protein Sequences
Protein RefSeqs XP_005391893 (Get FASTA)   NCBI Sequence Viewer  
  XP_005391894 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSCLAP00000024666
  ENSCLAP00000024666.1
  ENSCLAP00000024667.1
RefSeq Acc Id: XP_005391893   ⟸   XM_005391836
- Peptide Label: isoform X1
- UniProtKB: A0A8C2YUQ0 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_005391894   ⟸   XM_005391837
- Peptide Label: isoform X2
- UniProtKB: A0A8C2W488 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSCLAP00000024667   ⟸   ENSCLAT00000024905
Ensembl Acc Id: ENSCLAP00000024666   ⟸   ENSCLAT00000024904
Protein Domains
PI3K/PI4K catalytic   PIK helical


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCLAG00000016938 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSCLAT00000024904 ENTREZGENE
  ENSCLAT00000024904.1 UniProtKB/TrEMBL
  ENSCLAT00000024905.1 UniProtKB/TrEMBL
Gene3D-CATH 1.10.1070.11 UniProtKB/TrEMBL
  1.25.40.70 UniProtKB/TrEMBL
  Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 4 UniProtKB/TrEMBL
InterPro ARM-type_fold UniProtKB/TrEMBL
  Kinase-like_dom_sf UniProtKB/TrEMBL
  PI3/4_kinase_cat_dom UniProtKB/TrEMBL
  PI3/4_kinase_cat_sf UniProtKB/TrEMBL
  PI3/4_kinase_CS UniProtKB/TrEMBL
  PI3K_accessory_dom UniProtKB/TrEMBL
  PI3K_accessory_sf UniProtKB/TrEMBL
  PI4K_N UniProtKB/TrEMBL
  PI_Kinase UniProtKB/TrEMBL
NCBI Gene Pi4ka ENTREZGENE
PANTHER PHOSPHATIDYLINOSITOL 4-KINASE ALPHA UniProtKB/TrEMBL
  PTHR10048 UniProtKB/TrEMBL
Pfam PI3_PI4_kinase UniProtKB/TrEMBL
  PI3Ka UniProtKB/TrEMBL
  PI4K_N UniProtKB/TrEMBL
PROSITE PI3_4_KINASE_1 UniProtKB/TrEMBL
  PI3_4_KINASE_2 UniProtKB/TrEMBL
  PI3_4_KINASE_3 UniProtKB/TrEMBL
  PIK_HELICAL UniProtKB/TrEMBL
SMART PI3Ka UniProtKB/TrEMBL
  PI3Kc UniProtKB/TrEMBL
Superfamily-SCOP SSF48371 UniProtKB/TrEMBL
  SSF56112 UniProtKB/TrEMBL
UniProt A0A8C2W488 ENTREZGENE, UniProtKB/TrEMBL
  A0A8C2YUQ0 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-08-03 Pi4ka  phosphatidylinositol 4-kinase alpha    phosphatidylinositol 4-kinase, catalytic, alpha  Symbol and/or name change 5135510 APPROVED